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Identifying the immune interactions underlying HLA class I disease associations
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang
May 28, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
Multiphysics computational modeling in <i>C</i>Heart
J. Lee, A. Cookson, I. Roy, E. Kerfoot, L. Asner, G. Vigueras, T. Sochi, S. Deparis, C. Michler, N. P. Smith, D. A. Nordsletten
May 26, 2016
From basic science to translation, modern biomedical research demands computational models which integrate several interacting physical systems. This paper describes the infrastructural framework for generic multiphysics...
Multiphysics computational modeling in <i>C</i>Heart
J. Lee, A. Cookson, I. Roy, E. Kerfoot, L. Asner, G. Vigueras, T. Sochi, S. Deparis, C. Michler, N. P. Smith, D. A. Nordsletten
May 26, 2016
From basic science to translation, modern biomedical research demands computational models which integrate several interacting physical systems. This paper describes the infrastructural framework for generic multiphysics...
Identifying the immune interactions underlying HLA class I disease associations.
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Eduard J Sanders, Omu Anzala, Anatoli Kamali, Pontiano Kaleebu, Etienne Karita, William Kilembe, Mubiana Inambao, Shabir Lakhi, Susan Allen, Eric Hunter, Vinodh A Edward, Pat E Fast, Matt A Price, Jill Gilmour, Jianming Tang, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith
Jun 19, 2020
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
On the appearance of nitrite anion in [PdX(OAc)L<sub>2</sub>] and [Pd(X)(C∧N)L] syntheses (X = OAc or NO<sub>2</sub>)
S E Bajwa, T E Storr, Lauren E Hatcher, T J Williams, C G Baumann, A C Whitwood, D R Allan, S J Teat, Paul R Raithby, I J S Fairlamb
May 01, 2012
Pd 3(OAc) 5NO 2, an impurity in "Pd(OAc) 2" {formally Pd 3(OAc) 6}, emerges as a serious issue in the synthesis of pure Pd II complexes derived from Pd(OAc) 2, for example in our C-H activation precatalyst, Pd(OAc) 2(pip) 2 (pip...
Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease
Julian C van Capelleveen, Andrea E Bochem, S Matthijs Boekholdt, Samia Mora, Ron C Hoogeveen, Christie M Ballantyne, Paul M Ridker, Wensheng Sun, Philip J Barter, Alan R Tall, Aeilko H Zwinderman, John JP Kastelein, Nick J Wareham, Kay-Tee Khaw, G Kees Hovingh
Mar 22, 2018
BACKGROUND: The contribution of apolipoprotein A-I (apoA-I) to coronary heart disease (CHD) risk stratification over and above high-density lipoprotein cholesterol (HDL-C) is unclear. We studied the associations between plasma...
apolipoprotein A‐I cardiovascular disease coronary heart disease high‐density lipoprotein cholesterol Aged Antineoplastic Agents Apolipoprotein A-I Aspirin Cardiovascular Diseases Cholesterol HDL Coronary Disease Double-Blind Method England Female Humans Kaplan-Meier Estimate Male Middle Aged Neoplasms Platelet Aggregation Inhibitors Prognosis Prospective Studies Risk Factors Vitamin E Women's Health
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic
Rajiv V Dave, Beatrix Elsberger, Vicky P Taxiarchi, Ashu Gandhi, Cliona C Kirwan, Baek Kim, Elizabeth M Camacho, Charlotte E Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel R Leff, Stuart A McIntosh, Rachel O'Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey I Cutress, B-MaP-C study collaborative
Apr 17, 2023
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst...
New Data on Comparative Cytogenetics of the Mouse-Like Hamsters (<i>Calomyscus</i> Thomas, 1905) from Iran and Turkmenistan.
Svetlana A Romanenko, Vladimir G Malikov, Ahmad Mahmoudi, Feodor N Golenishchev, Natalya A Lemskaya, Jorge C Pereira, Vladimir A Trifonov, Natalia A Serdyukova, Malcolm A Ferguson-Smith, Mansour Aliabadian, Alexander S Graphodatsky
Aug 02, 2021
The taxonomy of the genus Calomyscus remains controversial. According to the latest systematics the genus includes eight species with great karyotypic variation. Here, we studied karyotypes of 14 Calomyscus...
