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Results: 253
RIME proteomics of estrogen and progesterone receptors in breast cancer.
Nuclear receptors play an important role in transcriptional regulation of diverse cellular processes and is also relevant in diseases such as cancer. In breast cancer, the nuclear receptors - estrogen receptor (ER) and...
C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling.
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.
Hisham Mohammed, Clive D'Santos, Aurelien A Serandour, H Raza Ali, Gordon D Brown, Alan Atkins, Oscar M Rueda, Kelly A Holmes, Vasiliki Theodorou, Jessica LL Robinson, Wilbert Zwart, Amel Saadi, Caryn S Ross-Innes, Suet-Feung Chin, Suraj Menon, John Stingl, Carlo Palmieri, Carlos Caldas, Jason S Carroll
Jan 18, 2021
Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting proteins have been limited. We purified...
Animals Breast Neoplasms Cell Line Tumor Chromatin Chromatin Immunoprecipitation Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Humans MCF-7 Cells Mice Mice SCID Neoplasm Proteins Protein Interaction Maps RNA Interference RNA Small Interfering Transcription Genetic Transplantation Heterologous
Modelling the Effects of Complacency and Educational Countermeasures on the Spread of HIV
In this project, we consider a system of five ordinary differential equations which describe the population dynamics of HIV/AIDS when individuals are tested for the virus and then moved onto antiretroviral therapy. We include a...
Published by: Winthrop University
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.
Petros A Tyrakis, Marie E Yurkovich, Marco Sciacovelli, Evangelia K Papachristou, Hannah R Bridges, Edoardo Gaude, Alexander Schreiner, Clive D'Santos, Judy Hirst, Juan Hernandez-Fernaud, Roger Springett, John R Griffiths, Christian Frezza
May 22, 2018
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial...
ZAP-70 constitutively regulates gene expression and protein synthesis in chronic lymphocytic leukemia.
Jingyu Chen, Vijitha Sathiaseelan, Andrew Moore, Shengjiang Tan, Chandra Sekkar Reddy Chilamakuri, Valar Nila Roamio Franklin, Arash Shahsavari, Constanze A Jakwerth, Sandra B Hake, Alan J Warren, Irina Mohorianu, Clive D'Santos, Ingo Ringshausen
Mar 15, 2021
The expression of ZAP-70 in a subset of chronic lymphocytic leukemia (CLL) patients strongly correlates with a more aggressive clinical course, although the exact underlying mechanisms remain elusive. The ability of ZAP-70 to...
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D'Santos, Silvia Deaglio, Daniel J Hodson, Jose I Martin-Subero, Ingo Ringshausen
Nov 20, 2022
Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells...
Asparagine bioavailability governs metastasis in a model of breast cancer.
Simon RV Knott, Elvin Wagenblast, Showkhin Khan, Sun Y Kim, Mar Soto, Michel Wagner, Marc-Olivier Turgeon, Lisa Fish, Nicolas Erard, Annika L Gable, Ashley R Maceli, Steffen Dickopf, Evangelia K Papachristou, Clive S D'Santos, Lisa A Carey, John E Wilkinson, J Chuck Harrell, Charles M Perou, Hani Goodarzi, George Poulogiannis, Gregory J Hannon
Aug 31, 2018
Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary sites. A...
Animals Asparaginase Asparagine Aspartate-Ammonia Ligase Biological Availability Breast Neoplasms Cell Line Tumor Disease Models Animal Disease Progression Epithelial-Mesenchymal Transition Female Humans Lung Neoplasms Male Mice Neoplasm Invasiveness Neoplasm Metastasis Prognosis Prostatic Neoplasms RNA Interference Reproducibility of Results
A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes.
