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Effects of vitamin D supplementation on adherence to and persistence with long-term statin therapy
Zhenqiang Wu, Carlos A Camargo, Kay-Tee Khaw, Debbie Waayer, Carlene MM Lawes, Les Toop, Robert Scragg
Oct 03, 2018
BACKGROUND AND AIMS: Long-term statin use increases survival. However, the adherence to and persistence with statin use are challenging and this influences the success of statin treatment. Our aim was to explore if monthly...
Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function
John D Sluyter, Carlos A Camargo, Debbie Waayer, Carlene MM Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
May 23, 2018
Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50-84 years...
forced expiratory volume in 1 s lung function Randomized controlled trial Spirometry vitamin D Aged Aged 80 and over Asthma Dietary Supplements Dose-Response Relationship Drug Double-Blind Method Female Follow-Up Studies Forced Expiratory Volume Humans Lung Male Middle Aged Pulmonary Disease Chronic Obstructive Spirometry vitamin D Vitamin D Deficiency
Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study
Robert Scragg, Alistair W Stewart, Debbie Waayer, Carlene MM Lawes, Les Toop, John Sluyter, Judy Murphy, Kay-Tee Khaw, Carlos A Camargo
Oct 03, 2018
Aged Aged 80 and over Angina Pectoris Arrhythmias Cardiac arteriosclerosis Cardiovascular Diseases Cholecalciferol Dietary Supplements Double-Blind Method Female Heart Failure Humans Hypertension Male Middle Aged Myocardial Infarction New Zealand Proportional Hazards Models stroke venous thrombosis Vitamin D Deficiency Vitamins
Monthly vitamin D supplementation, pain, and pattern of analgesic prescription
Zhenqiang Wu, Carlos A Camargo, Zarintaj Malihi, Jim Bartley, Debbie Waayer, Carlene MM Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
Aug 14, 2018
Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to...
Effect of Monthly Vitamin D Supplementation on Preventing Exacerbations of Asthma or Chronic Obstructive Pulmonary Disease in Older Adults
Carlos A Camargo, Les Toop, John Sluyter, Carlene MM Lawes, Debbie Waayer, Kay-Tee Khaw, Adrian R Martineau, Robert Scragg
Feb 07, 2021
Randomized controlled trials have suggested that vitamin D supplementation can prevent asthma and chronic obstructive pulmonary disease (COPD) exacerbations. For COPD, the benefit appears to be limited to individuals with...
Asthma Chronic obstructive pulmonary disease exacerbations oral corticosteroids Randomized controlled trial supplement vitamin D Aged Asthma Dietary Supplements Double-Blind Method Drug Administration Schedule Female Humans Male Middle Aged Proportional Hazards Models Pulmonary Disease Chronic Obstructive Secondary Prevention Symptom Flare Up Treatment Outcome vitamin D Vitamin D Deficiency Vitamins
QM/MM simulations for methyl transfer in solution and catalysed by COMT
Sampling of structures from QM/MM molecular dynamics reveals distinct families of reactant-state conformers and yields kinetic isotope effects for reactions in enzyme active sites and in solution, averaged over thermal...
QM/MM simulations for methyl transfer in solution and catalysed by COMT
Sampling of structures from QM/MM molecular dynamics reveals distinct families of reactant-state conformers and yields kinetic isotope effects for reactions in enzyme active sites and in solution, averaged over thermal...
QM/MM kinetic isotope effects for chloromethane hydrolysis in water
Computational simulations for chloromethane hydrolysis have been performed using hybrid quantum-mechanical/molecular-mechanical methods with explicit solvation by large numbers of water molecules. In the first part of the...
Kintsugi – identity change and reconstruction following an episode of psychosis
Aim
Research has shown that experiences of psychosis can have a significant impact on an individual's identity. Moreover, the way those who experience psychosis make sense of these changes appears to affect their recovery...
Research has shown that experiences of psychosis can have a significant impact on an individual's identity. Moreover, the way those who experience psychosis make sense of these changes appears to affect their recovery...
Measuring the Dust Masses of Protoplanetary Disks in Lupus with ALMA
Abstract
Accurate disk mass measurements are necessary to constrain disk evolution and the timescale of planet formation, but such measurements are difficult to make and are very...
QM/MM kinetic isotope effects for chloromethane hydrolysis in water
Computational simulations for chloromethane hydrolysis have been performed using hybrid quantum-mechanical/molecular-mechanical methods with explicit solvation by large numbers of water molecules. In the first part of the...
Kintsugi – identity change and reconstruction following an episode of psychosis
Aim
Research has shown that experiences of psychosis can have a significant impact on an individual's identity. Moreover, the way those who experience psychosis make sense of these changes appears to affect their recovery...
Research has shown that experiences of psychosis can have a significant impact on an individual's identity. Moreover, the way those who experience psychosis make sense of these changes appears to affect their recovery...
Stabilisation of the [SiH6]2– Anion within a Supramolecular Assembly
Ryan Huo, Alicia Armstrong, Gareth Nelmes, Douglas Lawes, Alison Edwards, Claire McMullin, Jamie Hicks
May 02, 2024
The hypercoordinate [SiH6]2– anion is not stable in solution. Here, we report the room temperature, solution stable molecular [SiH6]2– complex, [{KCa(NON)(OEt2)}2][SiH6] (NON =...
Computational mutagenesis reveals the role of active-site tyrosine in stabilising a boat conformation for the substrate
Molecular dynamics simulations have been performed for non-covalent complexes of phenyl beta-xylobioside with the retaining endo-beta-1,4-xylanase from B. circulans (BCX) and its Tyr69Phe mutant using a hybrid QM/MM methodology....
Computational mutagenesis reveals the role of active-site tyrosine in stabilising a boat conformation for the substrate
Molecular dynamics simulations have been performed for non-covalent complexes of phenyl beta-xylobioside with the retaining endo-beta-1,4-xylanase from B. circulans (BCX) and its Tyr69Phe mutant using a hybrid QM/MM methodology....
Stabilisation of the [SiH6]2– Anion within a Supramolecular Assembly
Ryan Huo, Alicia Armstrong, Gareth Nelmes, Douglas Lawes, Alison Edwards, Claire McMullin, Jamie Hicks
May 02, 2024
The hypercoordinate [SiH6]2– anion is not stable in solution. Here, we report the room temperature, solution stable molecular [SiH6]2– complex, [{KCa(NON)(OEt2)}2][SiH6] (NON =...
Sin, slave status, and the “city,” Zanzibar, 1865-c.1930
MM Greenfield-Liebst
Apr 20, 2017
The Universities’ Mission to Central Africa (UMCA) missionaries equated urbanity with moral contagion, to which those with slave status were especially vulnerable. To the ex-slaves who came into contact with the mission, the...
Intracranial pressure in outer space
Mr Michael M. Tymko is funded by an NSERC CGS doctoral grant. Mr Lindsey M. Boulet is funded by an NSERC CGS master's grant. Dr Joseph Donnelly is funded by a Woolf Fisher Scholarship.
Spatially Resolved Operando Synchrotron-Based X-Ray Diffraction Measurements of Ni-Rich Cathodes for Li-Ion Batteries
Understanding the performance of commercially relevant cathode materials for lithium-ion (Li-ion) batteries is vital to realize the potential of high-capacity materials for automotive applications. Of particular interest...
Andrew Stephen Leach, Alice V Llewellyn, Chao Xu, Chun Tan, Thomas MM Heenan, Alex Dimitrijevic, Karin Kleiner, Clare P Grey, Dan JL Brett, Chiu C Tang, Paul R Shearing, Rhodri Jervis
Jan 28, 2022
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