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DIA label-free proteomic analysis of murine bone-marrow-derived macrophages.
Christa P Baker, Iain R Phair, Alejandro J Brenes, Abdelmadjid Atrih, Dylan G Ryan, Roland Bruderer, Albena T Dinkova-Kostova, Douglas J Lamont, J Simon C Arthur, Andrew JM Howden
Oct 28, 2022
Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation...
A meta-analysis of techniques to promote motivation for health behaviour change from a self-determination theory perspective
A systematic review and meta-analysis was conducted of the techniques used to promote psychological need satisfaction and motivation within health interventions based on self-determination theory (SDT; Ryan & Deci, 2017)....
A meta-analysis of techniques to promote motivation for health behaviour change from a self-determination theory perspective
A systematic review and meta-analysis was conducted of the techniques used to promote psychological need satisfaction and motivation within health interventions based on self-determination theory (SDT; Ryan & Deci, 2017)....
TCA cycle signalling and the evolution of eukaryotes.
A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory depicts the origin of eukaryotic cell complexity as emerging from the...
IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.
Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to...
G-Quadruplexes
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention...
The Grizzly, February 7, 1995
Marc Ellman, Mark Leiser, Jayson Blocksidge, Michelle Ryan, Phil Caiazzo, Amy K. Davenport, Tarik Qasim, Nicole D'orsaneo, Michael A. Pizzi, Doug Plitt, Fred Klee, Joel Schofer, Ellen Cosgrove, Charlie Weingroff
Jan 01, 0001
Faculty and Administrators Focus on Sophomore Concerns Survey of Ursinus Freshmen Voice of Ursinus Rings Clear Border Dispute Between Ecuador and Peru Tabby Buckingham Dies at 16 Ursinus Students Attend March for Life ...
Ursinus College Collegeville Pennsylvania newspaper gymnastics Basketball Swimming Bridget Cauley Ellen Cosgrove campus security WVOU radio station Abortion Tabby Buckingham Michelle Ryan CIRP Sophomore Week cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Dylan G Ryan, Michael P Murphy, Christian Frezza, Hiran A Prag, Edward T Chouchani, Luke A O'Neill, Evanna L Mills
Feb 12, 2019
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists, with exciting advances providing new insights into underlying mechanisms of disease. Metabolites traditionally associated with...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Synthesis of Novel Regenerable 13X Zeolite-Polyimide Adsorbent Foams
A new generic synthesis method is presented for the production of a polyimide (PI)/adsorbent (80 wt% 13X zeolite) regenerable foam filter. The method uses a dual parallel reaction foaming process comprising CO 2...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia.
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates, Sua Myong, John K Kim
Apr 17, 2020
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the...
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.
Jutta Zimmer, Eliana MC Tacconi, Cecilia Folio, Sophie Badie, Manuela Porru, Kerstin Klare, Manuela Tumiati, Enni Markkanen, Swagata Halder, Anderson Ryan, Stephen P Jackson, Kristijan Ramadan, Sergey G Kuznetsov, Annamaria Biroccio, Julian E Sale, Madalena Tarsounas
Jan 13, 2016
Aminoquinolines Animals Antineoplastic Agents BRCA1 Protein BRCA2 Protein Biomarkers Tumor Cell Proliferation DNA Breaks Double-Stranded Dose-Response Relationship Drug Drug Resistance Neoplasm G-Quadruplexes G2 Phase Cell Cycle Checkpoints HEK293 Cells Humans Intracellular Signaling Peptides and Proteins Mad2 Proteins Male Mice Nude Molecular Targeted Therapy Neoplasms Picolinic Acids Poly(ADP-ribose) Polymerase Inhibitors RNA Interference Telomere Time Factors Transfection Tumor Burden Tumor Suppressor p53-Binding Protein 1 Xenograft Model Antitumor Assays
Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor.
Theoretical models of G protein-coupled receptor (GPCR) concentration-response relationships often assume an agonist producing a single functional response via a single active state of the receptor. These models have largely...
Remote stereocontrol in [3,3]-sigmatropic rearrangements
The Ireland - Claisen [3,3]-sigmatropic rearrangement has been used to access biologically important β,β′-dihydroxy α-amino acids. The rearrangement reported is highly stereoselective and offers excellent levels of remote...
Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases.
Alvin Djajadikerta, Swati Keshri, Mariana Pavel, Ryan Prestil, Laura Ryan, David C Rubinsztein
Dec 11, 2019
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic contents to lysosomes for degradation. Genetic studies have revealed extensive links between autophagy and neurodegenerative disease, and...
Supporting behaviour change in sedentary adults via real-time multidimensional physical activity feedback
BACKGROUND:
Increasing physical activity (PA) behaviour remains a public health priority and wearable technology is increasingly being used to support behaviour change efforts. Using wearables to capture and provide...
Increasing physical activity (PA) behaviour remains a public health priority and wearable technology is increasingly being used to support behaviour change efforts. Using wearables to capture and provide...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders
The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human...
Supporting behaviour change in sedentary adults via real-time multidimensional physical activity feedback
BACKGROUND:
Increasing physical activity (PA) behaviour remains a public health priority and wearable technology is increasingly being used to support behaviour change efforts. Using wearables to capture and provide...
Increasing physical activity (PA) behaviour remains a public health priority and wearable technology is increasingly being used to support behaviour change efforts. Using wearables to capture and provide...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
A practical graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>)based fluorescence sensor for the competitive detection of trithiocyanuric acid and mercury ions
Meng Li, Bo Wang, Xufei An, Zhiyong Li, Hongtao Zhu, Boyang Mao, David G. Calatayud, Tony D. James
Nov 01, 2019
A fluorescent sensor for the detection of trithiocyanuric acid (TCA)and Hg2+ was developed based on competitive interactions: non-covalent stacking between g-C3N4 and TCA vs coordinative...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
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