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MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes.
Héctor Albert-Gascó, Francisco Ros-Bernal, Esther Castillo-Gómez, Francisco E Olucha-Bordonau
Jun 24, 2020
The signaling pathway of the microtubule-associated protein kinase or extracellular regulated kinase (MAPK/ERK) is a common mechanism of extracellular information transduction from extracellular stimuli to the intracellular...
Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat.
Cristina García-Díaz, Isis Gil-Miravet, Hector Albert-Gasco, Aroa Mañas-Ojeda, Francisco Ros-Bernal, Esther Castillo-Gómez, Andrew L Gundlach, Francisco E Olucha-Bordonau
Jul 07, 2021
Spatial learning and memory processes depend on anatomical and functional interactions between the hippocampus and the entorhinal cortex. A key neurophysiological component of these processes is hippocampal theta rhythm, which...
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory.
Isis Gil-Miravet, Aroa Mañas-Ojeda, Francisco Ros-Bernal, Esther Castillo-Gómez, Hector Albert-Gascó, Andrew L Gundlach, Francisco E Olucha-Bordonau
Apr 01, 2021
Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the...
Metaphysics as a Fundamental Poise
Francisco Vicente Galán Vélez
Mar 16, 2022
Francisco Vicente Galán Vélez is a full-time professor in the philosophy department at the Universidad Iberoamericana in Mexico City. He oversaw the translation of Insight: Estudio sobre la comprensión humana, trad. Francisco...
Published by: Memorial University of Newfoundland
Metaphysics as a Fundamental Poise
Francisco Vicente Galán Vélez
Mar 16, 2022
Francisco Vicente Galán Vélez is a full-time professor in the philosophy department at the Universidad Iberoamericana in Mexico City. He oversaw the translation of Insight: Estudio sobre la comprensión humana, trad. Francisco...
Published by: Memorial University of Newfoundland
Intracellular Sources of ROS/H 2 O 2 in Health and Neurodegeneration
Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors....
Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis.
Matthew A Deragon, William D McCaig, Payal S Patel, Robert J Haluska, Alexa L Hodges, Sergey A Sosunov, Michael P Murphy, Vadim S Ten, Timothy J LaRocca
Dec 22, 2020
We have previously identified a shift from TNF-α-induced apoptosis to necroptosis that occurs under hyperglycemic conditions. This shift involves the downregulation or silencing of caspases and concurrent upregulation of...
Mitochondrial ROS cause motor deficits induced by synaptic inactivity
Eva Sidlauskaite, Jack W Gibson, Ian L Megson, Philip D Whitfield, Artak Tovmasyan, Ines Batinic-Haberle, Michael P Murphy, Peter R Moult, James N Cobley
Jun 18, 2018
Developmental synapse pruning refines burgeoning connectomes. The basic mechanisms of mitochondrial reactive oxygen species (ROS) production suggest they select inactive synapses for pruning: whether they do so is unknown. To...
Intracellular Sources of ROS/H2O2 in Health and Neurodegeneration
Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors....
Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.
Elizabeth C Hinchy, Anja V Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R Hall, Georgina Bates, Thomas P Bright, Thomas Krieg, David Carling, Michael P Murphy
Nov 21, 2018
Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal that transmits information from the organelle to the cell. Other mitochondrial signals, such as ATP, are sensed by enzymes, including the...
AMP-activated kinase (AMPK) Hydrogen Peroxide Mitochondria reactive oxygen species (ROS) redox signaling AMP-Activated Protein Kinases Adenosine Diphosphate Adenosine Triphosphate Animals Cell Line Enzyme Activation Humans Hydrogen Peroxide Mice Mitochondria Muscle Fibers Skeletal Oxidation-Reduction Reactive Oxygen Species
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Edward T Chouchani, Victoria R Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y Sundier, Ellen L Robb, Angela Logan, Sergiy M Nadtochiy, Emily NJ Ord, Anthony C Smith, Filmon Eyassu, Rachel Shirley, Chou-Hui Hu, Anna J Dare, Andrew M James, Sebastian Rogatti, Richard C Hartley, Simon Eaton, Ana SH Costa, Paul S Brookes, Sean M Davidson, Michael R Duchen, Kourosh Saeb-Parsy, Michael J Shattock, Alan J Robinson, Lorraine M Work, Christian Frezza, Thomas Krieg, Michael P Murphy
Jan 20, 2020
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many disorders, notably heart attack and stroke. While reperfusion of ischaemic tissue is essential for...
Adenosine Monophosphate Animals Aspartic Acid Citric Acid Cycle Disease Models Animal Electron Transport Electron Transport Complex I Fumarates Ischemia Malates Male Metabolomics Mice Mitochondria Myocardial Infarction Myocardium Myocytes Cardiac NAD Reactive Oxygen Species Reperfusion Injury stroke Succinate Dehydrogenase Succinic Acid
Regulation of neuronal development and function by ROS.
Reactive oxygen species (ROS) have long been studied as destructive agents in the context of nervous system ageing, disease and degeneration. Their roles as signalling molecules under normal physiological conditions is less well...
The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy
Cancer is one of the world’s deadliest afflictions. Despite recent advances in diagnostic and surgical technologies, as well as improved treatments of some individual tumor types, there is currently no universal cure to prevent...
Ionized gas (plasma) delivery of reactive oxygen species (ROS) into artificial cells
This study was designed to enhance our understanding of how reactive oxygen species (ROS), generated ex situ by ionized gas (plasma), can affect the regulation of signalling processes within cells. A model system, comprising of...
Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster.
Filippo Scialò, Ashwin Sriram, Rhoda Stefanatos, Ruth V Spriggs, Samantha HY Loh, L Miguel Martins, Alberto Sanz
Feb 26, 2021
Reactive Oxygen Species (ROS) are essential cellular messengers required for cellular homeostasis and regulate the lifespan of several animal species. The main site of ROS production is the mitochondrion, and within it...
Ionized gas (plasma) delivery of reactive oxygen species (ROS) into artificial cells
This study was designed to enhance our understanding of how reactive oxygen species (ROS), generated ex situ by ionized gas (plasma), can affect the regulation of signalling processes within cells. A model system, comprising of...
Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer.
13C nuclear spin hyperpolarization can increase the sensitivity of detection in an MRI experiment by more than 10,000-fold. 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between...
Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.
Ye-Ri Kim, Jeong-In Baek, Sung Hwan Kim, Min-A Kim, Byeonghyeon Lee, Nari Ryu, Kyung-Hee Kim, Deok-Gyun Choi, Hye-Min Kim, Michael P Murphy, Greg Macpherson, Yeon-Sik Choo, Jinwoong Bok, Kyu-Yup Lee, Jeen-Woo Park, Un-Kyung Kim
Jan 02, 2019
Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-producing enzyme which is essential for maintaining the mitochondrial redox balance in cells. We sought to determine whether IDH2 deficiency...
antioxidant Hearing Loss Idh2 MitoQ NADP(+) ROS Animals Apoptosis Biomarkers Disease Models Animal Fluorescent Antibody Technique Hair Cells Auditory Hearing Loss Sensorineural Homozygote Immunohistochemistry Isocitrate Dehydrogenase Mice Mice Knockout Mitochondria Organophosphorus Compounds Oxidation-Reduction Oxidative Stress Reactive Oxygen Species Spiral Ganglion Ubiquinone
Structural basis for a complex I mutation that blocks pathological ROS production.
Zhan Yin, Nils Burger, Duvaraka Kula-Alwar, Dunja Aksentijević, Hannah R Bridges, Hiran A Prag, Daniel N Grba, Carlo Viscomi, Andrew M James, Amin Mottahedin, Thomas Krieg, Michael P Murphy, Judy Hirst
Feb 17, 2021
Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia-reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point mutation...
Amino Acid Substitution Animals Cryoelectron Microscopy DNA Mitochondrial Disease Models Animal Disease Resistance Electron Transport Electron Transport Complex I Humans Isolated Heart Preparation Leucine Male Mice Mice Transgenic Mitochondria Mitochondrial Membranes Myocardial Reperfusion Injury NAD NADH Dehydrogenase Oxidation-Reduction Point Mutation Proline Reactive Oxygen Species
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling
Anindya Roy Chowdhury, Jacek Zielonka, Balaraman Kalyanaraman, Richard C Hartley, Michael P Murphy, Narayan G Avadhani
Jul 06, 2020
The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK...
TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish infected with Mycobacterium marinum or...
BAX Calcium ER ROS TNF-mediated necrosis Calcium Channel Blockers macrophage Mitochondrion ryanodine receptors Tuberculosis Animals Apoptosis Calcium Endoplasmic Reticulum Humans Lysosomes MACROPHAGES Membrane potential Mitochondrial Mitochondria Mycobacterium Infections Nontuberculous Mycobacterium marinum Mycobacterium tuberculosis Necrosis Reactive Oxygen Species THP-1 Cells Tuberculosis Tumor Necrosis Factor-alpha Zebrafish
The Impact of Mitochondrial Fission-Stimulated ROS Production on Pro-Apoptotic Chemotherapy.
Cancer is one of the world's deadliest afflictions. Despite recent advances in diagnostic and surgical technologies, as well as improved treatments of some individual tumor types, there is currently no universal cure to prevent...
Species- and tissue-specific differences in ROS metabolism during exposure to hypoxia and hyperoxia plus recovery in marine sculpins.
Animals that inhabit environments that fluctuate in oxygen must not only contend with disruptions to aerobic metabolism, but also the potential effects of reactive oxygen species (ROS). The goal of this study was to compare...
Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.
João PM António, Joana Inês Carvalho, Ana S André, Joana NR Dias, Sandra I Aguiar, Hélio Faustino, Ricardo MRM Lopes, Luis F Veiros, Gonçalo JL Bernardes, Frederico A da Silva, Pedro MP Gois
Oct 08, 2021
Antibody-drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells. In this study we show...
The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis.
Marta Roche-Molina, Bryn Hardwick, Cristina Sanchez-Ramos, David Sanz-Rosa, Dirk Gewert, Francisco M Cruz, Andres Gonzalez-Guerra, Vicente Andres, Joaquin A Palma, Borja Ibanez, Grahame McKenzie, Juan A Bernal
Jul 28, 2021
N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity properties remain elusive. Here, we report that...
Animals Anti-Inflammatory Agents Aorta Apoptosis Atherosclerosis Cell Adhesion Cell Line DNA Complementary Endothelial Cells Gene Expression Profiling Gene Library Human Umbilical Vein Endothelial Cells Humans Inflammation Kruppel-Like Transcription Factors Mice Mice Knockout ApoE Monocytes Pyrrolidinones RNA Small Interfering Solvents Tumor Necrosis Factor-alpha
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