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Results: 82
Co-registration of optoacoustic tomography and magnetic resonance imaging data from murine tumour models.
Marcel Gehrung, Michal Tomaszewski, Dominick McIntyre, Jonathan Disselhorst, Sarah Bohndiek
Mar 13, 2020
As optoacoustic tomography (OT) emerges as a mainstream pre-clinical imaging modality, understanding the relationship between optoacoustic and other imaging biomarkers in the context of the underlying tissue biology becomes...
Published by: Photoacoustics
Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases.
Nicola L Ainsworth, Mary A McLean, Dominick JO McIntyre, Davina J Honess, Anna M Brown, Susan V Harden, John R Griffiths
Apr 21, 2016
MRI brain metastasis Cancer Diffusion magnetization transfer texture analysis Aged Animals Brain Neoplasms Cell Line Tumor Diffusion Magnetic Resonance Imaging Discriminant Analysis Early Detection of Cancer Female Humans Linear Models Male Mice Mice SCID Middle Aged Neoplasm Metastasis Small Cell Lung Carcinoma
Survival Pathways of HIF-Deficient Tumour Cells
Monika A. Golinska, Marion Stubbs, Adrian L. Harris, Laszlo G. Boros, Madhu Basetti, Dominick J. O. McIntyre, John R. Griffiths
Dec 08, 2022
article HIF-1β deficiency Hepa-1 c4 cells hypoxia response 1 2-13C2-labelled glucose TCA fatty acid oxidation AMP-activated kinase phospho-p38 MAPK PPARα PGC-1α
Published by: MDPI
Survival Pathways of HIF-Deficient Tumour Cells
Monika A Golinska, Marion Stubbs, Adrian L Harris, Laszlo G Boros, Madhu Basetti, Dominick JO McIntyre, John R Griffiths
Jan 04, 2023
The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 therapy? We studied metabolic and...
A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.
Liam D Cassidy, Andrew RJ Young, Pedro A Pérez-Mancera, Birgit Nimmervoll, Adil Jaulim, Hung-Chang Chen, Dominick JO McIntyre, Rebecca Brais, Thomas Ricketts, Simon Pacey, Maike de la Roche, Richard J Gilbertson, David C Rubinsztein, Masashi Narita
Feb 14, 2018
Macroautophagy/autophagy is an evolutionarily conserved catabolic pathway whose modulation has been linked to diverse disease states, including age-associated disorders. Conventional and conditional whole-body knockout mouse...
Divided Scholarship Over Divided Government: Why do the President and Congress Seem Unable to Work Together?
Nicholas J. McIntyre
Jan 01, 0001
David Mayhew's book Divided We Govern (1991, 2005) has profoundly affected the way political scientists not only study but also understand "divided government" in American national politics. By analyzing hundreds of...
divided government unified government Legislation gridlock party polarization public mood Congressional coalitions presidential leadership American Politics Political Science Political Theory Social and Behavioral Sciences
Published by: Ursinus College
A Redemption of Meaning in Three Novels by Italo Calvino
Dominick J Knowles
Jan 01, 0001
In this thesis I present three readings of Italo Calvino's later novels: Invisible Cities (1972), If on a winter's night a traveler (1979), and Mr. Palomar (1983). My primary aim is to defend Calvino against dominant scholarly...
Calvino Postmodernism Theory Invisible Cities Mr. Palomar If on a winter's night a traveler Wittgenstein meaning creativity Arts and Humanities English Language and Literature
Published by: Ursinus College
Climate Uncertainties
This essay takes a brief personal look at aspects of the climate problem. The emphasis will be on some of the greatest scientific uncertainties, as suggested by what is known about past as well as present climates...
Michael Edgeworth McIntyre
Apr 19, 2022
The Grizzly, October 24, 2013
Sabrina McGettigan, David Rogers, Bethany Mitchell, Deana Harley, Nicholas DiMuzio, Vivek Reddy, Shawn Hartigan, Brandon Patterson, Adebayo Adeyemo, Dom Roher, Briana Mullan, Mary Deliberti, Derrick Falletta, Austin Fox, James Wilson
Jan 01, 0001
Ursinus Receives Largest Private Donation in History Parking at Ursinus History Department Takes Students to Gettysburg Pennsylvania Senator Rafferty and Representative Vereb Speak in Bear's Den UC Students Volunteer to...
Ursinus College Collegeville Pennsylvania newspaper John F. Rodenbaugh James L. Boswell Parking Homecoming Ross Doughty Dallett Hemphill Mike Vereb John Rafferty Perkiomen Watershed Conservancy Lynnewood Hall sustainability Holly Hubbs Berman Art Museum campus safety Reimert Hall Anahi McIntyre Volleyball Soccer Football field hockey cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Regionalisation of a PDM Model for Catchment Runoff in a Mountainous region of Korea
This study aims to regionalize a rainfall-runoff model within the mountainous Geum River catchment, Korea. A version of the Probability Distributed Moisture model is applied to 19 gauged sub-catchments. A Monte Carlo based...
