Search
Results: 503
Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy.
Jiaqi Li, Jie Qing Eu, Li Ren Kong, Lingzhi Wang, Yaw Chyn Lim, Boon Cher Goh, Andrea LA Wong
Oct 21, 2020
Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer treatment. The metabolic reprogramming that accompanies the development of malignancy creates targetable differences between cancer cells and...
Functional connexin35 increased in the myopic chicken retina.
Seema Banerjee, Qing Wang, George Tang, Chunghim So, Sze Wan Shan, King Kit Li, Chi-Wai Do, Feng Pan
Jun 14, 2021
Our previous research showed that increased phosphorylation of connexin (Cx)36 indicated extended coupling of AII amacrine cells (ACs) in the rod-dominant mouse myopic retina. This research will determine whether...
Extending the Reach of Quality With CARF Accreditation
Brian Boon
Jan 01, 2022
Accreditation is a common method to assess quality and plan for improvements in the delivery of health and human services. CARF accreditation was established to create standards of quality for specialty programs in...
Published by: IGI Global Scientific Publishing
Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.
Dana Wai Yi Tsui, Muhammed Murtaza, Alvin Seng Cheong Wong, Oscar M Rueda, Christopher G Smith, Dineika Chandrananda, Ross A Soo, Hong Liang Lim, Boon Cher Goh, Carlos Caldas, Tim Forshew, Davina Gale, Wei Liu, James Morris, Francesco Marass, Tim Eisen, Tan Min Chin, Nitzan Rosenfeld
Aug 15, 2018
Circulating tumour DNA Liquid biopsy Lung cancer resistance mechanisms targeted therapy Antineoplastic Agents Carcinoma Non-Small-Cell Lung DNA Copy Number Variations DNA Mutational Analysis DNA Neoplasm Drug Resistance Neoplasm ErbB Receptors Gefitinib Humans Hydroxychloroquine Longitudinal Studies Lung Neoplasms Mutation Prognosis Survival Analysis Treatment Outcome Tumor Suppressor Protein p53
Synergistic Activation of RD29A Via Integration of Salinity Stress and Abscisic Acid in Arabidopsis thaliana.
Plants perceive information from the surroundings and elicit appropriate molecular responses. How plants dynamically respond to combinations of external inputs is yet to be revealed, despite the detailed current knowledge of...
Combined stress Gene expression dynamics mathematical modeling Plant abiotic stresses Signaling cross-talk Abscisic Acid Arabidopsis Arabidopsis Proteins Computer Simulation Gene Expression Profiling Gene Expression Regulation Plant Models Biological Oligonucleotide Array Sequence Analysis Reproducibility of Results salinity Sodium Chloride Stress Physiological
A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma.
Li Ren Kong, Nur Afiqah Binte Mohamed Salleh, Richard Weijie Ong, Tuan Zea Tan, Nicholas L Syn, Robby Miguel Goh, Chee Wai Fhu, Daniel SW Tan, N Gopalakrishna Iyer, Srinivasaraghavan Kannan, Chandra S Verma, Yaw Chyn Lim, Ross Soo, Jingshan Ho, Yiqing Huang, Joline SJ Lim, Benedict Junrong Yan, Min En Nga, Seng Gee Lim, H Phillip Koeffler, Soo Chin Lee, Dennis Kappei, Huynh The Hung, Boon Cher Goh
Mar 25, 2021
c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbers, which can be inhibited by c-MET small molecule inhibitors. Here...
Animals Antineoplastic Agents Carcinoma Squamous Cell Cell Line Tumor Head and Neck Neoplasms Humans Lung Neoplasms Mice Mutation Phenotype Phosphorylation Polymorphism Genetic Prognosis Protein Binding Protein Interaction Domains and Motifs Protein Kinase Inhibitors Proto-Oncogene Proteins c-met Receptor ErbB-2 Signal Transduction Xenograft Model Antitumor Assays
Integrated genomics point to immune vulnerabilities in pleural mesothelioma
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C. Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G. Nicholson, Sanjay Popat, Anne E. Willis, Marion MacFarlane, Mark Lathrop, Anne M. Bowcock, Miriam F. Moffatt, William O. C. M. Cookson
Sep 27, 2021
Integrated genomics point to immune vulnerabilities in pleural mesothelioma.
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G Nicholson, Sanjay Popat, Anne Willis, Marion MacFarlane, Mark Lathrop, Anne M Bowcock, Miriam F Moffatt, William OCM Cookson
Nov 25, 2021
Pleural mesothelioma is an aggressive malignancy with limited effective therapies. In order to identify therapeutic targets, we integrated SNP genotyping, sequencing and transcriptomics from tumours and low-passage...
Integrated genomics point to immune vulnerabilities in pleural mesothelioma.
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G Nicholson, Sanjay Popat, Anne E Willis, Marion MacFarlane, Mark Lathrop, Anne M Bowcock, Miriam F Moffatt, William O C M Cookson
Oct 29, 2021
Published by: Scientific reports
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation.
Li Ren Kong, Richard Weijie Ong, Tuan Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, MiYoung Lee, Srinivasaraghavan Kannan, Chandra S Verma, Chwee Ming Lim, Wee Joo Chng, David P Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh
May 15, 2020
Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and acetylation. Here, we therapeutically exploit the oncogenic GOF mechanisms...
