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Results: 78802
Monitoring Ca2+ elevations in individual astrocytes upon local release of amyloid beta in acute brain slices.
Olga Tyurikova, Kaiyu Zheng, Annika Rings, Anna Drews, David Klenerman, Dmitri A Rusakov
May 29, 2018
The pathogenesis of Alzheimer's disease (AD) is thought to involve acute neurotoxic effects exerted by oligomeric forms of amyloid-β 1-42 (Aβ). Application of Aβ oligomers in physiological concentrations have been shown to...
amyloid beta Astroglia calcium imaging fluorescence lifetime imaging Hippocampus Amyloid beta-Peptides Animals Astrocytes Calcium cations Divalent Central Nervous System Agents Hippocampus Membrane Potentials Microscopy Fluorescence Neurons Patch-Clamp Techniques Peptide Fragments Rats Sprague-Dawley Single-Cell Analysis Tissue Culture Techniques
Mitochondrial ROS control neuronal excitability and cell fate in frontotemporal dementia.
Noemí Esteras, Olga Kopach, Marta Maiolino, Vincenzo Lariccia, Salvatore Amoroso, Seema Qamar, Selina Wray, Dmitri A Rusakov, Morana Jaganjac, Andrey Y Abramov
May 31, 2021
INTRODUCTION: The second most common form of early-onset dementia-frontotemporal dementia (FTD)-is often characterized by the aggregation of the microtubule-associated protein tau. Here we studied the mechanism of tau-induced...
4R tau AMPA receptors MAPT 10+16 NMDA receptors Calcium Signaling frontotemporal dementia Glutamate Induced Pluripotent Stem Cells mitochondrial antioxidants mitochondrial reactive oxygen species Tau frontotemporal dementia Humans Induced Pluripotent Stem Cells Mitochondria Neurons Reactive Oxygen Species Receptors N-Methyl-D-Aspartate tau Proteins
Imaging of barely visible impact damage on a complex composite stiffened panel using a nonlinear ultrasound stimulated thermography approach
Thermosonics, also known as ultrasonic stimulated thermography, is a rapid non-destructive evaluation technique that uses an infrared camera to visualise material defects by detecting the frictional heating at crack surfaces...
Imaging of barely visible impact damage on a complex composite stiffened panel using a nonlinear ultrasound stimulated thermography approach
Thermosonics, also known as ultrasonic stimulated thermography, is a rapid non-destructive evaluation technique that uses an infrared camera to visualise material defects by detecting the frictional heating at crack surfaces...
A unified framework for analysis of individual-based models in ecology and beyond.
Stephen J Cornell, Yevhen F Suprunenko, Dmitri Finkelshtein, Panu Somervuo, Otso Ovaskainen
Oct 16, 2020
Individual-based models, 'IBMs', describe naturally the dynamics of interacting organisms or social or financial agents. They are considered too complex for mathematical analysis, but computer simulations of them cannot give the...
SHM of Single Lap Adhesive Joints using Subharmonic Frequencies
The increased usage of adhesive bonding as a joining method in modern aerospace components has led to developing reliable ultrasonic health monitoring systems for detection of regions of poor adhesion. Nonlinear...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Anomalous Stochastic Transport of Particles with Self-Reinforcement and Mittag-Leffler Distributed Rest Times
We introduce a persistent random walk model for the stochastic transport of particles involving self-reinforcement and a rest state with Mittag–Leffler distributed residence times. The model involves a system of...
Effects of covid-19 pandemic on life expectancy and premature mortality in 2020
Nazrul Islam, Dmitri A Jdanov, Vladimir M Shkolnikov, Kamlesh Khunti, Ichiro Kawachi, Martin White, Sarah Lewington, Ben Lacey
Nov 04, 2021
Abstract: Objective: To estimate the changes in life expectancy and years of life lost in 2020 associated with the covid-19 pandemic. Design: Time series analysis. Setting: 37 upper-middle and high income countries or regions...
Effects of covid-19 pandemic on life expectancy and premature mortality in 2020
Nazrul Islam, Dmitri A Jdanov, Vladimir M Shkolnikov, Kamlesh Khunti, Ichiro Kawachi, Martin White, Sarah Lewington, Ben Lacey
Nov 05, 2021
OBJECTIVE: To estimate the changes in life expectancy and years of life lost in 2020 associated with the covid-19 pandemic. DESIGN: Time series analysis. SETTING: 37 upper-middle and high income countries or regions with...
Surface Crystallization of Liquid Au-Si and Its Impact on Catalysis.
Federico Panciera, Jerry Tersoff, Andrew D Gamalski, Mark C Reuter, Dmitri Zakharov, Eric A Stach, Stephan Hofmann, Frances M Ross
Dec 17, 2018
In situ transmission electron microscopy reveals that an atomically thin crystalline phase at the surface of liquid Au-Si is stable over an unexpectedly wide range of conditions. By measuring the surface structure as a function...
Nonlinear ultrasonic stimulated thermography for damage assessment in isotropic fatigued structures
Gian Piero Malfense Fierro, Danielle Calla, Dmitri Ginzburg, Francesco Ciampa, Michele Meo
Sep 15, 2017
Traditional non-destructive evaluation (NDE) and structural health monitoring (SHM) systems are used to analyse that a structure is free of any harmful damage. However, these techniques still lack sensitivity to detect the...
Hydrogen storage performance of the multi-principal-component CoFeMnTiVZr alloy in electrochemical and gas-solid reactions.
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
Effects of covid-19 pandemic on life expectancy and premature mortality in 2020
Nazrul Islam, Dmitri A Jdanov, Vladimir M Shkolnikov, Kamlesh Khunti, Ichiro Kawachi, Martin White, Sarah Lewington, Ben Lacey
Nov 05, 2021
Abstract: Objective: To estimate the changes in life expectancy and years of life lost in 2020 associated with the covid-19 pandemic. Design: Time series analysis. Setting: 37 upper-middle and high income countries or regions...
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect thepatient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and iffound...
Published by: IJHS Medical Association
Sentiment Analysis on Movie Reviews Dataset Using Support Vector Machines and Ensemble Learning
The internet makes it easier for people to connect to each other and has become a platform to express ideas and share information with the world. The growth of the internet has indirectly led to the development of social...
Published by: IGI Global Scientific Publishing
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
SHM of Single Lap Adhesive Joints using Subharmonic Frequencies
The increased usage of adhesive bonding as a joining method in modern aerospace components has led to developing reliable ultrasonic health monitoring systems for detection of regions of poor adhesion. Nonlinear...
Knowledge and Attitude among High School Students towards HIV / AIDS in Rural areas of Belagavi–A Cross Sectional Study
Asha A. Bellad and Rajesh R Kulkarni
Mar 25, 2015
Introduction Since its emergence in 1981, the HIV/AIDS pandemic, which poses a serious challenge to mankind, without doubt, has become one of the most serious infectious diseases. Many adolescents around the world are sexually...
Published by: IJHS Medical Association
Right sided eventration of diaphragm with clinodactyly
A. Sareen and K. Mahajan
Apr 21, 2015
Diaphragmatic hernia can be of two types-absence or deficiency of the diaphragm, or eventration resulting in elevation of a portion of the diaphragm as a result of incomplete muscularization. Complete eventration almost...
Published by: IJHS Medical Association
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