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Results: 41
The evolving view of the hematopoietic stem cell niche.
Hematopoietic stem cells (HSCs) reside in specialized microenvironments known as niches. The niche is essential to support HSC function and to maintain a correct balance between self-renewal and differentiation. Recent advances...
Global population attributable fraction of potentially modifiable risk factors for mental disorders
Elena Dragioti, Joaquim Radua, Marco Solmi, Celso Arango, Dominic Oliver, Samuele Cortese, Peter B. Jones, Jae Il Shin, Christoph U. Correll, Paolo Fusar-Poli
Apr 07, 2023
Numerous risk factors for mental disorders have been identified. However, we do not know how many disorders we could prevent and to what extent by modifying these risk factors. This study quantifies the Population Attributable...
Global population attributable fraction of potentially modifiable risk factors for mental disorders
Elena Dragioti, Joaquim Radua, Marco Solmi, Celso Arango, Dominic Oliver, Samuele Cortese, Peter B Jones, Jae Il Shin, Christoph U Correll, Paolo Fusar-Poli
Nov 29, 2022
Numerous risk factors for mental disorders have been identified. However, we do not know how many disorders we could prevent and to what extent by modifying these risk factors. This study quantifies the Population Attributable...
Risk and protective factors for mental disorders beyond genetics
Celso Arango, Elena Dragioti, Marco Solmi, Samuele Cortese, Katharina Domschke, Robin M Murray, Peter B Jones, Rudolf Uher, Andre F Carvalho, Abraham Reichenberg, Jae Ii Shin, Ole A Andreassen, Christoph U Correll, Paolo Fusar-Poli
Apr 15, 2021
Decades of research have revealed numerous risk factors for mental disorders beyond genetics, but their consistency and magnitude remain uncer-tain. We conducted a "meta-umbrella" systematic synthesis of umbrella reviews, which...
Functional Magnetic Resonance Imaging Connectivity Accurately Distinguishes Cases With Psychotic Disorders From Healthy Controls, Based on Cortical Features Associated With Brain Network Development.
Sarah E Morgan, Jonathan Young, Ameera X Patel, Kirstie J Whitaker, Cristina Scarpazza, Thérèse van Amelsvoort, Machteld Marcelis, Jim van Os, Gary Donohoe, David Mothersill, Aiden Corvin, Celso Arango, Andrea Mechelli, Martijn van den Heuvel, René S Kahn, Philip McGuire, Michael Brammer, Edward T Bullmore
Jun 09, 2020
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia.
Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the...
Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points.
Maria L Vainieri, Andrew M Blagborough, Adam L MacLean, Myriam LR Haltalli, Nicola Ruivo, Helen A Fletcher, Michael PH Stumpf, Robert E Sinden, Cristina Lo Celso
Mar 18, 2021
Haematopoiesis is the complex developmental process that maintains the turnover of all blood cell lineages. It critically depends on the correct functioning of rare, quiescent haematopoietic stem cells (HSCs) and more numerous...
Severe Pediatric TBI Management in a Middle-Income Country and a High-Income Country
Jorge I Arango, Laeth George, Dylan P Griswold, Erica D Johnson, Maria N Suarez, Laura D Caquimbo, Milton Molano, Raul A Echeverri, Andres M Rubiano, P David Adelson
Nov 05, 2021
Background: Traumatic brain injury (TBI) is a global public health issue with over 10 million deaths or hospitalizations each year. However, access to specialized care is dependent on institutional resources and public health...
Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of first episode psychosis patients and controls
Musa Sami, Diego Quattrone, Laura Ferraro, Giada Tripoli, Erika La Cascia, Charlotte Gayer-Anderson, Jean-Paul Selten, Celso Arango, Miguel bernardo, Ilaria Tarricone, Andrea Tortelli, Giusy Gatto, Simona Del Peschio, Cristina Marta Del-Ben, Bart P Rutten, Peter B Jones, Jim van Os, Lieuwe de Haan, Craig Morgan, Cathryn Lewis, Sagnik Bhattacharyya, Tom P Freeman, Michael Lynskey, Robin M Murray, Marta Di Forti
Sep 30, 2021
BACKGROUND: First episode psychosis (FEP) patients who use cannabis experience more frequent psychotic and euphoric intoxication experiences compared to controls. It is not clear whether this is consequent to patients being...
