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The International Human Epigenome Consortium
The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal...
“He Was the One With the Gun!” Associative Memory for White and Black Faces Seen With Weapons
Much research has found that implicit associations between Black male faces and aggression afect dispositional judgments and decision-making, but there have been few investigations into downstream efects on explicit episodic...
Published by: Digital Commons @ Texas A&M University-San Antonio
The human body at cellular resolution
HuBMAP Consortium
Nov 29, 2019
Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program...
The human body at cellular resolution
Shin Lin, Amanda Posgai, Mark Atkinson, Aviv Regev, Jennifer Rood, Orit Rozenblatt-Rosen, Leslie Gaffney, Anna Hupalowska, Rahul Satija, Nils Gehlenborg, Jay Shendure, Julia Laskin, Pehr Harbury, Nicholas A. Nystrom, Jonathan C. Silverstein, Ziv Bar-Joseph, Kun Zhang, Katy Börner, Yiing Lin, Richard Conroy, Dena Procaccini, Ananda L. Roy, Ajay Pillai, Marishka Brown, Zorina S. Galis, Long Cai, Cole Trapnell, Dana Jackson, Michael P. Snyder, Garry Nolan, William James Greenleaf, Sylvia Plevritis, Sara Ahadi, Stephanie A. Nevins, Hayan Lee, Christian Martijn Schuerch, Sarah Black, Vishal Gautham Venkataraaman, Ed Esplin, Aaron Horning, Amir Bahmani, Xin Sun, Sanjay Jain, James Hagood, Gloria Pryhuber, Peter Kharchenko, Bernd Bodenmiller, Todd Brusko, Michael Clare-Salzler, Harry Nick, Kevin Otto, Clive Wasserfall, Marda Jorgensen, Maigan Brusko, Sergio Maffioletti, Richard M. Caprioli, Jeffrey M. Spraggins, Danielle Gutierrez, Nathan Heath Patterson, Elizabeth K. Neumann, Raymond Harris, Mark deCaestecker, Agnes B. Fogo, Raf van de Plas, Ken Lau, Guo-Cheng Yuan, Qian Zhu, Ruben Dries, Peng Yin, Sinem K. Saka, Jocelyn Y. Kishi, Yu Wang, Isabel Goldaracena, DongHye Ye, Kristin E. Burnum-Johnson, Paul D. Piehowski, Charles Ansong, Ying Zhu, Tushar Desai, Jay Mulye, Peter Chou, Monica Nagendran, Sarah A. Teichmann, Benedict Paten, Robert F. Murphy, Jian Ma, Vladimir Yu. Kiselev, Carl Kingsford, Allyson Ricarte, Maria Keays, Sushma A. Akoju, Matthew Ruffalo, Margaret Vella, Chuck McCallum, Leonard E. Cross, Samuel H. Friedman, Randy Heiland, Bruce Herr, Paul Macklin, Ellen M. Quardokus, Lisel Record, James P. Sluka, Griffin M. Weber, Philip D. Blood, Alexander J. Ropelewski, William E. Shirey, Robin M. Scibek, Paula Mabee, W. Christopher Lenhardt, Kimberly Robasky, Stavros Michailidis, John Marioni, Andrew Butler, Tim Stuart, Eyal Fisher, Shila Ghazanfar, Gokcen Eraslan, Tommaso Biancalani, Eeshit D. Vaishnav, Ananda Roy, Zorina Galis, Pothur Srinivas, Aaron Pawlyk, Salvatore Sechi, Elizabeth Wilder, James Anderson
Oct 08, 2020
Abstract: Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular...
The Geography of Human Capital
This paper explores the spatial heterogeneity in the human capital potential of Indonesia’s next generation by constructing and analyzing sub-national human capital indices (HCI) for 34 provinces and 514 districts in Indonesia....
Professor and Columbia Judge-Alumna Selected as Liberty Fellows
Winthrop University
Jan 01, 0001
The 23 Liberty Fellows are described as action-oriented leaders with ambitious goals for a stronger South Carolina and were selected from more than 400 nominations from across the state. Chosen as Winthrop Fellows are: DeAndrea...
Published by: Winthrop University
The Geography of Human Capital
This paper explores the spatial heterogeneity in the human capital potential of Indonesia’s next generation by constructing and analyzing sub-national human capital indices (HCI) for 34 provinces and 514 districts in Indonesia....
