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Results: 71
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Jue-Sheng Ong, Jiyuan An, Xikun Han, Matthew H Law, Priyanka Nandakumar, 23andMe Research Team, Esophageal Cancer Consortium, Johannes Schumacher, Ines Gockel, Anne Bohmer, Janusz Jankowski, Claire Palles, Catherine M Olsen, Rachel E Neale, Rebecca Fitzgerald, Aaron P Thrift, Thomas L Vaughan, Matthew F Buas, David A Hinds, Puya Gharahkhani, Bradley J Kendall, Stuart MacGregor
Jul 28, 2021
OBJECTIVE: Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with...
Determinants of gastroesophageal reflux disease, including hookah smoking and opium use- a cross-sectional analysis of 50,000 individuals.
Farhad Islami, Siavosh Nasseri-Moghaddam, Akram Pourshams, Hossein Poustchi, Shahryar Semnani, Farin Kamangar, Arash Etemadi, Shahin Merat, Masoud Khoshnia, Sanford M Dawsey, Paul D Pharoah, Paul Brennan, Christian C Abnet, Paolo Boffetta, Reza Malekzadeh
Sep 21, 2018
BACKGROUND: Gastroesophageal reflux disease (GERD) is a common cause of discomfort and morbidity worldwide. However, information on determinants of GERD from large-scale studies in low- to medium-income countries is limited. We...
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases.
Jiyuan An, Puya Gharahkhani, Matthew H Law, Jue-Sheng Ong, Xikun Han, Catherine M Olsen, Rachel E Neale, John Lai, Tom L Vaughan, Ines Gockel, René Thieme, Anne C Böhmer, Janusz Jankowski, Rebecca C Fitzgerald, Johannes Schumacher, Claire Palles, BEACON, 23andMe Research Team, David C Whiteman, Stuart MacGregor
Oct 03, 2019
Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has high prevalence and is the major risk factor for Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). We conduct a large...
A Structural Basis for Host Cytoskeletal Disruption and Virulence by Yersinia Protein Kinase A
Gerd Prehna
Jan 01, 0001
Yersinia spp. cause gastroenteritis and the plague, representing historically devastating pathogens that are currently an important biodefense and antibiotic resistance concern. Although several antibiotic therapies exist, the...
Published by: Rockefeller University
Detailed investigation of overwash on a gravel barrier
This paper uses results obtained from a prototype-scale experiment (Barrier Dynamics Experiment; BARDEX) undertaken in the Delta flume, the Netherlands, to investigate overwash hydraulics and morphodynamics of a prototype gravel...
Reply to commentaries on “Transparent modelling of influenza incidence”
We structure this response to the commentaries to our article “Transparent modeling of influenza incidence: Big data or a single data point from psychological theory?” around the concept of psychological AI, Herbert Simon's...
Research advances in esophageal diseases
Over the last year, significant steps have been made toward understanding the pathogenesis of esophageal diseases and translating this knowledge to clinical practice. Gastroesophageal reflux disease (GERD) is the most common...
Transparent modeling of influenza incidence:
Simple, transparent rules are often frowned upon while complex, black-box models are seen as holding greater promise. Yet in quickly changing situations, simple rules can protect against overfitting and adapt quickly. We show...
Transparent modeling of influenza incidence:
Simple, transparent rules are often frowned upon while complex, black-box models are seen as holding greater promise. Yet in quickly changing situations, simple rules can protect against overfitting and adapt quickly. We show...
International chemical identifier for reactions (RInChI).
The Reaction InChI (RInChI) extends the idea of the InChI, which provides a unique descriptor of molecular structures, towards reactions. Prototype versions of the RInChI have been available since 2011. The first official...
Reply to commentaries on “Transparent modelling of influenza incidence”
We structure this response to the commentaries to our article “Transparent modeling of influenza incidence: Big data or a single data point from psychological theory?” around the concept of psychological AI, Herbert Simon's...
Comprehensive field study of swash-zone processes, part 2
Thijs Lanckriet, Jack A. Puleo, Gerd Masselink, Ian L. Turner, Daniel Conley, C Blenkinsopp, Paul Russell
Jan 01, 2014
Sheet flow sediment concentration profiles were measured in natural conditions for the first time as part of a comprehensive field study on swash-zone hydrodynamics and sediment transport. Three conductivity concentration...
Performance of a dynamic cobble berm revetment for coastal protection, under increasing water level.
Paul Bayle, Chris Blenkinsopp, Daniel Conley, Gerd Masselink, Tomas Beuzen, Rafael Almar
Aug 31, 2020
In a changing climate, sea level rise and projected regional–scale changes in storminess may increase the vulnerability of sandy coastlines to coastal erosion and flooding. As a result, there is increased interest in the...
Elucidating the mechanisms underlying GATA-1 activity
Roland Gamsjaeger, Ana Silva, Nicholas Shepherd, Lorna Wilkinson-White, Ernest Laue, Gerd Blobel, Jacgui Matthews, Joel Mackav
Mar 18, 2013
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
Detailed investigation of overwash on a gravel barrier
This paper uses results obtained from a prototype-scale experiment (Barrier Dynamics Experiment; BARDEX) undertaken in the Delta flume, the Netherlands, to investigate overwash hydraulics and morphodynamics of a prototype gravel...
Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants.
