Search
Results: 62
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2020
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk.
Qin Qin Huang, Howard HF Tang, Shu Mei Teo, Danny Mok, Scott C Ritchie, Artika P Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J Holt, Chiea Chuen Khor, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye
Aug 25, 2020
Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting myeloid...
Autoimmune Diseases Butyrophilins CD4-Positive T-Lymphocytes Cathepsin H Child Child Development Child Preschool Datasets as Topic Fetal Blood Gene Expression Profiling Gene Expression Regulation Developmental Gene Regulatory Networks Genetic Predisposition to Disease Genome-Wide Association Study HLA-C Antigens Humans Hypersensitivity Infant Infant Newborn Mendelian Randomization Analysis Myeloid Cells Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Prospective Studies Quantitative Trait Loci
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin Qin Huang, Howard H. F. Tang, Shu Mei Teo, Danny Mok, Scott C. Ritchie, Artika P. Nath, Marta Brozynska, Agus Salim, Andrew Bakshi, Barbara J. Holt, Chiea Chuen Khor, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye
Jul 28, 2021
Abstract: Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we map expression quantitative trait loci (eQTLs) in resting...
Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing.
Lourdes Ortiz-Fernández, Elio G Carmona, Martin Kerick, Paul Lyons, Francisco David Carmona, Raquel López Mejías, Chiea Chuen Khor, Peter C Grayson, Enrico Tombetti, Lindi Jiang, Haner Direskeneli, Guher Saruhan-Direskeneli, José-Luis Callejas-Rubio, Augusto Vaglio, Carlo Salvarani, Jose Hernández-Rodríguez, Maria Cinta Cid, Ann W Morgan, Peter A Merkel, David Burgner, Kenneth GC Smith, Miguel Angel Gonzalez-Gay, Amr H Sawalha, Javier Martin, Ana Marquez
Feb 21, 2023
Multi-trait genome-wide association study identifies new loci associated with optic disc parameters.
Pieter WM Bonnemaijer, Elisabeth M van Leeuwen, Adriana I Iglesias, Puya Gharahkhani, Veronique Vitart, Anthony P Khawaja, Mark Simcoe, René Höhn, Angela J Cree, Rob P Igo, International Glaucoma Genetics Consortium, NEIGHBORHOOD Consortium, UK Biobank Eye and Vision Consortium, Aslihan Gerhold-Ay, Stefan Nickels, James F Wilson, Caroline Hayward, Thibaud S Boutin, Ozren Polašek, Tin Aung, Chiea Chuen Khor, Najaf Amin, Andrew J Lotery, Janey L Wiggs, Ching-Yu Cheng, Pirro G Hysi, Christopher J Hammond, Alberta AHJ Thiadens, Stuart MacGregor, Caroline CW Klaver, Cornelia M van Duijn
Nov 26, 2020
genome-wide association studies Optic Nerve Diseases Case-Control Studies Computational Biology Gene Expression Profiling Genetic Association Studies Genetic Predisposition to Disease Genome-Wide Association Study Glaucoma Humans Molecular Sequence Annotation Optic Disk Optic Nerve Diseases Polymorphism Single Nucleotide Quantitative Trait Loci Quantitative Trait Heritable Signal Transduction
Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.
Jibril B Hirbo, Francesca Pasutto, Eric R Gamazon, Patrick Evans, Priyanka Pawar, Daniel Berner, Julia Sealock, Ran Tao, Peter S Straub, Anuar I Konkashbaev, Max A Breyer, Ursula Schlötzer-Schrehardt, André Reis, Milam A Brantley, Chiea C Khor, Karen M Joos, Nancy J Cox
Feb 17, 2023
BACKGROUND: Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is...
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam.
Kathryn E Holt, Paul McAdam, Phan Vuong Khac Thai, Nguyen Thuy Thuong Thuong, Dang Thi Minh Ha, Nguyen Ngoc Lan, Nguyen Huu Lan, Nguyen Thi Quynh Nhu, Hoang Thanh Hai, Vu Thi Ngoc Ha, Guy Thwaites, David J Edwards, Artika P Nath, Kym Pham, David B Ascher, Jeremy Farrar, Chiea Chuen Khor, Yik Ying Teo, Michael Inouye, Maxine Caws, Sarah J Dunstan
Sep 05, 2018
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates...
Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.
Jibril B Hirbo, Francesca Pasutto, Eric R Gamazon, Patrick Evans, Priyanka Pawar, Daniel Berner, Julia Sealock, Ran Tao, Peter S Straub, Anuar I Konkashbaev, Max A Breyer, Ursula Schlötzer-Schrehardt, André Reis, Milam A Brantley, Chiea C Khor, Karen M Joos, Nancy J Cox
Mar 19, 2023
Background
Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations....
GWAS transcriptomics Exfoliation syndrome TWAS GTEx predicted expressions Humans Amino Acid Oxidoreductases DNA-Binding Proteins RNA Messenger Gene Expression Mutation Missense Polymorphism Single Nucleotide B7 Antigens
Published by: BMC genomics
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
Steve Eyre, John Bowes, Dorothée Diogo, Annette Lee, Anne Barton, Paul Martin, Alexandra Zhernakova, Eli Stahl, Sebastien Viatte, Kate McAllister, Christopher I Amos, Leonid Padyukov, Rene EM Toes, Tom WJ Huizinga, Cisca Wijmenga, Gosia Trynka, Lude Franke, Harm-Jan Westra, Lars Alfredsson, Xinli Hu, Cynthia Sandor, Paul IW de Bakker, Sonia Davila, Chiea Chuen Khor, Khai Koon Heng, Robert Andrews, Sarah Edkins, Sarah E Hunt, Cordelia Langford, Deborah Symmons, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Wellcome Trust Case Control Consortium, Pat Concannon, Suna Onengut-Gumuscu, Stephen S Rich, Panos Deloukas, Miguel A Gonzalez-Gay, Luis Rodriguez-Rodriguez, Lisbeth Ärlsetig, Javier Martin, Solbritt Rantapää-Dahlqvist, Robert M Plenge, Soumya Raychaudhuri, Lars Klareskog, Peter K Gregersen, Jane Worthington
May 28, 2021
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European...
