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Modeling human embryo development with embryonic and extra-embryonic stem cells
Early human post-implantation development involves extensive growth combined with a series of complex morphogenetic events. The lack of precise spatial and temporal control over these processes leads to pregnancy loss. Given the...
Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester.
While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects many other organs leading to other complications. It has emerged that advanced age and obesity are risk factors for complications but...
Reconstructing aspects of human embryogenesis with pluripotent stem cells.
Berna Sozen, Victoria Jorgensen, Bailey AT Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Aug 26, 2021
Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Adaptor Proteins Signal Transducing Biomarkers Blastocyst Cell Culture Techniques Cell Lineage Embryo Mammalian Embryonic Development GATA3 Transcription Factor Gene Expression Humans Models Biological Phospholipase C beta Pluripotent Stem Cells SOXB1 Transcription Factors SOXF Transcription Factors Sequence Analysis RNA Single-Cell Analysis
An in vitro stem cell model of human epiblast and yolk sac interaction.
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz
Sep 17, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of...
human Cell Biology embryology MOUSE Pluripotency developmental biology Stem Cells human development Epiblast hypoblast
Published by: eLife
Developmental potential of aneuploid human embryos cultured beyond implantation.
Marta N Shahbazi, Tianren Wang, Xin Tao, Bailey AT Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D Smith, Antonio Pellicer, Richard T Scott, Emre Seli, Magdalena Zernicka-Goetz
Jul 20, 2020
Aneuploidy, the presence of an abnormal number of chromosomes, is a major cause of early pregnancy loss in humans. Yet, the developmental consequences of specific aneuploidies remain unexplored. Here, we determine the extent of...
Aneuploidy Antigens CD Cadherins Cell Adhesion Cell Cycle Checkpoints Cell Lineage Chromosome Segregation Chromosomes Human Pair 16 Chromosomes Human Pair 21 Embryo Implantation Embryo Mammalian Embryonic Development Female Genes erbB-1 Genetic Testing Humans Monosomy Mosaicism Pregnancy Stem Cells Trisomy
Reconstructing aspects of human embryogenesis with pluripotent stem cells
Berna Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Sep 21, 2021
Abstract: Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Reconstructing aspects of human embryogenesis with pluripotent stem cells.
Berna Sozen, Victoria Jorgensen, Bailey A T Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Oct 23, 2021
Understanding human development is of fundamental biological and clinical importance. Despite its significance, mechanisms behind human embryogenesis remain largely unknown. Here, we attempt to model human early embryo...
Pluripotent Stem Cells Blastocyst Humans Adaptor Proteins Signal Transducing Cell Culture Techniques Sequence Analysis RNA Gene Expression Cell Lineage Embryonic Development Models Biological GATA3 Transcription Factor Embryo Mammalian Phospholipase C beta SOXB1 Transcription Factors SOXF Transcription Factors Single-Cell Analysis Biomarkers
Published by: Nature Communications
Usage and User Experience in an Academic Law Library
Abstract This article, written by Josephine Bailey and Kate Faulkner, discusses the collection of library usage data at the Squire Law Library, an academic law library embedded in the Faculty of...
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim HH Coorens, Marta N Shahbazi, Antonia Weberling, Bailey AT Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
May 13, 2021
Bone Morphogenetic Protein 1 Cell Lineage Cells Cultured Embryo Implantation Embryo Mammalian Embryonic Development Fibroblast Growth Factors Gastrulation Gene Expression Regulation Developmental Germ Layers Humans Image Processing Computer-Assisted Multigene Family Nodal Protein RNA-seq Single-Cell Analysis Spatio-Temporal Analysis Wnt Signaling Pathway
Seasoned Antisemitism: Cannibalism in The Destruction of Jerusalem
Bailey Ludwig
Jan 01, 0001
My project examines an episode of maternal cannibalism within the medieval poem The Destruction of Jerusalem. Several variations of the story of the 70 AD Roman siege of Jerusalem that include this particular episode exist; the...
