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Interrogation and Manipulation of the IGG FC Glycan
Aaron Keshav Gupta
Jan 01, 0001
Antibody signaling is a cardinal feature of successful adaptive immune responses. The magnitude and direction of this signaling is determined by the structure of a given antibody's fragment crystallizable (Fc) domain, which...
Published by: Rockefeller University
Selective blockade of the inhibitory Fc? receptor (Fc?RIIB) in human dendritic cells and monocytes induces a type I interferon response program
The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies, we have shown that selective antibody-mediated blockade of inhibitory Fc?RIIB receptor on human DCs in the...
Published by: Rockefeller University
John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York
Eric Severson
May 04, 2009
[Book Review] Eric Severson reviews John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York: Fordham University Press, 2005.
Published by: Memorial University of Newfoundland
Theory of mind impairment and its clinical correlates in patients with schizophrenia, major depressive disorder and bipolar disorder.
Yan-Yu Wang, Yi Wang, Ying-Min Zou, Ke Ni, Xue Tian, Hong-Wei Sun, Simon SY Lui, Eric FC Cheung, John Suckling, Raymond CK Chan
Jun 21, 2018
BACKGROUND: Although Theory of Mind (ToM) impairment has been observed in patients with a wide range of mental disorders, the similarity and uniqueness of these deficits across diagnostic groups has not been thoroughly...
Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, HT Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers
Jan 28, 2022
BACKGROUND: Despite extensive clinical use, the mechanisms that lead to therapeutic resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain elusive. Here, we sought to determine how interactions...
Internalization and degradation of macrophage Fc receptors during receptor-mediated phagocytosis
Macrophage receptors for the Fc domain of immunoglobulin G (IgG) can mediate the efficient binding and phagocytosis of IgG-coated particles. After internalization, phagocytic vacuoles fuse with lysosomes, initiating the...
Published by: Rockefeller University
Improving motivation through real-time fMRI-based self-regulation of the nucleus accumbens.
Zhi Li, Chen-Yuan Zhang, Jia Huang, Yi Wang, Chao Yan, Ke Li, Ya-Wei Zeng, Zhen Jin, Eric FC Cheung, Li Su, Raymond CK Chan
Nov 07, 2017
OBJECTIVE: Impaired nucleus accumbens (NAcc) activation is associated with amotivation and anhedonia, which are resistant to treatment with antipsychotics and antidepressants in schizophrenia. In this study, healthy participants...
John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York
Eric Severson
May 04, 2009
[Book Review] Eric Severson reviews John Panteleimon Manoussakis, ed. After God: Richard Kearney and the Religious Turn in Continental Philosophy. New York: Fordham University Press, 2005.
Published by: Memorial University of Newfoundland
Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.
Eric Severson
May 04, 2009
Book Review. Eric Severson reviews Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.: Northwestern University Press, 2007.
Published by: Memorial University of Newfoundland
Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.
Eric Severson
May 04, 2009
Book Review. Eric Severson reviews Peter Gratton and John Panteleimon Manoussakis, eds. Traversing the Imaginary: Richard Kearney and the Postmodern Challenge. Evanston, Ill.: Northwestern University Press, 2007.
Published by: Memorial University of Newfoundland
ERIC-PCR Analysis of the Clinical and Environmental strains of V. cholerae during 2013 Epidemic in Nigeria
Smith Stella, Nwaokorie Francisca, Awoderu Oluwatoyin, Bamidele Tajudeen, Akinsinde Kehinde, Ochoga Michael, Oladele David, Bamidele Moses, Fesobi Toun, Afocha Eberechukwu, Amoo Samuel, Ajayi Morakinyo, Atat Prince, Ogbonna Francisca, Nduaga Samuel, Idika Nneoma, Oparaugo Chinedu, Musa Adesola, Adeneye Adeniyi, Ijeh Margaret, Ujah Innocent
Nov 21, 2015
Background: Molecular markers are important tools in the monitoring of toxigenic strains of Vibrio cholerae in environmental and clinical samples.
Objectives: The study was aimed at determining the clinical and environmental...
Published by: IJHS Medical Association
Selective blockade of inhibitory Fc? receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
he final differentiation or maturation of dendritic cells (DCs) in response to environmental stimuli influences their ability to both initiate immunity and determine the quality of the response to antigens. Circulating immune...
Published by: Rockefeller University
ERIC-PCR Analysis of the Clinical and Environmental strains of V. cholerae during 2013 Epidemic in Nigeria
Smith Stella, Nwaokorie Francisca, Awoderu Oluwatoyin, Bamidele Tajudeen, Akinsinde Kehinde, Ochoga Michael, Oladele David, Bamidele Moses, Fesobi Toun, Afocha Eberechukwu, Amoo Samuel, Ajayi Morakinyo, Atat Prince, Ogbonna Francisca, Nduaga Samuel, Idika Nneoma, Oparaugo Chinedu, Musa Adesola, Adeneye Adeniyi, Ijeh Margaret, Ujah Innocent
Nov 21, 2015
Background: Molecular markers are important tools in the monitoring of toxigenic strains of Vibrio cholerae in environmental and clinical samples.
Objectives: The study was aimed at determining the clinical and environmental...
Published by: IJHS Medical Association
Suspiciousness in young minds
Han-Yu Zhou, Keri Ka-Yee Wong, Li-Juan Shi, Xi-Long Cui, Yun Qian, Wen-Qing Jiang, Ya-Song Du, Simon SY Lui, Xue-Rong Luo, Zheng-Hui Yi, Eric FC Cheung, Anna R Docherty, Raymond CK Chan
Jun 06, 2018
BACKGROUND: We validated the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. METHODS: In Study 1, a...
