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Results: 53
Global analysis of the evolution and mechanism of echinocandin resistance in <em>Candida glabrata</em>
S.D. Singh-Babak, T. Babak, S. Diezmann, J. A. Hill, J. L. Xie, Y.-L. Chen, S. M. Poutanen, R. P. Rennie, J. Heitman, L. E. Cowen
May 01, 2012
The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are...
Global analysis of the evolution and mechanism of echinocandin resistance in <em>Candida glabrata</em>
S.D. Singh-Babak, T. Babak, S. Diezmann, J. A. Hill, J. L. Xie, Y.-L. Chen, S. M. Poutanen, R. P. Rennie, J. Heitman, L. E. Cowen
May 01, 2012
The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are...
Restricted Boltzmann machine representation for the groundstate and excited states of Kitaev Honeycomb model
Abstract
In this work, the capability of restricted Boltzmann machines (RBMs) to find solutions for the Kitaev honeycomb model with periodic boundary conditions is investigated....
Restricted Boltzmann machine representation for the groundstate and excited states of Kitaev Honeycomb model
Abstract
In this work, the capability of restricted Boltzmann machines (RBMs) to find solutions for the Kitaev honeycomb model with periodic boundary conditions is investigated....
Low defect and high electrical conductivity of graphene through plasma graphene healing treatment monitored with in situ optical emission spectroscopy.
Mohammad Salehi, Parnia Bastani, Loghman Jamilpanah, Abbas Madani, Seyed Majid Mohseni, Babak Shokri
Oct 13, 2021
Fundamental studies on graphene (Gr) and its real device applications have been affected by unavoidable defects and impurities which are usually present in synthesized Gr. Therefore, post treatment methods on Gr have been an...
The Dark Side of Using Online Social Networks
Research on online social networks (OSNs) has focused overwhelmingly on their benefits and potential, with their negative effects overlooked. This study builds on the limited existing work on the so-called ‘dark side’ of using...
Published by: IGI Global Scientific Publishing
Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke
Ajay Gupta, Hediyeh Baradaran, Khalid Al-Dasuqi, Ashley Knight-Greenfield, Ashley E Giambrone, Diana Delgado, Drew Wright, Zhongzhao Teng, James K Min, Babak B Navi, Costantino Iadecola, Hooman Kamel
Oct 11, 2016
Cerebral Infarction culprit artery enhancement gadolinium ischemic stroke Magnetic Resonance Imaging Plaque vessel wall imaging Aged Aged 80 and over Brain Ischemia Cerebral Infarction Contrast Media Female Gadolinium Humans Intracranial Arteriosclerosis Magnetic Resonance Angiography Male Middle Aged Plaque Atherosclerotic Prospective Studies Retrospective Studies stroke
Patient Experience in Early-Stage Parkinson's Disease
DfrA-thyA double deletion in para-aminosalicylic acid resistant Mycobacterium tuberculosis Beijing strains
dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains.
ADA2 deficiency complicated by EBV-driven lymphoproliferative disease.
Emily Staples, Ilenia Simeoni, Jonathan C Stephens, Hana Lango Allen, NIHR-BioResource, Penny Wright, E Graham Davies, Babak Javid, Effrossyni Gkrania-Klotsas, Michael Gattens, Helen Firth, Olga Shamardina, Sri VV Deevi, Matina Prapa, Ben Uttenthal, Dinakantha Kumararatne, James ED Thaventhiran
May 14, 2020
A 29-year old male with recurrent respiratory and skin infections, anaemia and neutropaenia during childhood required immunoglobulin replacement for antibody deficiency from age 16. He remained relatively well until age 28 when...
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.
