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Results: 90
Converging evidence points towards a role of insulin signaling in regulating compulsive behavior.
Ilse IGM van de Vondervoort, Houshang Amiri, Muriel MK Bruchhage, Charlotte A Oomen, Nitin Rustogi, Jason D Cooper, Jack JA van Asten, Arend Heerschap, Sabine Bahn, Steven Cr Williams, Jan K Buitelaar, Geert Poelmans, Jeffrey C Glennon
Sep 11, 2020
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we...
Animals Anxiety Blood Glucose Brain Brain-Derived Neurotrophic Factor Compulsive Behavior Diabetes mellitus Type 2 Diffusion tensor imaging Disease Models Animal Insulin Insulin-Like Growth Factor I KCNQ1 Potassium Channel Magnetic Resonance Spectroscopy Mice Proteomics Signal Transduction white matter
Excitatory/inhibitory imbalance in autism
Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan GM Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily JH Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaijen
Jan 21, 2023
Social and non-social autism symptoms and trait domains are genetically dissociable
Varun Warrier, Roberto Toro, Hyejung Won, Claire S. Leblond, Freddy Cliquet, Richard Delorme, Ward De Witte, Janita Bralten, Bhismadev Chakrabarti, Anders D. Børglum, Jakob Grove, Geert Poelmans, David A. Hinds, Thomas Bourgeron, Simon Baron-Cohen
Sep 02, 2020
Abstract: The core diagnostic criteria for autism comprise two symptom domains – social and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to...
Ten false beliefs in neurocritical care.
In acute brain injury, the need for specific expertise on central nervous pathophysiology is evident. However, even when the primary reason for ICU admission is extracranial, the brain may be affected too, through inadequate...
The efficacy of attentional distraction and sensory monitoring in chronic pain patients
Attentional strategies, such as distraction and sensory monitoring, are often offered to reduce pain and pain-related distress. However, evidence for their efficacy in chronic pain patients is equivocal. We report a...
The efficacy of attentional distraction and sensory monitoring in chronic pain patients
Attentional strategies, such as distraction and sensory monitoring, are often offered to reduce pain and pain-related distress. However, evidence for their efficacy in chronic pain patients is equivocal. We report a...
Methods for studying naturally occurring human pain and their analogues
Methods for investigating human pain have been developed over the last 100 years. Typically, researchers focus on people with clinical pain, or on healthy participants undergoing laboratory-controlled pain-induction techniques...
The experience of cognitive intrusion of pain
Nina Attridge, Geert Crombez, Dimitri Van Ryckeghem, Edmund Keogh, Christopher Eccleston
Oct 31, 2015
Patients with chronic pain often report their cognition to be impaired by pain, and this observation has been supported by numerous studies measuring the effects of pain on cognitive task performance. Furthermore, cognitive...
The experience of cognitive intrusion of pain
Nina Attridge, Geert Crombez, Dimitri Van Ryckeghem, Edmund Keogh, Christopher Eccleston
Oct 31, 2015
Patients with chronic pain often report their cognition to be impaired by pain, and this observation has been supported by numerous studies measuring the effects of pain on cognitive task performance. Furthermore, cognitive...
Excitatory/inhibitory imbalance in autism
Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan GM Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily JH Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaijen
Feb 21, 2023
The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism. However, how E/I imbalance...
Methods for studying naturally occurring human pain and their analogues
Methods for investigating human pain have been developed over the last 100 years. Typically, researchers focus on people with clinical pain, or on healthy participants undergoing laboratory-controlled pain-induction techniques...
A deep learning approach to bilingual lexicon induction in the biomedical domain.
BACKGROUND: Bilingual lexicon induction (BLI) is an important task in the biomedical domain as translation resources are usually available for general language usage, but are often lacking in domain-specific settings. In this...
Choosing Estimands in Clinical Trials
Bohdana Ratitch, James Bell, Craig Mallinckrodt, Jonathan W Bartlett, Niti Goel, Geert Molenberghs, Michael O'Kelly, Pritibha Singh, Ilya Lipkovich
Mar 01, 2020
The National Research Council (NRC) Expert Panel Report on Prevention and Treatment of Missing Data in Clinical Trials highlighted the need for clearly defining objectives and estimands. That report sparked considerable...
Ethylene Receptors, CTRs and EIN2 Target Protein Identification and Quantification Through Parallel Reaction Monitoring During Tomato Fruit Ripening.
Clara I Mata, Bertrand Fabre, Harriet T Parsons, Maarten LATM Hertog, Geert Van Raemdonck, Geert Baggerman, Bram Van de Poel, Kathryn S Lilley, Bart M Nicolaï
Feb 07, 2019
Ethylene, the plant ripening hormone of climacteric fruit, is perceived by ethylene receptors which is the first step in the complex ethylene signal transduction pathway. Much progress has been made in elucidating the mechanism...