The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.
Somatically acquired, activating mutations of GNAS, the gene encoding the stimulatory G-protein Gsalpha subunit, have been identified in kidney, thyroid, pituitary, leydig cell, adrenocortical and, more recently, in colorectal...
Adenoma Adenomatous Polyposis Coli Protein Alleles Animals Cell Differentiation Cell Proliferation Chromogranins Colorectal Neoplasms Cyclic AMP Disease Progression Epithelial Cells Female GTP-Binding Protein alpha Subunits Gs Gene Expression Regulation Neoplastic Genetic Loci Humans Intestinal Mucosa MAP Kinase Signaling System Male Membrane Glycoproteins Mice Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mutant Proteins Mutation Organ Specificity Phosphoric Diester Hydrolases Promoter Regions Genetic Stem Cells Substrate Specificity Up-Regulation Wnt Proteins
Regionalisation of a PDM Model for Catchment Runoff in a Mountainous region of Korea
This study aims to regionalize a rainfall-runoff model within the mountainous Geum River catchment, Korea. A version of the Probability Distributed Moisture model is applied to 19 gauged sub-catchments. A Monte Carlo based...
Engineering short, strong, charge-assisted hydrogen bonds in benzoic acid dimers through co-crystallisation with proton sponge
Lynne H. Thomas, Andrew O. F. Jones, Andras A. Kallay, Garry J. Mcintyre, Chick C. Wilson
Apr 06, 2016
A series of molecular complexes of the proton sponge 1,8-bis(dimethylamino)naphthalene (DMAN) with mono-substituted halobenzoic acids are reported, illustrating the designed exploitation of the characteristics of the proton...
Looking to relate
Abstract: Mobile eye-tracking was used to investigate the link between teacher gaze and student-rated teacher interpersonal behaviour. Teacher gaze was recorded for 10 min during a teacher-centred part of a naturally occurring...
Looking to relate
Abstract: Mobile eye-tracking was used to investigate the link between teacher gaze and student-rated teacher interpersonal behaviour. Teacher gaze was recorded for 10 min during a teacher-centred part of a naturally occurring...
The Grizzly, October 11, 1994
Marc Ellman, Mark Leiser, Hope Rinehimer, Stephanie Piraino, Amy K. Davenport, Jayson Blocksidge, Michelle Ryan, Heather Leach, Alex Schaal, Nicole D'orsaneo, Erik Ferragut, Heather Mead, Colin Tucker, Tarik Qasim, Charlie Weingroff, Joel Schofer, Richard P. Richter, David Gaft, Ashok Parameswaran
Jan 01, 0001
The Last Pledging Season? Homecoming '94 a Success The American Sexual Landscape Fire, Fire! Religious Sect Linked to Murder-Suicides Campus Artwork Encounters Vandalism Soup Kitchen Visit Provides Eye-Opening Experience ...
Ursinus College Collegeville Pennsylvania newspaper Football Soccer Kenneth E. Walker Barbara Golley Linda McIntyre fraternities sororities pledging career planning Homecoming prospective students Larry Kirlin Gay and Lesbian and Allies Wil Schrack Newman Society vandalism Berman Art Museum campus sculptures Collegeville Fire Company cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Grizzly, October 13, 1992
Tom Wilusz, Melissa Chido, Erika Compton, Sara Jacobson, Mark Leiser, Jaymie Burkhart, Dana Kushwara, Heather Mead, Ian Rhile, Annette Rawls, Christian P. Sockel, Hope Rinehimer, Claire Erfle, Harley David Rubin, David Van Benthuysen, J. Houghton Kane, David Webb
Jan 01, 0001
Homecoming 1992 A Question of Queens U.C.'s Past Meets its Present AFAC Dampens Coffee House Plans U.C. Alum to Speak on Venusian Voyage Philadelphia Renaissance Wind Band to Perform at Ursinus Conversations with The Dead ...
Ursinus College Collegeville Pennsylvania newspaper Football Soccer field hockey Volleyball Hope Arroliga Racism sororities pledging campus security John Cafferty Barry Perlus Grateful Dead student government coffee house James F. Scott III Homecoming Lauren Medica Maria Rojas cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Role of Interests in STEM Pursuit and Academic Performance
A good fit between students' interests, academic major, and subsequent career is critical for occupational success and satisfaction. Substantial work has examined how individual differences in interests are linked with academic...
Published by: IGI Global Scientific Publishing
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