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Results: 14
Absolute choline tissue concentration mapping for prostate cancer localization and characterization using 3D 1 H MRSI without water-signal suppression.
PURPOSE: Until now, 1 H MRSI of the prostate has been performed with suppression of the large water signal to avoid distortions of metabolite signals. However, this signal can be used for absolute quantification and spectral...
Converging evidence points towards a role of insulin signaling in regulating compulsive behavior.
Ilse IGM van de Vondervoort, Houshang Amiri, Muriel MK Bruchhage, Charlotte A Oomen, Nitin Rustogi, Jason D Cooper, Jack JA van Asten, Arend Heerschap, Sabine Bahn, Steven Cr Williams, Jan K Buitelaar, Geert Poelmans, Jeffrey C Glennon
Sep 11, 2020
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with childhood onset, and is characterized by intrusive thoughts and fears (obsessions) that lead to repetitive behaviors (compulsions). Previously, we...
Animals Anxiety Blood Glucose Brain Brain-Derived Neurotrophic Factor Compulsive Behavior Diabetes mellitus Type 2 Diffusion tensor imaging Disease Models Animal Insulin Insulin-Like Growth Factor I KCNQ1 Potassium Channel Magnetic Resonance Spectroscopy Mice Proteomics Signal Transduction white matter
Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.
Sandra Heskamp, Linda Heijmen, Danny Gerrits, Janneke DM Molkenboer-Kuenen, Edwin GW Ter Voert, Kathrin Heinzmann, Davina J Honess, Donna-Michelle Smith, John R Griffiths, Sabrina Doblas, Ralph Sinkus, Peter Laverman, Wim JG Oyen, Arend Heerschap, Otto C Boerman
Jan 06, 2017
5-Fluorouracil colorectal cancer diffusion-weighted MRI Response monitoring [18F]FLT PET Animals Cell Death Cell Line Tumor Cell Proliferation Colorectal Neoplasms Dideoxynucleosides Diffusion Magnetic Resonance Imaging Disease Models Animal Fluorouracil Immunohistochemistry Liver Neoplasms Positron-Emission Tomography Rats Tomography Emission-Computed Single-Photon Tomography X-Ray Computed Treatment Outcome
Nef divisors for moduli spaces of complexes with compact support
In Bayer and Macrì (J Am Math Soc 27(3):707–752, 2014), the first author and Macrì constructed a family of nef divisors on any moduli space of Bridgeland-stable objects on a smooth projective variety X. In this article, we...
31 P magnetic resonance spectroscopy in skeletal muscle
Martin Meyerspeer, Chris Boesch, Donnie Cameron, Monika Dezortová, Sean C Forbes, Arend Heerschap, Jeroen AL Jeneson, Hermien E Kan, Jane Kent, Gwenaël Layec, Jeanine J Prompers, Harmen Reyngoudt, Alison Sleigh, Ladislav Valkovič, Graham J Kemp, Experts' Working Group on 31P MR Spectroscopy of Skeletal Muscle
Apr 19, 2021
Skeletal muscle phosphorus-31 31 P MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of 31 P MRS in skeletal muscle depend on the research question, and to assess those...
Nef divisors for moduli spaces of complexes with compact support
In Bayer and Macrì (J Am Math Soc 27(3):707–752, 2014), the first author and Macrì constructed a family of nef divisors on any moduli space of Bridgeland-stable objects on a smooth projective variety X. In this article, we...
Prolongation of allograft survival by passenger donor regulatory T cells.
