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Results: 463
Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics.
Stephan Gerhard, Ingrid Andrade, Richard D Fetter, Albert Cardona, Casey M Schneider-Mizell
Jan 25, 2018
During postembryonic development, the nervous system must adapt to a growing body. How changes in neuronal structure and connectivity contribute to the maintenance of appropriate circuit function remains unclear. Previously , we...
The Grizzly, March 16, 2023
Layla Halterman, Marie Sykes, Tatiana Kent, Chase Portaro, Ava Compagnoni, Brian Tague, Katie Cressman
Jan 01, 0001
Dean Schneider to Leave Ursinus: Announcement Raises Questions for Many Faculty Members Maker's Club Promises Creative Fun for All Majors Anarchy at Ursinus? Meet the New President, Alisa Zenchenko '25 Softball Season Back...
Ursinus College Collegeville Pennsylvania newspaper Mark Schneider makerspaces vandalism Alisa Zenchenko student government softball Intramural Sports tennis cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Thomas Oellerich, Constanze Schneider, Dominique Thomas, Kirsten M Knecht, Olga Buzovetsky, Lars Kaderali, Christoph Schliemann, Hanibal Bohnenberger, Linus Angenendt, Wolfgang Hartmann, Eva Wardelmann, Tamara Rothenburger, Sebastian Mohr, Sebastian Scheich, Federico Comoglio, Anne Wilke, Philipp Ströbel, Hubert Serve, Martin Michaelis, Nerea Ferreirós, Gerd Geisslinger, Yong Xiong, Oliver T Keppler, Jindrich Cinatl
Aug 01, 2020
Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the treatment of acute myeloid leukemia (AML). However, their mechanisms of action remain incompletely understood, and predictive biomarkers...
Animals Antimetabolites Antineoplastic Azacitidine Biomarkers Tumor Bone Marrow Cell Line Tumor DNA Methylation Decitabine Drug Resistance Neoplasm Female Gene Expression Regulation Leukemic Humans Leukemia Myeloid Acute Mice Patient Selection Primary Cell Culture Retrospective Studies SAM Domain and HD Domain-Containing Protein 1 Treatment Outcome Xenograft Model Antitumor Assays
Interest group size and legislative lobbying
Maik Schneider
Oct 01, 2014
We develop a model of legislative decision making in which lobbying and public policy are jointly determined. We examine how policy outcomes depend on the sizes of the interest groups. While a larger size typically involves...
The Ursinus Weekly, March 21, 1968
Draft security lost; Exemptions ended Dismissal of two mourned in black Wednesday protest Who's Who elects eight UC seniors U.C. holds primary to voice '68 choice Students to sponsor dramatic productions Judy Schneider...
Ursinus College Collegeville Pennsylvania newspaper draft exemptions Who's who Wesley Clymer Gary Waldo Choice 68 Judith A. Schneider Curtain Club Robert Heisler track team Basketball baseball wrestling sororities fraternities cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
The Grizzly, September 21, 2017
Valerie Osborne, Johnny Myers, Courtney A DuChene, Emily Shue, Skyler L Gailing, Kevin Leon, Paige Szmodis, Sophia DiBattista, David Mendelsohn
Jan 01, 0001
CSCG Brings Biologist and Policy Maker Nina Federoff to Campus Students Surprised by New Student Senate Requirements International Film Festival Kicks Off Q&A with Dean Mark Schneider Beekeeping Society Creates Some Buzz ...
Ursinus College Collegeville Pennsylvania newspaper Nina Federoff student government Mark Schneider Beekeeping Society Brandon Carey Pi Omega Delta cross country golf cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Tax contracts and elections
In this paper we examine the impact of tax contracts as a novel institution on elections, policies, and welfare. We consider a political game in which three parties compete to form the government and voters may behave...
Macroeconomic Rationales for Public Investments in Science
Maik T. Schneider
Apr 01, 2021
What is the economic rationale for investing in science? Based on an open economy model of creative destruction, we characterize four key factors of optimal investment in basic research: the stage of economic development, the...