Amir-Babak Sioofy-Khojine, Sarah J Richardson, Jonathan M Locke, Sami Oikarinen, Noora Nurminen, Antti-Pekka Laine, Kate Downes, Johanna Lempainen, John A Todd, Riitta Veijola, Jorma Ilonen, Mikael Knip, Noel G Morgan, Heikki Hyöty, Mark Peakman, Martin Eichmann
Sep 15, 2022
Autoimmunity Enterovirus genetic risk IFIH-1 Interferon induced with helicase C domain 1 MDA5 Melanoma differentiation-associated protein 5 Pancreatic islets type 1 diabetes rs1990760 Adult Alleles Autoantibodies Child DEAD-box RNA Helicases Diabetes mellitus Type 1 Enterovirus Enterovirus Infections Genetic Predisposition to Disease Humans Insulins Interferon-Induced Helicase IFIH1 Leukocytes Mononuclear RNA
Adaptive designs in clinical trials
Philip Pallmann, Alun W Bedding, Babak Choodari-Oskooei, Munyaradzi Dimairo, Laura Flight, Lisa V Hampson, Jane Holmes, Adrian P Mander, Lang'o Odondi, Matthew R Sydes, Sofía S Villar, James MS Wason, Christopher J Weir, Graham M Wheeler, Christina Yap, Thomas Jaki
Jun 12, 2018
Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial's course in accordance with pre-specified rules. Trials with an adaptive design are often more efficient...
Countermeasures for Preventing and Treating Opioid Overdose
Charles P. France, Gerard P. Ahern, Saadyah Averick, Alex Disney, Heather A. Enright, Babak Esmaeli-Azad, Arianna Federico, Lisa R. Gerak, Stephen M. Husbands, Benedict Kolber, Edmond Y. Lau, Victoria Lao, David R. Maguire, Michael A. Malfatti, Girardo Martinez, Brian P. Mayer, Marco Pravetoni, Niaz Sahibzada, Phil Skolnick, Evan Y. Snyder, Nestor Tomycz, Carlos A. Valdez, Jim Zapf
Mar 31, 2021
The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the US Food and Drug Administration (FDA) nearly 50 years ago. Because of its pharmacokinetic and pharmacodynamic...
A Disease Progression Model to Quantify the Nonmotor Symptoms of Parkinson's Disease in Participants With Leucine-Rich Repeat Kinase 2 Mutation.
Malidi Ahamadi, Nitin Mehrotra, Nathan Hanan, Ka Lai Yee, Ferdous Gheyas, Judith Anton, Massimo Bani, Babak Boroojerdi, Hans Smit, Jonas Weidemann, Sreeraj Macha, Vincent Thuillier, Chao Chen, Minhua Yang, Caroline H Williams-Gray, Glenn T Stebbins, Gennaro Pagano, Yaming Hang, Kenneth Marek, Charles S Venuto, Monica Javidnia, David Dexter, Anne Pedata, Bob Stafford, Mussie Akalu, Diane Stephenson, Klaus Romero, Vikram Sinha, Critical Path for Parkinson’s Consortium
Mar 19, 2021
Leucine-rich repeat kinase 2 (LRRK2) inhibitors are currently in clinical development as interventions to slow progression of Parkinson's disease (PD). Understanding the rate of progression in PD as measured by both motor and...
Adult Age Factors Aged Aged 80 and over Antiparkinson Agents Databases Factual Disease Progression Female Glucosylceramidase Heterozygote Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Longitudinal Studies Male Middle Aged Models Theoretical Mutation Parkinson Disease Predictive Value of Tests Severity of Illness Index ALPHA-SYNUCLEIN
Countermeasures for Preventing and Treating Opioid Overdose
Charles P. France, Gerard P. Ahern, Saadyah Averick, Alex Disney, Heather A. Enright, Babak Esmaeli-Azad, Arianna Federico, Lisa R. Gerak, Stephen M. Husbands, Benedict Kolber, Edmond Y. Lau, Victoria Lao, David R. Maguire, Michael A. Malfatti, Girardo Martinez, Brian P. Mayer, Marco Pravetoni, Niaz Sahibzada, Phil Skolnick, Evan Y. Snyder, Nestor Tomycz, Carlos A. Valdez, Jim Zapf
Mar 31, 2021
The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the US Food and Drug Administration (FDA) nearly 50 years ago. Because of its pharmacokinetic and pharmacodynamic...