Choosing Estimands in Clinical Trials
Bohdana Ratitch, James Bell, Craig Mallinckrodt, Jonathan W Bartlett, Niti Goel, Geert Molenberghs, Michael O'Kelly, Pritibha Singh, Ilya Lipkovich
Mar 01, 2020
The National Research Council (NRC) Expert Panel Report on Prevention and Treatment of Missing Data in Clinical Trials highlighted the need for clearly defining objectives and estimands. That report sparked considerable...
Continuously tuneable critical current in superconductor-ferromagnet multilayers
Peter Curran, Jangyong Kim, Nathan Satchell, James Witt, Gavin Burnell, Machiel Geert Flokstra, Steve Lee, Simon Bending
Jun 27, 2017
We demonstrate that the critical current of superconducting Nb/Ni multilayers can be continuously tuned by up to a factor of three during magnetization reversal of the Ni films under an applied in-plane magnetic field. Our...
Abundancy of polymorphic CGG repeats in the human genome suggest a broad involvement in neurological disease.
Dale J Annear, Geert Vandeweyer, Ellen Elinck, Alba Sanchis-Juan, Courtney E French, Lucy Raymond, R Frank Kooy
Jan 28, 2021
Alleles Computational Biology Genetic Association Studies Genetic Predisposition to Disease Genome Human Genomic Instability Humans Microsatellite Instability Molecular Sequence Annotation Nervous System Diseases Neurodevelopmental Disorders Polymorphism Genetic Trinucleotide Repeat Expansion Trinucleotide Repeats
Continuously tuneable critical current in superconductor-ferromagnet multilayers
Peter Curran, Jangyong Kim, Nathan Satchell, James Witt, Gavin Burnell, Machiel Geert Flokstra, Steve Lee, Simon Bending
Jun 27, 2017
We demonstrate that the critical current of superconducting Nb/Ni multilayers can be continuously tuned by up to a factor of three during magnetization reversal of the Ni films under an applied in-plane magnetic field. Our...
Tumors Widely Express Hundreds of Embryonic Germline Genes.
Jan Willem Bruggeman, Naoko Irie, Paul Lodder, Ans MM van Pelt, Jan Koster, Geert Hamer
Dec 22, 2020
We have recently described a class of 756 genes that are widely expressed in cancers, but are normally restricted to adult germ cells, referred to as germ cell cancer genes (GC genes). We hypothesized that carcinogenesis...
Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin
Steve Stegen, Ingrid Stockmans, Karen Moermans, Bernard Theinpont, Patrick H Maxwell, Peter Carmeliet, Geert Carmeliet
Oct 04, 2018
Acetylation Adaptor Proteins Signal Transducing Animals Bone Density Carbazoles Cell Line Coculture Techniques Disease Models Animal Epigenesis Genetic Female Glycoproteins Heterocyclic Compounds 4 or More Rings Humans Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Inducible Factor-Proline Dioxygenases Intercellular Signaling Peptides and Proteins Male Mice Inbred C57BL Mice Transgenic Osteocytes Osteogenesis Osteoporosis Oxygen Primary Cell Culture Promoter Regions Genetic Sirtuin 1 Wnt Signaling Pathway
Transcriptome Sequence of the Bloodstream Form of Trypanoplasma borreli, a Hematozoic Parasite of Fish Transmitted by Leeches.
Here, we report a transcriptome sequence of Trypanoplasma borreli isolated from its natural host, the common carp, Cyprinus carpio The transcriptome allows an analysis of abundant cell surface proteins and acts as a comparator...
Neurocomputational mechanisms underpinning aberrant social learning in young adults with low self-esteem.
Geert-Jan Will, Michael Moutoussis, Palee M Womack, Edward T Bullmore, Ian M Goodyer, Peter Fonagy, Peter B Jones, Robb B Rutledge, Raymond J Dolan
Apr 19, 2020
Low self-esteem is a risk factor for a range of psychiatric disorders. From a cognitive perspective a negative self-image can be maintained through aberrant learning about self-worth derived from social feedback. We previously...
Published by: Translational psychiatry
Defining Efficacy Estimands in Clinical Trials
Bohdana Ratitch, Niti Goel, Craig Mallinckrodt, James Bell, Jonathan W Bartlett, Geert Molenberghs, Pritibha Singh, Ilya Lipkovich, Michael O'Kelly
Apr 09, 2019
This paper provides examples of defining estimands in real-world scenarios following ICH E9(R1) guidelines. Detailed discussions on choosing the estimands and estimators can be found in our companion papers. Three scenarios...
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