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Results: 544
Anti-cN-1A autoantibodies are absent in juvenile dermatomyositis
Objective: To assess anti–cytosolic 5′-nucleotidase 1A (anti–cN-1A) autoantibodies in children with juvenile dermatomyositis (DM) and healthy controls, using 3 different methods of antibody detection, as well as verification...
Anti-cN-1A autoantibodies are absent in juvenile dermatomyositis
Objective: To assess anti–cytosolic 5′-nucleotidase 1A (anti–cN-1A) autoantibodies in children with juvenile dermatomyositis (DM) and healthy controls, using 3 different methods of antibody detection, as well as verification...
Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer.
RAC 3, one of the p160 family of co-activators is known to enhance the transcriptional activity of a number of steroid receptors. As co-activators are also known to enhance androgen receptor (AR) activity, we investigated the...
Adenocarcinoma Aged Aged 80 and over Androgens Biomarkers Tumor Disease Progression Epithelial Cells Gene Expression Regulation Neoplastic Humans In Situ Hybridization Male Middle Aged Neoplasm Proteins Neoplasm Staging Neoplasms Hormone-Dependent Nuclear Receptor Coactivator 3 Prostate-specific antigen Prostatic Hyperplasia Prostatic Neoplasms RNA Messenger RNA Neoplasm Receptors Androgen Trans-Activators Transcription Factors Transcription Genetic Transfection Tumor Cells Cultured
FGF8 isoform b expression in human prostate cancer.
Overexpression of fibroblast growth factor 8 (FGF8) mRNA has been previously described in prostate cancer. Of its four isoforms, FGF8b is thought to be the most important in carcinogenesis. We hypothesised that immunodetection...
Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease.
BACKGROUND: The fibroblast growth factor (FGF) axis is an important mitogenic stimulus in prostate carcinogenesis. We have previously reported that transcript level of human similar expression to FGF (hSef), a key regulator of...
Constraining cold accretion onto supermassive black holes
Tom Rose, A. C. Edge, F. Combes, M. Gaspari, S. Hamer, N. Nesvadba, A. B. Peck, C. Sarazin, G. R. Tremblay, S. A. Baum, M. N. Bremer, B. R. McNamara, C. O'Dea, J. B. R. Oonk, H. Russell, P. Salomé, M. Donahue, A. C. Fabian, G. Ferland, R. Mittal, A. Vantyghem
Oct 31, 2019
To advance our understanding of the fuelling and feedback processes which power the Universe's most massive black holes, we require a significant increase in our knowledge of the molecular gas which exists in their immediate...
Constraining cold accretion onto supermassive black holes
Tom Rose, A. C. Edge, F. Combes, M. Gaspari, S. Hamer, N. Nesvadba, A. B. Peck, C. Sarazin, G. R. Tremblay, S. A. Baum, M. N. Bremer, B. R. McNamara, C. O'Dea, J. B. R. Oonk, H. Russell, P. Salomé, M. Donahue, A. C. Fabian, G. Ferland, R. Mittal, A. Vantyghem
Oct 31, 2019
To advance our understanding of the fuelling and feedback processes which power the Universe's most massive black holes, we require a significant increase in our knowledge of the molecular gas which exists in their immediate...
Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates
M Moad, E Hannezo, SJ Buczacki, L Wilson, A El-Sherif, D Sims, R Pickard, NA Wright, SC Williamson, DM Turnbull, RW Taylor, L Greaves, CN Robson, BD Simons, R Heer
Oct 02, 2017
Evidence of Next-Nearest-Neighbor Electronic Coupling in a Series of Cyano-Bridged trans-Fe(II)-Pt(IV)-M(II) (M=Fe, Ru) Asymmetric Trimers
Michael C Esposito
Jan 01, 0001
This work describes the synthesis and characterization of a series of cyano-bridged dimers and trimers of the M-Pt (M = Fe, Ru) and M-Pt-M' (M/M' = Fe, Ru) type and their electronic properties in the UV-Visible spectrum. These...
Marcus-Hush Theory Remote Electronic Coupling charge transfer Chemistry Physical Sciences and Mathematics
Published by: Ursinus College
The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum
Efthymia Maria Kapasouri, Diomidis C Ioannidis, Donnie Cameron, Vassilios S Vassiliou, Michael Hornberger
Jan 25, 2023
We sought to systematically review and meta-analy the role of cerebral blood flow (CBF) in the medial temporal lobe (MTL) using arterial spin labeling magnetic resonance imaging (ASL-MRI) and compare this in patients with...
Intraoperative Monitoring of the Cochlear Nerve during Neurofibromatosis Type-2 Vestibular Schwannoma Surgery and Description of a "Test Intracochlear Electrode".
Anand V Kasbekar, Yu Chuen Tam, Robert P Carlyon, John M Deeks, Neil Donnelly, James Tysome, Richard Mannion, Patrick R Axon
Mar 15, 2019
Objectives A decision on whether to insert a cochlear implant can be made in neurofibromatosis 2 (NF2) if there is objective evidence of cochlear nerve (CN) function post vestibular schwannoma (VS) excision. We aimed to develop...
Prognostic effect of cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma
Tobias Klatte, Kate Fife, Sarah J Welsh, Manavi Sachdeva, James N Armitage, Tevita 'Aho, Antony C Riddick, Athena Matakidou, Tim Eisen, Grant D Stewart
Feb 23, 2018
PURPOSE: To test the hypothesis that cytoreductive nephrectomy (CN) improves overall survival (OS) of patients with synchronous metastatic renal cell carcinoma (mRCC), who subsequently receive targeted therapies (TT). METHODS...