Destruction of Jerusalem cannibalism Eusebius antisemitism La Vengeance de Nostre-Seigneur the siege of Jerusalem transubstantiation Arts and Humanities English Language and Literature Jewish Studies Medieval Studies
Published by: Ursinus College
The Grizzly, January 27, 1989
Kevin Murphy, Michelle L. Grande, Todd Koser, Richard P. Richter, Coleen Casciano, Bob Gonnella, Matt Weintraub, Bridget Algeo, Lora L. Hart, Sharon Festa, Judd Woytek, Lenore Bailey, Gabriel Laboca, Steven Grim, Katherine Grim
Jan 01, 0001
Constructium Ursini Ad Hoc Hoists Honor New GPA: 2.25 or Dive! Letter: Green Shirt Makes Reed Red Fair Not Just for Freshmen Security Shacks in Reimert Beverly Oehlert Named to Pottstown Board of Directors Final Red and...
Ursinus College Collegeville Pennsylvania newspaper Wismer dining hall Jonny King Quintet Robin Greenstein campus security George Bush board of directors Llewellyn F. Dryfoos David J. Knauer field hockey Adele Boyd Swimming Basketball Beverly Oehlert Pottstown Memorial Medical Center Reimert Hall Red and Gold day activities fair grading system Olin Hall construction honor code cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
A Sample of Understudied Works in Aberdeen MS 123
Bailey Ludwig
Jan 01, 0001
This project examines and transcribes various understudied texts from the University of Aberdeen's MS 123 in order to create a more complete picture of this manuscript. Chapter one looks at the "Sultan Letters" and "List of...
aberdeen ms 123 middle english miscellany crusades Medicine Gender Arts and Humanities English Language and Literature Medieval Studies
Published by: Ursinus College
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Matteo A Molè, Tim H H Coorens, Marta N Shahbazi, Antonia Weberling, Bailey A T Weatherbee, Carlos W Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jul 28, 2021
Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in...
Cells Cultured Germ Layers Humans Fibroblast Growth Factors Gene Expression Regulation Developmental Cell Lineage Embryonic Development Embryo Implantation Multigene Family Image Processing Computer-Assisted Embryo Mammalian Gastrulation Bone Morphogenetic Protein 1 Nodal Protein Single-Cell Analysis Wnt Signaling Pathway Spatio-Temporal Analysis RNA-seq
Published by: Nature Communications
A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre
Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Jun 17, 2021
Abstract: Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain...
W454-001A-01 - Inn at Winthrop: General Office Publications: Publications
Inn at Winthrop
Jan 01, 0001
Published by: Winthrop University
Breast lesion detection and characterization with contrast-enhanced magnetic resonance imaging
Paola Clauser, Thomas H Helbich, Panagiotis Kapetas, Katja Pinker, Maria Bernathova, Ramona Woitek, Andreas Kaneider, Pascal AT Baltzer
Sep 09, 2019
BACKGROUND: Contrast-enhanced magnetic resonance imaging (CE-MRI) of the breast is highly sensitive for breast cancer detection. Multichannel coils and 3T scanners can increase signal, spatial, and temporal resolution. In...
Sullivan Endowment Provides Unrestricted Dollars to Winthrop
Winthrop University
Jan 01, 0001
Sullivan, of Lancaster, S.C., who died in 2010, spent much of her working career as a home economics teacher and librarian at Buford High School in Lancaster. Three of Sullivan's four sisters also attended Winthrop. They are...
Published by: Winthrop University
In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor
Accumulating evidence supports a role for κ−opioid receptor antagonists in the treatment of mood disorders. Standard κ-antagonists have an unusual pharmacodynamic action, with a single injection blocking receptor signaling for...
In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor
Accumulating evidence supports a role for κ−opioid receptor antagonists in the treatment of mood disorders. Standard κ-antagonists have an unusual pharmacodynamic action, with a single injection blocking receptor signaling for...
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