Challenges in microbial ecology
Stefanie Widder, Rosalind J Allen, Thomas Pfeiffer, Thomas P Curtis, Carsten Wiuf, William T Sloan, Otto X Cordero, Sam P Brown, Babak Momeni, Wenying Shou, Helen Kettle, Harry J Flint, Andreas F Haas, Béatrice Laroche, Jan-Ulrich Kreft, Paul B Rainey, Shiri Freilich, Stefan Schuster, Kim Milferstedt, Jan R van der Meer, Tobias Groβkopf, Jef Huisman, Andrew Free, Cristian Picioreanu, Christopher Quince, Isaac Klapper, Simon Labarthe, Barth F Smets, Harris Wang, Isaac Newton Institute Fellows, Orkun S Soyer
Nov 24, 2017
The importance of microbial communities (MCs) cannot be overstated. MCs underpin the biogeochemical cycles of the earth's soil, oceans and the atmosphere, and perform ecosystem functions that impact plants, animals and humans....
Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.
Dongbing Lai, Babak Alipanahi, Pierre Fontanillas, Tae-Hwi Schwantes-An, Jan Aasly, Roy N Alcalay, Gary W Beecham, Daniela Berg, Susan Bressman, Alexis Brice, Kathrin Brockman, Lorraine Clark, Mark Cookson, Sayantan Das, Vivianna Van Deerlin, Jordan Follett, Matthew J Farrer, Joanne Trinh, Thomas Gasser, Stefano Goldwurm, Emil Gustavsson, Christine Klein, Anthony E Lang, J William Langston, Jeanne Latourelle, Timothy Lynch, Karen Marder, Connie Marras, Eden R Martin, Cory Y McLean, Helen Mejia-Santana, Eric Molho, Richard H Myers, Karen Nuytemans, Laurie Ozelius, Haydeh Payami, Deborah Raymond, Ekaterina Rogaeva, Michael P Rogers, Owen A Ross, Ali Samii, Rachel Saunders-Pullman, Birgitt Schüle, Claudia Schulte, William K Scott, Caroline Tanner, Eduardo Tolosa, James E Tomkins, Dolores Vilas, John Q Trojanowski, 23andMe Research Team, Ryan Uitti, Jeffery M Vance, Naomi P Visanji, Zbigniew K Wszolek, Cyrus P Zabetian, Anat Mirelman, Nir Giladi, Avi Orr Urtreger, Paul Cannon, Brian Fiske, Tatiana Foroud
Jul 29, 2021
OBJECTIVE: The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease. METHODS: We performed the first genomewide association...
Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run
R Abbott, TD Abbott, F Acernese, K Ackley, C Adams, N Adhikari, RX Adhikari, VB Adya, C Affeldt, D Agarwal, M Agathos, K Agatsuma, N Aggarwal, OD Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, S Albanesi, A Allocca, PA Altin, A Amato, C Anand, S Anand, A Ananyeva, SB Anderson, WG Anderson, M Ando, T Andrade, N Andres, T Andrić, SV Angelova, S Ansoldi, JM Antelis, S Antier, S Appert, K Arai, K Arai, Y Arai, S Araki, A Araya, MC Araya, JS Areeda, M Arène, N Aritomi, N Arnaud, SM Aronson, KG Arun, H Asada, Y Asali, G Ashton, Y Aso, M Assiduo, SM Aston, P Astone, F Aubin, C Austin, S Babak, F Badaracco, MKM Bader, C Badger, S Bae, Y Bae, AM Baer, S Bagnasco, Y Bai, M Bailes, L Baiotti, J Baird, R Bajpai, M Ball, G Ballardin, SW Ballmer, A Balsamo, G Baltus, S Banagiri, D Bankar, JC Barayoga, C Barbieri, BC Barish, D Barker, P Barneo, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, MA Barton, I Bartos, R Bassiri, A Basti, M Bawaj, JC Bayley, AC Baylor, M Bazzan, B Bécsy, VM Bedakihale, M Bejger, I Belahcene
Jun 29, 2022
Isolated neutron stars that are asymmetric with respect to their spin axis
are possible sources of detectable continuous gravitational waves. This paper
presents a fully-coherent search for such signals from eighteen pulsars in...