Karyotype Chromosome Painting banding fluorescent in situ hybridization type locality Molecular cytogenetics painting probes
Published by: Genes
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer
Debashis Sarker, Ruth Plummer, Tim Meyer, Mikael H Sodergren, Bristi Basu, Cheng Ean Chee, Kai-Wen Huang, Daniel H Palmer, Yuk Ting Ma, TR Jeff Evans, Duncan RC Spalding, Madhava Pai, Rohini Sharma, David J Pinato, James Spicer, Sarah Hunter, Vineet Kwatra, Joanna P Nicholls, David Collin, Robert Nutbrown, Helen Glenny, Sonia Fairbairn, Vikash Reebye, Jon Voutila, Stephanie Dorman, Pinelopi Andrikakou, Peter Lloyd, Steve Felstead, Jenni Vasara, Robert Habib, Chris Wood, Pal Saetrom, Hans E Huber, David C Blakey, John J Rossi, Nagy Habib
May 13, 2020
PURPOSE: Transcription factor C/EBP-α (CCAAT/enhancer-binding protein alpha) acts as a master regulator of hepatic and myeloid functions and multiple oncogenic processes. MTL-CEBPA is a first-in-class small activating RNA...
Adult Aged Aged 80 and over Antineoplastic Agents CCAAT-Enhancer-Binding Proteins Carcinoma Hepatocellular Dose-Response Relationship Drug Female Gene Expression Regulation Neoplastic Humans Infusions Intravenous Liposomes Liver Neoplasms Male Middle Aged Nanoparticles Neoplasm Staging Oligoribonucleotides Treatment Outcome Tumor Microenvironment Up-Regulation
Nearest Neighbor Decoding and Pilot-AidedChannel Estimation for Fading Channels
We study the information rates of noncoherent, stationary, Gaussian, and multiple-input multiple-output (MIMO) flat-fading channels that are achievable with nearest neighbor decoding and pilot-aided channel estimation. In...
Molecular Genetic Characteristics of <i>FANCI</i>, a Proposed New Ovarian Cancer Predisposing Gene.
Caitlin T Fierheller, Wejdan M Alenezi, Corinne Serruya, Timothée Revil, Setor Amuzu, Karine Bedard, Deepak N Subramanian, Eleanor Fewings, Jeffrey P Bruce, Stephenie Prokopec, Luigi Bouchard, Diane Provencher, William D Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Marc Tischkowitz, Ian G Campbell, Trevor J Pugh, Celia M T Greenwood, Jiannis Ragoussis, Patricia N Tonin
Mar 28, 2023
FANCI was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of FANCI c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular...
ovarian cancer Hereditary cancer Whole exome sequencing TCGA Fanci Fanconi Anemia Pathway Cancer Predisposing Gene Humans Ovarian Neoplasms Genetic Predisposition to Disease Molecular Biology Mutation Genes BRCA2 Female Fanconi Anemia Complementation Group Proteins
Published by: Genes
Breast cancer management pathways during the COVID-19 pandemic
Rajiv V Dave, Baek Kim, Alona Courtney, Rachel O'Connell, Tim Rattay, Vicky P Taxiarchi, Jamie J Kirkham, Elizabeth M Camacho, Patricia Fairbrother, Nisha Sharma, Christopher WJ Cartlidge, Kieran Horgan, Stuart A McIntosh, Daniel R Leff, Raghavan Vidya, Shelley Potter, Chris Holcombe, Ellen Copson, Charlotte E Coles, Ramsey I Cutress, Ashu Gandhi, Cliona C Kirwan, B-MaP-C study collaborative
Apr 14, 2021
BACKGROUND: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. METHODS: This...
