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Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Chan-Vese Reformulation for Selective Image Segmentation.
Selective segmentation involves incorporating user input to partition an image into foreground and background, by discriminating between objects of a similar type. Typically, such methods involve introducing additional...
Validation of Performance Homogeneity of Chan-Vese Model on Selected Tumour Cells
This study aims to analyze the Chan-Vese model's performance using a variety of tumor images. The processes involve the tumors' segmentation, detecting the tumors, identifying the segmented tumor region, and extracting the...
Published by: IGI Global Scientific Publishing
The ‘ownership’ of science
Dr Catherine Rhodes is a research fellow at the Institute for Science, Ethics and Innovation specialising in the international regulations relevant to control of biotechnology. Professor John Harris is director of the Institute...
Psychiatric Co-morbidity in Ketamine and Methamphetamine Dependence
Wai Kwong Tang, Huajun Liang, Yong Lin, Chenxi Zhang, Alan Tang, Fu Chan, Tom P. Freeman, Gabor S. Ungvari
Aug 01, 2017
Both ketamine and methamphetamine (MA) have become very popular and have been abused worldwide over the past two decades. However, the relationship between dependence on ketamine or MA and psychiatric comorbidities is still...
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
Comparing effects of episodic future thinking and cue salience to improve different types of prospective memory in typically developing school-age children
Chen-wei Yuan, Tian-xiao Yang, Sascha Zuber, Xiao-min Su, Fu-sen An, Shuai-biao Li, De-heng Wang, Ya Wang, Raymond C.K. Chan
Nov 01, 2025
Published by: Elsevier BV
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
Intensive Imaging-based Follow-up of Surgically Treated Localised Renal Cell Carcinoma Does Not Improve Post-recurrence Survival
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
Dec 03, 2018
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association...
Psychiatric Co-morbidity in Ketamine and Methamphetamine Dependence
Wai Kwong Tang, Huajun Liang, Yong Lin, Chenxi Zhang, Alan Tang, Fu Chan, Tom P. Freeman, Gabor S. Ungvari
Aug 01, 2017
Both ketamine and methamphetamine (MA) have become very popular and have been abused worldwide over the past two decades. However, the relationship between dependence on ketamine or MA and psychiatric comorbidities is still...
Topical treatment of actinic keratoses in organ transplant recipients
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N Matin, Victoria Homer, John T Lear, Ferina Ismail, Tristan Whitmarsh, Adele C Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J Bowden, Piers Gaunt, Keith Wheatley, Charlotte M Proby, Catherine A Harwood
Jun 14, 2022
BACKGROUND: The risk of cutaneous squamous cell carcinoma (cSCC) is significantly increased in organ transplant recipients (OTRs). Clearance of actinic keratoses (AKs) is generally regarded as a surrogate biomarker for cSCC...
Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates.
Shengxue Luo, Panli Zhang, Bochao Liu, Chan Yang, Chaolan Liang, Qi Wang, Ling Zhang, Xi Tang, Jinfeng Li, Shuiping Hou, Jinfeng Zeng, Yongshui Fu, Jean-Pierre Allain, Tingting Li, Yuming Zhang, Chengyao Li
Jun 17, 2021
ABSTRACTCOVID-19 vaccines are being developed urgently worldwide. Here, we constructed two adenovirus vectored COVID-19 vaccine candidates of Sad23L-nCoV-S and Ad49L-nCoV-S carrying the full-length gene of SARS-CoV-2 spike...
COVID-19 Vaccines human adenovirus 49 vector mice and non-human primates prime-boost vaccination simian adenovirus 23 vector Adenoviridae Animals Antibodies Neutralizing Antibodies Viral covid-19 COVID-19 Vaccines Female Genetic Vectors HEK293 Cells Humans Immunization Secondary Macaca mulatta Male Mice Mice Inbred BALB C Mice Inbred C57BL SARS-CoV-2 T-Lymphocytes
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
A Corpus-Based Study on the Translation Style of Five English Versions of Fu Sheng Liu Ji, Vol I
Bing Zhang
Oct 31, 2022
Using a corpus approach, this article investigates the translation styles of the first chapter of Fu Sheng Liu Ji at three levels: the statistical parameters, the translation of culture-specific lexis, and readability...
Published by: IGI Global Scientific Publishing
Uncovering Regulators of Whole-Body Metabolism by Chemoproteomic Profiling of the Adipocyte Secretome
Chan Hee J Choi
Jan 01, 0001
A major threat to human health, obesity is associated with increased risk of cardiometabolic complications such as cardiovascular disease, type 2 diabetes, hypertension, and many types of cancers. Whereas white adipocytes...
Published by: Rockefeller University
Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior
Chan Lek Tan
Jan 01, 0001
MicroRNAs constitute a vital new component of our evolving understanding of regulatory mechanisms that shape cellular gene expression. As ubiquitous regulators of protein translation, microRNAs have a unique regulatory function...
Published by: Rockefeller University
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
Controversial Issues in Arthroscopic Surgery for Femoroacetabular Impingement.
Femoroacetabular impingement (FAI) is a common cause of painful hip in the young and middle-aged population. This condition frequently leads to a labral tear, damage of acetabular cartilage, and secondary arthritis of the hip....
Bilateral Habenula deep brain stimulation for treatment-resistant depression
Chencheng Zhang, Yingying Zhang, Huichun Luo, Xinmeng Xu, Ti-Fei Yuan, Dianyou Li, Yi-Yun Cai, Hengfen Gong, Dai-Hui Peng, Yi-Ru Fang, Valerie Voon, Bomin Sun
Mar 07, 2022
Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward...
“Small, yet Beautiful”
We reconsider whether a grand multi-winner contest elicits more equilibrium effort than a collection of sub-contests. Fu and Lu (2009) employ a sequential winner-selection mechanism and find support for running a grand contest....
Anti-tumour efficacy of capecitabine in a genetically engineered mouse model of pancreatic cancer.
Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
Feb 12, 2020
Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC). However, limited...
Animals Antineoplastic Combined Chemotherapy Protocols Capecitabine Carcinoma Pancreatic Ductal Cell Line Tumor Cytidine Deaminase Deoxycytidine Disease Models Animal Drug Screening Assays Antitumor Fluorouracil Mice Mice Transgenic Neoplasm Transplantation Pancreatic Neoplasms prodrugs Tissue Distribution Gemcitabine
Long-run marginal cost pricing based on network spare capacity
Fu-Rong Li
Jan 01, 0001
This paper proposes a novel approach for providing long-run marginal cost (LRMC) pricing in network charges. The proposed approach makes use of the unused capacity of an exiting network to reflect the cost of advancing or...
Long-run marginal cost pricing based on network spare capacity
Fu-Rong Li
Jan 01, 0001
This paper proposes a novel approach for providing long-run marginal cost (LRMC) pricing in network charges. The proposed approach makes use of the unused capacity of an exiting network to reflect the cost of advancing or...
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