Global Biobank Meta-analysis Initiative
Wei Zhou, Masahiro Kanai, Kuan-Han H Wu, Humaira Rasheed, Kristin Tsuo, Jibril B Hirbo, Ying Wang, Arjun Bhattacharya, Huiling Zhao, Shinichi Namba, Ida Surakka, Brooke N Wolford, Valeria Lo Faro, Esteban A Lopera-Maya, Kristi Läll, Marie-Julie Favé, Juulia J Partanen, Sinéad B Chapman, Juha Karjalainen, Mitja Kurki, Mutaamba Maasha, Ben M Brumpton, Sameer Chavan, Tzu-Ting Chen, Michelle Daya, Yi Ding, Yen-Chen A Feng, Lindsay A Guare, Christopher R Gignoux, Sarah E Graham, Whitney E Hornsby, Nathan Ingold, Said I Ismail, Ruth Johnson, Triin Laisk, Kuang Lin, Jun Lv, Iona Y Millwood, Sonia Moreno-Grau, Kisung Nam, Priit Palta, Anita Pandit, Michael H Preuss, Chadi Saad, Shefali Setia-Verma, Unnur Thorsteinsdottir, Jasmina Uzunovic, Anurag Verma, Matthew Zawistowski, Xue Zhong, Nahla Afifi, Kawthar M Al-Dabhani, Asma Al Thani, Yuki Bradford, Archie Campbell, Kristy Crooks, Geertruida H de Bock, Scott M Damrauer, Nicholas J Douville, Sarah Finer, Lars G Fritsche, Eleni Fthenou, Gilberto Gonzalez-Arroyo, Christopher J Griffiths, Yu Guo, Karen A Hunt, Alexander Ioannidis, Nomdo M Jansonius, Takahiro Konuma, Ming Ta Michael Lee, Arturo Lopez-Pineda, Yuta Matsuda, Riccardo E Marioni, Babak Moatamed, Marco A Nava-Aguilar, Kensuke Numakura, Snehal Patil, Nicholas Rafaels, Anne Richmond, Agustin Rojas-Muñoz, Jonathan A Shortt, Peter Straub, Ran Tao, Brett Vanderwerff, Manvi Vernekar, Yogasudha Veturi, Kathleen C Barnes, Marike Boezen, Zhengming Chen, Chia-Yen Chen, Judy Cho, George Davey Smith, Hilary K Finucane, Lude Franke, Eric R Gamazon, Andrea Ganna, Tom R Gaunt, Tian Ge, Hailiang Huang, Jennifer Huffman, Nicholas Katsanis, Jukka T Koskela, Clara Lajonchere, Matthew H Law, Liming Li, Cecilia M Lindgren, Ruth JF Loos, Stuart MacGregor, Koichi Matsuda, Catherine M Olsen, David J Porteous, Jordan A Shavit, Harold Snieder, Tomohiro Takano, Richard C Trembath, Judith M Vonk, David C Whiteman, Stephen J Wicks, Cisca Wijmenga, John Wright, Jie Zheng, Xiang Zhou, Philip Awadalla, Michael Boehnke, Carlos D Bustamante, Nancy J Cox, Segun Fatumo, Daniel H Geschwind, Caroline Hayward, Kristian Hveem, Eimear E Kenny, Seunggeun Lee, Yen-Feng Lin, Hamdi Mbarek, Reedik Mägi, Hilary C Martin, Sarah E Medland, Yukinori Okada, Aarno V Palotie, Bogdan Pasaniuc, Daniel J Rader, Marylyn D Ritchie, Serena Sanna, Jordan W Smoller, Kari Stefansson, David A van Heel, Robin G Walters, Sebastian Zöllner, Biobank of the Americas, Biobank Japan project, BioMe, BioVU, CanPath - Ontario Health Study, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank of Korea, Penn Medicine BioBank, Qatar Biobank, QSkin Sun and Health Study, Taiwan Biobank, HUNT Study, UCLA ATLAS Community Health Initiative, Uganda Genome Resource, UK Biobank, Alicia R Martin, Cristen J Willer, Mark J Daly, Benjamin M Neale
Mar 16, 2023
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