Acetate accumulation enhances mixed culture fermentation of biomass to lactic acid
Lactic acid is a high-in-demand chemical, which can be produced through fermentation of lignocellulosic feedstock. However, fermentation of complex substrate produces a mixture of products at efficiencies too low to justify a...
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
Apr 26, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
Acetate accumulation enhances mixed culture fermentation of biomass to lactic acid
Lactic acid is a high-in-demand chemical, which can be produced through fermentation of lignocellulosic feedstock. However, fermentation of complex substrate produces a mixture of products at efficiencies too low to justify a...
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis C Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
May 27, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Jul 31, 2020
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data...
Sentic-Emotion Classifier on eWallet Reviews
Emotion classification using hybrid framework using lexicon and machine learning algorithms have been proven to be more accurate. This research analyses emotions from reviews of a popular eWallet mobile application in Malaysia....
Published by: IGI Global Scientific Publishing
Effect of Chronic Stimulation and Stimulus Level on Temporal Processing by Cochlear Implant Listeners.
Robert P Carlyon, François Guérit, Alexander J Billig, Yu Chuen Tam, Frances Harris, John M Deeks
Dec 21, 2018
A series of experiments investigated potential changes in temporal processing during the months following activation of a cochlear implant (CI) and as a function of stimulus level. Experiment 1 tested patients on the day of...
European polygenic risk score for prediction of breast cancer shows similar performance in Asian women
Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P. Tyrer, Manjeet K. Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K. Park, Sung-Won Kim, Chen-Yang Shen, Jyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H. Wu, Daniel O. Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L. Chan, Su Ming Tan, Jaime Seah, Esther M. John, Allison W. Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J. Spinelli, Kristan J. Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D. P. Pharoah, Wei Zheng, Alison M. Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F. Easton, Soo-Hwang Teo, Antonis C. Antoniou
Aug 02, 2021
Abstract: Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data...
Development and evaluation of a deep learning model for the detection of multiple fundus diseases based on colour fundus photography.
Bing Li, Huan Chen, Bilei Zhang, Mingzhen Yuan, Xuemin Jin, Bo Lei, Jie Xu, Wei Gu, David Chuen Soong Wong, Xixi He, Hao Wang, Dayong Ding, Xirong Li, Youxin Chen, Weihong Yu
Apr 01, 2021
AIM: To explore and evaluate an appropriate deep learning system (DLS) for the detection of 12 major fundus diseases using colour fundus photography. METHODS: Diagnostic performance of a DLS was tested on the detection of normal...
Electrolytic extraction drives volatile fatty acid chain elongation through lactic acid and replaces chemical pH control in thin stillage fermentation
Stephen J. Andersen, Pieter Candry, Thais Basadre, Way Cern Khor, Hugo Roume, Emma Hernandez-Sanabria, Marta Coma, Korneel Rabaey
Dec 21, 2015
Background: Volatile fatty acids (VFA) are building blocks for the chemical industry. Sustainable, biological production is constrained by production and recovery costs, including the need for intensive pH correction....
Electrolytic extraction drives volatile fatty acid chain elongation through lactic acid and replaces chemical pH control in thin stillage fermentation
Stephen J. Andersen, Pieter Candry, Thais Basadre, Way Cern Khor, Hugo Roume, Emma Hernandez-Sanabria, Marta Coma, Korneel Rabaey
Dec 21, 2015
Background: Volatile fatty acids (VFA) are building blocks for the chemical industry. Sustainable, biological production is constrained by production and recovery costs, including the need for intensive pH correction....
Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors.
Fung-Wei Chang, Hueng-Chuen Fan, Jui-Ming Liu, Tai-Ping Fan, Jin Jing, Chia-Ling Yang, Ren-Jun Hsu
Mar 22, 2018
BACKGROUND: Multidrug resistance is a major obstacle in the successful therapy of breast cancer. Studies have proved that this kind of drug resistance happens in both human cancers and cultured cancer cell lines. Understanding...
ATP-binding cassette sub-family G member 2 (ABCG2) Breast Cancer Estrogen estrogen receptor α (ERα) mitoxantrone (MX) ATP Binding Cassette Transporter Subfamily G Member 2 Adenosine Triphosphate Breast Neoplasms Cell Death Cell Hypoxia Drug Resistance Neoplasm Estrogens Female Gene Expression Regulation Neoplastic Genes Mitochondrial Humans MCF-7 Cells Models Biological Oligonucleotide Array Sequence Analysis Reactive Oxygen Species Receptors Estrogen
An Investigation of Patient Decisions to Use eHealth
eHealth service has received increasing attention. Patients can consult online doctors via the Internet, and then physically visit the doctors for further diagnosis and treatments. Although extant research has focused on the...
Published by: IGI Global Scientific Publishing
|
|< |
< |
1 |