Hanfei and Truth
Henrique Schneider
Apr 26, 2016
Characterization of a Novel Sensing Mechanism Governing Antigenic Variation in P. Falciparum
Victoria M Schneider
Jan 01, 0001
Plasmodium falciparum expresses a multi-copy gene family called var in the intraerythroyctic stages of its life cycle in a mutually exclusive manner. var genes encode the chief antigenic and virulence determinant of P....
Published by: Rockefeller University
Book Review: Youssef Cassis, Richard S. Grossman & Catherine R. Schenk eds., The Oxford handbook of banking and financial history (Oxford
SA-MI Schneider
Jan 25, 2017
The Oxford Handbook of Banking and Financial History is a timely work of synthesis that consolidates the recent resurgence of scholarly interest in the long-term evolution of the global financial system. Its editors have...
Interest group size and legislative lobbying
Maik Schneider
Oct 01, 2014
We develop a model of legislative decision making in which lobbying and public policy are jointly determined. We examine how policy outcomes depend on the sizes of the interest groups. While a larger size typically involves...
Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.
Ionel Sandovici, Constanze M Hammerle, Wendy N Cooper, Noel H Smith, Jane L Tarry-Adkins, Benjamin J Dunmore, Julien Bauer, Simon R Andrews, Giles SH Yeo, Susan E Ozanne, Miguel Constância
Sep 12, 2016
Ageing DNA Methylation epigenetics Inflammageing Pancreatic islets Type 2 diabetes aging Animals Chemokine CXCL9 Collagen Type III DNA Methylation Diabetes mellitus Type 2 Epigenesis Genetic Inflammation Islets of Langerhans KCNQ1 Potassium Channel Male Phosphoric Diester Hydrolases Pyrophosphatases Rats Sulfonylurea Receptors Tetraspanins
Han Fei and Justice
Henrique Schneider
Apr 26, 2016
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Katharina Koch, Rudolf Hartmann, Julia Tsiampali, Constanze Uhlmann, Ann-Christin Nickel, Xiaoling He, Marcel A Kamp, Michael Sabel, Roger A Barker, Hans-Jakob Steiger, Daniel Hänggi, Dieter Willbold, Jaroslaw Maciaczyk, Ulf D Kahlert
Apr 20, 2020
Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover. Limiting the supply of macromolecular precursors by targeting enzymes involved in biosynthesis is a promising strategy in cancer therapy....
Comparison of the Protein Contents of Bovine Zymogen Granules and of Pancreatic Juice
Lewis Joel Greene
Jan 01, 0001
A zymogen granule fraction has been isolated from bovine pancreas by differential centrifugation under conditions designed to favor homogeneity at the expense of yield. The fraction has been examined in the electron microscope...
Published by: Rockefeller University
Macroeconomic Rationales for Public Investments in Science
Maik T. Schneider
Apr 01, 2021
What is the economic rationale for investing in science? Based on an open economy model of creative destruction, we characterize four key factors of optimal investment in basic research: the stage of economic development, the...
Characterization of RNA aptamers that disrupt the RUNX1-CBFbeta/DNA complex.
Jenny L Barton, David HJ Bunka, Stuart E Knowling, Pascal Lefevre, Alan J Warren, Constanze Bonifer, Peter G Stockley
Jan 29, 2020
The transcription factor RUNX1 (AML1) is an important regulator of haematopoiesis, and an important fusion partner in leukaemic translocations. High-affinity DNA binding by RUNX1 requires the interaction of the RUNX1...
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
Ionel Sandovici, Constanze M. Hammerle, Sam Virtue, Yurena Vivas-Garcia, Adriana Izquierdo-Lahuerta, Susan E. Ozanne, Antonio Vidal-Puig, Gema Medina-Gómez, Miguel Constância
Jul 28, 2021
Abstract: When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas...
On the global supply of basic research
In a two-country Schumpeterian growth model, we study the incentives for basic research investments by governments in a globalized world. A country’s basic research investments increase with the country’s level of human capital...
Endogenous enforcement of intellectual property, North-South trade, and growth
After most countries have harmonized intellectual property rights (IPR) legislation as a consequence of signing the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPs), the dispute about the optimal level...
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