W412-005 - Personnel Office: Newsletter
Published by: Winthrop University
SGBS cells as a model of human adipocyte browning
Chia Rou Yeo, Madhur Agrawal, Shawn Hoon, Asim Shabbir, Manu Kunaal Shrivastava, Shiqi Huang, Chin Meng Khoo, Vanna Chhay, M Shabeer Yassin, E Shyong Tai, Antonio Vidal-Puig, Sue-Anne Toh
Oct 09, 2020
The Simpson Golabi Behmel Syndrome (SGBS) pre-adipocyte cell strain is widely considered to be a representative in vitro model of human white pre-adipocytes. A recent study suggested that SGBS adipocytes exhibit an unexpected...
The Human Cell Atlas.
Aviv Regev, Sarah A Teichmann, Eric S Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Göttgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Emma Lundberg, Joakim Lundeberg, Partha Majumder, John C Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe'er, Anthony Phillipakis, Chris P Ponting, Stephen Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua Sanes, Rahul Satija, Ton N Schumacher, Alex Shalek, Ehud Shapiro, Padmanee Sharma, Jay W Shin, Oliver Stegle, Michael Stratton, Michael JT Stubbington, Fabian J Theis, Matthias Uhlen, Alexander van Oudenaarden, Allon Wagner, Fiona Watt, Jonathan Weissman, Barbara Wold, Ramnik Xavier, Nir Yosef, Human Cell Atlas Meeting Participants
Feb 16, 2018
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in...
Raman micro-spectroscopy for accurate identification of primary human bronchial epithelial cells.
Jakub M Surmacki, Benjamin J Woodhams, Alexandria Haslehurst, Bruce AJ Ponder, Sarah E Bohndiek
Nov 05, 2018
Live cell Raman micro-spectroscopy is emerging as a promising bioanalytical technique for label-free discrimination of a range of different cell types (e.g. cancer cells and fibroblasts) and behaviors (e.g. apoptosis). The aim...
Monocytes Latently Infected with Human Cytomegalovirus Evade Neutrophil Killing.
Elizabeth Elder, Benjamin Krishna, James Williamson, Yusuf Aslam, Neda Farahi, Alexander Wood, Veronika Romashova, Kate Roche, Eain Murphy, Edwin Chilvers, Paul J Lehner, John Sinclair, Emma Poole
Feb 01, 2019
One site of latency of human cytomegalovirus (HCMV) in vivo is in undifferentiated cells of the myeloid lineage. Although latently infected cells are known to evade host T cell responses by suppression of T cell effector...
A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells.
Fang Fang, Benjamin Angulo, Ninuo Xia, Meena Sukhwani, Zhengyuan Wang, Charles C Carey, Aurélien Mazurie, Jun Cui, Royce Wilkinson, Blake Wiedenheft, Naoko Irie, M Azim Surani, Kyle E Orwig, Renee A Reijo Pera
Sep 11, 2018
Dysregulation of genetic pathways during human germ cell development leads to infertility. Here, we analysed bona fide human primordial germ cells (hPGCs) to probe the developmental genetics of human germ cell specification and...
Animals Cell Differentiation Cell Line Gene Editing Gene Expression Regulation Developmental Human Embryonic Stem Cells Humans Male Mice Nude Octamer Transcription Factor-3 PAX5 Transcription Factor Positive Regulatory Domain I-Binding Factor 1 Protein Binding SOXB1 Transcription Factors Signal Transduction Spermatozoa Testis Time Factors Transcription Genetic
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.
Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Mar 28, 2020
BACKGROUND:Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously...
Published by: BMC developmental biology
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids
Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Feb 25, 2021
Abstract: Background: Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while...
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.
Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Feb 05, 2020
BACKGROUND: Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously...
Chemically defined hydrogel Genetic stability In vivo safety Organoid Pancreas Primary cultures Cell Differentiation Cells Cultured Female Flow Cytometry Genomic Instability Humans In Vitro Techniques Lentivirus Male Organ Culture Techniques Organoids Pancreas Reverse Transcriptase Polymerase Chain Reaction
Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency.