Ines G Harper, Olivera Gjorgjimajkoska, Jacqueline HY Siu, Jasvir Parmar, Arend Mulder, Frans HJ Claas, Sarah A Hosgood, Michael L Nicholson, Reza Motallebzadeh, Gavin J Pettigrew
Jan 04, 2019
T cell biology cellular biology immune regulation immunobiology lymphocyte biology organ transplantation in general tolerance: experimental tolerance: mechanisms Adoptive Transfer Allografts Animals Cell Lineage Graft Rejection Graft Survival Heart Transplantation Humans Immune System Immunity Humoral Isoantibodies Kidney Transplantation Lung Transplantation Mice Organ Preservation Perfusion T-Lymphocytes Regulatory Tissue Donors Transplantation Homologous Treatment Outcome
Recombinant human monoclonal HLA antibodies of different IgG subclasses recognising the same epitope
Cynthia SM Kramer, Marry EI Franke-van Dijk, Ashley J Priddey, Tamás Pongrácz, Elena Gnudi, Helena Car, Gonca E Karahan, Els van Beelen, Chalana CC Zilvold-van den Oever, Hendrik J Rademaker, Noortje de Haan, Manfred Wuhrer, Vasilis Kosmoliaptsis, Paul WHI Parren, Arend Mulder, Dave L Roelen, Frans HJ Claas, Sebastiaan Heidt
Oct 29, 2019
In the field of transplantation, the humoural immune response against mismatched HLA antigens of the donor is associated with inferior graft survival, but not in every patient. Donor-specific HLA antibodies (DSA) of different...
A genome wide dosage suppressor network reveals genomic robustness.
Biranchi Patra, Yoshiko Kon, Gitanjali Yadav, Anthony W Sevold, Jesse P Frumkin, Ravishankar R Vallabhajosyula, Arend Hintze, Bjørn Østman, Jory Schossau, Ashish Bhan, Bruz Marzolf, Jenna K Tamashiro, Amardeep Kaur, Nitin S Baliga, Elizabeth J Grayhack, Christoph Adami, David J Galas, Alpan Raval, Eric M Phizicky, Animesh Ray
Nov 01, 2018
Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.
Chunyu Liu, Aldi T Kraja, Jennifer A Smith, Jennifer A Brody, Nora Franceschini, Joshua C Bis, Kenneth Rice, Alanna C Morrison, Yingchang Lu, Stefan Weiss, Xiuqing Guo, Walter Palmas, Lisa W Martin, Yii-Der Ida Chen, Praveen Surendran, Fotios Drenos, James P Cook, Paul L Auer, Audrey Y Chu, Ayush Giri, Wei Zhao, Johanna Jakobsdottir, Li-An Lin, Jeanette M Stafford, Najaf Amin, Hao Mei, Jie Yao, Arend Voorman, CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, Martin G Larson, Megan L Grove, Albert V Smith, Shih-Jen Hwang, Han Chen, Tianxiao Huan, Gulum Kosova, Nathan O Stitziel, Sekar Kathiresan, Nilesh Samani, Heribert Schunkert, Panos Deloukas, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia, Man Li, Christian Fuchsberger, Cristian Pattaro, Mathias Gorski, CKDGen consortium, Charles Kooperberg, George J Papanicolaou, Jacques E Rossouw, Jessica D Faul, Sharon LR Kardia, Claude Bouchard, Leslie J Raffel, André G Uitterlinden, Oscar H Franco, Ramachandran S Vasan, Christopher J O'Donnell, Kent D Taylor, Kiang Liu, Erwin P Bottinger, Omri Gottesman, E Warwick Daw, Franco Giulianini, Santhi Ganesh, Elias Salfati, Tamara B Harris, Lenore J Launer, Marcus Dörr, Stephan B Felix, Rainer Rettig, Henry Völzke, Eric Kim, Wen-Jane Lee, I-Te Lee, Wayne H-H Sheu, Krystal S Tsosie, Digna R Velez Edwards, Yongmei Liu, Adolfo Correa, David R Weir, Uwe Völker, Paul M Ridker, Eric Boerwinkle, Vilmundur Gudnason, Alexander P Reiner, Cornelia M van Duijn, Ingrid B Borecki, Todd L Edwards, Aravinda Chakravarti, Jerome I Rotter, Bruce M Psaty, Ruth JF Loos, Myriam Fornage, Georg B Ehret, Christopher Newton-Cheh, Daniel Levy, Daniel I Chasman
Nov 20, 2017
Meta-analyses of association results for blood pressure using exome-centric single-variant and gene-based tests identified 31 new loci in a discovery stage among 146,562 individuals, with follow-up and meta-analysis in 180,726...