Search
Results: 28
PICALM modulates autophagy activity and tau accumulation.
Kevin Moreau, Angeleen Fleming, Sara Imarisio, Ana Lopez Ramirez, Jacob L Mercer, Maria Jimenez-Sanchez, Carla F Bento, Claudia Puri, Eszter Zavodszky, Farah Siddiqi, Catherine P Lavau, Maureen Betton, Cahir J O'Kane, Daniel S Wechsler, David C Rubinsztein
Oct 09, 2014
Animals Autophagy Autophagy-Related Protein 12 Cell Line Drosophila Endocytosis Female FIBROBLASTS Genome-Wide Association Study HEK293 Cells HeLa Cells Humans Male Mice Monomeric Clathrin Assembly Proteins Phagosomes Protein Binding RNA Small Interfering Risk Factors Small Ubiquitin-Related Modifier Proteins Transfection Vesicle-Associated Membrane Protein 2 Zebrafish tau Proteins
Multivariate moment closure techniques for stochastic kinetic models.
Stochastic effects dominate many chemical and biochemical processes. Their analysis, however, can be computationally prohibitively expensive and a range of approximation schemes have been proposed to lighten the computational...
Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines
Edina Karai, Kornélia Szebényi, Tímea Windt, Sára Fehér, Eszter Szendi, Valéria Dékay, Péter Vajdovich, Gergely Szakács, András Füredi
Apr 30, 2020
Background: Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR). One of the main contributors of MDR is the overexpression P-glycoprotein...
Comparison of permutationally invariant polynomials, neural networks, and Gaussian approximation potentials in representing water interactions through many-body expansions.
Typology of how 'harmful commodity industries' interact with local governments in England
The Impact of the Universal Infant Free School Meal Policy on Dietary Quality in English and Scottish Primary School Children
Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines.
Edina Karai, Kornélia Szebényi, Tímea Windt, Sára Fehér, Eszter Szendi, Valéria Dékay, Péter Vajdovich, Gergely Szakács, András Füredi
Jul 17, 2020
BACKGROUND: Treatment of malignancies is still a major challenge in human and canine cancer, mostly due to the emergence of multidrug resistance (MDR). One of the main contributors of MDR is the overexpression P-glycoprotein...
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jul 22, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
Enabling transformative economic change in the post‐2020 biodiversity agenda
Esther Turnhout, Pamela McElwee, Mireille Chiroleu‐Assouline, Jennifer Clapp, Cindy Isenhour, Eszter Kelemen, Tim Jackson, Daniel C Miller, Graciela M Rusch, Joachim H Spangenberg, Anthony Waldron
May 03, 2021
Abstract: The COVID‐19 pandemic, its impact on the global economy, and current delays in the negotiation of the post‐2020 global biodiversity agenda of the Convention on Biological Diversity heighten the urgency to build back...
Typology of how 'harmful commodity industries' interact with local governments in England
A Compendium of Mutational Signatures of Environmental Agents.
Jill E Kucab, Xueqing Zou, Sandro Morganella, Madeleine Joel, A Scott Nanda, Eszter Nagy, Celine Gomez, Andrea Degasperi, Rebecca Harris, Stephen P Jackson, Volker M Arlt, David H Phillips, Serena Nik-Zainal
Mar 04, 2019
Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79...
MEANS
Sisi Fan, Quentin Geissmann, Eszter Lakatos, Saulius Lukauskas, Angelique Ale, Ann C Babtie, Paul DW Kirk, Michael PH Stumpf
Jul 16, 2018
MOTIVATION: Many biochemical systems require stochastic descriptions. Unfortunately these can only be solved for the simplest cases and their direct simulation can become prohibitively expensive, precluding thorough analysis. As...
The Impact of the Universal Infant Free School Meal Policy on Dietary Quality in English and Scottish Primary School Children
The Universal Infant Free School Meal (UIFSM) policy was introduced in September 2014 in England and January 2015 in Scotland and offered all infant schoolchildren (ages 4–7 years) a free school lunch, regardless of...
