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Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer.
A Saini, AR Norman, D Cunningham, I Chau, M Hill, D Tait, T Hickish, T Iveson, F Lofts, D Jodrell, PJ Ross, J Oates
Sep 02, 2020
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard bolus regimen of 5-FU and folinic...
Lithium-ion conductivity in Li<sub>6</sub>Y(BO<sub>3</sub>)<sub>3</sub>
Beatriz Lopez-Bermuda, Wolfgang G. Zeier, Shiliang Zhou, Anna J. Lehner, Jerry Hu, David O. Scanlon, Benjamin J. Morgan, Brent C. Melot
May 14, 2016
The development of new frameworks for solid electrolytes that exhibit fast Li-ion diffusion is critical for enabling new energy storage technologies. Here, we present a combined experimental and computational investigation into...
Lithium-ion conductivity in Li<sub>6</sub>Y(BO<sub>3</sub>)<sub>3</sub>
Beatriz Lopez-Bermuda, Wolfgang G. Zeier, Shiliang Zhou, Anna J. Lehner, Jerry Hu, David O. Scanlon, Benjamin J. Morgan, Brent C. Melot
May 14, 2016
The development of new frameworks for solid electrolytes that exhibit fast Li-ion diffusion is critical for enabling new energy storage technologies. Here, we present a combined experimental and computational investigation into...
Optimizing Supply Chain Management Through BO-CNN-LSTM for Demand Forecasting and Inventory Management
This project addresses demand forecasting and inventory optimization in supply chain management. Traditional methods have limitations with complex demand patterns and large-scale data. Deep learning techniques are employed to...
Published by: IGI Global Scientific Publishing
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
Ca Solubility in a BiFeO3-Based System with a Secondary Bi2O3 Phase on a Nanoscale.
Ulrich Haselmann, Thomas Radlinger, Weijie Pei, Maxim N Popov, Tobias Spitaler, Lorenz Romaner, Yurii P Ivanov, Jian Chen, Yunbin He, Gerald Kothleitner, Zaoli Zhang
Jun 13, 2022
In BiFeO3 (BFO), Bi2O3 (BO) is a known secondary phase, which can appear under certain growth conditions. However, BO is not just an unwanted parasitic phase but can be used to create the super-tetragonal BFO phase in films on...
Polymorphisms in Genes of Relevance for Oestrogen and Oxytocin Pathways and Risk of Barrett's Oesophagus and Oesophageal Adenocarcinoma
Katarina Lagergren, Weronica E Ek, David Levine, Wong-Ho Chow, Leslie Bernstein, Alan G Casson, Harvey A Risch, Nicholas J Shaheen, Nigel C Bird, Brian J Reid, Douglas A Corley, Laura J Hardie, Anna H Wu, Rebecca C Fitzgerald, Paul Pharoah, Carlos Caldas, Yvonne Romero, Thomas L Vaughan, Stuart MacGregor, David Whiteman, Lars Westberg, Olof Nyren, Jesper Lagergren
Feb 13, 2020
BACKGROUND: The strong male predominance in oesophageal adenocarcinoma (OAC) and Barrett's oesophagus (BO) continues to puzzle. Hormonal influence, e.g. oestrogen or oxytocin, might contribute. METHODS: This...
ADP-ribosyl Cyclase 1 Adenocarcinoma Aromatase Barrett Esophagus Esophageal Neoplasms Estrogen Receptor alpha Estrogen Receptor beta Female Genetic Association Studies Genetic Predisposition to Disease Humans Male Membrane Glycoproteins Oxytocin Polymorphism Single Nucleotide Receptors Oxytocin Sex Factors
Screening for Barrett's Oesophagus
PURPOSE OF REVIEW: The targeted approach adopted for Barrett's oesophagus (BO) screening is sub-optimal considering the large proportion of BO cases that are currently missed. We reviewed the literature highlighting recent...
Intensive Imaging-based Follow-up of Surgically Treated Localised Renal Cell Carcinoma Does Not Improve Post-recurrence Survival
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
Dec 03, 2018
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association...
Sub-picosecond photo-induced displacive phase transition in two-dimensional MoTe 2
Bo Peng, Hao Zhang, Weiwen Chen, Bowen Hou, Zhi-Jun Qiu, Hezhu Shao, Heyuan Zhu, Bartomeu Monserrat, Desheng Fu, Hongming Weng, Costas M. Soukoulis
Jun 12, 2020
Abstract: Photo-induced phase transitions (PIPTs) provide an ultrafast, energy-efficient way for precisely manipulating the topological properties of transition-metal ditellurides and can be used to stabilize a topological phase...
