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Genome-Scale Genetics: Lessons from Founder Populations
Eimear Elizabeth Kenny
Jan 01, 0001
The potential benefits of using population isolates in genetic mapping due to reduced genetic and environmental heterogeneity are offset by the challenges posed by these populations for traditional association methods....
population isolates genetic mapping genotype mapping haplotypic mapping Kosrae Ashkenazi Jews Life Sciences
Published by: Rockefeller University
Cross-Currents
Isobel Maddison
Nov 05, 2018
When Elizabeth von Arnim's novel 'Introduction to Sally' appeared in 1926, the critical response was divided. Dame Ethel Smyth may have told von Arnim the book was her 'masterpiece' but some were less convinced; the reviewer in...
Declines in freshwater mussel density, size and productivity in the River Thames over the past half century.
A pioneering, quantitative study published in Journal of Animal Ecology in 1966 on freshwater mussel populations in the River Thames, UK, continues to be cited extensively as evidence of the major contribution that mussels make...
The meaning of my feelings depends on who I am
Theory and research on affect in organizations has mostly approached emotions from a valence perspective, suggesting that positive emotions lead to positive outcomes and negative emotions to negative outcomes for organizations....
Swimming in nature
Purpose: Open water swimming (also known as outdoor or wild swimming) is a popular blue activity which has become of recent interest in the mental health sphere. Moreover, it is an accessible and low-cost activity, requiring...
Defending, contesting and rejecting formal drinker categories
Definitions of drinker ‘categories’ (e.g., ‘light drinkers’) typically ignore the role of self-identification involved in drinking practices. To explore this, we presented self-identified ‘non’ or ‘light’ drinkers with...
Percentage of High Schoolers' with Daily Soda Consumption by State Compared to the Percentage of High Schoolers with Obesity by State
We will be presenting a poster on the percentage of high schoolers' with daily soda consumption by state compared to the percentage of high schoolers with obesity by state.
Published by: Winthrop University
Translating the Cognitive Model of PTSD to the Treatment of Very Young Children
Benjamin Goodall, Isobel Chadwick, Anna McKinnon, Aliza Werner-Seidler, Richard Meiser-Stedman, Patrick Smith, Tim Dalgleish
Jan 21, 2020
Posttraumatic stress disorder (PTSD) is a clinical condition that occurs after a discrete traumatic event, such as an accident or assault. Research into PTSD has primarily been adult-focused; however, there is a growing body of...
Swimming in nature
Purpose: Open water swimming (also known as outdoor or wild swimming) is a popular blue activity which has become of recent interest in the mental health sphere. Moreover, it is an accessible and low-cost activity, requiring...
Four Eccentric Mergers Increase the Evidence that LIGO-Virgo-KAGRA's Binary Black Holes Form Dynamically
Abstract
The growing population of compact binary mergers detected with gravitational waves contains multiple events that are challenging to explain through isolated binary...
Development of directed global inhibition, competitive inhibition and behavioural inhibition during the transition between infancy and toddlerhood.
Alexandra Hendry, Isobel Greenhalgh, Rhiannon Bailey, Abigail Fiske, Henrik Dvergsdal, Karla Holmboe
Dec 24, 2021
Inhibitory control (IC) is a core executive function integral to self-regulation and cognitive control, yet is itself multi-componential. Directed global inhibition entails stopping an action on demand. Competitive inhibition is...
Defending, contesting and rejecting formal drinker categories
Definitions of drinker ‘categories’ (e.g., ‘light drinkers’) typically ignore the role of self-identification involved in drinking practices. To explore this, we presented self-identified ‘non’ or ‘light’ drinkers with...
A unified model of post-stroke language deficits including discourse production and their neural correlates.
The clinical profiles of individuals with post-stroke aphasia demonstrate considerable variation in the presentation of symptoms. Recent aphasiological studies have attempted to account for this individual variability using a...
The Poor Old Heart of the Milky Way
Abstract
Our Milky Way should host an ancient, metal-poor, and centrally concentrated stellar population, which reflects the star formation and enrichment in the few most massive...
HW Rix, V Chandra, R Andrae, AM Price-Whelan, DH Weinberg, C Conroy, M Fouesneau, DW Hogg, F De Angeli, RP Naidu, M Xiang, D Ruz-Mieres
Dec 12, 2022
CTCF genomic binding sites in Drosophila and the organisation of the bithorax complex.
Eimear E Holohan, Camilla Kwong, Boris Adryan, Marek Bartkuhn, Martin Herold, Rainer Renkawitz, Steven Russell, Robert White
Mar 27, 2020
Insulator or enhancer-blocking elements are proposed to play an important role in the regulation of transcription by preventing inappropriate enhancer/promoter interaction. The zinc-finger protein CTCF is well studied in...
Animals Base Sequence Binding Sites CCCTC-Binding Factor Chromatin Immunoprecipitation Consensus Sequence DNA DNA Primers DNA-Binding Proteins Drosophila Drosophila Proteins Enhancer Elements Genetic Genes Insect Genome Insect Insulator Elements Models Genetic Oligonucleotide Array Sequence Analysis Repressor Proteins
Analysis of seaweeds from South West England as a biorefinery feedstock
Tracey A. Beacham, Isobel S. Cole, Louisa S. DeDross, Sofia Raikova, Christopher J. Chuck, John Macdonald, Leopoldo Herrera, Tariq Ali, Ruth L. Airs, Andrew Landels, Michael J. Allen
Oct 21, 2019
Seaweeds contain many varied and commercially valuable components, from individual pigments and metabolites through to whole biomass, and yet they remain an under cultivated and underutilised commodity. Currently, commercial...
Don't move a mussel? Parasite and disease risk in conservation action
Abstract: Freshwater mussels are one of the most endangered animal groups globally, making them a high conservation priority. Conservationists increasingly employ translocation or captive breeding procedures to support ailing...
POLICY PERSPECTIVE POLICY PERSPECTIVES captive breeding freshwater pathogen prevalence Translocation transmission unionid
Published by: Conservation Letters
Emergency care for older people living with frailty
Background Little is known about how frailty impacts on older people’s experiences of emergency care, despite patient experience being essential to providing person-centred care. This...
Emma Regen, Kay Phelps, James David van Oppen, Peter Riley, Jagruti Lalseta, Graham Martin, Suzanne M Mason, Simon Conroy
Aug 22, 2022
Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.
Matthias Richard, Ana Victoria Gutiérrez, Albertus Viljoen, Daniela Rodriguez-Rincon, Françoise Roquet-Baneres, Mickael Blaise, Isobel Everall, Julian Parkhill, R Andres Floto, Laurent Kremer
May 16, 2019
New therapeutic approaches are needed against Mycobacterium abscessus, a respiratory mycobacterial pathogen that evades efforts to successfully treat infected patients. Clofazimine and bedaquiline, two drugs used for the...
EMSA MmpL Mycobacterium abscessus TetR regulator bedaquiline clofazimine drug resistance mechanisms efflux pumps Antitubercular Agents Clofazimine Diarylquinolines Drug Resistance Multiple Bacterial Genome Bacterial Humans Membrane Transport Proteins Microbial Sensitivity Tests Mycobacterium abscessus Tetracycline Resistance Trans-Activators Tuberculosis Multidrug-Resistant whole genome sequencing
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