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Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno.
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
MACROPHAGES Phagocytosis Actin Cytoskeleton Arf GTPases Wave regulatory complex host–pathogen interplay
Published by: International journal of molecular sciences
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
Arf6 Can Trigger Wave Regulatory Complex-Dependent Actin Assembly Independent of Arno.
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have...
SSBP1-Disease Update
Neringa Jurkute, Fabiana D'Esposito, Anthony G Robson, Robert DS Pitceathly, Francesca Cordeiro, F Lucy Raymond, Anthony T Moore, Michel Michaelides, Patrick Yu-Wai-Man, Andrew R Webster, Gavin Arno, Genomics England Research Consortium
Jan 28, 2022
Adolescent Amino Acid Sequence Child Preschool DNA Mitochondrial DNA-Binding Proteins Electroretinography Female Genes Recessive Genotyping Techniques Humans Male Middle Aged Mitochondrial Diseases Mitochondrial Proteins Molecular Conformation Molecular Sequence Data Mutation Missense Optic Atrophy Pedigree Penetrance Protein Stability Protein Structure Quaternary Retinal Dystrophies whole genome sequencing
Assessment of the incorporation of CNV surveillance into gene panel next-generation sequencing testing for inherited retinal diseases.
Jamie M Ellingford, Bradley Horn, Christopher Campbell, Gavin Arno, Stephanie Barton, Catriona Tate, Sanjeev Bhaskar, Panagiotis I Sergouniotis, Rachel L Taylor, Keren J Carss, Lucy FL Raymond, Michel Michaelides, Simon C Ramsden, Andrew R Webster, Graeme CM Black
Mar 23, 2018
BACKGROUND: Diagnostic use of gene panel next-generation sequencing (NGS) techniques is commonplace for individuals with inherited retinal dystrophies (IRDs), a highly genetically heterogeneous group of disorders. However, these...
copy-number variation inherited retinal disease Molecular genetics next-generation sequencing Adaptor Proteins Signal Transducing Algorithms Cytoskeletal Proteins DNA Copy Number Variations Gene Duplication Gene Frequency Genetic Predisposition to Disease High-Throughput Nucleotide Sequencing Humans Membrane Proteins Retinal Dystrophies Ribonucleoproteins Small Nuclear Workflow
There Is Sometimes A Buggy: Queering the Cowboy
Kelsey Gavin
Jan 01, 0001
For my honors thesis project and body of work for the Annual Student Exhibition 2022, I will be interpreting stills from David Lynch's movie Mulholland Drive, sourcing from a singular four-minute scene referred to as The Cowboy...
David Lynch Mulholland Drive Cowboy queer Adam Kesher painting Arts and Humanities Feminist, Gender, and Sexuality Studies Film and Media Studies Fine Arts Interdisciplinary Arts and Media painting
Published by: Ursinus College
The Nested Kingman Coalescent
The nested Kingman coalescent describes the ancestral tree of a population undergoing neutral evolution at the level of individuals and at the level of species, simultaneously. We study the speed at which the number of...
Social identity formation during the emergence of the Occupy movement
The Occupy movement made a series of local ‘sit-ins’ in cities across the world in response to financial and political injustices. Prior to the movement’s emergence, the Internet provided a transnational forum for people across...
Revenge pornography
Purpose: Drawing on gender-role stereotypes and defensive attribution theory, the purpose of this paper is to investigate the influence of perpetrator-victim sex, observer sex and observer sexting experience on perceptions of...
Attributions of victim responsibility in revenge pornography
Purpose: Revenge pornography is a growing risk among adolescents and young adults. Often stemming from sexting, some victims of revenge pornography report experiencing victim-blame similar to that accompanying the reporting...
Men’s perspectives on their grooming practices and appearance concerns
This mixed method study explores importance of and influences on men’s grooming behaviors and appearance concerns. Survey data from 83 men based in the United Kingdom showed high social media users engaged in significantly more...
Attributions of victim responsibility in revenge pornography
Purpose: Revenge pornography is a growing risk among adolescents and young adults. Often stemming from sexting, some victims of revenge pornography report experiencing victim-blame similar to that accompanying the reporting...