Search for the doubly heavy baryons Ω<inf>bc</inf><sup>0</sup>and Ξ<inf>bc</inf><sup>0</sup>decaying to Λ<inf>c</inf><sup>+</sup>π- And Ξ<inf>c</inf><sup>+</sup>π- And c
C Nguyen-Mau, R Aaij, C Abellán Beteta, T Ackernley, B Adeva, M Adinolfi, H Afsharnia, CA Aidala, S Aiola, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, Z Aliouche, G Alkhazov, P Alvarez Cartelle, S Amato, Y Amhis, L An, L Anderlini, A Andreianov, M Andreotti, F Archilli, A Artamonov, M Artuso, K Arzymatov, E Aslanides, M Atzeni, B Audurier, S Bachmann, M Bachmayer, JJ Back, P Baladron Rodriguez, V Balagura, W Baldini, J Baptista Leite, RJ Barlow, S Barsuk, W Barter, M Bartolini, F Baryshnikov, JM Basels, G Bassi, B Batsukh, A Battig, A Bay, M Becker, F Bedeschi, I Bediaga, A Beiter, V Belavin, S Belin, V Bellee, K Belous, I Belov, I Belyaev, G Bencivenni, E Ben-Haim, A Berezhnoy, R Bernet, D Berninghoff, HC Bernstein, C Bertella, A Bertolin, C Betancourt, F Betti, I Bezshyiko, S Bhasin, J Bhom, L Bian, MS Bieker, S Bifani, P Billoir, M Birch, FCR Bishop, A Bitadze, A Bizzeti, M Bj rn, MP Blago, T Blake, F Blanc, S Blusk, D Bobulska, JA Boelhauve, O Boente Garcia, T Boettcher, A Boldyrev, A Bondar, N Bondar, S Borghi, M Borisyak, M Borsato, JT Borsuk, SA Bouchiba, TJV Bowcock, A Boyer, C Bozzi, MJ Bradley
Aug 31, 2021
The first search for the doubly heavy $\it{\Omega}_{bc}^{\rm0}$ baryon and a
search for $\it{\Xi}_{bc}^{\rm0}$ baryon are performed using $pp$ collision
data collected via the LHCb experiment from 2016 to 2018 at a...
An Invariant Arginine in Common with MHC Class II Allows Extension at the C-Terminal End of Peptides Bound to Chicken MHC Class I.
Jin Xiao, Wangzhen Xiang, Yongli Zhang, Weiyu Peng, Min Zhao, Ling Niu, Yan Chai, Jianxun Qi, Fei Wang, Peng Qi, Chungang Pan, Lingxia Han, Ming Wang, Jim Kaufman, George F Gao, William J Liu
Dec 17, 2018
MHC molecules are found in all jawed vertebrates and are known to present peptides to T lymphocytes. In mammals, peptides can hang out either end of the peptide-binding groove of classical class II molecules, whereas the N and C...
<i>RAD51D</i> Aberrant Splicing in Breast Cancer
Elena Bueno-Martínez, Lara Sanoguera-Miralles, Alberto Valenzuela-Palomo, Víctor Lorca, Alicia Gómez-Sanz, Sara Carvalho, Jamie Allen, Mar Infante, Pedro Pérez-Segura, Conxi Lázaro, Douglas F Easton, Peter Devilee, Maaike P G Vreeswijk, Miguel de la Hoya, Eladio A Velasco
Aug 02, 2021
RAD51D loss-of-function variants increase lifetime risk of breast and ovarian cancer. Splicing disruption is a frequent pathogenic mechanism associated with variants in susceptibility genes. Herein, we have assessed the...
Breast Cancer ovarian cancer susceptibility genes ESE ESS VUS aberrant splicing minigene RAD51D clinical interpretation
Published by: Cancers
Exploring the Impact of Terminators on Transgene Expression in <i>Chlamydomonas reinhardtii</i> with a Synthetic Biology Approach.
Katrin Geisler, Mark A Scaife, Paweł M Mordaka, Andre Holzer, Eleanor V Tomsett, Payam Mehrshahi, Gonzalo I Mendoza Ochoa, Alison G Smith
Oct 29, 2021
Chlamydomonas reinhardtii has many attractive features for use as a model organism for both fundamental studies and as a biotechnological platform. Nonetheless, despite the many molecular tools and resources that have...
The <i>JWST</i> FRESCO Survey
P A Oesch, G Brammer, R P Naidu, R J Bouwens, J Chisholm, G D Illingworth, J Matthee, E Nelson, Y Qin, N Reddy, A Shapley, I Shivaei, P van Dokkum, A Weibel, K Whitaker, S Wuyts, A Covelo-Paz, R Endsley, Y Fudamoto, E Giovinazzo, T Herard-Demanche, J Kerutt, I Kramarenko, I Labbe, E Leonova, J Lin, D Magee, D Marchesini, M Maseda, C Mason, J Matharu, R A Meyer, C Neufeld, G Prieto Lyon, D Schaerer, R Sharma, M Shuntov, R Smit, M Stefanon, J S B Wyithe, M Xiao
Oct 31, 2023
We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124...
The <i>JWST</i> FRESCO Survey
P A Oesch, G Brammer, R P Naidu, R J Bouwens, J Chisholm, G D Illingworth, J Matthee, E Nelson, Y Qin, N Reddy, A Shapley, I Shivaei, P van Dokkum, A Weibel, K Whitaker, S Wuyts, A Covelo-Paz, R Endsley, Y Fudamoto, E Giovinazzo, T Herard-Demanche, J Kerutt, I Kramarenko, I Labbe, E Leonova, J Lin, D Magee, D Marchesini, M Maseda, C Mason, J Matharu, R A Meyer, C Neufeld, G Prieto Lyon, D Schaerer, R Sharma, M Shuntov, R Smit, M Stefanon, J S B Wyithe, M Xiao
Oct 31, 2023
We present the JWST cycle 1 53.8 h medium program FRESCO, short for 'First Reionization Epoch Spectroscopically Complete Observations'. FRESCO covers 62 arcmin2 in each of the two GOODS/CANDELS fields for a total area of 124...
Nearest Neighbor Decoding and Pilot-AidedChannel Estimation for Fading Channels
We study the information rates of noncoherent, stationary, Gaussian, and multiple-input multiple-output (MIMO) flat-fading channels that are achievable with nearest neighbor decoding and pilot-aided channel estimation. In...
Lamin A/C modulates spatial organization and function of the Hsp70 gene locus via nuclear myosin I.
The structure-function relationship of the nucleus is tightly regulated, especially during heat shock. Typically, heat shock activates molecular chaperones that prevent protein misfolding and preserve genome integrity. However...
Regioselective Radical Arene Amination for the Concise Synthesis of <i>ortho</i>-Phenylenediamines.
The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactive N-centered...
Published by: Journal of the American Chemical Society
Pf7
Muzamil Mahdi Abdel Hamid, Mohamed Hassan Abdelraheem, Desmond Omane Acheampong, Ambroise Ahouidi, Mozam Ali, Jacob Almagro-Garcia, Alfred Amambua-Ngwa, Chanaki Amaratunga, Lucas Amenga-Etego, Ben Andagalu, Tim Anderson, Voahangy Andrianaranjaka, Ifeyinwa Aniebo, Enoch Aninagyei, Felix Ansah, Patrick O Ansah, Tobias Apinjoh, Paulo Arnaldo, Elizabeth Ashley, Sarah Auburn, Gordon A Awandare, Hampate Ba, Vito Baraka, Alyssa Barry, Philip Bejon, Gwladys I Bertin, Maciej F Boni, Steffen Borrmann, Teun Bousema, Marielle Bouyou-Akotet, Oralee Branch, Peter C Bull, Huch Cheah, Keobouphaphone Chindavongsa, Thanat Chookajorn, Kesinee Chotivanich, Antoine Claessens, David J Conway, Vladimir Corredor, Erin Courtier, Alister Craig, Umberto D'Alessandro, Souleymane Dama, Nicholas Day, Brigitte Denis, Mehul Dhorda, Mahamadou Diakite, Abdoulaye Djimde, Christiane Dolecek, Arjen Dondorp, Seydou Doumbia, Chris Drakeley, Eleanor