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Results: 37
From the King’s Hunt to the Ladies’ Cavalcade
Valerio Zanetti
Nov 27, 2019
Published by: The Court Historian
Holding the Reins
Valerio Zanetti
Apr 15, 2020
Effects of an innovative densification process on mechanical and physical properties of beech and Norway spruce veneers
Abstract Increased wood density is obtained by compressing the wood porous structure under suitable moisture and temperature conditions to improve its physical, mechanical and color properties. A...
Rotating group design for vane pump flow ripple reduction
It is well known that the hydraulic pump is the main source of noise in hydraulic power steering systems. This noise is produced by the pulsating flow transmitted through the fluid due to the cyclic pumping mechanism. This flow...
Rotating group design for vane pump flow ripple reduction
It is well known that the hydraulic pump is the main source of noise in hydraulic power steering systems. This noise is produced by the pulsating flow transmitted through the fluid due to the cyclic pumping mechanism. This flow...
Urinary Albumin, Sodium, and Potassium and Cardiovascular Outcomes in the UK Biobank
Daniela Zanetti, Helene Bergman, Stephen Burgess, Themistocles L Assimes, Vivek Bhalla, Erik Ingelsson
Feb 10, 2020
Urinary biomarkers are associated with cardiovascular disease, but the nature of these associations is not well understood. We performed multivariable-adjusted regression models to assess associations of random spot measurements...
blood pressure Cardiovascular Diseases Coronary Artery Disease Heart Failure type 2 diabetes mellitus Adiposity Adult Aged Albuminuria Biomarkers Cardiovascular Diseases Causality Comorbidity Confounding Factors Epidemiologic Diabetes mellitus Type 2 Dyslipidemias Female Follow-Up Studies Genetic Pleiotropy Genome-Wide Association Study Humans Kidney Diseases Longitudinal Studies Male Middle Aged Polymorphism Single Nucleotide Potassium Proportional Hazards Models Risk Factors sodium United Kingdom
Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease
Daniela Zanetti, Emmi Tikkanen, Stefan Gustafsson, James R Priest, Stephen Burgess, Erik Ingelsson
Aug 16, 2018
BACKGROUND: Low birthweight has been associated with a higher risk of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease. The Barker hypothesis posits that intrauterine growth restriction resulting in lower...
cardiovascular disease Diabetes mellitus Type 2 Genetics Hypertension obesity Adult Aged Birth Weight Blood Glucose blood pressure Body Mass Index Cardiovascular Diseases Diabetes mellitus Type 2 Female Genome-Wide Association Study Humans Incidence Male Mendelian Randomization Analysis Middle Aged Observational Studies as Topic Risk Factors United States
Techniques and future perspectives for the prevention and treatment of endoleaks after endovascular repair of abdominal aortic aneurysms.
Gianluigi Orgera, Marcello Andrea Tipaldi, Florindo Laurino, Pierleone Lucatelli, Alberto Rebonato, Ioannis Paraskevopoulos, Michele Rossi, Miltiadis Krokidis
Sep 22, 2020
The presence of endoleaks remains one of the main drawbacks of endovascular repair of abdominal aortic aneurysms leading to the increase of the size of the aneurysmal sac and in most of the cases to repeated interventions. A...
Structural basis of synaptic vesicle assembly promoted by α-synuclein.
Giuliana Fusco, Tillmann Pape, Amberley D Stephens, Pierre Mahou, Ana Rita Costa, Clemens F Kaminski, Gabriele S Kaminski Schierle, Michele Vendruscolo, Gianluigi Veglia, Christopher M Dobson, Alfonso De Simone
Mar 04, 2020
α-synuclein (αS) is an intrinsically disordered protein whose fibrillar aggregates are the major constituents of Lewy bodies in Parkinson's disease. Although the specific function of αS is still unclear, a general consensus is...
The Metabolomics Society-Current State of the Membership and Future Directions.
Krista A Zanetti, Robert D Hall, Julian L Griffin, Sastia Putri, Reza M Salek, Mark P Styczynski, Fidele Tugizimana, Justin JJ van der Hooft
Jul 18, 2019
Background: In 2017, the Metabolomics Society conducted a survey among its members to assess the degree of its current success, define opportunities for improving its service to the community and make plans to establish future...
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases.
Michael A Metrick, Natália do Carmo Ferreira, Eri Saijo, Allison Kraus, Kathy Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Ghetti, Byron Caughey
Mar 09, 2020
Multiple neurodegenerative diseases are characterized by aggregation of tau molecules. Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding repeats (3R or 4R tau). Different diseases involve...
