Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error
Qiao Fan,
Alfred Pozarickij,
Nicholas Y. Q. Tan,
Xiaobo Guo,
Virginie J. M. Verhoeven,
Veronique Vitart,
Jeremy A. Guggenheim,
Masahiro Miyake,
J. Willem L. Tideman,
Anthony P. Khawaja,
Liang Zhang,
Stuart MacGregor,
René Höhn,
Peng Chen,
Ginevra Biino,
Juho Wedenoja,
Seyed Ehsan Saffari,
Milly S. Tedja,
Jing Xie,
Carla Lanca,
Ya Xing Wang,
Srujana Sahebjada,
Johanna Mazur,
Alireza Mirshahi,
Nicholas G. Martin,
Seyhan Yazar,
Craig E. Pennell,
Maurice Yap,
Annechien E. G. Haarman,
Clair A. Enthoven,
JanRoelof Polling,
Alex W. Hewitt,
Vincent W. V. Jaddoe,
Cornelia M. van Duijn,
Caroline Hayward,
Ozren Polasek,
E-Shyong Tai,
Hosoda Yoshikatsu,
Pirro G. Hysi,
Terri L. Young,
Akitaka Tsujikawa,
Jie Jing Wang,
Paul Mitchell,
Norbert Pfeiffer,
Olavi Pärssinen,
Paul J. Foster,
Maurizio Fossarello,
Shea Ping Yip,
Cathy Williams,
Christopher J. Hammond,
Jost B. Jonas,
Mingguang He,
David A. Mackey,
Tien-Yin Wong,
Caroline C. W. Klaver,
Seang-Mei Saw,
Paul N. Baird,
Ching-Yu Cheng,
Joan E. Bailey-Wilson,
Amutha Barathi Veluchamy,
Kathryn P. Burdon,
Harry Campbell,
Li Jia Chen,
Emily Y. Chew,
Jamie E. Craig,
Phillippa M. Cumberland,
Margaret M. Deangelis,
Cécile Delcourt,
Xiaohu Ding,
David M. Evans,
Puya Gharahkhani,
Adriana I. Iglesias,
Toomas Haller,
Xikun Han,
Quan Hoang,
Robert P., Jr. Igo,
Sudha K. Iyengar,
Mika Kähönen,
Jaakko Kaprio,
Barbara E. Klein,
Ronald Klein,
Jonathan H. Lass,
Kris Lee,
Terho Lehtimäki,
Deyana D. Lewis,
Qing Li,
Shi-Ming Li,
Leo-Pekka Lyytikäinen,
Akira Meguro,
Andres Metspalu,
Candace D. Middlebrooks,
Nobuhisa Mizuki,
Anthony M. Musolf,
Stefan Nickels,
Konrad Oexle,
Chi Pui Pang,
Andrew D. Paterson,
Jugnoo S. Rahi,
Olli Raitakari,
Igor Rudan,
Dwight Stambolian,
Claire L. Simpson,
Ningli Wang,
Wen Bin Wei,
Katie M. Williams,
James F. Wilson,
Robert Wojciechowski,
Kenji Yamashiro,
Jason C. S. Yam,
Xiangtian Zhou,
Tariq Aslam,
Sarah A. Barman,
Jenny H. Barrett,
Paul Bishop,
Peter Blows,
Catey Bunce,
Roxana O. Carare,
Usha Chakravarthy,
Michelle Chan,
Sharon Y. L. Chua,
David P. Crabb,
Philippa M. Cumberland,
Alexander Day,
Parul Desai,
Bal Dhillon,
Andrew D. Dick,
Cathy Egan,
Sarah Ennis,
Marcus Fruttiger,
John E. J. Gallacher,
David F. Garway-Heath,
Jane Gibson,
Dan Gore,
Alison Hardcastle,
Simon P. Harding,
Ruth E. Hogg,
Pearse A. Keane,
Sir Peng T. Khaw,
Gerassimos Lascaratos,
Andrew J. Lotery,
Tom Macgillivray,
Sarah Mackie,
Keith Martin,
Michelle McGaughey,
Bernadette McGuinness,
Gareth J. McKay,
Martin McKibbin,
Danny Mitry,
Tony Moore,
James E. Morgan,
Zaynah A. Muthy,
Eoin O’Sullivan,
Chris G. Owen,
Praveen Patel,
Euan Paterson,
Tunde Peto,
Axel Petzold,
Alicja R. Rudnikca,
Jay Self,
Sobha Sivaprasad,
David Steel,
Irene Stratton,
Nicholas Strouthidis,
Cathie Sudlow,
Dhanes Thomas,
Emanuele Trucco,
Adnan Tufail,
Stephen A. Vernon,
Ananth C. Viswanathan,
Katie Williams,
Jayne V. Woodside,
Max M. Yates,
Jennifer Yip,
Yalin Zheng
Feb 17, 2021
Abstract: Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature...