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Intracranial Pressure-Derived Cerebrovascular Reactivity Indices, Chronological Age, and Biological Sex in Traumatic Brain Injury
Carleen Batson, Kevin Y Stein, Alwyn Gomez, Amanjyot Singh Sainbhi, Logan Froese, Arsalan Alizadeh, Francois Mathieu, Frederick A Zeiler
Mar 06, 2022
To date, there has been limited literature exploring the association between age and sex with cerebrovascular reactivity (CVR) in moderate/severe traumatic brain injury (TBI). Given the known link between age, sex, and...
Health Determinants among North Americans Experiencing Homelessness and Traumatic Brain Injury
Traumatic brain injury (TBI) in those experiencing homelessness has been described in recent literature as a contributor to increased morbidity, decreased functional independence, and early mortality. In this systematically...
The Winnipeg Intraspinal Pressure Monitoring Study (WISP)
BACKGROUND: Research efforts have been focused on limiting secondary injury after traumatic spinal cord injury by performing spinal decompression and early optimization of spinal cord perfusion. The Winnipeg Intraspinal Pressure...
Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI
Alwyn Gomez, Amanjyot Singh Sainbhi, Logan Froese, Carleen Batson, Arsalan Alizadeh, Asher A Mendelson, Frederick A Zeiler
Jan 07, 2022
Multimodal monitoring has been gaining traction in the critical care of patients following traumatic brain injury (TBI). Through providing a deeper understanding of the individual patient's comprehensive physiologic state, or...
First-order synchronization transition in a large population of strongly coupled relaxation oscillators.
Onset and loss of synchronization in coupled oscillators are of fundamental importance in understanding emergent behavior in natural and man-made systems, which range from neural networks to power grids. We report on experiments...
Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury
The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the...
Transcranial Doppler Based Cerebrovascular Reactivity Indices in Adult Traumatic Brain Injury
Background: Disruption in cerebrovascular reactivity following traumatic brain injury (TBI) is a known phenomenon that may hold prognostic value and clinical relevance. Ultimately, improved knowledge of this process and more...
A Description of a New Continuous Physiological Index in Traumatic Brain Injury Using the Correlation between Pulse Amplitude of Intracranial Pressure and Cerebral Perfusion Pressure.
Frederick A Zeiler, Joseph Donnelly, David K Menon, Peter Smielewski, Peter JA Hutchinson, Marek Czosnyka
Feb 12, 2018
To describe a new continuous index of physiologic measurement in a traumatic brain injury (TBI) population, the moving correlation coefficient between intracranial pressure (ICP) pulse amplitude (AMP) and cerebral perfusion...
Association of Age and Sex With Multi-Modal Cerebral Physiology in Adult Moderate/Severe Traumatic Brain Injury
The impact of age and biological sex on outcome in moderate/severe traumatic brain injury (TBI) has been documented in large cohort studies, with advanced age and male sex linked to worse long-term outcomes. However, the...
A systematic review of cerebral microdialysis and outcomes in TBI
Frederick A Zeiler, Eric Peter Thelin, Adel Helmy, Marek Czosnyka, Peter JA Hutchinson, David K Menon
Apr 18, 2018
OBJECTIVE: To perform a systematic review on commonly measured cerebral microdialysis (CMD) analytes and their association to: (A) patient functional outcome, (B) neurophysiologic measures, and (C) tissue outcome; after...
Cerebrovascular Response to Phenylephrine in Traumatic Brain Injury
Intravenous phenylephrine (PE) is utilized commonly in critical care for cardiovascular support. Its impact on the cerebrovasculature is unclear and its use may have important implications during states of critical neurological...
Optimal cerebral perfusion pressure via transcranial Doppler in TBI
Individualized cerebral perfusion pressure (CPP) targets may be derived via assessing the minimum of the parabolic relationship between an index of cerebrovascular reactivity and CPP. This minimum is termed the optimal CPP...
Transcranial Doppler Based Cerebrovascular Reactivity Indices in Adult Traumatic Brain Injury
Background: Disruption in cerebrovascular reactivity following traumatic brain injury (TBI) is a known phenomenon that may hold prognostic value and clinical relevance. Ultimately, improved knowledge of this process and more...
Non-linear control of a hydraulic piezo-valve using a generalized Prandtl-Ishlinskii hysteresis model
Frederik Stefanski, Bartosz Minorowicz, Johan Persson, Andrew Plummer, Christopher Bowen
Jan 01, 2017
The potential to actuate proportional flow control valves using piezoelectric ceramics or other smart materials has been investigated for a number of years. Although performance advantages compared to electromagnetic actuation...
Association Between Processed Electroencephalogram-Based Objectively Measured Depth of Sedation and Cerebrovascular Response
Logan Froese, Joshua Dian, Alwyn Gomez, Carleen Batson, Amanjyot Singh Sainbhi, Frederick A. Zeiler
Sep 03, 2021
Background: Current understanding of the impact that sedative agents have on neurovascular coupling, cerebral blood flow (CBF) and cerebrovascular response remains uncertain. One confounding factor regarding the impact of...
Optimal bispectral index level of sedation and cerebral oximetry in traumatic brain injury
Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Carleen Batson, Trevor Slack, Kevin Y Stein, Francois Mathieu, Frederick A Zeiler
Sep 13, 2022
BACKGROUND: Impaired cerebral autoregulation has been linked with worse outcomes, with literature suggesting that current therapy guidelines fail to significantly impact cerebrovascular reactivity. The cerebral oximetry index...
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