The benefits of explicit teaching of language for curriculum learning in the Physical Education classroom
Among the many subjects taught at primary, secondary and tertiary institutions physical education (PE) has had limited discussion with respect to the language of PE. As an examination subject in secondary school, physical...
The benefits of explicit teaching of language for curriculum learning in the Physical Education classroom
Among the many subjects taught at primary, secondary and tertiary institutions physical education (PE) has had limited discussion with respect to the language of PE. As an examination subject in secondary school, physical...
Introducing Fog Computing (FC) Technology to Internet of Things (IoT) Cloud-Based Anti-Theft Vehicles Solutions
Eissa Alreshidi
Aug 02, 2022
Securing vehicles, especially against theft, has become a significant concern. Smart antitheft solutions have emerged to provide better protection. However, most existing smart vehicle antitheft solutions use (GSM) and (GPS)...
Published by: IGI Global Scientific Publishing
Review of Eric L. Jenkins, Free to Say No? Free Will and Augustine’s Evolving Doctrines of Grace and Election (Cambridge
Seamus O'Neill
Mar 23, 2016
Eric Jenkins’ Free to Say No? Free Will and Augustine’s Evolving Doctrines of Grace and Election is a relatively concise and highly readable investigation into Augustine’s changing position on the freedom of the will and various...
Published by: Memorial University of Newfoundland
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Frederick Arce Vargas, Andrew JS Furness, Kevin Litchfield, Kroopa Joshi, Rachel Rosenthal, Ehsan Ghorani, Isabelle Solomon, Marta H Lesko, Nora Ruef, Claire Roddie, Jake Y Henry, Lavinia Spain, Assma Ben Aissa, Andrew Georgiou, Yien Ning Sophia Wong, Myles Smith, Dirk Strauss, Andrew Hayes, David Nicol, Tim O'Brien, Linda Mårtensson, Anne Ljungars, Ingrid Teige, Björn Frendéus, TRACERx Melanoma, TRACERx Renal, TRACERx Lung consortia, Martin Pule, Teresa Marafioti, Martin Gore, James Larkin, Samra Turajlic, Charles Swanton, Karl S Peggs, Sergio A Quezada
Jun 29, 2018
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo...
CTLA-4 Fc-gamma receptors IgG subclass antibody-dependent cell-mediated cytotoxicity immune checkpoints immune regulatory antibodies ipilimumab regulatory T cell depletion tremelimumab tumor immunotherapy Animals Antibodies Monoclonal Antibodies Monoclonal Humanized Antineoplastic Agents Immunological CTLA-4 Antigen Cell Line Tumor Female Humans Ipilimumab Melanoma Mice Polymorphism Single Nucleotide Receptors IgG T-Lymphocytes Regulatory Treatment Outcome Xenograft Model Antitumor Assays
Economic Insecurity Threatens Public Safety and Social Order in South Africa
Eric Niyitunga
Jan 01, 2024
This paper analyses how economic insecurity poses immense threats to public safety and social order in South Africa. It was found that economic insecurity threatens public safety and social order because it disrupts the delivery...
Published by: IGI Global Scientific Publishing
Review of Eric L. Jenkins, Free to Say No? Free Will and Augustine’s Evolving Doctrines of Grace and Election (Cambridge
Seamus O'Neill
Mar 23, 2016
Eric Jenkins’ Free to Say No? Free Will and Augustine’s Evolving Doctrines of Grace and Election is a relatively concise and highly readable investigation into Augustine’s changing position on the freedom of the will and various...
Published by: Memorial University of Newfoundland
Evaluation of Teacher-Student Interaction
Driving Taiwan's digital revolution, the DIGI Plus 2017-2025 policy, a cornerstone of the Smart Nation 2025 initiative (Executive Yuan, 2021), prioritized rural empowerment in education amidst COVID-19 challenges. In this study...
Published by: IGI Global Scientific Publishing
Antibody-Effector Functions in Antiviral Response
Kevin Shuolong Kao
Jan 01, 0001
Antibodies are a fundamental component of the adaptive arm of the immune system. Interactions of the antibody's fragment crystallizable (Fc) domain with Fc receptors (FcR) on effector leukocytes is essential for proper...
Published by: Rockefeller University
The 4IR-Health Service Delivery Nexus
Eric Niyitunga
Jan 01, 2023
The delivery of quality healthcare services to citizens is not only a constitutional right, but also the task and obligation of every government. However, bribery, lack of financial accountability and counterfeit drugs, a...
Published by: IGI Global Scientific Publishing
The Lantern Vol. 75, No. 2, Spring 2008
Robert Whitehead, Stephanie Bartusis, Natalie Rokaski, Dayna Stein, Jennifer Mingolello, Josh Krigman, Tori Wynne, Jen Bowlan, India McGhee, Nicole Dillie, John Lukacs, Steven Markoe, Andy Brienza, Christopher Schaeffer, Joshua Solomon, Christopher Curley, Eric Relvas, Michael Taggart, Dan Sergeant, Samantha Owen, Patrick Hayakawa, Laurel Salvo, Ian O'Neill
Jan 01, 0001
In a French Courtyard at the Philadelphia Museum of Art Picky Mangoes And for My Un-Birthday I Drank Poets' Tea and Got to See Tree-Baby Wrestling With Plants I Smile Walking Home The Wall Between Phalangese, or...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
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