Acetylation Animals Antineoplastic Agents Apoptosis Caspase 3 Cell Line Tumor Cell Proliferation cisplatin Codon Epigenesis Genetic Gain of Function Mutation Gene Expression Regulation Neoplastic Humans Hydroxamic Acids Mice SCID Models Biological Mutant Proteins Mutation NF-kappa B Neoplasms Nucleotide Motifs Poly(ADP-ribose) Polymerases Protein Binding Protein Isoforms Sulfonamides Topotecan Tumor Suppressor Protein p53 Ubiquitin-Protein Ligases Xenograft Model Antitumor Assays
Automated identification of Monogeneans using digital image processing and K-nearest neighbour approaches.
BACKGROUND: Monogeneans are flatworms (Platyhelminthes) that are primarily found on gills and skin of fishes. Monogenean parasites have attachment appendages at their haptoral regions that help them to move about the body...
Prediction and identification of synergistic compound combinations against pancreatic cancer cells.
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L Bramhall, Tai-Ping Fan, Andreas Bender
Nov 22, 2021
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations...
The Grizzly, February 26, 1991
Krishni Patrick, Sara Jacobson, Dawn Deraney, Erika Compton, Terri Johnson, Chris Major, Jennifer Strawbridge, Danielle Owens, Tonya Ugoretz, Laura Zobel, Judd Woytek, Christin Outwin, Eleanore Hajian, Gina Solensky, Richard P. Richter, Antoni Castells-Talens, Neil Schafer
Jan 01, 0001
The Gulf War: How Will It Affect the Economy? Airband Competition Enters Its Eighth Year Sears-Roebuck Award, A Boon for Faculty How Will the War End? My First College Field Trip McCabe Wins Contest John Lionarons...
Ursinus College Collegeville Pennsylvania newspaper pre-medical program Chronic fatigue syndrome Olin Hall Wismer Center track team Basketball wrestling Swimming Al Angelos Berman Art Museum campus security Alan McCabe Three Mile Island Nicholas Berry Gulf War student government Air Band cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Integrated genomics point to immune vulnerabilities in pleural mesothelioma.
Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G Nicholson, Sanjay Popat, Anne E Willis, Marion MacFarlane, Mark Lathrop, Anne M Bowcock, Miriam F Moffatt, William OCM Cookson
Mar 21, 2022
Aged Aged 80 and over Antineoplastic Agents Biomarkers Tumor Biopsy DNA Copy Number Variations Female Gene Expression Profiling Gene Expression Regulation Neoplastic Genomics Hippo Signaling Pathway Humans Male Mesothelioma Malignant Middle Aged Mutation Pleura Pleural Neoplasms Primary Cell Culture whole genome sequencing
Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.
Siang-Boon Koh, Yann Wallez, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Tashinga E Bapiro, Frances M Richards, Duncan I Jodrell
Jun 29, 2018
Combination of cytotoxic therapy with emerging DNA damage response inhibitors (DDRi) has been limited by tolerability issues. However, the goal of most combination trials has been to administer DDRi with standard-of-care doses...
Animals Antineoplastic Combined Chemotherapy Protocols Cell Cycle Proteins Cell Line Tumor Cell Proliferation Checkpoint Kinase 1 DNA Damage DNA Replication Deoxycytidine Drug Synergism Female Humans Mice Mice Inbred BALB C Mice Nude Nuclear Proteins Protein-Tyrosine Kinases Xenograft Model Antitumor Assays Gemcitabine
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
Li Ren Kong, Richard Weijie Ong, Tuan Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, MiYoung Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Chwee Ming Lim, Wee Joo Chng, David P. Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh
Apr 29, 2021
Abstract: Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and acetylation. Here, we therapeutically exploit the oncogenic GOF...
Hydrodynamic voltammetry at a rocking disc electrode
Sunyhik D. Ahn, Karthik Somasundaram, H. Viet Nguyen, Erik Birgersson, Jim Yang Lee, Xiangming Gao, Adrian C. Fisher, Paul E. Frith, Frank Marken
Jan 10, 2016
Rocking disc electrode voltammetry (RoDE) is introduced as an experimentally convenient and versatile alternative to rotating disc voltammetry. A 1.6 mm diameter disc electrode is employed with an overall rocking angle of θ =...
Hydrodynamic voltammetry at a rocking disc electrode
Sunyhik D. Ahn, Karthik Somasundaram, H. Viet Nguyen, Erik Birgersson, Jim Yang Lee, Xiangming Gao, Adrian C. Fisher, Paul E. Frith, Frank Marken
Jan 10, 2016
Rocking disc electrode voltammetry (RoDE) is introduced as an experimentally convenient and versatile alternative to rotating disc voltammetry. A 1.6 mm diameter disc electrode is employed with an overall rocking angle of θ =...
An Inquiry Into the Use of Generative AI and Its Implications in Education
The emergence of generative AI technologies has provoked considerable debate among educators regarding their role in education. This study is an investigation of the benefits, disadvantages, and potential strategies for...
Published by: IGI Global Scientific Publishing
Physical Exercise (Riyazat) a Boon for Expecting Mothers
Creation has endowed the female of the species with the gift of pro-creation. Therefore this unique gift is the greatest happiness for a woman, who is aware that she and her kind are the ones who have brought mankind in this...
Published by: IJHS Medical Association
Physical Exercise (Riyazat) a Boon for Expecting Mothers
Creation has endowed the female of the species with the gift of pro-creation. Therefore this unique gift is the greatest happiness for a woman, who is aware that she and her kind are the ones who have brought mankind in this...
Published by: IJHS Medical Association
|
|< |
< |
1 |