Jing Dong, Matthew F Buas, Puya Gharahkhani, Bradley J Kendall, Lynn Onstad, Shanshan Zhao, Lesley A Anderson, Anna H Wu, Weimin Ye, Nigel C Bird, Leslie Bernstein, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Paul D Pharoah, Harvey A Risch, Prasad G Iyer, Brian J Reid, Laura J Hardie, Jesper Lagergren, Nicholas J Shaheen, Douglas A Corley, Rebecca C Fitzgerald, Stomach and Oesophageal Cancer Study (SOCS) consortium, David C Whiteman, Thomas L Vaughan, Aaron P Thrift
Feb 23, 2018
BACKGROUND & AIMS: We developed comprehensive models to determine risk of Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC) based on genetic and non-genetic factors. METHODS: We used pooled data from 3288 patients with...
BEACON Environmental Exposures neoplasm SNP Adenocarcinoma Area Under Curve Australia Barrett Esophagus Case-Control Studies Databases Factual Decision Support Techniques Esophageal Neoplasms Europe Female Gene-Environment Interaction Genetic Predisposition to Disease Genome-Wide Association Study Humans Life Style Logistic Models Male Middle Aged Models Genetic molecular epidemiology Multifactorial Inheritance North America Odds Ratio Phenotype Polymorphism Single Nucleotide Predictive Value of Tests ROC Curve Risk Assessment Risk Factors
Diagnosis and management of Sandifer syndrome in children with intractable neurological symptoms.
Irina Mindlina
Feb 11, 2020
Sandifer syndrome is a rare complication of gastro-oesophageal reflux disease (GERD) when a patient presents with extraoesophageal symptoms, typically neurological. The aim of this study was to review the existing literature and...
Published by: European journal of pediatrics
Comprehensive field study of swash-zone processes, part 2
Thijs Lanckriet, Jack A. Puleo, Gerd Masselink, Ian L. Turner, Daniel Conley, C Blenkinsopp, Paul Russell
Jan 01, 2014
Sheet flow sediment concentration profiles were measured in natural conditions for the first time as part of a comprehensive field study on swash-zone hydrodynamics and sediment transport. Three conductivity concentration...
Primary prevention of overweight and obesity in adolescents
Summary The aim of this overview of systematic reviews was to summarize evidence from up-to-date reviews of the effectiveness of interventions aimed at preventing overweight and obesity in adolescents aged 10 to 19 years. We...
Performance of a dynamic cobble berm revetment for coastal protection, under increasing water level.
Paul Bayle, Chris Blenkinsopp, Daniel Conley, Gerd Masselink, Tomas Beuzen, Rafael Almar
Aug 31, 2020
In a changing climate, sea level rise and projected regional–scale changes in storminess may increase the vulnerability of sandy coastlines to coastal erosion and flooding. As a result, there is increased interest in the...
Towards a cancer mission in Horizon Europe
Anton Berns, Ulrik Ringborg, Julio E Celis, Manuel Heitor, Neil K Aaronson, Nancy Abou-Zeid, Hans-Olov Adami, Kathi Apostolidis, Michael Baumann, Alberto Bardelli, René Bernards, Yvonne Brandberg, Carlos Caldas, Fabien Calvo, Caroline Dive, Angelika Eggert, Alexander Eggermont, Carolina Espina, Frederik Falkenburg, Jérôme Foucaud, Douglas Hanahan, Ulrike Helbig, Bengt Jönsson, Mette Kalager, Sakari Karjalainen, Miklós Kásler, Pamela Kearns, Klas Kärre, Denis Lacombe, Francesco de Lorenzo, Françoise Meunier, Gerd Nettekoven, Simon Oberst, Péter Nagy, Thierry Philip, Richard Price, Joachim Schüz, Eric Solary, Peter Strang, Josep Tabernero, Emile Voest
Sep 04, 2020
A comprehensive translational cancer research approach focused on personalized and precision medicine, and covering the entire cancer research-care-prevention continuum has the potential to achieve in 2030 a 10-year...
Diagnosis and management of Sandifer syndrome in children with intractable neurological symptoms.
Irina Mindlina
Jan 23, 2020
Sandifer syndrome is a rare complication of gastro-oesophageal reflux disease (GERD) when a patient presents with extraoesophageal symptoms, typically neurological. The aim of this study was to review the existing literature and...
Gastro-oesophageal Reflux Disease Intractable Neurological Symptoms Misdiagnosis Sandifer Syndrome Anemia Iron-Deficiency Brain Diseases Child Developmental Disabilities Diagnosis Differential Diagnostic Errors Female Gastroesophageal Reflux Humans Male Peripheral Nervous System Diseases Risk Assessment Severity of Illness Index Torticollis Treatment Outcome United Kingdom
Endoscopic measurement of gastric pH associates with persistent acid reflux in patients treated with proton-pump inhibitors for gastroesophageal reflux disease.
Wladyslaw Januszewicz, James Hartley, William Waldock, Geoffrey Roberts, Bincy Alias, Anthony Hobson, Lorenz Wernisch, Massimiliano di Pietro
Aug 13, 2020
BACKGROUND: Proton-pump inhibitors (PPIs) are the mainstay of gastroesophageal reflux disease (GERD) treatment, however, up to 30% of patients have a poor symptomatic response. PH-impedance is the gold standard to assess whether...
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