Perceived major experiences of discrimination, ethnic group, and risk of psychosis in a six-country case-control study.
Supriya Misra, Bizu Gelaye, David R Williams, Karestan C Koenen, Christina PC Borba, Diego Quattrone, Marta Di Forti, Giada Tripoli, Caterina La Cascia, Daniele La Barbera, Laura Ferraro, Ilaria Tarricone, Domenico Berardi, Antonio Lasalvia, Sarah Tosato, Andrei Szöke, Pierre-Michel Llorca, Celso Arango, Andrea Tortelli, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B Jones, Hannah E Jongsma, James B Kirkbride, Bart PF Rutten, Jim van Os, Robin M Murray, Charlotte Gayer-Anderson, Craig Morgan
Feb 15, 2021
Social disadvantage, linguistic distance, ethnic minority status and first-episode psychosis
Hannah E Jongsma, Charlotte Gayer-Anderson, Ilaria Tarricone, Eva Velthorst, Els van der Ven, Diego Quattrone, Marta Di Forti, EU-GEI WP2 Group, Paulo Rossi Menezes, Christina Marta Del-Ben, Celso Arango, Antonio Lasalvia, Domenico Berardi, Caterina La Cascia, Julio Bobes, Miguel bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Lieuwe de Haan, Andrea Tortelli, Andrei Szöke, Robin M Murray, Bart P Rutten, Jim van Os, Craig Morgan, Peter B Jones, James B Kirkbride
Feb 18, 2020
discrimination EPIDEMIOLOGY Ethnicity Psychotic Disorders social disadvantage Adolescent Adult Black People Case-Control Studies Communication Barriers Ethnic and Racial Minorities Ethnicity Europe Female Gene-Environment Interaction Health Status Disparities Humans Male Middle Aged Odds Ratio Psychotic Disorders Schizophrenia Social Determinants of Health White People Young Adult
Association of extent of cannabis use and psychotic like intoxication experiences in a multi-national sample of first episode psychosis patients and controls
Musa Sami, Diego Quattrone, Laura Ferraro, Giada Tripoli, Erika La Cascia, Charlotte Gayer-Anderson, Jean-Paul Selten, Celso Arango, Miguel bernardo, Ilaria Tarricone, Andrea Tortelli, Giusy Gatto, Simona Del Peschio, Cristina Marta Del-Ben, Bart P Rutten, Peter B Jones, Jim van Os, Lieuwe de Haan, Craig Morgan, Cathryn Lewis, Sagnik Bhattacharyya, Tom P Freeman, Michael Lynskey, Robin M Murray, Marta Di Forti
Sep 30, 2021
BACKGROUND: First episode psychosis (FEP) patients who use cannabis experience more frequent psychotic and euphoric intoxication experiences compared to controls. It is not clear whether this is consequent to patients being...
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis
Diego Quattrone, Ulrich Reininghaus, Alex L Richards, Giada Tripoli, Laura Ferraro, Andrea Quattrone, Paolo Marino, Victoria Rodriguez, Edoardo Spinazzola, Charlotte Gayer-Anderson, Hannah E Jongsma, Peter B Jones, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Elena Bonora, Sarah Tosato, Antonio Lasalvia, Andrei Szöke, Celso Arango, Miquel Bernardo, Julio Bobes, Cristina Marta Del Ben, Paulo Rossi Menezes, Pierre-Michel Llorca, Jose Luis Santos, Julio Sanjuán, Manuel Arrojo, Andrea Tortelli, Eva Velthorst, Steven Berendsen, Lieuwe de Haan, Bart PF Rutten, Michael T Lynskey, Tom P Freeman, James B Kirkbride, Pak C Sham, Michael C O'Donovan, Alastair G Cardno, Evangelos Vassos, Jim van Os, Craig Morgan, Robin M Murray, Cathryn M Lewis, Marta Di Forti, EU-GEI collaborators
Jul 12, 2021
Population interconnectivity over the past 120,000 years explains distribution and diversity of Central African hunter-gatherers.
Cecilia Padilla-Iglesias, Lane M Atmore, Jesús Olivero, Karen Lupo, Andrea Manica, Epifanía Arango Isaza, Lucio Vinicius, Andrea Bamberg Migliano
Jun 18, 2022
The evolutionary history of African hunter-gatherers holds key insights into modern human diversity. Here, we combine ethnographic and genetic data on Central African hunter-gatherers (CAHG) to show that their current...
Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study
Hannah E Jongsma, Charlotte Gayer-Anderson, Antonio Lasalvia, Diego Quattrone, Alice Mulè, Andrei Szöke, Jean-Paul Selten, Caitlin Turner, Celso Arango, Ilaria Tarricone, Domenico Berardi, Andrea Tortelli, Pierre-Michel Llorca, Lieuwe de Haan, Julio Bobes, Miguel bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Robin M Murray, Bart P Rutten, Peter B Jones, Jim van Os, Craig Morgan, James B Kirkbride, European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2 (EU-GEI WP2) Group
Feb 08, 2018
The EUropean Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI)
Charlotte Gayer-Anderson, Hannah E Jongsma, Marta Di Forti, Diego Quattrone, Eva Velthorst, Lieuwe de Haan, Jean-Paul Selten, Andrei Szöke, Pierre-Michel Llorca, Andrea Tortelli, Celso Arango, Julio Bobes, Miguel bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Mara Parellada, Ilaria Tarricone, Domenico Berardi, Mirella Ruggeri, Antonio Lasalvia, Laura Ferraro, Caterina La Cascia, Daniele La Barbera, Paulo Rossi Menezes, Cristina Marta Del-Ben, EU-GEI WP2 Group, Bart P Rutten, Jim van Os, Peter B Jones, Robin M Murray, James B Kirkbride, Craig Morgan
Jan 09, 2020
Transdiagnostic dimensions of psychopathology at first episode psychosis
Diego Quattrone, Marta Di Forti, Charlotte Gayer-Anderson, Laura Ferraro, Hannah E Jongsma, Giada Tripoli, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Andrei Szöke, Celso Arango, Antonio Lasalvia, Andrea Tortelli, Pierre-Michel Llorca, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, EU-GEI WP2 Group, Peter B Jones, James B Kirkbride, Alexander L Richards, Michael C O'Donovan, Pak C Sham, Evangelos Vassos, Bart PF Rutten, Jim van Os, Craig Morgan, Cathryn M Lewis, Robin M Murray, Ulrich Reininghaus
Jan 09, 2020
BACKGROUND: The value of the nosological distinction between non-affective and affective psychosis has frequently been challenged. We aimed to investigate the transdiagnostic dimensional structure and associated characteristics...
Bifactor model diagnostic categories First episode psychosis Psychopathology symptom dimensions Adult Affective Disorders Psychotic Bipolar Disorder Depression Europe Female Humans Male Models Psychological Psychiatric Status Rating Scales Psychopathology Psychotic Disorders ROC Curve Schizophrenia Schizophrenic Psychology Young Adult
The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI)
Marta Di Forti, Diego Quattrone, Tom P Freeman, Giada Tripoli, Charlotte Gayer-Anderson, Harriet Quigley, Victoria Rodriguez, Hannah E Jongsma, Laura Ferraro, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Andrei Szöke, Celso Arango, Andrea Tortelli, Eva Velthorst, Miguel bernardo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B Jones, James B Kirkbride, Bart PF Rutten, Lieuwe de Haan, Pak C Sham, Jim van Os, Cathryn M Lewis, Michael Lynskey, Craig Morgan, Robin M Murray, EU-GEI WP2 Group
Nov 27, 2019
BACKGROUND: Cannabis use is associated with increased risk of later psychotic disorder but whether it affects incidence of the disorder remains unclear. We aimed to identify patterns of cannabis use with the strongest effect on...
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis
Diego Quattrone, Ulrich Reininghaus, Alex L Richards, Giada Tripoli, Laura Ferraro, Andrea Quattrone, Paolo Marino, Victoria Rodriguez, Edoardo Spinazzola, Charlotte Gayer-Anderson, Hannah E Jongsma, Peter B Jones, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Elena Bonora, Sarah Tosato, Antonio Lasalvia, Andrei Szöke, Celso Arango, Miquel Bernardo, Julio Bobes, Cristina Marta Del Ben, Paulo Rossi Menezes, Pierre-Michel Llorca, Jose Luis Santos, Julio Sanjuán, Manuel Arrojo, Andrea Tortelli, Eva Velthorst, Steven Berendsen, Lieuwe de Haan, Bart P F Rutten, Michael T Lynskey, Tom P Freeman, James B Kirkbride, Pak C Sham, Michael C O'Donovan, Alastair G Cardno, Evangelos Vassos, Jim van Os, Craig Morgan, Robin M Murray, Cathryn M Lewis, Marta Di Forti
Sep 11, 2021
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on...
