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Embryonic origins of human vascular smooth muscle cells
Vascular smooth muscle cells (SMCs) arise from multiple origins during development, raising the possibility that differences in embryological origins between SMCs could contribute to site-specific localization of vascular...
A Novel Human Pluripotent Stem Cell-Derived Neural Crest Model of Treacher Collins Syndrome Shows Defects in Cell Death and Migration.
Felipe Serrano, William George Bernard, Alessandra Granata, Dharini Iyer, Ben Steventon, Matthew Kim, Ludovic Vallier, Laure Gambardella, Sanjay Sinha
Dec 10, 2018
The neural crest (NC) is a transient multipotent cell population present during embryonic development. The NC can give rise to multiple cell types and is involved in a number of different diseases. Therefore, the development of...
Treacher Collins syndrome DIFFERENTIATION Disease Modeling Human pluripotent stem cells Neural Crest Adaptor Proteins Signal Transducing Animals Benzamides Cell Death Cell Differentiation Cell Movement Cellular Reprogramming Techniques Chick Embryo Dioxoles Fibroblast Growth Factor 2 Humans Mandibulofacial Dysostosis Neural Crest Neural Stem Cells Nuclear Proteins Phosphoproteins Pluripotent Stem Cells SOXE Transcription Factors Transcription Factor AP-2 Transcription Factors Twist-Related Protein 1
Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation.
Johannes Bargehr, Lucinda Low, Christine Cheung, William G Bernard, Dharini Iyer, Martin R Bennett, Laure Gambardella, Sanjay Sinha
Feb 25, 2016
Embryological origin Endothelial Cells Lineage specific Network formation Smooth muscle cells Cell Differentiation Cell Lineage Cells Cultured Coculture Techniques Embryonic Stem Cells Human Umbilical Vein Endothelial Cells Humans Muscle Smooth Vascular Myocytes Smooth Muscle Neovascularization Physiologic
Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration.
Johannes Bargehr, Lay Ping Ong, Maria Colzani, Hongorzul Davaapil, Peter Hofsteen, Shiv Bhandari, Laure Gambardella, Nicolas Le Novère, Dharini Iyer, Fotios Sampaziotis, Florian Weinberger, Alessandro Bertero, Andrea Leonard, William G Bernard, Amy Martinson, Nichola Figg, Michael Regnier, Martin R Bennett, Charles E Murry, Sanjay Sinha
May 16, 2019
Religion and Depression in Adolescence.
Depression is the leading cause of illness and disability in adolescence. Many studies show a correlation between religiosity and mental health, yet the question remains whether the relationship is causal. We exploit...
Virtual Events and Use of Technology
This research brings the relationships of human and technology interactions to the forefront in the delivery of an event and focuses upon the description of the various elements and their relationships within the Unified Theory...
Published by: IGI Global Scientific Publishing
Dynamical models for random simplicial complexes
We study a general model of random dynamical simplicial complexes and derive a formula for the asymptotic degree distribution. This asymptotic formula generalises results for a number of existing models, including random...
The second law of black hole mechanics in effective field theory
Abstract
We investigate the second law of black hole mechanics in gravitational theories with higher derivative terms in the action. Wall has described a...
Dynamical models for random simplicial complexes
We study a general model of random dynamical simplicial complexes and derive a formula for the asymptotic degree distribution. This asymptotic formula generalises results for a number of existing models, including random...
Impact of Advertising on Educational Apps Used by Children
India’s education sector is being impacted by COVID-19 in unprecedented ways. The pandemic is disrupting the traditional education system, affecting over 320 million students. This sector is trying to develop robust, innovative...
Published by: IGI Global Scientific Publishing
A simulation study of how religious fundamentalism takes root
Religious fundamentalism is observed across the world. We investigate its roots
using agent-based simulations of religiosity dynamics in a spatially dispersed population. Agents’ religiosity responds to neighbors via direct...
Crystal structure of X-prolyl aminopeptidase from <i>Caenorhabditis elegans</i>
Shalini Iyer, Penelope J. La-Borde, Karl A P Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya
Jan 01, 2015
Eukaryotic aminopeptidase P1 (APP1), also known as X-prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N-terminus of peptides possessing a...
Crystal structure of X-prolyl aminopeptidase from <i>Caenorhabditis elegans</i>
Shalini Iyer, Penelope J. La-Borde, Karl A P Payne, Mark R. Parsons, Anthony J. Turner, R. Elwyn Isaac, K. Ravi Acharya
Jan 01, 2015
Eukaryotic aminopeptidase P1 (APP1), also known as X-prolyl aminopeptidase (XPNPEP1) in human tissues, is a cytosolic exopeptidase that preferentially removes amino acids from the N-terminus of peptides possessing a...
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice.
Rebecca E McIntyre, Jérôme Nicod, Carla Daniela Robles-Espinoza, John Maciejowski, Na Cai, Jennifer Hill, Ruth Verstraten, Vivek Iyer, Alistair G Rust, Gabriel Balmus, Richard Mott, Jonathan Flint, David J Adams
Jun 29, 2016
Micronuclei Outbred mice genetic mapping Genome-wide association study (GWAS) Genomic Instability Animals Chromosome Breakage Chromosome Mapping Female Genome-Wide Association Study Genomic Instability Genotype Male Mice Micronuclei Chromosome-Defective Phenotype Polymorphism Single Nucleotide Quantitative Trait Loci Sex Characteristics
Barrett oesophagus.
Yonne Peters, Ali Al-Kaabi, Nicholas J Shaheen, Amitabh Chak, Andrew Blum, Rhonda F Souza, Massimiliano di Pietro, Prasad G Iyer, Oliver Pech, Rebecca C Fitzgerald, Peter D Siersema
Nov 01, 2019
Barrett oesophagus (BE), the only known histological precursor of oesophageal adenocarcinoma (EAC), is a condition in which the squamous epithelium of the oesophagus is replaced by columnar epithelium as an adaptive response to...
Acceptability, Accuracy, and Safety of Disposable Transnasal Capsule Endoscopy for Barrett's Esophagus Screening.
Sarmed S Sami, Prasad G Iyer, Prachi Pophali, Magnus Halland, Massimiliano di Pietro, Jacobo Ortiz-Fernandez-Sordo, Jonathan R White, Michele Johnson, Indra Neil Guha, Rebecca C Fitzgerald, Krish Ragunath
Sep 08, 2018
BACKGROUND & AIMS: Screening for Barrett's esophagus (BE) with conventional esophagogastroduodenoscopy (C-EGD) is expensive. We assessed the performance of a clinic-based, single use transnasal capsule endoscope (EG Scan II) for...
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
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