Evangelia K Papachristou, Kamal Kishore, Andrew N Holding, Kate Harvey, Theodoros I Roumeliotis, Chandra Sekhar Reddy Chilamakuri, Soleilmane Omarjee, Kee Ming Chia, Alex Swarbrick, Elgene Lim, Florian Markowetz, Matthew Eldridge, Rasmus Siersbaek, Clive S D'Santos, Jason S Carroll
Sep 26, 2018
Understanding the dynamics of endogenous protein-protein interactions in complex networks is pivotal in deciphering disease mechanisms. To enable the in-depth analysis of protein interactions in chromatin-associated protein...
Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer.
Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.
Amanda J Collier, Adam Bendall, Charlene Fabian, Andrew A Malcolm, Katarzyna Tilgner, Claudia I Semprich, Katarzyna Wojdyla, Paola Serena Nisi, Kamal Kishore, Valar Nila Roamio Franklin, Bahar Mirshekar-Syahkal, Clive D'Santos, Kathrin Plath, Kosuke Yusa, Peter J Rugg-Gunn
Apr 25, 2022
Uncovering the mechanisms that establish naïve pluripotency in humans is crucial for the future applications of pluripotent stem cells including the production of human blastoids. However, the regulatory pathways that control...
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription.
Mami Oikawa, Angela Simeone, Eva Hormanseder, Marta Teperek, Vincent Gaggioli, Alan O'Doherty, Emma Falk, Matthieu Sporniak, Clive D'Santos, Valar Nila Roamio Franklin, Kamal Kishore, Charles R Bradshaw, Declan Keane, Thomas Freour, Laurent David, Adrian T Grzybowski, Alexander J Ruthenburg, John Gurdon, Jerome Jullien
Aug 13, 2020
Sperm contributes genetic and epigenetic information to the embryo to efficiently support development. However, the mechanism underlying such developmental competence remains elusive. Here, we investigated whether all sperm...
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth.
Alessio Lepore, Pui Man Choy, Nathan CW Lee, Maria Annunziata Carella, Rosy Favicchio, Marco A Briones-Orta, Shannon S Glaser, Gianfranco Alpini, Clive D'Santos, Reuben M Tooze, Mihaela Lorger, Wing-Kin Syn, Athanasios Papakyriakou, Georgios Giamas, Concetta Bubici, Salvatore Papa
Sep 15, 2021
BACKGROUND AND AIMS: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c-Jun N-terminal kinase (JNK) pathway is a key feature in ICC...
Animals Antineoplastic Agents Bile Duct Neoplasms Carcinogenesis Cell Line Tumor Cholangiocarcinoma Female Gene Knockdown Techniques Humans MAP Kinase Signaling System Mice Mice Inbred NOD Mice SCID Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 NIMA-Interacting Peptidylprolyl Isomerase Phosphorylation RNA Small Interfering Tretinoin Tumor Burden Xenograft Model Antitumor Assays
IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis.
Rasmus Siersbaek, Valentina Scabia, Sankari Nagarajan, Igor Chernukhin, Evangelia K Papachristou, Rebecca Broome, Simon J Johnston, Stacey EP Joosten, Andrew R Green, Sanjeev Kumar, Julia Jones, Soleilmane Omarjee, Ruben Alvarez-Fernandez, Silvia Glont, Sarah J Aitken, Kamal Kishore, Danya Cheeseman, Emad A Rakha, Clive D'Santos, Wilbert Zwart, Alasdair Russell, Cathrin Brisken, Jason S Carroll
Jul 24, 2020
The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a key oncogenic pathway, which has been thought to be functionally connected to estrogen receptor α (ER) in breast cancer. We demonstrate that...
FOXA1 IL6 STAT3 Breast Cancer estrogen receptor metastasis mouse intraductal xenograft model pioneer factor Animals Antineoplastic Agents Hormonal Breast Neoplasms Enhancer Elements Genetic Estrogen Receptor alpha Female Fulvestrant Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Interleukin-6 Kaplan-Meier Estimate MCF-7 Cells Mice Inbred NOD Mice Knockout Mice SCID Neoplasm Metastasis STAT3 Transcription Factor Signal Transduction Xenograft Model Antitumor Assays
Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape.