Jennie C Parnham, Kiara Chang, Christopher Millett, Anthony A Laverty, Stephanie von Hinke, Jonathan Pearson-Stuttard, Frank De Vocht, Martin White, Eszter P Vamos
Apr 13, 2022
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G Boutelle, Eszter Farkas, Jens P Dreier, Martin Fabricius, C William Shuttleworth, Andrew Carlson
Jul 29, 2019
The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, "What should a clinician do when spreading depolarizations are...
Cortical Spreading Depression Electroencephalography Intracerebral hemorrhage ischemic stroke outcome Subarachnoid Hemorrhage Traumatic brain injury Brain Injuries Traumatic Cortical Spreading Depression Electrocorticography Electroencephalography Excitatory Amino Acid Antagonists Humans Ketamine Outcome Assessment Health Care Precision Medicine stroke Subarachnoid Hemorrhage
What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balança, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
Jun 06, 2020
Abstract: The International Conference on Spreading Depolarizations (iCSD) held in Boca Raton, Florida, in the September of 2018 devoted a section to address the question, “What should a clinician do when spreading...
The DANTE trial protocol
Oliver Coen, Pippa Corrie, Helen Marshall, Ruth Plummer, Christian Ottensmeier, Jane Hook, Sue Bell, Gurdeep S Sagoo, David Meads, Janine Bestall, Galina Velikova, Ferdia A Gallagher, Alexandra Smith, Helen Howard, Ellen Mason, Eszter Katona, Shobha Silva, Michelle Collinson, Simon Rodwell, Sarah Danson
Aug 02, 2021
Background
Immunotherapy is revolutionising the treatment of patients diagnosed with melanoma and other cancers. The first immune checkpoint inhibitor, ipilimumab (targeting cytotoxic T-lymphocyte-associated antigen 4...
Safety Immunotherapy Quality of life EFFICACY Metastatic melanoma schedule Anti-PD-1 checkpoint inhibitor
Published by: BMC cancer
The DANTE trial protocol
Oliver Coen, Pippa Corrie, Helen Marshall, Ruth Plummer, Christian Ottensmeier, Jane Hook, Sue Bell, Gurdeep S. Sagoo, David Meads, Janine Bestall, Galina Velikova, Ferdia A. Gallagher, Alexandra Smith, Helen Howard, Ellen Mason, Eszter Katona, Shobha Silva, Michelle Collinson, Simon Rodwell, Sarah Danson
Jul 02, 2021
Abstract: Background: Immunotherapy is revolutionising the treatment of patients diagnosed with melanoma and other cancers. The first immune checkpoint inhibitor, ipilimumab (targeting cytotoxic T-lymphocyte-associated antigen 4...
The DANTE trial protocol
Oliver Coen, Pippa Corrie, Helen Marshall, Ruth Plummer, Christian Ottensmeier, Jane Hook, Sue Bell, Gurdeep S Sagoo, David Meads, Janine Bestall, Galina Velikova, Ferdia A Gallagher, Alexandra Smith, Helen Howard, Ellen Mason, Eszter Katona, Shobha Silva, Michelle Collinson, Simon Rodwell, Sarah Danson
Sep 05, 2021
BACKGROUND: Immunotherapy is revolutionising the treatment of patients diagnosed with melanoma and other cancers. The first immune checkpoint inhibitor, ipilimumab (targeting cytotoxic T-lymphocyte-associated antigen 4...
The m.13051G>A mitochondrial DNA mutation results in variable neurology and activated mitophagy.