Nephrectomy Pazopanib Prognosis Sunitinib survival Aged Anilides Antibodies Monoclonal Antineoplastic Agents Carcinoma Renal Cell Cohort Studies Combined Modality Therapy Cytoreduction Surgical Procedures Female Humans Indazoles Indoles Kaplan-Meier Estimate Kidney Neoplasms Liver Neoplasms Lung Neoplasms Male Middle Aged Molecular Targeted Therapy Neoplasm Metastasis Nephrectomy Nivolumab Probability Prognosis Proportional Hazards Models Pyridines Pyrimidines Pyrroles Retrospective Studies Sex Factors Sulfonamides Sunitinib Survival Rate Thrombocytosis
Rational Design of Carbon Nitride Photoelectrodes with High Activity Toward Organic Oxidations
Carolina Pulignani, Camilo A Mesa, Sam AJ Hillman, Taylor Uekert, Sixto Giménez, James R Durrant, Erwin Reisner
Nov 15, 2022
Carbon nitride (CN x ) is a light‐absorber with excellent performance in photocatalytic suspension systems, but the activity of CN x photoelectrodes has remained low. Here, cyanamide‐functionalized CN x (NCNCN x ) was...
Construction of Bi<sub>2</sub>WO<sub>6</sub>/RGO/g-C<sub>3</sub>N<sub>4</sub> 2D/2D/2D hybrid Z-scheme heterojunctions with large interfacial contact area for efficient charge separation and high-performance photoreduction of CO<sub>2</sub> and H<sub>2</sub>O into solar fuels
We have rationally constructed a hybrid heterojunction comprising of Bi2WO6, reduced graphene oxide, and g-C3N4 (BWO/RGO/CN) with a 2D/2D/2D configuration for efficient...
Nonlinear mechanisms in Al and Ti superconducting travelling-wave parametric amplifiers
The underlying nonlinear mechanisms behind the operation of travelling-wave
parametric amplifiers (TWPAs) are important in determining their performance in
terms of added noise, maximum gain, and bandwidth. We describe a method...
Construction of Bi<sub>2</sub>WO<sub>6</sub>/RGO/g-C<sub>3</sub>N<sub>4</sub> 2D/2D/2D hybrid Z-scheme heterojunctions with large interfacial contact area for efficient charge separation and high-performance photoreduction of CO<sub>2</sub> and H<sub>2</sub>O into solar fuels
We have rationally constructed a hybrid heterojunction comprising of Bi2WO6, reduced graphene oxide, and g-C3N4 (BWO/RGO/CN) with a 2D/2D/2D configuration for efficient...
Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.
Philip C Schouten, Anita Grigoriadis, Thomas Kuilman, Hasan Mirza, Johnathan A Watkins, Saskia A Cooke, Ewald van Dyk, Tesa M Severson, Oscar M Rueda, Marlous Hoogstraat, Caroline VM Verhagen, Rachael Natrajan, Suet-Feung Chin, Esther H Lips, Janneke Kruizinga, Arno Velds, Marja Nieuwland, Ron M Kerkhoven, Oscar Krijgsman, Conchita Vens, Daniel Peeper, Petra M Nederlof, Carlos Caldas, Andrew N Tutt, Lodewyk F Wessels, Sabine C Linn
Nov 09, 2017
Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be 'BRCA1-like' or 'non-BRCA1-like', which refers to resembling a BRCA1-mutated...
N-doped C dot/CoAl-layered double hydroxide/g-C3N4 hybrid composites for efficient and selective solar-driven conversion of CO2 into CH4
Converting CO 2 into value-added fuel by utilizing abundant solar energy could in principle minimize fossil fuel consumption and anthropogenic CO 2 emissions. However, developing catalytic systems with...
Stable<i> trans</i> isomer as the kinetic and theromodynamic product for the oxidative addition of MeI to cycloplatinated(II) complexes comprising isocyanide ligands
Hamid R. Shahsavari, Reza Babadi Aghakhanpour, Mojdeh Hossein-Abadi, Reza Kia, Paul R. Raithby
Apr 01, 2018
The present investigation introduces a new series of cycloplatinated(II) complexes, with the general formula Pt(O-bpy)(Me)(CN-R)] (R = benzyl, 2-naphtyl and tert-butyl), which are able to generate the stable trans-Pt(IV)...
Stable<i> trans</i> isomer as the kinetic and theromodynamic product for the oxidative addition of MeI to cycloplatinated(II) complexes comprising isocyanide ligands
Hamid R. Shahsavari, Reza Babadi Aghakhanpour, Mojdeh Hossein-Abadi, Reza Kia, Paul R. Raithby
Apr 01, 2018
The present investigation introduces a new series of cycloplatinated(II) complexes, with the general formula Pt(O-bpy)(Me)(CN-R)] (R = benzyl, 2-naphtyl and tert-butyl), which are able to generate the stable trans-Pt(IV)...
A genome-wide association study of mitochondrial DNA copy number in two population-based cohorts.
Anna L Guyatt, Rebecca R Brennan, Kimberley Burrows, Philip AI Guthrie, Raimondo Ascione, Susan M Ring, Tom R Gaunt, Angela Pyle, Heather J Cordell, Debbie A Lawlor, Patrick F Chinnery, Gavin Hudson, Santiago Rodriguez
Mar 19, 2019
BACKGROUND: Mitochondrial DNA copy number (mtDNA CN) exhibits interindividual and intercellular variation, but few genome-wide association studies (GWAS) of directly assayed mtDNA CN exist. We undertook a GWAS of qPCR-assayed...
Asymptotic Weyl double copy
Abstract
A characteristic value formulation of the Weyl double copy leads to an asymptotic formulation. We find that the Weyl double copy holds...
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