Elizabeth G Elder, Benjamin A Krishna, James Williamson, Eleanor Y Lim, Emma Poole, George X Sedikides, Mark Wills, Christine M O'Connor, Paul J Lehner, John Sinclair
Jan 06, 2020
Human cytomegalovirus (HCMV) latency is an active process which remodels the latently infected cell to optimize latent carriage and reactivation. This is achieved, in part, through the expression of viral genes, including the...
A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues
Samuel Furse, Denise S. Fernandez-Twinn, Benjamin Jenkins, Claire L. Meek, Huw E. L. Williams, Gordon C. S. Smith, D. Stephen Charnock-Jones, Susan E. Ozanne, Albert Koulman
Mar 07, 2021
Abstract: Lipidomics is of increasing interest in studies of biological systems. However, high-throughput data collection and processing remains non-trivial, making assessment of phenotypes difficult. We describe a platform for...
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids
Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Jun 06, 2020
Abstract: Background: Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while...
Dance Major from Lugoff, S.C., Earned Tillman Award
Winthrop University
Jan 01, 0001
Amanda Floyd earned a Bachelor of Arts degree in dance and wants to teach dance with the ultimate goal of working in choreography. The Tillman Award is the university's highest academic honor. Established in 1940 to honor former...
Published by: Winthrop University
Perception and Processing of Faces in the Human Brain Is Tuned to Typical Feature Locations.
Benjamin de Haas, D Samuel Schwarzkopf, Ivan Alvarez, Rebecca P Lawson, Linda Henriksson, Nikolaus Kriegeskorte, Geraint Rees
Oct 03, 2018
UNLABELLED: Faces are salient social stimuli whose features attract a stereotypical pattern of fixations. The implications of this gaze behavior for perception and brain activity are largely unknown. Here, we characterize and...
decoding fMRI Face perception gaze behavior occipital face area retinotopy Adult Attention Face Female Fixation Ocular Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Occipital Lobe Oxygen pattern recognition Visual Photic Stimulation RECOGNITION psychology Young Adult
Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.
Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso, Paul D Upton, John P Waters, Mark L Ormiston, Jeremy N Skepper, Gerard Nash, Amer A Rana, Nicholas W Morrell
Jun 14, 2018
The endothelial cell has a remarkable ability for sub-specialisation, adapted to the needs of a variety of vascular beds. The role of developmental programming versus the tissue contextual environment for this specialization is...
Adult Animals Cell Differentiation Cell Line Cluster Analysis Embryonic Stem Cells Endothelial Cells Fetus Gene Expression Profiling Gene Ontology Genes Homeobox Homeodomain Proteins Humans Lung Mice Neovascularization Physiologic Oligonucleotide Array Sequence Analysis Organ Specificity Phenotype Pulmonary Artery RNA Messenger Rats Real-Time Polymerase Chain Reaction Reproducibility of Results
Direct Human-AI Comparison in the Animal-AI Environment.
Konstantinos Voudouris, Matthew Crosby, Benjamin Beyret, José Hernández-Orallo, Murray Shanahan, Marta Halina, Lucy G Cheke
Jun 07, 2022
Artificial Intelligence is making rapid and remarkable progress in the development of more sophisticated and powerful systems. However, the acknowledgement of several problems with modern machine learning approaches has prompted...
Regulation of host and viral promoters during human cytomegalovirus latency via US28 and CTCF.
Viral latency is an active process during which the host cell environment is optimized for latent carriage and reactivation. This requires control of both viral and host gene promoters and enhancers often at the level of...
CTCF Chromatin Cytomegalovirus latency viral gene expression virus-host interactions CCCTC-Binding Factor Calgranulin A Calgranulin B Cytomegalovirus Cytomegalovirus Infections Enhancer Elements Genetic Gene Expression Regulation Genes Immediate-Early Host-Pathogen Interactions Humans Monocytes Promoter Regions Genetic Receptors Chemokine Viral Proteins Virus Latency
A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues
Samuel Furse, Denise S. Fernandez-Twinn, Benjamin Jenkins, Claire L. Meek, Huw E. L. Williams, Gordon C. S. Smith, D. Stephen Charnock-Jones, Susan E. Ozanne, Albert Koulman
Jun 06, 2020
Abstract: Lipidomics is of increasing interest in studies of biological systems. However, high-throughput data collection and processing remains non-trivial, making assessment of phenotypes difficult. We describe a platform for...
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