Topical treatment of actinic keratoses in organ transplant recipients
Zeeshaan-Ul Hasan, Ikhlaaq Ahmed, Rubeta N Matin, Victoria Homer, John T Lear, Ferina Ismail, Tristan Whitmarsh, Adele C Green, Jason Thomson, Alan Milligan, Sarah Hogan, Vanessa Van-de-Velde, Liza Mitchell-Worsford, Jonathan Kentley, Claire Gaunt, Yolande Jefferson-Hulme, Sarah J Bowden, Piers Gaunt, Keith Wheatley, Charlotte M Proby, Catherine A Harwood
Jun 14, 2022
BACKGROUND: The risk of cutaneous squamous cell carcinoma (cSCC) is significantly increased in organ transplant recipients (OTRs). Clearance of actinic keratoses (AKs) is generally regarded as a surrogate biomarker for cSCC...
Density-driven structural transformations in B<sub>2</sub> O<sub>3</sub> glass
A. Zeidler, K. Wezka, D.A.J. Whittaker, P.S. Salmon, A. Baroni, S. Klotz, H.E. Fischer, M.C. Wilding, C.L. Bull, M.G. Tucker, M. Salanne, G. Ferlat, M. Micoulaut
Jul 31, 2014
The method of in situ high-pressure neutron diffraction is used to investigate the structure of B2O3glass on compression in the range from ambient to 17.5(5) GPa. The...
Density-driven structural transformations in B<sub>2</sub> O<sub>3</sub> glass
A. Zeidler, K. Wezka, D.A.J. Whittaker, P.S. Salmon, A. Baroni, S. Klotz, H.E. Fischer, M.C. Wilding, C.L. Bull, M.G. Tucker, M. Salanne, G. Ferlat, M. Micoulaut
Jul 31, 2014
The method of in situ high-pressure neutron diffraction is used to investigate the structure of B2O3glass on compression in the range from ambient to 17.5(5) GPa. The...
On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity
Shobbir Hussain
May 01, 2020
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5...
Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis.
Sebastien Viatte, James C Lee, Bo Fu, Marion Espéli, Mark Lunt, Jack NE De Wolf, Lily Wheeler, John A Reynolds, Madhura Castelino, Deborah PM Symmons, Paul A Lyons, Anne Barton, Kenneth GC Smith
Jun 13, 2016
Adult Aged Animals Arthritis Arthritis Experimental Arthritis Rheumatoid C-Reactive Protein Cohort Studies Female Forkhead Box Protein O3 Humans Inflammation Longitudinal Studies Male Mice Mice Knockout Middle Aged Mutation Polymorphism Single Nucleotide Prospective Studies Severity of Illness Index
A Corpus-Based Study on the Translation Style of Five English Versions of Fu Sheng Liu Ji, Vol I
Bing Zhang
Oct 31, 2022
Using a corpus approach, this article investigates the translation styles of the first chapter of Fu Sheng Liu Ji at three levels: the statistical parameters, the translation of culture-specific lexis, and readability...
Published by: IGI Global Scientific Publishing
A Privacy Perspective of Open Government
Bo Zhao
Jan 05, 2018
Open government and freedom of information are key values in today's democracy, rule of law, and public governance. Their further development may have to be equally taken into consideration with other important public interests...
Published by: IGI Global Scientific Publishing
Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles
Jin-Tai Yu, Jie-Qiong Li, John Suckling, Lei Feng, An Pan, Yan-Jiang Wang, Bo Song, Shan-Liang Zhu, De-Hu Li, Hui-Fu Wang, Chen-Chen Tan, Qiang Dong, Lan Tan, Vincent Mok, Paul S Aisen, Michael M Weiner, Alzheimer's Disease Neuroimaging Initiative
Aug 21, 2019
INTRODUCTION: We aimed to estimate the frequency of each AT(N) (β-amyloid deposition [A], pathologic tau [T], and neurodegeneration [N]) profile in different clinical diagnosis groups and to describe the longitudinal change in...
Barrett's oesophagus and oesophageal adenocarcinoma.
Oesophageal adenocarcinoma (OAC) has increased dramatically in Western countries, including the UK, over the past 30 years. It usually presents de novo, but is often preceded by Barrett's oesophagus (BO), a premalignant...
Integration of Multi-Omics Data to Identify Cancer Biomarkers
A novel method for integrating multi-omics data, including gene expression, copy number variation, DNA methylation, and miRNA data, is proposed to identify biomarkers of cancer prognosis. First, survival analysis was performed...
Published by: IGI Global Scientific Publishing
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
SC3s
BACKGROUND: Today it is possible to profile the transcriptome of individual cells, and a key step in the analysis of these datasets is unsupervised clustering. For very large datasets, efficient algorithms are required to ensure...
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