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Missing the missing values
Abstract: Nowadays, there is an increasing concern in machine learning about the causes underlying unfair decision making, that is, algorithmic decisions discriminating some groups over others, especially with groups that are...
The Characterization of Zn Hydrolase Using De Novo Due Ferri Single Chain (DFsc) Proteins
Joseph Pantel
Jan 01, 0001
Many natural enzymes can be found in nature that contain a metal ion. These enzymes have the potential for becoming new drugs and further biotechnology, but not all of the metalloenzymes' functions are fully understood. Through...
Published by: Ursinus College
Small Molecule Phosphatase Activity and Metal Binding Equivalencies of De Novo Due Ferri Single Chain Proteins
Avraham Goldschmidt
Jan 01, 0001
The de novo Due Ferri Single Chain protein model has been shown to be a viable protein scaffold to study functional characteristics through its thermodynamically favored and structurally sound four-helix bundle motif. Previous...
metalloproteins phosphatase four-helix de novo proteins Biochemistry Biochemistry, Biophysics, and Structural Biology Inorganic Chemistry Life Sciences Molecular Biology physical chemistry
Published by: Ursinus College
DNA Cleavage Activity of de novo Designed Due Ferri Single Chain (DFsc) Proteins
Alana Huynh
Jan 01, 0001
Metalloproteins are found in nature and involved in biological processes, especially in the cleavage of various molecular bonds. Of particular relevance are metallohydrolases, a class of enzymes that have the ability to catalyze...
metalloprotein DNA Hydrolysis Metallohydrolase Biochemistry, Biophysics, and Structural Biology Life Sciences
Published by: Ursinus College
Electrochemical Properties of de novo Designed Due Ferri Single Chain Proteins Using Cyclic Voltammetry
Alana Huynh
Jan 01, 0001
Many proteins that are found in nature and involved in biological processes have metal ions bound at their core. Iron is commonly used by proteins because of its high bioavailability and redox properties, which make it well...
Published by: Ursinus College
Redox Properties of the de Novo Designed Due Ferri Single-Chain (G4DFsc) Model Protein
Kailyn Cohen
Jan 01, 0001
The due ferri single chain (DFsc) protein is a de novo designed four-helix bundle designed to mimic the 2-histidine/4-carboxylate active site of natural non-heme diiron enzymes such as methane monooxygenase and ribonucleotide...
nonheme diiron Proteins Cyclic voltammetry biofuel cells Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Copper Binding and Reactivity of de novo Designed Due Ferri Single Chain (DFsc) Protein Variants
Brian Van Dyke
Jan 01, 0001
Binuclear, copper enzymes such as tyrosinase and catechol oxidase are involved meleninization and sclerotization processes. Understanding the kinetics of the polyphenol oxidation activity in these enzymes is crucial in...
Published by: Ursinus College
Hydrolase Activity of cis-His and trans-His Due Ferri Single Chain Proteins
Danny Leach
Jan 01, 0001
Metalloproteins use metal cations or metal containing cofactors to confer specific structural and reactive properties to a protein. Their natural prevalence makes them of interest to scientists, and one way to study their roles...
Published by: Ursinus College
Creation and Characterization of de novo Due Ferri Single Chain Proteins with trans-His Active Site Configurations
Danny Leach
Jan 01, 0001
Metalloproteins use small metal cations or metal containing cofactors to provide specific structural and reactive properties. Their high prevalence makes them of interest to scientists, and one way to study their role in...
De novo design metalloproteins Metallohydrolase RNase and DNase Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Modeling Coupled Binuclear Copper Enzymes With de Novo Designed Due Ferri Single-Chain Protein Variants
Brian Van Dyke
Jan 01, 0001
Coupled binuclear copper proteins (CBCs) such as hemocyanins, catechol oxidases, and tyrosinases utilize dioxygen for storage, oxidase, and monoxygenase behavior, respectively. However, all three protein families have a common...
Published by: Ursinus College
Phosphatase Activities and Metal Binding Equivalencies of the De Novo Due Ferri Single Chain Proteins
Avraham Goldschmidt
Jan 01, 0001
The de novo Due Ferri Single Chain protein model has been shown to be a viable protein scaffold to study functional characteristics through its thermodynamically favored and structurally sound four-helix bundle motif. Previous...