Maurizio Mangolini, Alba Maiques-Diaz, Stella Charalampopoulou, Elena Gerhard-Hartmann, Johannes Bloehdorn, Andrew Moore, Giorgia Giachetti, Junyan Lu, Valar Nila Roamio Franklin, Chandra Sekkar Reddy Chilamakuri, Ilias Moutsopoulos, Andreas Rosenwald, Stephan Stilgenbauer, Thorsten Zenz, Irina Mohorianu, Clive D'Santos, Silvia Deaglio, Daniel J Hodson, Jose I Martin-Subero, Ingo Ringshausen
Oct 24, 2022
Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells...
Progesterone receptor modulates ERα action in breast cancer.
Hisham Mohammed, I Alasdair Russell, Rory Stark, Oscar M Rueda, Theresa E Hickey, Gerard A Tarulli, Aurelien A Serandour, Stephen N Birrell, Alejandra Bruna, Amel Saadi, Suraj Menon, James Hadfield, Michelle Pugh, Ganesh V Raj, Gordon D Brown, Clive D'Santos, Jessica LL Robinson, Grace Silva, Rosalind Launchbury, Charles M Perou, John Stingl, Carlos Caldas, Wayne D Tilley, Jason S Carroll
Aug 13, 2015
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Chromatin DNA Copy Number Variations Disease Progression Estrogen Receptor alpha Estrogens Female Gene Expression Regulation Neoplastic Humans Ligands Mice Progesterone Protein Binding Receptors Progesterone Transcription Genetic Xenograft Model Antitumor Assays
The Feasibility of Integrating Wearable Cameras and Health Trackers for Measuring Personal Exposure to Urban Features
Built environment factors such as greenery, walkability, and crowd density are related to physical activity and mental health. New emerging wearable sensors provide an opportunity to objectively monitor human exposure to...
Published by: IGI Global Scientific Publishing
EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis.
Guillermo Peluffo, Ashim Subedee, Nicholas W Harper, Natalie Kingston, Bojana Jovanović, Felipe Flores, Laura E Stevens, Francisco Beca, Anne Trinh, Chandra Sekhar Reddy Chilamakuri, Evangelia K Papachristou, Katherine Murphy, Ying Su, Andriy Marusyk, Clive S D'Santos, Oscar M Rueda, Andrew H Beck, Carlos Caldas, Jason S Carroll, Kornelia Polyak
Jul 09, 2019
To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of...
Raising juveniles
This paper investigates how families decide how juveniles use their time. The problem is analyzed in three variations: (i) a ‘decentralized’ scheme, in which parents control the main budget, but their children dispose of their...
A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer.
Anne Y Warren, Charlie E Massie, Kate Watt, Katarina Luko, Folake Orafidiya, Luke A Selth, Hisham Mohammed, Brinder S Chohan, Suraj Menon, Ajoeb Baridi, Wanfeng Zhao, Carles Escriu, Thanakorn Pungsrinont, Clive D'Santos, Xiaoping Yang, Chris Taylor, Arham Qureshi, Vincent R Zecchini, Greg L Shaw, Scott M Dehm, Ian G Mills, Jason S Carroll, Wayne D Tilley, Iain J McEwan, Aria Baniahmad, David E Neal, Mohammad Asim
Nov 16, 2018
Elucidation of mechanisms underlying the increased androgen receptor (AR) activity and subsequent development of aggressive prostate cancer (PrCa) is pivotal in developing new therapies. Using a systems biology approach, we...
SnRE at the BBC
Clive Upton
Sep 30, 2014
Two strands - perhaps "strains" might at times be thought a more accurate word -exist within dialectology. One, geographical and historical, charts linguistic variation on the ground and seeks to study language in its diachronic...
Published by: Atlantic Provinces Linguistic Association
SnRE at the BBC
Clive Upton
Sep 30, 2014
Two strands - perhaps "strains" might at times be thought a more accurate word -exist within dialectology. One, geographical and historical, charts linguistic variation on the ground and seeks to study language in its diachronic...
Published by: Atlantic Provinces Linguistic Association
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