Drury, Patrick Duffy, Diego F Echeverry, Thomas G Egwang, Sonia Maria Mauricio Enosse, Berhanu Erko, Rick M Fairhurst, Abdul Faiz, Caterina A Fanello, Mark Fleharty, Matthew Forbes, Mark Fukuda, Dionicia Gamboa, Anita Ghansah, Lemu Golassa, Sonia Goncalves, G L Abby Harrison, Sara Anne Healy, Jason A Hendry, Anastasia Hernandez-Koutoucheva, Tran Tinh Hien, Catherine A Hill, Francis Hombhanje, Amanda Hott, Ye Htut, Mazza Hussein, Mallika Imwong, Deus Ishengoma, Scott A Jackson, Chris G Jacob, Julia Jeans, Kimberly J Johnson, Claire Kamaliddin, Edwin Kamau, Jon Keatley, Theerarat Kochakarn, Drissa S Konate, Abibatou Konaté, Aminatou Kone, Dominic P Kwiatkowski, Myat P Kyaw, Dennis Kyle, Mara Lawniczak, Samuel K Lee, Martha Lemnge, Pharath Lim, Chanthap Lon, Kovana M Loua, Celine I Mandara, Jutta Marfurt, Kevin Marsh, Richard James Maude, Mayfong Mayxay, Oumou Maïga-Ascofaré, Olivo Miotto, Toshihiro Mita, Victor Mobegi, Abdelrahim Osman Mohamed, Olugbenga A Mokuolu, Jaqui Montgomery, Collins Misita Morang'a, Ivo Mueller, Kathryn Murie, Paul N Newton, Thang Ngo Duc, Thuy Nguyen, Thuy-Nhien Nguyen, Tuyen Nguyen Thi Kim, Hong Nguyen Van, Harald Noedl, Francois Nosten, Rintis Noviyanti, Vincent Ntui-Njock Ntui, Alexis Nzila, Lynette Isabella Ochola-Oyier, Harold Ocholla, Abraham Oduro, Irene Omedo, Marie A Onyamboko, Jean-Bosco Ouedraogo, Kolapo Oyebola, Wellington Aghoghovwia Oyibo, Richard Pearson, Norbert Peshu, Aung P Phyo, Christopher V Plowe, Ric N Price, Sasithon Pukrittayakamee, Huynh Hong Quang, Milijaona Randrianarivelojosia, Julian C Rayner, Pascal Ringwald, Anna Rosanas-Urgell, Eduard Rovira-Vallbona, Valentin Ruano-Rubio, Lastenia Ruiz, David Saunders, Alex Shayo, Peter Siba, Victoria J Simpson, Mahamadou S Sissoko, Christen Smith, Xin-Zhuan Su, Colin Sutherland, Shannon Takala-Harrison, Arthur Talman, Livingstone Tavul, Ngo Viet Thanh, Vandana Thathy, Aung Myint Thu, Mahamoudou Toure, Antoinette Tshefu, Federica Verra, Joseph Vinetz, Thomas E Wellems, Jason Wendler, Nicholas J White, Georgia Whitton, William Yavo, Rob W van der Pluijm
Apr 02, 2023
We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries...
Published by: Wellcome open research
Diversity of the Genomes and Neurotoxins of Strains of Clostridium botulinum Group I and Clostridium sporogenes Associated with Foodborne, Infant and Wound Botulism.
Jason Brunt, Arnoud HM van Vliet, Andrew T Carter, Sandra C Stringer, Corinne Amar, Kathie A Grant, Gauri Godbole, Michael W Peck
Sep 12, 2020
Clostridium botulinum Group I and Clostridium sporogenes are closely related bacteria responsible for foodborne, infant and wound botulism. A comparative genomic study with 556 highly diverse strains of C. botulinum Group I and...
Botulism Clostridium botulinum Clostridium sporogenes Foodborne Genomes Infant Neurotoxins Wound Botulinum Toxins Botulism Clostridium Clostridium botulinum Genome Bacterial Genotype Humans Infant molecular epidemiology Phenotype Phylogeny Polymorphism Single Nucleotide whole genome sequencing Wound Infection
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