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Regulating needs
Amanda Nancy Sferruzzi-Perri
Mar 16, 2018
During pregnancy, the fetus requires nutrients supplied by the mother to grow and develop. However, the mother also requires sufficient resources to support the pregnancy, as well as, to maintain her health. Failure to regulate...
Pregnancy-induced changes in β-cell function
Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity, which enables glucose to be available in...
Placental adaptations supporting fetal growth during normal and adverse gestational environments.
NEW FINDINGS: What is the topic of this review? How the placenta, which transports nutrients and oxygen to the fetus, may alter its support of fetal growth developmentally and with adverse gestational conditions. What advances...
Developmental programming of offspring adipose tissue biology and obesity risk
Abstract: Obesity is reaching epidemic proportions and imposes major negative health crises and an economic burden in both high and low income countries. The multifaceted nature of obesity represents a major health challenge...
Interview with Nancy Hinson Cox
Nancy Hinson Cox
Jan 01, 0001
In her July 16, 1974 interview with Ann Yarborough Evans, Nancy Cox recalls Winthrop customs from 1930-1934. This interview was conducted for inclusion into the Louise Pettus Archives and Special Collections Oral History Program.
Home economics teaching Dorm Life Rules and Regulations daisy chain blue line McLaurin Lancaster Swimming religion Oral History
Published by: Winthrop University
Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age.
Conditions such as small for gestational age (SGA), which is defined as birthweight less than 10th percentile for gestational age can predispose to neurodevelopmental abnormalities compared to babies with normal birthweight....
Developmental programming of offspring adipose tissue biology and obesity risk.
Obesity is reaching epidemic proportions and imposes major negative health crises and an economic burden in both high and low income countries. The multifaceted nature of obesity represents a major health challenge, with obesity...
Assessment of Placental Transport Function in Studies of Disease Programming.
Amanda N Sferruzzi-Perri
Feb 11, 2019
Environmental conditions during pregnancy affect fetal growth and development and program the offspring for poor future health. These effects may be mediated by the placenta, which develops to transfer nutrients from the mother...
Near to One's Heart
The development of the fetal heart is exquisitely controlled by a multitude of factors, ranging from humoral to mechanical forces. The gatekeeper regulating many of these factors is the placenta, an external fetal organ. As...
Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress.
The results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as 'developmental programming', whereby the presence of a stressor during gestation predisposes...
Fused placentas
Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this...
Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress
Abstract: The results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as ‘developmental programming’, whereby the presence of a stressor during gestation...
Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin resistance.
Yuehui Zhang, Min Hu, Fan Yang, Yizhuo Zhang, Shuting Ma, Dongqi Zhang, Xu Wang, Amanda Nancy Sferruzzi-Perri, Xiaoke Wu, Mats Brännström, Linus R Shao, Håkan Billig
Sep 21, 2021
Androgen receptor Flutamide Implantation Mitochondrial function POLYCYSTIC OVARY SYNDROME Pregnant uterus Androgens Animals Decidua Dihydrotestosterone Embryo Implantation Endometrium Female Hyperandrogenism Insulin Insulin Resistance Male Mitochondria POLYCYSTIC OVARY SYNDROME Pregnancy Rats Rats Sprague-Dawley Receptors Androgen Uterus
Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth.
Amanda N Sferruzzi-Perri, Josephine S Higgins, Owen R Vaughan, Andrew J Murray, Abigail L Fowden
May 21, 2019
Mitochondria respond to a range of stimuli and function in energy production and redox homeostasis. However, little is known about the developmental and environmental control of mitochondria in the placenta, an organ vital for...
Developmental programming of the female reproductive system-a review.
Exposures to adverse conditions in utero can lead to permanent changes in the structure and function of key physiological systems in the developing fetus, increasing the risk of disease and premature aging in later postnatal...
The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life
The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978. ART use is currently on the rise, given growing infertility and the...
The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life
The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978. ART use is currently on the rise, given growing infertility...
Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology.
In mice, the labyrinth zone of the placenta exchanges nutrients and gases between mother and fetus. This placental zone is complex in structure and defects in its morphogenesis can compromise substrate exchange and thus, fetal...
Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation.
PI3K Fetus nutrient transport Placenta resource allocation 3-O-Methylglucose Animals Biological Transport Body Weight Cell Lineage Class I Phosphatidylinositol 3-Kinases Endocrine System Enzyme Activation Female Fetal Development Fetus Gene Expression Regulation Developmental Genome Liver Maternal-Fetal Exchange Metabolomics Mice Knockout Models Biological Organ Size Placenta Pregnancy Signal Transduction beta-Alanine
Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats.
Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This...
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation.
During pregnancy, the mother must adapt her body systems to support nutrient and oxygen supply for growth of the baby in utero and during the subsequent lactation. These include changes in the cardiovascular, pulmonary, immune...
Exploring the causes and consequences of maternal metabolic maladaptations during pregnancy
Pregnancy is a remarkable physiological state, during which the metabolic system of the mother adapts to ensure that nutrients are made available for transfer to the fetus for growth and development. Adaptations of maternal...
Advanced maternal age compromises fetal growth and induces sex-specific changes in placental phenotype in rats.
Advanced maternal age is associated with an increased risk of pregnancy complications. It programmes sex-specific cardiovascular dysfunction in rat offspring, however the intrauterine mechanisms involved remain unknown. This...
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