Published by: Translational psychiatry
Early Parental Death and Risk of Psychosis in Offspring
Supriya Misra, Bizu Gelaye, Karestan C Koenen, David R Williams, Christina PC Borba, Diego Quattrone, Marta Di Forti, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Andrei Szöke, Celso Arango, Andrea Tortelli, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, Peter B Jones, James B Kirkbride, EU-GEI WP2 Group, Bart PF Rutten, Jim van Os, Robin M Murray, Charlotte Gayer-Anderson, Craig Morgan
Sep 06, 2019
Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal...
The lived experience of mental disorders in adolescents
Paolo Fusar-Poli, Andrés Estradé, Cecilia Esposito, René Rosfort, Ilaria Basdonne, Milena Mancini, Giovanni Stanghellini, Jummy Otaiku, Oluwadamilola Olanrele, Lucas Allen, Muskan Lamba, Catherine Alaso, Judy Ieri, Margret Atieno, Yvonne Oluoch, Phides Ireri, Ephraim Tembo, Innocent Zilole, Duncan Nkhoma, Noah Sichone, Candy Siadibbi, Pharidah R.I.O. Sundi, Nyathi Ntokozo, Laura Fusar-Poli, Valentina Floris, Martina M. Mensi, Renato Borgatti, Stefano Damiani, Umberto Provenzani, Ilaria Bonoldi, Joaquim Radua, Kate Cooper, Jae Il Shin, Samuele Cortese, Andrea Danese, Sarah Bendall, Celso Arango, Universitätsmedizin Berlin, Mario Maj
Jun 30, 2024
We provide here the first bottom-up review of the lived experience of mental disorders in adolescents co-designed, co-conducted and co-written by experts by experience and academics. We screened first-person accounts within and...
Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients
Diego Quattrone, Laura Ferraro, Giada Tripoli, Caterina La Cascia, Harriet Quigley, Andrea Quattrone, Hannah E Jongsma, Simona Del Peschio, Giusy Gatto, EU-GEI group, Charlotte Gayer-Anderson, Peter B Jones, James B Kirkbride, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Sarah Tosato, Antonio Lasalvia, Andrei Szöke, Celso Arango, Miquel Bernardo, Julio Bobes, Cristina Marta Del Ben, Paulo Rossi Menezes, Pierre-Michel Llorca, Jose Luis Santos, Julio Sanjuán, Andrea Tortelli, Eva Velthorst, Lieuwe de Haan, Bart PF Rutten, Michael T Lynskey, Tom P Freeman, Pak C Sham, Alastair G Cardno, Evangelos Vassos, Jim van Os, Craig Morgan, Ulrich Reininghaus, Cathryn M Lewis, Robin M Murray, Marta Di Forti
Jan 16, 2020
The lived experience of mental disorders in adolescents
Paolo Fusar-Poli, Andrés Estradé, Cecilia Esposito, René Rosfort, Ilaria Basdonne, Milena Mancini, Giovanni Stanghellini, Jummy Otaiku, Oluwadamilola Olanrele, Lucas Allen, Muskan Lamba, Catherine Alaso, Judy Ieri, Margret Atieno, Yvonne Oluoch, Phides Ireri, Ephraim Tembo, Innocent Zilole, Duncan Nkhoma, Noah Sichone, Candy Siadibbi, Pharidah R.I.O. Sundi, Nyathi Ntokozo, Laura Fusar-Poli, Valentina Floris, Martina M. Mensi, Renato Borgatti, Stefano Damiani, Umberto Provenzani, Ilaria Bonoldi, Joaquim Radua, Kate Cooper, Jae Il Shin, Samuele Cortese, Andrea Danese, Sarah Bendall, Celso Arango, Universitätsmedizin Berlin, Mario Maj
Jun 30, 2024
We provide here the first bottom-up review of the lived experience of mental disorders in adolescents co-designed, co-conducted and co-written by experts by experience and academics. We screened first-person accounts within and...
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