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Results: 64
Hereditary diffuse gastric cancer
Rachel S van der Post, Ingrid P Vogelaar, Fátima Carneiro, Parry Guilford, David Huntsman, Nicoline Hoogerbrugge, Carlos Caldas, Karen E Chelcun Schreiber, Richard H Hardwick, Margreet Gem Ausems, Linda Bardram, Patrick R Benusiglio, Tanya M Bisseling, Vanessa Blair, Eveline Bleiker, Alex Boussioutas, Annemieke Cats, Daniel Coit, Lynn DeGregorio, Joana Figueiredo, James M Ford, Esther Heijkoop, Rosella Hermens, Bostjan Humar, Pardeep Kaurah, Gisella Keller, Jennifer Lai, Marjolijn JL Ligtenberg, Maria O'Donovan, Carla Oliveira, Hugo Pinheiro, Krish Ragunath, Esther Rasenberg, Susan Richardson, Franco Roviello, Hans Schackert, Raquel Seruca, Amy Taylor, Anouk Ter Huurne, Marc Tischkowitz, Sheena Tjon A Joe, Benjamin van Dijck, Nicole CT van Grieken, Richard van Hillegersberg, Johanna W van Sandick, Rianne Vehof, J Han van Krieken, Rebecca C Fitzgerald
Feb 13, 2020
Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies...
Cancer: breast Cancer: gastric Clinical genetics Diagnostics Stomach and duodenum Antigens CD Breast Neoplasms Cadherins Colorectal Neoplasms DNA Mutational Analysis Early Detection of Cancer Female Genetic Counseling Genetic Testing Germ-Line Mutation Heterozygote Humans Population Surveillance Practice Guidelines as Topic Pregnancy Stomach Neoplasms
Coincident relapsing polychondritis and IgG4-related disease
Relapsing polychondritis (RP) and immunoglobulin G4–related disease (IgG4-RD) are rare multi-organ immune-mediated diseases. Both can present with nonspecific symptoms of fatigue, weight loss, arthralgia, raised inflammatory...
Visual loss in giant cell arteritis 3 weeks after steroid initiation.
Giant cell arteritis (GCA) is the most common vasculitis in adults and blindness is a common complication if left untreated. Oral glucocorticoids are the mainstay of treatment and if started promptly, loss of vision can usually...
Inside-out, outside-in, or all-in-one? The role of network sequencing in the elaboration of ideas
The structure of advice and support networks within organizations has a profound impact on the elaboration of novel ideas. We explore how the sequence in which individuals expose ideas to their network contacts affects their...
The Pseudomonas aeruginosa T6SS Delivers a Periplasmic Toxin that Disrupts Bacterial Cell Morphology.
Thomas E Wood, Sophie A Howard, Andreas Förster, Laura M Nolan, Eleni Manoli, Nathan P Bullen, Hamish CL Yau, Abderrahman Hachani, Richard D Hayward, John C Whitney, Waldemar Vollmer, Paul S Freemont, Alain Filloux
Jul 13, 2020
The type VI secretion system (T6SS) is crucial in interbacterial competition and is a virulence determinant of many Gram-negative bacteria. Several T6SS effectors are covalently fused to secreted T6SS structural components such...
Different compositions of pharmaceuticals in Dutch and Belgian rivers explained by consumption patterns and treatment efficiency
In the current study, 43 pharmaceuticals and 18 transformation products were studied in the river Meuse at the Belgian-Dutch border and four tributaries of the river Meuse in the southern part of the Netherlands. The tributaries...
Inside-out, outside-in, or all-in-one? The role of network sequencing in the elaboration of ideas
The structure of advice and support networks within organizations has a profound impact on the elaboration of novel ideas. We explore how the sequence in which individuals expose ideas to their network contacts affects their...
Different compositions of pharmaceuticals in Dutch and Belgian rivers explained by consumption patterns and treatment efficiency
In the current study, 43 pharmaceuticals and 18 transformation products were studied in the river Meuse at the Belgian-Dutch border and four tributaries of the river Meuse in the southern part of the Netherlands. The tributaries...
Place of death and end-of-life transitions experienced by very old people with differing cognitive status
Anouk J Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M Buiting, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
Jun 14, 2019
BACKGROUND: Despite fast-growing 'older old' populations, 'place of care' trajectories for very old people approaching death with or without dementia are poorly described and understood. AIM: To explore end-of-life transitions...
80 and over COGNITIVE IMPAIRMENT Aged Delivery of Health Care Dementia Frail Elderly Homes for the Aged Nursing Homes Patient Transfer residential characteristics Terminal Care Aged 80 and over Cognition Disorders Cohort Studies Female Hospital Mortality Humans Male Nursing Homes Terminal Care Terminally Ill United Kingdom
Guan Yu
Noga Ganany
Dec 09, 2019
A critical study of the rich religious tradition surrounding Guan Yu 關羽
(Guandi 關帝 / Guangong 關公 / Lord Guan) was long overdue. Bared ter Haar’s recent book rises up to the task with commendable thoroughness, a tour de force of...