Eszter Dombi, Alan Diot, Karl Morten, Janet Carver, Tiffany Lodge, Carl Fratter, Yi Shiau Ng, Chunyan Liao, Rebecca Muir, Emma L Blakely, Iain Hargreaves, Mazhor Al-Dosary, Gopa Sarkar, Simon J Hickman, Susan M Downes, Sandeep Jayawant, Patrick Yu-Wai-Man, Robert W Taylor, Joanna Poulton
Jun 28, 2018
acidosis Lactic Adolescent Adult Aged Aged 80 and over antioxidants Cells Cultured Child Child Preschool DNA Mitochondrial Female FIBROBLASTS Humans Infant Infant Newborn Leigh Disease Male Microtubule-Associated Proteins Middle Aged Mitochondrial Dynamics Mitochondrial Membrane Transport Proteins Mitochondrial Precursor Protein Import Complex Proteins mitophagy Mutation Neurology Ubiquinone Young Adult
Scoping article
Thomas Hickmann, Frank Biermann, Carole-Anne Sénit, Yixian Sun, Magdalena Bexell, Mitzi Bolton, Basil Bornemann, Jacel Censoro, Aurelie Charles, Rodrigo Correa Ramiro, Dominique Coy, Frederik Dahlmann, Mark Elder, Felicitas Fritzsche, Thiago Gehre Galvão, Jarrod Grainger-Brown, Cristina Inoue, Kristina Jönsson, Montserrat Koloffon Rosas, Kerstin Krellenberg, Enayat Moallemi, Ivonne Lobos Alva, Shirin Malekpour, Dianty Ningrum, Aneliya Paneva, Lena Partzsch, Rob Raven, Eszter Szedlacsek, John Thompson, Melanie van Driel, Jéssica Viani Damasceno, Robert Webb, Sabine Weiland
Jan 24, 2024
A recent meta-analysis on the political impact of the Sustainable Development Goals (SDGs) has shown that these global goals are moving political processes forward only incrementally, with much variation across countries...
The major barriers to evidence-informed conservation policy and possible solutions.
David C Rose, William J Sutherland, Tatsuya Amano, Juan P González-Varo, Rebecca J Robertson, Benno I Simmons, Hannah S Wauchope, Eszter Kovacs, América Paz Durán, Alice BM Vadrot, Weiling Wu, Maria P Dias, Martina MI Di Fonzo, Sarah Ivory, Lucia Norris, Matheus Henrique Nunes, Tobias Ochieng Nyumba, Noa Steiner, Juliet Vickery, Nibedita Mukherjee
Jul 17, 2018
Conservation policy decisions can suffer from a lack of evidence, hindering effective decision-making. In nature conservation, studies investigating why policy is often not evidence-informed have tended to focus on Western...
Scoping article
Thomas Hickmann, Frank Biermann, Carole-Anne Sénit, Yixian Sun, Magdalena Bexell, Mitzi Bolton, Basil Bornemann, Jacel Censoro, Aurelie Charles, Rodrigo Correa Ramiro, Dominique Coy, Frederik Dahlmann, Mark Elder, Felicitas Fritzsche, Thiago Gehre Galvão, Jarrod Grainger-Brown, Cristina Inoue, Kristina Jönsson, Montserrat Koloffon Rosas, Kerstin Krellenberg, Enayat Moallemi, Ivonne Lobos Alva, Shirin Malekpour, Dianty Ningrum, Aneliya Paneva, Lena Partzsch, Rob Raven, Eszter Szedlacsek, John Thompson, Melanie van Driel, Jéssica Viani Damasceno, Robert Webb, Sabine Weiland
Jan 24, 2024
A recent meta-analysis on the political impact of the Sustainable Development Goals (SDGs) has shown that these global goals are moving political processes forward only incrementally, with much variation across countries...
Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.
Katherine M Wilson, Eszter Katona, Idoia Glaria, Mireia Carcolé, Imogen J Swift, Aitana Sogorb-Esteve, Carolin Heller, Arabella Bouzigues, Amanda J Heslegrave, Ashvini Keshavan, Kathryn Knowles, Saurabh Patil, Susovan Mohapatra, Yuanjing Liu, Jaya Goyal, Raquel Sanchez-Valle, Robert Jr Laforce, Matthis Synofzik, James B Rowe, Elizabeth Finger, Rik Vandenberghe, Christopher R Butler, Alexander Gerhard, John C van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Alexandre de Mendonça, Mario Masellis, M Carmela Tartaglia, Markus Otto, Caroline Graff, Simon Ducharme, Jonathan M Schott, Andrea Malaspina, Henrik Zetterberg, Ramakrishna Boyanapalli, Jonathan D Rohrer, Adrian M Isaacs, Genetic FTD Initiative (GENFI)
Apr 07, 2022
|
|< |
< |
1 |