Alzheimer Disease Chronic Traumatic Encephalopathy neurodegeneration Pick disease Primary age-related tauopathy protein misfolding RT-QuIC Seed Tau Adult Aged Aged 80 and over Alzheimer Disease Biological Assay Biomarkers Brain Female Humans Male Middle Aged Pick Disease of the Brain protein aggregation Pathological tau Proteins
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases
Michael A. Metrick, Natália do Carmo Ferreira, Eri Saijo, Allison Kraus, Kathy Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Ghetti, Byron Caughey
Jun 06, 2020
Abstract: Multiple neurodegenerative diseases are characterized by aggregation of tau molecules. Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding repeats (3R or 4R tau). Different diseases...
Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents
Christophe Chipot, François Dehez, Jason R Schnell, Nicole Zitzmann, Eva Pebay-Peyroula, Laurent J Catoire, Bruno Miroux, Edmund RS Kunji, Gianluigi Veglia, Timothy A Cross, Paul Schanda
Apr 23, 2018
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular mechanisms whereby they fulfill these functions requires detailed biophysical and structural investigations. Detergents have proven pivotal...
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases
Michael A., II Metrick, Natália do Carmo Ferreira, Eri Saijo, Allison Kraus, Kathy Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Ghetti, Byron Caughey
Feb 21, 2021
Abstract: Multiple neurodegenerative diseases are characterized by aggregation of tau molecules. Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding repeats (3R or 4R tau). Different diseases...
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases.
Michael A Metrick, Natália do Carmo Ferreira, Eri Saijo, Allison Kraus, Kathy Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Ghetti, Byron Caughey
Mar 26, 2020
Multiple neurodegenerative diseases are characterized by aggregation of tau molecules. Adult humans express six isoforms of tau that contain either 3 or 4 microtubule binding repeats (3R or 4R tau). Different diseases involve...
Seed Alzheimer Disease Tau neurodegeneration protein misfolding RT-QuIC Chronic Traumatic Encephalopathy Primary age-related tauopathy Pick disease
Published by: Acta neuropathologica communications
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy.
Cristina Olivieri, Geoffrey C Li, Yingjie Wang, Manu V S, Caitlin Walker, Jonggul Kim, Carlo Camilloni, Alfonso De Simone, Michele Vendruscolo, David A Bernlohr, Susan S Taylor, Gianluigi Veglia
Sep 02, 2022
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate...
A global sampler of single particle tracking solutions for single molecule microscopy.
Michael Hirsch, Richard Wareham, Ji W Yoon, Daniel J Rolfe, Laura C Zanetti-Domingues, Michael P Hobson, Peter J Parker, Marisa L Martin-Fernandez, Sumeetpal S Singh
Sep 09, 2019
The dependence on model-fitting to evaluate particle trajectories makes it difficult for single particle tracking (SPT) to resolve the heterogeneous molecular motions typical of cells. We present here a global spatiotemporal...
Making sense of big data in health research
Charles Auffray, Rudi Balling, Inês Barroso, László Bencze, Mikael Benson, Jay Bergeron, Enrique Bernal-Delgado, Niklas Blomberg, Christoph Bock, Ana Conesa, Susanna Del Signore, Christophe Delogne, Peter Devilee, Alberto Di Meglio, Marinus Eijkemans, Paul Flicek, Norbert Graf, Vera Grimm, Henk-Jan Guchelaar, Yi-Ke Guo, Ivo Glynne Gut, Allan Hanbury, Shahid Hanif, Ralf-Dieter Hilgers, Ángel Honrado, D Rod Hose, Jeanine Houwing-Duistermaat, Tim Hubbard, Sophie Helen Janacek, Haralampos Karanikas, Tim Kievits, Manfred Kohler, Andreas Kremer, Jerry Lanfear, Thomas Lengauer, Edith Maes, Theo Meert, Werner Müller, Dörthe Nickel, Peter Oledzki, Bertrand Pedersen, Milan Petkovic, Konstantinos Pliakos, Magnus Rattray, Josep Redón I Màs, Reinhard Schneider, Thierry Sengstag, Xavier Serra-Picamal, Wouter Spek, Lea AI Vaas, Okker van Batenburg, Marc Vandelaer, Peter Varnai, Pablo Villoslada, Juan Antonio Vizcaíno, John Peter Mary Wubbe, Gianluigi Zanetti
Jul 26, 2019
Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with...
The future of metabolomics in ELIXIR.