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R. Boonzaier, Tomasz Matys, Stephen J. Price
Jun 17, 2021
Abstract: The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its...
Noninvasive high-intensity focused ultrasound treatment of twin-twin transfusion syndrome
Caroline J Shaw, John Civale, Kimberley J Botting, Youguo Niu, Gail Ter Haar, Ian Rivens, Dino A Giussani, Christoph C Lees
Oct 03, 2018
We investigated the efficacy, maternofetal responses, and safety of using high-intensity focused ultrasound (HIFU) for noninvasive occlusion of placental vasculature compared to sham treatment in anesthetized pregnant sheep....
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R. Boonzaier, Tomasz Matys, Stephen J. Price
Aug 11, 2020
Abstract: The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its...
Unbinned multivariate observables for global SMEFT analyses from machine learning
Abstract
Theoretical interpretations of particle physics data, such as the determination of the Wilson coefficients of the Standard Model Effective Field...
Anouk van der Hoorn, Jiun-Lin Yan, Timothy J Larkin, Natalie R Boonzaier, Tomasz Matys, Stephen J Price
May 12, 2016
Apparent diffusion coefficient Brain tumor Glioblastoma Magnetic Resonance Imaging treatment response Aged Brain Neoplasms Cohort Studies Diffusion Magnetic Resonance Imaging Female Glioblastoma Humans Image Processing Computer-Assisted Male Middle Aged Neoplasm Recurrence Local Regression Analysis Survival Analysis Treatment Outcome Tumor Burden
Validation of a semi-automatic co-registration of MRI scans in patients with brain tumors during treatment follow-up.
Anouk van der Hoorn, Jiun-Lin Yan, Timothy J Larkin, Natalie R Boonzaier, Tomasz Matys, Stephen J Price
Apr 01, 2016
MRI brain tumors high-grade gliomas linear co-registration non-linear co-registration structural similarity treatment response validation Adult Aged Algorithms Brain Neoplasms Female Follow-Up Studies Glioblastoma Humans Image Enhancement Image Interpretation Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged pattern recognition Automated Sensitivity and Specificity Subtraction Technique Treatment Outcome
Ventricle contact is associated with lower survival and increased peritumoral perfusion in glioblastoma.
Bart Roelf Jan van Dijken, Peter Jan van Laar, Chao Li, Jiun-Lin Yan, Natalie Rosella Boonzaier, Stephen John Price, FCRS, Anouk van der Hoorn
Sep 05, 2018
Glioblastoma Lateral Ventricles Magnetic Resonance Imaging oncology Perfusion survival Adult Aged Brain Neoplasms Cerebral Ventricles Cerebrovascular Circulation Cohort Studies Female Glioblastoma Humans Magnetic Resonance Imaging Male Middle Aged Multimodal Imaging Survival Rate Treatment Outcome Young Adult
Competitive binding of MatP and topoisomerase IV to the MukB hinge domain.
Gemma Lm Fisher, Jani R Bolla, Karthik V Rajasekar, Jarno Mäkelä, Rachel Baker, Man Zhou, Josh P Prince, Mathew Stracy, Carol V Robinson, Lidia K Arciszewska, David J Sherratt
Oct 30, 2021
Structural Maintenance of Chromosomes (SMC) complexes have ubiquitous roles in compacting DNA linearly, thereby promoting chromosome organization-segregation. Interaction between the Escherichia coli SMC complex, MukBEF, and...
Overcoming adversity through diversity
Carbon concentrating mechanism (CCM) systems, asso- ciated with evolutionarily diverse aquatic photosynthetic organisms, make a major contribution to global net primary productivity and marine carbon sequestration. Here, an...
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R. Boonzaier, Tomasz Matys, Stephen J. Price
Jun 16, 2020
Abstract: The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its...
A Neural Network Approach to Identify the Peritumoral Invasive Areas in Glioblastoma Patients by Using MR Radiomics.
Jiun-Lin Yan, Chao Li, Anouk van der Hoorn, Natalie R Boonzaier, Tomasz Matys, Stephen J Price
Jul 02, 2020
The challenge in the treatment of glioblastoma is the failure to identify the cancer invasive area outside the contrast-enhancing tumour which leads to the high local progression rate. Our study aims to identify its progression...
Adult Aged Aminolevulinic Acid Brain Neoplasms Cohort Studies Contrast Media Diffusion Magnetic Resonance Imaging Disease Progression Female Glioblastoma Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged Neural Networks Computer Optical Imaging Retrospective Studies
Cardiac decompensation revealing giant cell arteritis.
Karl Emil Nelveg-Kristensen, Anouk Le Goueff, Rona M Smith, Kevin Loudon, Allyson C Egan, David RW Jayne
Nov 22, 2021
Cardiac decompensation revealing giant cell arteritis.
Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound.
Caroline J Shaw, Ian Rivens, John Civale, Kimberley J Botting, Gail Ter Haar, Dino A Giussani, Christoph C Lees
Nov 22, 2018
Pre-clinically, High Intensity Focused Ultrasound (HIFU) has been shown to safely and effectively occlude placental blood vessels in the acute setting, when applied through the uterus. However, further development of the...
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