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Direitos Sociais na Constituição Uma Análise da Constitucionalização dos Direitos Sociais em Portugal, 1975-76
Embora todas as constituições incluam direitos, e muitas delas incluam direitos sociais, a verdade é que algumas são mais generosas do que outras a este respeito. Mas nenhuma se aproxima da Constituição da República Portuguesa...
A Hybrid Binary Bird Swarm Optimization (BSO) and Dragonfly Algorithm (DA) for VM Allocation and Load Balancing in Cloud
The cloud platform is becoming one of the fastest-rising environments in human activities, connecting the whole world in the upcoming decades. The three crucial aspects of cloud computing that enhance the quality of service are...
Published by: IGI Global Scientific Publishing
Giovanni Canestrini’s models of Leonardo da Vinci’s friction experiments
IM Hutchings
Feb 16, 2017
Among the exhibits at the 2016 Leonardo da Vinci exhibition at the Science Museum, London, was one that purported to illustrate Leonardo’s experiments on friction. The models involved were the work of Giovanni Canestrini...
Program for the Stage Production of Two One-Act Plays: She Was Only a Farmer's Daughter & Aria Da Capo
Curtain Club
Jan 01, 0001
This two-page program details the Curtain Club of Ursinus College's production of two one-act plays, "She Was Only a Farmer's Daughter" and "Aria Da Capo", held March 19, 1966. It includes information about the casting and...
She Was Only a Farmer's Daughter Aria Da Capo Millard Crosby Edna St. Vincent Millay Curtain Club Ursinus College theater program Theatre and Performance Studies Theatre History
Published by: Ursinus College
Monitoring ash dieback (Hymenoscyphus fraxineus) in British forests using hyperspectral remote sensing
Abstract: Large‐scale dieback of ash trees (Fraxinus spp.) caused by the fungus Hymenoscyphus fraxineus is posing an immense threat to forest health in Europe, requiring effective monitoring at large scales. In this study, a...
Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson's Disease.
Federica Murgia, Luigi Atzori, Ezio Carboni, Maria Laura Santoru, Aran Hendren, Augusta Pisanu, Pierluigi Caboni, Laura Boi, Giuliana Fusco, Anna R Carta
Sep 15, 2020
Parkinson's disease (PD) is considered a synucleinopathy because of the intraneuronal accumulation of aggregated α-synuclein (αSyn). Recent evidence points to soluble αSyn-oligomers (αSynO) as the main cytotoxic species...
Parkinson model Biomarkers gas chromatography mass spectrometry mesencephalic tissue Metabolomics serum α-synuclein oligomers Animals Biomarkers Corpus Striatum Disease Models Animal Dopamine Humans Male Metabolome Metabolomics Neurons Oxidative Stress Parkinson Disease Rats Rats Sprague-Dawley Substantia Nigra ALPHA-SYNUCLEIN
Classic Models for New Perspectives
Whilst a wealth of data indicate that infections by gastrointestinal helminths are accompanied by significant alterations in the composition of the vertebrate gut flora, little is known of the immune-molecular mechanisms that...
Learn to Model Blurry Motion via Directional Similarity and Filtering
It is difficult to recover the motion field from a real-world footage given a mixture of camera shake and other photometric effects. In this paper we propose a hybrid framework by interleaving a Convolutional Neural Network...
Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson's Disease.
Vanessa Penna, Niamh Moriarty, Yi Wang, Kevin CL Law, Carlos W Gantner, Richard J Williams, David R Nisbet, Clare L Parish
Apr 25, 2022
Clinical studies have provided evidence for dopamine (DA) cell replacement therapy in Parkinson's Disease. However, grafts derived from foetal tissue or pluripotent stem cells (PSCs) remain heterogeneous, with a high proportion...
Parkinson’s disease SDF1 biomaterials Dopamine Hydrogel Laminin self-assembling peptide Stem Cells stromal cell-derived factor 1 Transplantation Animals Biomimetics Cell Differentiation Chemokine CXCL12 Dopamine Dopaminergic Neurons Extracellular Matrix Fetus Hydrogels Laminin Parkinson Disease Rodentia
The Existentialist Moment
Filipe Carreira da Silva
Apr 19, 2016
This is the author accepted manuscript. The final version is available from SAGE Publications via http://dx.doi.org/10.1177/0001699316641859
Learn to Model Blurry Motion via Directional Similarity and Filtering
It is difficult to recover the motion field from a real-world footage given a mixture of camera shake and other photometric effects. In this paper we propose a hybrid framework by interleaving a Convolutional Neural Network...
Variations on fetal heart rate variability.
