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Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.
FoxA2 Myc Tcf7l1 Embryonic Stem Cells Endoderm Activins Animals Cell Differentiation Cells Cultured Embryonic Stem Cells Endoderm Gene Expression Regulation Glycogen Synthase Kinase 3 Hepatocyte Nuclear Factor 3-beta Mice Proto-Oncogene Proteins c-myc Signal Transduction Transcription Factor 7-Like 1 Protein beta Catenin
Estimating dormant and active hematopoietic stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics.
Bone marrow hematopoietic stem cells (HSCs) are responsible for both lifelong daily maintenance of all blood cells and for repair after cell loss. Until recently the cellular mechanisms by which HSCs accomplish these two very...
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Larissa S Carnevalli, Roberta Scognamiglio, Nina Cabezas-Wallscheid, Susann Rahmig, Elisa Laurenti, Kohei Masuda, Lars Jöckel, Andrea Kuck, Stefanie Sujer, Apostolos Polykratis, Miriam Erlacher, Manolis Pasparakis, Marieke AG Essers, Andreas Trumpp
Aug 28, 2020
The serine protease granzyme B (GzmB) is stored in the granules of cytotoxic T and NK cells and facilitates immune-mediated destruction of virus-infected cells. In this study, we use genetic tools to report novel roles for GzmB...
Animals Apoptosis Bone Marrow Cell Proliferation Colony-Forming Units Assay DNA Primers Drug Therapy Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorouracil Gene Expression Regulation Granzymes Hematopoietic Stem Cells Immunohistochemistry Lipopolysaccharides Mice Mice Inbred C57BL Mice Knockout Microarray Analysis Mitochondria Real-Time Polymerase Chain Reaction Signal Transduction Stress Physiological
Practicing Local Data Journalism
Andreas Veglis
Jul 01, 2024
The use of local data journalism has the power to fundamentally change local news. Local journalists can find vital insights, spot trends, and shed light on significant issues that have an impact on their communities by...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
A Template for Defining Enterprise Modelling Constructs
The paper explains the need for a standard way of defining modelling constructs from different enterprise modelling languages and proposes a template for defining enterprise modelling constructs in a way that facilitates...
Published by: IGI Global Scientific Publishing
Short laws for finite groups and residual finiteness growth
We prove that for every
Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
Mehmet Saçma, Johannes Pospiech, Ruzhica Bogeska, Walter de Back, Jan-Philipp Mallm, Vadim Sakk, Karin Soller, Gina Marka, Angelika Vollmer, Rebekah Karns, Nina Cabezas-Wallscheid, Andreas Trumpp, Simón Méndez-Ferrer, Michael D Milsom, Medhanie A Mulaw, Hartmut Geiger, Maria Carolina Florian
Nov 15, 2019
With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in impaired tissue homeostasis, reduced engraftment following transplantation and increased susceptibility to diseases. However, whether ageing...
aging Animals Bone Marrow Capillaries Cell Differentiation Cell Division Cell Polarity Cell Tracking Doxycycline Fluorouracil Gene Expression Regulation Genes Reporter Green Fluorescent Proteins Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Histones Homeostasis Jagged-2 Protein Mice Mice Inbred C57BL Mice Transgenic Myeloablative Agonists Stem Cell Niche
Combined Assessment of Software Safety and Security Requirements
Safety is a fundamental concern in modern society, and security is a precondition for safety. Ensuring safety and security of complex integrated systems requires a coordinated approach that involve different stakeholder groups...
Published by: IGI Global Scientific Publishing
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Jan 27, 2021
Which Democratic Way to Go?
There are concerns amongst researchers and the general public that social media platforms threaten democratic values. Social media corporations and their engineers have responded to these concerns with various design solutions....
Published by: IGI Global Scientific Publishing
A Participatory Design and Formal Study Investigation into Mobile Text Entry for Older Adults
Text entry remains key to many tasks on touchscreen smartphones and is an important factor in the usability of such devices. The known problems of text entry can be particularly acute for older adults due to physical and...
Published by: IGI Global Scientific Publishing
Applying the Computational Intelligence Paradigm to Nuclear Power Plant Operation
In the guise of artificial neural networks (ANNs), genetic/evolutionary computation algorithms (GAs/ECAs), fuzzy logic (FL) inference systems (FLIS) and their variants as well as combinations, the computational intelligence (CI)...
Published by: IGI Global Scientific Publishing
A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
Jerome Jatzlau, Wiktor Burdzinski, Michael Trumpp, Leon Obendorf, Kilian Roßmann, Katharina Ravn, Marko Hyvönen, Francesca Bottanelli, Johannes Broichhagen, Petra Knaus
Jan 25, 2023
Published by: Nature Publishing Group UK
Addressing Sustainability of Sanitation Systems
Recently, a technical draft of the international standard ISO/DIS 30500 for non-sewered sanitation systems has been developed (publication expected for 2018). Its innovative feature is the inclusion of sustainable aspects. This...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Jan 20, 2021
Innovations, challenges, and minimal information for standardization of humanized mice.
Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl-Dimiter Bissig, Brian Soper, Terrence Meeham, Li-Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb-Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol Bult, Leonard Shultz
Jul 31, 2020
Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can...
Vesalius' fabrica
This article provides a listing of known copies of the first two folio editions of Andreas Vesalius’ $\textit{De humani corporis fabrica}$ (1543 and 1555), revising earlier estimates. It shows that the $\textit{Fabrica}$...
Technological change, population dynamics, and natural resource depletion
Andreas Schaefer
Sep 01, 2014
In this paper, we integrate fertility and educational choices into a scale-invariant model of directed technological change with non-renewable natural resources, in order to reveal the interaction between population dynamics...
The U-shape of income inequality over the 20th century
Andreas Schaefer
Apr 30, 2021
We propose an overlapping generations model with three social classes to investigate the effects of higher education on the evolution of inequality. Initially, no social class invests in higher education and inequality is driven...
Response to: 'Prevention of infections in patients with antineutrophil cytoplasm antibody-associated vasculitis
Response to: 'Prevention of infections in patients with antineutrophil cytoplasm antibody-associated vasculitis: Potential role of hydroxychloroquine' by Novikov et al
Learning and herding using case-based decisions with local interactions
Andreas Krause
May 01, 2009
We evaluate repeated decisions of individuals using a variant of the case-based decision theory (CBDT), where individuals base their decisions on their own past experience and the experience of neighboring individuals. Looking...
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