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Sorting apples from oranges in single-cell expression comparisons.
Two methods for comparing single-cell expression datasets help address the challenge of integrating data across conditions and experiments.
Dysregulation of haematopoietic stem cell regulatory programs in acute myeloid leukaemia.
Haematopoietic stem cells (HSC) are situated at the apex of the haematopoietic differentiation hierarchy, ensuring the life-long supply of mature haematopoietic cells and forming a reservoir to replenish the haematopoietic...
A new RNASeq-based reference transcriptome for sugar beet and its application in transcriptome-scale analysis of vernalization and gibberellin responses.
Beta vulgaris Cold Temperature Computational Biology Gene Expression Profiling Gene Expression Regulation Plant Gene Regulatory Networks Genotype Gibberellins Molecular Sequence Annotation Molecular Sequence Data Plant Growth Regulators Plant Shoots RNA Messenger RNA Plant Sequence Analysis RNA Transcriptome
The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.
Adaptor Proteins Signal Transducing Animals Base Sequence Binding Sites Cell Line Cell Line Tumor Core Binding Factor alpha Subunits Enhancer Elements Genetic GATA2 Transcription Factor Gene Expression Regulation Hematopoiesis Humans Jurkat Cells LIM Domain Proteins Mice Molecular Sequence Data Myeloid Progenitor Cells Protein Binding Proto-Oncogene Proteins Regulatory Sequences Nucleic Acid Sequence Homology Nucleic Acid Silencer Elements Transcriptional T-Lymphocytes
Single cell genomics and developmental biology
Major developmental processes such as gastrulation and early embryogenesis rely on a complex network of cell-cell interactions, chromatin remodeling, and transcriptional regulators. This makes it challenging to study early...
A graphical model approach visualizes regulatory relationships between genome-wide transcription factor binding profiles.
ChIP-seq Haematopoiesis Network Transcriptional regulation Algorithms Animals Binding Sites Cells Cultured Chromatin Immunoprecipitation Computational Biology Computer Graphics Gene Expression Regulation Genome Hematopoietic Stem Cells Leukemia Mice Models Statistical Protein Binding Transcription Factors
Single-cell transcriptional profiling
During mammalian embryonic development, a single fertilized egg cell will proliferate and differentiate into all the cell lineages and cell types that eventually form the adult organism. Cell lineage diversification involves...
Single-Cell Analysis of Hematopoietic Stem Cells.
Bone Marrow Gene Regulatory Networks Hematopoiesis Hematopoietic stem cell Smart-Seq2 Transcriptome mcSCRB-Seq mcSmart-Seq2 scRNA-seq Animals Cell Lineage Cell Separation Flow Cytometry Gene Expression Profiling Gene Library Gene Regulatory Networks Hematopoiesis Hematopoietic Stem Cells Mice Phenotype RNA-seq Single-Cell Analysis Transcriptome
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