Merlijn van Rijswijk, Charlie Beirnaert, Christophe Caron, Marta Cascante, Victoria Dominguez, Warwick B Dunn, Timothy MD Ebbels, Franck Giacomoni, Alejandra Gonzalez-Beltran, Thomas Hankemeier, Kenneth Haug, Jose L Izquierdo-Garcia, Rafael C Jimenez, Fabien Jourdan, Namrata Kale, Maria I Klapa, Oliver Kohlbacher, Kairi Koort, Kim Kultima, Gildas Le Corguillé, Pablo Moreno, Nicholas K Moschonas, Steffen Neumann, Claire O'Donovan, Martin Reczko, Philippe Rocca-Serra, Antonio Rosato, Reza M Salek, Susanna-Assunta Sansone, Venkata Satagopam, Daniel Schober, Ruth Shimmo, Rachel A Spicer, Ola Spjuth, Etienne A Thévenot, Mark R Viant, Ralf JM Weber, Egon L Willighagen, Gianluigi Zanetti, Christoph Steinbeck
Jan 19, 2018
Metabolomics, the youngest of the major omics technologies, is supported by an active community of researchers and infrastructure developers across Europe. To coordinate and focus efforts around infrastructure building for...
PhenoMeNal
Kristian Peters, James Bradbury, Sven Bergmann, Marco Capuccini, Marta Cascante, Pedro de Atauri, Timothy MD Ebbels, Carles Foguet, Robert Glen, Alejandra Gonzalez-Beltran, Ulrich L Günther, Evangelos Handakas, Thomas Hankemeier, Kenneth Haug, Stephanie Herman, Petr Holub, Massimiliano Izzo, Daniel Jacob, David Johnson, Fabien Jourdan, Namrata Kale, Ibrahim Karaman, Bita Khalili, Payam Emami Khonsari, Kim Kultima, Samuel Lampa, Anders Larsson, Christian Ludwig, Pablo Moreno, Steffen Neumann, Jon Ander Novella, Claire O'Donovan, Jake TM Pearce, Alina Peluso, Marco Enrico Piras, Luca Pireddu, Michelle AC Reed, Philippe Rocca-Serra, Pierrick Roger, Antonio Rosato, Rico Rueedi, Christoph Ruttkies, Noureddin Sadawi, Reza M Salek, Susanna-Assunta Sansone, Vitaly Selivanov, Ola Spjuth, Daniel Schober, Etienne A Thévenot, Mattia Tomasoni, Merlijn van Rijswijk, Michael van Vliet, Mark R Viant, Ralf JM Weber, Gianluigi Zanetti, Christoph Steinbeck
Jan 02, 2019
BACKGROUND: Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism's metabolism. The research field is dynamic and expanding with applications across biomedical...
Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress
Luiza Mendonça, Andrew Howe, James B. Gilchrist, Yuewen Sheng, Dapeng Sun, Michael L. Knight, Laura C. Zanetti-Domingues, Benji Bateman, Anna-Sophia Krebs, Long Chen, Julika Radecke, Vivian D. Li, Tao Ni, Ilias Kounatidis, Mohamed A. Koronfel, Marta Szynkiewicz, Maria Harkiolaki, Marisa L. Martin-Fernandez, William James, Peijun Zhang
Jul 30, 2021
Abstract: Since the outbreak of the SARS-CoV-2 pandemic, there have been intense structural studies on purified viral components and inactivated viruses. However, structural and ultrastructural evidence on how the SARS-CoV-2...
Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress.
Luiza Mendonça, Andrew Howe, James B Gilchrist, Yuewen Sheng, Dapeng Sun, Michael L Knight, Laura C Zanetti-Domingues, Benji Bateman, Anna-Sophia Krebs, Long Chen, Julika Radecke, Vivian D Li, Tao Ni, Ilias Kounatidis, Mohamed A Koronfel, Marta Szynkiewicz, Maria Harkiolaki, Marisa L Martin-Fernandez, William James, Peijun Zhang
Aug 31, 2021
Anorectal emergencies
Antonio Tarasconi, Gennaro Perrone, Justin Davies, Raul Coimbra, Ernest Moore, Francesco Azzaroli, Hariscine Abongwa, Belinda De Simone, Gaetano Gallo, Giorgio Rossi, Fikri Abu-Zidan, Vanni Agnoletti, Gianluigi de’Angelis, Nicola de’Angelis, Luca Ansaloni, Gian Luca Baiocchi, Paolo Carcoforo, Marco Ceresoli, Alain Chichom-Mefire, Salomone Di Saverio, Federica Gaiani, Mario Giuffrida, Andreas Hecker, Kenji Inaba, Michael Kelly, Andrew Kirkpatrick, Yoram Kluger, Ari Leppäniemi, Andrey Litvin, Carlos Ordoñez, Vittoria Pattonieri, Andrew Peitzman, Manos Pikoulis, Boris Sakakushev, Massimo Sartelli, Vishal Shelat, Edward Tan, Mario Testini, George Velmahos, Imtiaz Wani, Dieter Weber, Walter Biffl, Federico Coccolini, Fausto Catena
Sep 16, 2021
Abstract: Anorectal emergencies comprise a wide variety of diseases that share common symptoms, i.e., anorectal pain or bleeding and might require immediate management. While most of the underlying conditions do not need...
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