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Corrections to: Use of the BOADICEA Web Application in clinical practice
Anne Brédart, Jean-Luc Kop, Antonis C Antoniou, Alex P Cunningham, Antoine de Pauw, Marc Tischkowitz, Hans Ehrencrona, Sylvie Dolbeault, Léonore Robieux, Kerstin Rhiem, Douglas F Easton, Peter Devilee, Dominique Stoppa-Lyonnet, Rita Schmutlzer
Jan 23, 2018
The article "Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries" written by Anne Brédart · Jean‑Luc Kop · Antonis C. Antoniou · Alex P. Cunningham · Antoine De Pauw ·Marc...
Shipping Digital Twin Data Management With the Use of Knowledge Graphs
This chapter explores the data management challenges inherent in a digital twin framework and elucidates the pivotal role of knowledge graphs in meeting these demands. The author introduces a functional metamodel designed to...
Sustainable Development Business and Management Operations and Service Management Computer Science and Information Technology Life Sciences
Published by: IGI Global Scientific Publishing
Enhanced and Holistic Voyage Planning Using Digital Twins
The chapter explains techniques and approaches to optimize a ship's voyage in terms of environmental and business parameters, utilizing the digital twin (DT) concept. It demonstrates how voyage planning and navigation...
Sustainable Development Business and Management Operations and Service Management Computer Science and Information Technology Life Sciences
Published by: IGI Global Scientific Publishing
Management earnings forecast and IPO performance
Companies making initial public offerings (IPOs) in Greece were obliged to include next-year profit forecast in their prospectuses until the regulation changed in 2001 to voluntary disclosure. This research takes advantage of...
Political money contributions of US IPO firms
We produce the first study to explore the effect of political money contributions on IPO valuation. Drawing evidence from the U.S., we show that both lobbying and PAC expenditure pay off on issue day as donors incur less...
Political money contributions of US IPO firms
We produce the first study to explore the effect of political money contributions on IPO valuation. Drawing evidence from the U.S., we show that both lobbying and PAC expenditure pay off on issue day as donors incur less...
Management earnings forecast and IPO performance
Companies making initial public offerings (IPOs) in Greece were obliged to include next-year profit forecast in their prospectuses until the regulation changed in 2001 to voluntary disclosure. This research takes advantage of...
Risks of second non-breast primaries following breast cancer in women
Isaac Allen, Hend Hassan, Eleni Sofianopoulou, Diana Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C Antoniou
Mar 14, 2023
BACKGROUND: Second primary cancer incidence is rising among breast cancer survivors. We examined the risks of non-breast second primaries, in combination and at specific cancer sites, through a systematic review and...
Letter to the editor
Daniele Giardiello, Antonis C Antoniou, Luigi Mariani, Douglas F Easton, Ewout W Steyerberg
Mar 05, 2020
A recent paper [1] compared two well-known breast cancer risk prediction models (BCRAT and BOADICEA) with eight different machine learning (ML) methods. The authors found a striking improvement in cancer prediction with ML....
Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis.
Evelina Charidemou, Maria A Tsiarli, Andria Theophanous, Vural Yilmaz, Chrysoula Pitsouli, Katerina Strati, Julian L Griffin, Antonis Kirmizis
Feb 21, 2022
BACKGROUND: Epigenetic regulation relies on the activity of enzymes that use sentinel metabolites as cofactors to modify DNA or histone proteins. Thus, fluctuations in cellular metabolite levels have been reported to affect...
Drosophila melanogaster epigenetics Fat body Histone Acetyltransferases Lipid Metabolism metabolic disorders NAA40 acetyl-CoA Acetyl Coenzyme A Animals Drosophila melanogaster Epigenesis Genetic Histone Acetyltransferases Histones Humans Insulin Lipids Lipogenesis Mice N-Terminal Acetyltransferase D
Management of lupus nephritis
Myrto Kostopoulou, Antonis Fanouriakis, Kim Cheema, John Boletis, George Bertsias, David Jayne, Dimitrios T Boumpas
Nov 24, 2020
OBJECTIVES: To analyse the current evidence for the management of lupus nephritis (LN) informing the 2019 update of the EULAR/European Renal Association-European Dialysis and Transplant Association recommendations. METHODS...