This is the final version of the article. It first appeared from Wiley via http://dx.doi.org/10.1113/JP270717
Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.
Reinhard Roessler, Sebastien A Smallwood, Jesse V Veenvliet, Petros Pechlivanoglou, Su-Ping Peng, Koushik Chakrabarty, Marian JA Groot-Koerkamp, R Jeroen Pasterkamp, Evelyn Wesseling, Gavin Kelsey, Erik Boddeke, Marten P Smidt, Sjef Copray
Jun 24, 2019
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro generation of disease-relevant cell types, such as mesodiencephalic dopaminergic (mdDA) neurons involved in Parkinson's disease. Although iPSC-derived...
The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease.
Dopaminergic (DA) cell replacement therapies are a promising experimental treatment for Parkinson's disease (PD) and a number of different types of DA cell-based therapies have already been trialled in patients. To date, the...
Helminth-microbiota cross-talk - A journey through the vertebrate digestive system.
The gastrointestinal (GI) tract of vertebrates is inhabited by a vast array of organisms, i.e., the microbiota and macrobiota. The former is composed largely of commensal microorganisms, which play vital roles in host nutrition...
Bacterial 16S rRNA sequencing Gastrointestinal Tract Helminth-microbiota interactions Lactobacilli Microbial diversity microbial richness Prevotella Ancylostomatoidea Animals Ascaris Gastrointestinal Tract Helminths host-parasite interactions Humans Immunity mucosal Intestinal Mucosa Intestine Large Intestine Small Lactobacillus Microbiota Nematoda Platyhelminths Schistosoma Stomach strongyloides stercoralis Trematoda Trichuris
Hypoxia, fetal and neonatal physiology
This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1113/JP272000
Nitrous oxide emissions from sugarcane fields in the Brazilian Cerrado
J Fonseca da Silva, A Moreira de Carvalho, TA Rein, T Rodrigues Coser, W Quadros Ribeiro, D Lino Vieira, DA Coomes
Nov 24, 2017
Brazil meets about 16% of its energy needs with bioethanol and other sugarcane products and leads the world in biofuel energy production. However, there are concerns over the environmental credentials of the sugarcane given the...
Text Chat-Mediated Dynamic Assessment Towards Self-Regulation in Language Learning
Even though the importance of corrective feedback (CF) is widely recognized, there is no agreement on the most effective type of CF for promoting self-regulation. Thus, this study adopts a sociocultural perspective on learning...
Published by: IGI Global Scientific Publishing
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson's disease.
Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Oct 24, 2022
We have developed an efficient approach to generate functional induced dopaminergic (DA) neurons from adult human dermal fibroblasts. When performing DA neuronal conversion of patient fibroblasts with idiopathic Parkinson's...
Helminths, hosts, and their microbiota
INTRODUCTION: Evidence is emerging of complex interactions occurring between gastrointestinal (GI) parasites of ruminants and the resident gut flora, with likely implications for the pathophysiology of worm infection and...
Effects of quinpirole in the ventral tegmental area on impulsive behaviour during performance on the five-choice serial reaction time task.
Impulsive behaviour on the five-choice serial reaction time task (5CSRTT), a task measuring attention and impulsivity in rodents, is known to depend on dopamine (DA) neurotransmission in the mesolimbic DA pathway. Previous...
Dual mode imaging in mid infrared with thermal signal reconstruction for innovative diagnostics of the "Monocromo" by Leonardo da Vinci.
Dual mode imaging in the mid infrared band, a joint use of thermography and quasi-thermal reflectography, was recently proposed as a full field diagnostic tool in cultural heritage. Here we discuss for the first time, to the...
Tissue-specific transcriptomes of Anisakis simplex (sensu stricto) and Anisakis pegreffii reveal potential molecular mechanisms involved in pathogenicity.
Serena Cavallero, Fabrizio Lombardo, Xiaopei Su, Marco Salvemini, Cinzia Cantacessi, Stefano D'Amelio
Feb 05, 2018
Background: Larval stages of the sibling species of parasitic nematodes Anisakis simplex sensu stricto (AS) and Anisakis pegreffii (AP) are responsible for a fish-borne zoonosis, known as anisakiasis, that humans acquire via the...
Cyathostomine egg reappearance period following ivermectin treatment in a cohort of UK Thoroughbreds.
Rebecca A Molena, Laura E Peachey, Angela Di Cesare, Donato Traversa, Cinzia Cantacessi
Mar 02, 2018
Background: In spite of the emergence of populations of drug-resistant cyathostomins worldwide, little is known of parasite species responsible for 'early egg shedding' in cohorts of horses subjected to treatment with widely...
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