Revenge pornography
Purpose: Drawing on gender-role stereotypes and defensive attribution theory, the purpose of this paper is to investigate the influence of perpetrator-victim sex, observer sex and observer sexting experience on perceptions of...
Men’s perspectives on their grooming practices and appearance concerns
This mixed method study explores importance of and influences on men’s grooming behaviors and appearance concerns. Survey data from 83 men based in the United Kingdom showed high social media users engaged in significantly more...
Dr. Daniel F. Mahony Selected as President of Winthrop University
Winthrop University
Jan 01, 0001
Mahony will begin his duties on July 1, 2015. The President's House will be home to Mahony, his wife Laura and their two children, Gavin, 15, and Elena, 12. Dr. Daniel F. Mahony, dean of the College of Education, Health and...
Published by: Winthrop University
The Nested Kingman Coalescent
The nested Kingman coalescent describes the ancestral tree of a population undergoing neutral evolution at the level of individuals and at the level of species, simultaneously. We study the speed at which the number of...
SSBP1 mutations in dominant optic atrophy with variable retinal degeneration.
Neringa Jurkute, Costin Leu, Hans-Martin Pogoda, Gavin Arno, Anthony G Robson, Gudrun Nürnberg, Janine Altmüller, Holger Thiele, Susanne Motameny, Mohammad Reza Toliat, Kate Powell, Wolfgang Höhne, Michel Michaelides, Andrew R Webster, Anthony T Moore, Matthias Hammerschmidt, Peter Nürnberg, Patrick Yu-Wai-Man, Marcela Votruba
Jul 26, 2019
OBJECTIVE: Autosomal dominant optic atrophy (ADOA) starts in early childhood with loss of visual acuity and color vision deficits. OPA1 mutations are responsible for the majority of cases, but in a portion of patients with a...
Complex structural variants in Mendelian disorders
Alba Sanchis-Juan, Jonathan Stephens, Courtney E French, Nicholas Gleadall, Karyn Mégy, Christopher Penkett, Olga Shamardina, Kathleen Stirrups, Isabelle Delon, Eleanor Dewhurst, Helen Dolling, Marie Erwood, Detelina Grozeva, Luca Stefanucci, Gavin Arno, Andrew R Webster, Trevor Cole, Topun Austin, Ricardo Garcia Branco, Willem H Ouwehand, F Lucy Raymond, Keren J Carss
Feb 18, 2019
BACKGROUND: Studies have shown that complex structural variants (cxSVs) contribute to human genomic variation and can cause Mendelian disease. We aimed to identify cxSVs relevant to Mendelian disease using short-read...
ARID1B CDKL5 CEP78 Complex structural variant genome sequencing HNRNPU nanopore next-generation sequencing Cell Cycle Proteins DNA-Binding Proteins Female Genetic Predisposition to Disease Genome Human Genomic Structural Variation Heterogeneous-Nuclear Ribonucleoprotein U High-Throughput Nucleotide Sequencing Humans Male Mutation Protein Serine-Threonine Kinases Sequence Analysis DNA Transcription Factors
Face Masks Protect From Infection but May Impair Social Cognition in Older Adults and People With Dementia.
The coronavirus disease 2019 (COVID-19) pandemic will have a high impact on older adults and people with Alzheimer's disease and other dementias. Social cognition enables the understanding of another individual's feelings...
Autistic adults’ experience of restricted repetitive behaviours
Background: Restricted and Repetitive Behaviours (RRB) are a core characteristic of autism, though little is known about autistic people’s lived experience of these phenomena. Research has defined RRB in terms of: 1) a...
The presentation of self-harm recovery:
Little is known about how recovery from self-harm is understood by individuals with personal experience of self-harm. YouTube is an important online venue for posting and discussion of user-generated self-harm videos. Drawing on...
Shy Geek, Likes Music, Technology, and Gaming
Dating involves a range of complex social skills that autistic adults can often find challenging. Many autistic adults have turned to online dating, which in theory may ameliorate these social difficulties. The aim of this study...
Social identity formation during the emergence of the Occupy movement
The Occupy movement made a series of local ‘sit-ins’ in cities across the world in response to financial and political injustices. Prior to the movement’s emergence, the Internet provided a transnational forum for people across...
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