DFsc metal protein Electrophoresis phosphatase spectroscopy Biochemistry Inorganic Chemistry Molecular Biology
Published by: Ursinus College
Copper-Binding, Oxygen Activation, and 2-Electron Oxidation Kinetics of de novo Designed Due Ferri Single-Chain (DFsc) Variants: a Type 3 Copper Oxidase Model
Brian Van Dyke
Jan 01, 0001
Binuclear copper enzymes, such as tyrosinase and catechol oxidase, are involved in the melaninization and sclerotization processes. Understanding the mechanism of the diphenol oxidn. activity in these enzymes is crucial to...
De novo design dicopper protein Biochemistry Chemistry Inorganic Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
Uncertainty due to experimental conditions in co-ordinate measuring machines
Any measurement method of a physical quantity cannot provide an exact unequivocal result owing to the infinite amount of information necessary to characterize fully both the physical quantity to be measured and the measuring...
Sources of variability in the set-up of an Indoor GPS
An increasing demand for an extended flexibility to model types and production volumes in the manufacture of large-size assemblies has generated a growing interest in the reduction of jigs and fixtures deployment during assembly...
Calibration of a white light interferometer for the measurement of micro-scale dimensions
Calibration is central to most measurement procedures. This is especially true in those cases where a large number of difficult-to-identify and difficult-to-control factors hinder the experimenters in their efforts to obtain...
Are mass-media campaigns effective in preventing drug use? A Cochrane systematic review and meta-analysis.
OBJECTIVE: To determine whether there is evidence that mass-media campaigns can be effective in reducing illicit drug consumption and the intent to consume. DESIGN: Systematic review of randomised and non-randomised studies....
Uncertainty due to experimental conditions in co-ordinate measuring machines
Any measurement method of a physical quantity cannot provide an exact unequivocal result owing to the infinite amount of information necessary to characterize fully both the physical quantity to be measured and the measuring...
Calibration of a white light interferometer for the measurement of micro-scale dimensions
Calibration is central to most measurement procedures. This is especially true in those cases where a large number of difficult-to-identify and difficult-to-control factors hinder the experimenters in their efforts to obtain...
Sources of variability in the set-up of an Indoor GPS
An increasing demand for an extended flexibility to model types and production volumes in the manufacture of large-size assemblies has generated a growing interest in the reduction of jigs and fixtures deployment during assembly...
Continuous feedback on a quantum gas coupled to an optical cavity
We present an active feedback scheme acting continuously on the state of a
quantum gas dispersively coupled to a high-finesse optical cavity. The quantum
gas is subject to a transverse pump laser field inducing a...
Nuclease Activity of Zinc DFsc Proteins
Brendan Cherrey
Jan 01, 0001
In nature, enzymes utilize metals to assist with various forms of catalysis. The De Novo Due Ferri Single Chain (DFsc) protein is a computationally designed four bundle helix model protein that mimics the active site of...
Published by: Ursinus College
Measurement of Hydrolytic Activity of DFsc Proteins Using 4-Methylumbelliferyl Phosphate and Bis(4-nitrophenyl) Phosphate
Joseph Pantel
Jan 01, 0001
Many proteins that are found in nature contain metals that help perform catalytic functions. Metallohydrolases are one such class of enzymes that cleave chemical bonds using water and are responsible for important biological...
Proteins Hydrolases Enzymes Metallohydrolases metalloenzymes Amino Acids, Peptides, and Proteins Chemistry Enzymes and Coenzymes Inorganic Chemistry Other Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
The Design and Characterization of de novo Coupled Binuclear Copper Model Proteins
Kailyn Cohen
Jan 01, 0001
Nearly half of all known proteins contain metal cofactors that impart unique structural changes on the polypeptide backbone. This allows the metalloprotein to accomplish functions that would not otherwise be possible in its...
De novo copper proteins dicopper Proteins Pymol DFsc Biochemistry Biochemistry, Biophysics, and Structural Biology Chemistry Other Biochemistry, Biophysics, and Structural Biology structural biology
Published by: Ursinus College
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