Lupus Erythematosus Lupus Nephritis systemic therapeutics Biomarkers Biopsy Calcineurin Clinical Decision-Making Disease Management Disease Susceptibility Drug Resistance Humans Immunosuppressive Agents Kidney Kidney Failure Chronic Lupus Nephritis Molecular Targeted Therapy Practice Guidelines as Topic Severity of Illness Index Treatment Outcome
Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis.
Evelina Charidemou, Maria A Tsiarli, Andria Theophanous, Vural Yilmaz, Chrysoula Pitsouli, Katerina Strati, Julian L Griffin, Antonis Kirmizis
Jan 28, 2022
BACKGROUND: Epigenetic regulation relies on the activity of enzymes that use sentinel metabolites as cofactors to modify DNA or histone proteins. Thus, fluctuations in cellular metabolite levels have been reported to affect...
Public health programmes to promote mental health in young people
Nuwan Darshana Wickramasinghe, Nelum Samarutilake, Mihiri Chami Wettasinghe, Julie Feiler, Antony Morgan, Antonis A Kousoulis, Tine Van Bortel
Sep 29, 2020
INTRODUCTION: In light of the ever-growing mental health disease burden among young people worldwide, we aim to systematically review the global literature to identify the public health programmes targeted at promoting mental...
Potential of polygenic risk scores for improving population estimates of women's breast cancer genetic risks.
Michael Wolfson, Steve Gribble, Nora Pashayan, Douglas F Easton, Antonis C Antoniou, Andrew Lee, Sasha van Katwyk, Jacques Simard
Jul 09, 2021
PURPOSE: Breast cancer risk has conventionally been assessed using family history (FH) and rare high/moderate penetrance pathogenic variants (PVs), notably in BRCA1/2, and more recently PALB2, CHEK2, and ATM. In addition to...
Risks of second non-breast primaries following breast cancer in women
Abstract
Background
Second primary cancer incidence is rising among breast cancer survivors. We examined the risks of non-breast...
Isaac Allen, Hend Hassan, Eleni Sofianopoulou, Diana Eccles, Clare Turnbull, Marc Tischkowitz, Paul Pharoah, Antonis C Antoniou
Feb 10, 2023
Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women.
Shreeya Patel, Rosa Legood, D Gareth Evans, Clare Turnbull, Antonis C Antoniou, Usha Menon, Ian Jacobs, Ranjit Manchanda
Mar 09, 2018
BACKGROUND: Population-based BRCA1/BRCA2 founder-mutation testing has been demonstrated as cost effective compared with family history based testing in Ashkenazi Jewish women. However, only 1 of the 3 Ashkenazi Jewish...
BRCA Sephardi Jewish cost effectiveness population testing Adult Cost-Benefit Analysis Female Genes BRCA1 Genetic Testing Hereditary Breast and Ovarian Cancer Syndrome Heterozygote Hormone Replacement Therapy Humans Jews Life Expectancy Magnetic Resonance Imaging Mammography Markov Chains Middle Aged Mutation Ovariectomy Prophylactic Mastectomy Prophylactic Surgical Procedures Quality-Adjusted Life Years United Kingdom United States
A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effects.
Mental health among healthcare workers and other vulnerable groups during the COVID-19 pandemic and other coronavirus outbreaks
Eleonora P Uphoff, Chiara Lombardo, Gordon Johnston, Lauren Weeks, Mark Rodgers, Sarah Dawson, Catherine Seymour, Antonis A Kousoulis, Rachel Churchill
Sep 08, 2021
INTRODUCTION: Although most countries and healthcare systems worldwide have been affected by the COVID-19 pandemic, some groups of the population may be more vulnerable to detrimental effects of the pandemic on mental health...
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