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Results: 386
POSEIDON Trial Phase 1b Results
Richard D Baird, Annelot GJ van Rossum, Mafalda Oliveira, Karin Beelen, Meiling Gao, Mariette Schrier, Ingrid AM Mandjes, Javier Garcia-Corbacho, Anne-Laure Vallier, Greig Dougall, Erik Van Werkhoven, Constanza Linossi, Sanjeev Kumar, Harm van Tinteren, Maurizio Callari, Emma Beddowes, José-Manuel Perez-Garcia, Hilde Rosing, Else Platte, Petra Nederlof, Margaret Schot, Aurelia de Vries Schultink, René Bernards, Cristina Saura, William Gallagher, Javier Cortès, Carlos Caldas, Sabine C Linn
Oct 02, 2019
PURPOSE: The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)-positive breast cancer, but new agents and combinations with a better therapeutic index are urgently...
Adult Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Breast Neoplasms Circulating Tumor DNA Female Humans Imidazoles Middle Aged Mutation Neoplasm Metastasis Neoplasm Staging Oxazepines Receptors Estrogen Receptors Progesterone Retreatment Tamoxifen Treatment Outcome
Ensuring Core Competencies for Cybersecurity Specialists
Within an organization, it is critical that all employees possess a security awareness and thus play a part in the protection of said organization's information assets. Some employees will have key roles and responsibilities and...
Published by: IGI Global Scientific Publishing
Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris.
In murine models of Schistosoma mansoni infection, egg production is associated with a switch from T helper cell (Th)1- to Th2-type responses to both schistosome-specific and unrelated antigens. Polyparasitism is common in human...
YouIdiot.com
Mark Y. Herring
Jan 01, 0001
While researching something else, I ran across an item in a business journal my eye ran across another item. In research this is called serendipity, something we do not hear so much about any more these days.
Published by: Winthrop University
Mathematical Models of Desire, Need, Attention, and Will Effort
Alexander Ovsich
Jan 25, 2017
According to Spinoza, “Love is nothing else but pleasure accompanied by the idea of an external cause”. Author proposes that desire is nothing else but a change of pleasure accompanied by the idea of its cause, that terms...
Biologically-Inspired Computing Computer Science and Information Technology Artificial Intelligence Media and Communications
Published by: IGI Global Scientific Publishing
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.
The IkappaB kinase (IKK) complex is composed of three subunits, IKKalpha, IKKbeta, and IKKgamma (NEMO). While IKKalpha and IKKbeta are highly similar catalytic subunits, both capable of IkappaB phosphorylation in vitro, IKKgamma...
Musicians’ views on the role of reading music in learning, performance, and understanding
Reading music notation is not an easy skill to acquire and can take years of training to master. In addition, it is not strictly necessary to be able to read music to make music. Nevertheless, music teaching and learning in the...
Save the Internet
Mark Y. Herring
Jan 01, 0001
With rare exception, nothing has galvanized activists and those of us in libraries more these days than net neutrality. It's also "a thing" with just about everyone else. If you "google" the phrase, the first two or three...
Published by: Winthrop University
Citizen Adoption in E-Government Systems
Electronic Government (e-Government) refers to a system of information, communication and interaction between government and its citizens. E-Government adoption has been studied for more than a decade with several meta-analytic...
Published by: IGI Global Scientific Publishing
Non-smooth Hopf-type bifurcations arising from impact–friction contact events in rotating machinery
We analyse the novel dynamics arising in a nonlinear rotor dynamic system by investigating the discontinuity-induced bifurcations corresponding to collisions with the rotor housing (touchdown bearing surface interactions). The...
Surveillance recommendations for DICER1 pathogenic variant carriers
Jette J Bakhuizen, Helen Hanson, Karin van der Tuin, Fiona Lalloo, Marc Tischkowitz, Karin Wadt, Marjolijn CJ Jongmans, SIOPE Host Genome Working Group, CanGene-CanVar Clinical Guideline Working Group, Expert Network Members
Oct 01, 2021
DICER1 syndrome is a rare genetic disorder that predisposes to a wide spectrum of tumors. Developing surveillance protocols for this syndrome is challenging because uncertainty exists about the clinical efficacy of surveillance...
Save the Internet
Mark Y. Herring
Jan 01, 0001
With rare exception, nothing has galvanized activists and those of us in libraries more these days than net neutrality. It's also "a thing" with just about everyone else. If you "google" the phrase, the first two or three...
Published by: Winthrop University
Hearing where the eyes see
To reduce sensory uncertainty, humans combine cues from multiple senses. However, in everyday life, many co‐occurring cues are irrelevant to the task at hand. How do humans know which cues to ignore? And does this ability change...
Whole tissue cervical mapping of HPV infection
Anne Hammer, Maurits Nc de Koning, Jan Blaakaer, Torben Steiniche, John Doorbar, Heather Griffin, Else Mejlgaard, Hans Svanholm, Wim Gv Quint, Patti E Gravitt
May 09, 2019
In this study, we aimed to provide molecular evidence of HPV latency in humans and discuss potential challenges of conducting studies on latency. We analyzed the entire cervix of two women who underwent hysterectomy unrelated to...
High Trait Anxiety Enhances Optimal Integration of Auditory and Visual Threat Cues
Background
Emotion perception is essential to human interaction and relies on effective integration of emotional cues across sensory modalities. Despite initial evidence for anxiety-related biases in multisensory...
Emotion perception is essential to human interaction and relies on effective integration of emotional cues across sensory modalities. Despite initial evidence for anxiety-related biases in multisensory...
The Effects of Explicit and Implicit Cognitive Factors on the Learning Patterns in the Iowa Gambling Task
The Iowa Gambling Task (IGT) has become a standard tool in the area of decision making, but recent studies have indicated that cognitive factors might distort the implicit learning expected from the original design of the task....
Published by: Digital Commons @ Texas A&M University-San Antonio
I do not know what else to do
Excessive Reassurance Seeking (ERS) is an under-researched and poorly understood behavior that resembles the compulsive behaviors that are typically seen in OCD. ERS can be complex, persistent, extensive, debilitating and may...
A journal for the modern era.
Mark Gurnell
Jun 27, 2018
We live in a time of “now,” when we can pretty much find anything we need at the click of a button, have it delivered to our door within hours, and often without the need to compromise on quality. The market place is more...
I do not know what else to do
Excessive Reassurance Seeking (ERS) is an under-researched and poorly understood behavior that resembles the compulsive behaviors that are typically seen in OCD. ERS can be complex, persistent, extensive, debilitating and may...
Can Open Access Save Us?
Mark Y. Herring
Jan 01, 0001
Just about every time I open a journal or read a blog online, I see something about e-books saving newspapers and magazines. Both magazines and newspapers-and really all scholalry communication-are going the way of all flesh...
Published by: Winthrop University
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