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When small data beats big data
Small data is sometimes preferable to big data. A high quality small sample can produce superior inferences to a low quality large sample. Data has acquisition, computation and privacy costs which require costs to be balanced...
Local bounds for stochastic reaction diffusion equations
We prove a priori bounds for solutions of stochastic reaction diffusion equations with super-linear damping in the reaction term. These bounds provide a control on the supremum of solutions on any compact space-time set which...
A priori bounds for rough differential equations with a non-linear damping term
We consider a rough differential equation with a non-linear damping drift term: dY(t)=−|Y|m−1Y(t)dt+σ(Y(t))dX(t), where X is a branched rough path of arbitrary regularity α>0, m>1 and where σ is smooth and satisfies an m...
GAMs with integrated model selection using penalized regression splines and applications to environmental modelling
Generalized additive models (GAMs) have been popularized by the work of Hastie and Tibshirani (Generalized Additive Models (1990)) and the availability of user friendly gam software in Splus. However, whilst it is flexible and...
Local bounds for stochastic reaction diffusion equations
We prove a priori bounds for solutions of stochastic reaction diffusion equations with super-linear damping in the reaction term. These bounds provide a control on the supremum of solutions on any compact space-time set which...
A priori bounds for rough differential equations with a non-linear damping term
We consider a rough differential equation with a non-linear damping drift term: dY(t)=−|Y|m−1Y(t)dt+σ(Y(t))dX(t), where X is a branched rough path of arbitrary regularity α>0, m>1 and where σ is smooth and satisfies an m...
On quantile quantile plots for generalized linear models
The distributional assumption for a generalized linear model is often checked by plotting the ordered deviance residuals against the quantiles of a standard normal distribution. Such plots can be difficult to interpret, because...
Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease
The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over...
Triploid plover female provides support for a role of the W chromosome in avian sex determination
Two models, Z Dosage and Dominant W, have been proposed to explain sex determination in birds, in which males are characterized by the presence of two Z chromosomes, and females are hemizygous with a Z and a W chromosome....
Modelling fat mass as a function of weekly physical activity profiles measured by Actigraph accelerometers
We show results on the Avon longitudinal study of parents and children (ALSPAC) using a new approach for modelling the relationship between health outcomes and physical activity assessed by accelerometers. The key feature of the...
Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis—A Multicenter European Prospective Cohort Study (EPIC)
Yunxia Lu, Raul Zamora-Ros, Simon Chan, Amanda J Cross, Heather Ward, Paula Jakszyn, Robert Luben, Jorrit L Opstelten, Bas Oldenburg, Göran Hallmans, Pontus Karling, Olof Grip, Timothy Key, Manuela M Bergmann, Heiner Boeing, Kim Overvad, Domenico Palli, Giovanna Masala, Kay-Tee Khaw, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Vibeke Andersen, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Rosario Tumino, Antonia Trichopoulou, Augustin Scalbert, Elio Riboli, Andrew R Hart
Mar 26, 2018
Revised classification of kinases based on bioactivity data
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
GAMs with integrated model selection using penalized regression splines and applications to environmental modelling
Generalized additive models (GAMs) have been popularized by the work of Hastie and Tibshirani (Generalized Additive Models (1990)) and the availability of user friendly gam software in Splus. However, whilst it is flexible and...
Modelling fat mass as a function of weekly physical activity profiles measured by Actigraph accelerometers
We show results on the Avon longitudinal study of parents and children (ALSPAC) using a new approach for modelling the relationship between health outcomes and physical activity assessed by accelerometers. The key feature of the...
When small data beats big data
Small data is sometimes preferable to big data. A high quality small sample can produce superior inferences to a low quality large sample. Data has acquisition, computation and privacy costs which require costs to be balanced...
The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements.
Augustin de Vanssay, Amandine Touzeau, Olivier Arnaiz, Andrea Frapporti, Jamie Phipps, Sandra Duharcourt
Sep 15, 2020
In Paramecium tetraurelia, a large proportion of the germline genome is reproducibly removed from the somatic genome after sexual events via a process involving small (s)RNA-directed heterochromatin formation and DNA excision...
Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease
The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over...
Nonsteroidal anti-inflammatory drug use and breast cancer risk in a European prospective cohort study.
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra Hm Peeters, Carla H van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Sep 26, 2018
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to...
Modelling a response as a function of high frequency count data
Accelerometers are widely used in health sciences, ecology and other application areas. They quantify the intensity of physical activity as counts per epoch over a given period of time. Currently, health scientists use very...
On quantile quantile plots for generalized linear models
The distributional assumption for a generalized linear model is often checked by plotting the ordered deviance residuals against the quantiles of a standard normal distribution. Such plots can be difficult to interpret, because...
Registered report
Hannes Jarke, Lea Jakob, Lana Bojanić, Eduardo Garcia-Garzon, Silvana Mareva, Augustin Mutak, Jovana Gjorgjiovska
Feb 28, 2022
The use of Open Science practices is often proposed as a way to improve research practice, especially in psychology. Open Science can increase transparency and therefore reduce questionable research practices, making research...
Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort.
Mercedes Gil-Lespinard, Jazmín Castañeda, Enrique Almanza-Aguilera, Jesús Humberto Gómez, Anne Tjønneland, Cecilie Kyrø, Kim Overvad, Verena Katzke, Matthias B Schulze, Giovanna Masala, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Cristina Lasheras, Esther Molina-Montes, José María Huerta, Aurelio Barricarte, Pilar Amiano, Emily Sonestedt, Marisa da Silva, Ingegerd Johansson, Johan Hultdin, Anne M May, Nita G Forouhi, Alicia K Heath, Heinz Freisling, Elisabete Weiderpass, Augustin Scalbert, Raul Zamora-Ros
Jan 24, 2023
Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to...
Modelling a response as a function of high frequency count data
Accelerometers are widely used in health sciences, ecology and other application areas. They quantify the intensity of physical activity as counts per epoch over a given period of time. Currently, health scientists use very...
Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study.
Jazmin Castañeda, Mercedes Gil-Lespinard, Enrique Almanza-Aguilera, Fjorida Llaha, Jesús-Humberto Gómez, Nicola Bondonno, Anne Tjønneland, Kim Overvad, Verena Katzke, Matthias B Schulze, Giovanna Masala, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Magritt Brustad, Cristina Lasheras, Esther Molina-Montes, María-Dolores Chirlaque, Aurelio Barricarte, Emily Sonestedt, Marisa da Silva, Ingegerd Johansson, Johan Hultdin, Anne M May, Nita G Forouhi, Alicia K Heath, Heinz Freisling, Elisabete Weiderpass, Augustin Scalbert, Raul Zamora-Ros
Jan 25, 2023
OBJECTIVE: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years. METHODS: A total of 349,165 men and...
Triploid plover female provides support for a role of the W chromosome in avian sex determination
Two models, Z Dosage and Dominant W, have been proposed to explain sex determination in birds, in which males are characterized by the presence of two Z chromosomes, and females are hemizygous with a Z and a W chromosome....
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