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Results: 19
Stenting for symptomatic vertebral artery stenosis
Hugh S Markus, Eric L Harshfield, Annette Compter, Wilhelm Kuker, L Jaap Kappelle, Andrew Clifton, H Bart van der Worp, Peter Rothwell, Ale Algra, Vertebral Stenosis Trialists' Collaboration
Apr 05, 2019
BACKGROUND: Symptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. Vertebral artery stenosis can be treated with stenting with...
Statistical reanalysis of vascular event outcomes in primary and secondary vascular prevention trials.
Lisa J Woodhouse, Alan A Montgomery, Jonathan Mant, Barry R Davis, Ale Algra, Jean-Louis Mas, Jan A Staessen, Lutgarde Thijs, Andrew Tonkin, Adrienne Kirby, Stuart J Pocock, John Chalmers, Graeme J Hankey, J David Spence, Peter Sandercock, Hans-Christoph Diener, Shinichiro Uchiyama, Nikola Sprigg, Philip M Bath
Oct 18, 2021
BACKGROUND: Vascular prevention trials typically use dichotomous event outcomes although this may be inefficient statistically and gives no indication of event severity. We assessed whether ordinal outcomes would be more...
A comparative study of interface-conforming ALE-FE scheme and diffuse interface AMR-LB scheme for interfacial dynamics
In this work, a comparative study for two simulation methods is conducted for interfacial flows in two dimensions: an arbitrary Lagrangian Eulerian (ALE) finite element method (FEM) on interface-conforming meshes and a phase...
Multivariate moment closure techniques for stochastic kinetic models.
Stochastic effects dominate many chemical and biochemical processes. Their analysis, however, can be computationally prohibitively expensive and a range of approximation schemes have been proposed to lighten the computational...
Online Adaptive Learning
Adaptive Learning (AL), a new web-based online learning environment, requires self-regulated learners who act autonomously. However, to date, there appears to be no existing model to conceptualize different aspects of SRL skills...
Published by: IGI Global Scientific Publishing
Altered likelihood of brain activation in attention and working memory networks in patients with multiple sclerosis
Multiple sclerosis (MS) is a chronic neurological disease, frequently affecting attention and working memory functions. Functional imaging studies investigating those functions in MS patients are hard to compare, as they include...
Phosphorelay of non-orthodox two component systems functions through a bi-molecular mechanism in vivo
Goran Jovanovic, Xia Sheng, Angelique Ale, Elisenda Feliu, Heather A Harrington, Paul Kirk, Carsten Wiuf, Martin Buck, Michael PH Stumpf
Jul 16, 2018
Two-component systems play a central part in bacterial signal transduction. Phosphorelay mechanisms have been linked to more robust and ultra-sensitive signalling dynamics. The molecular machinery that facilitates such a...
MEANS
Sisi Fan, Quentin Geissmann, Eszter Lakatos, Saulius Lukauskas, Angelique Ale, Ann C Babtie, Paul DW Kirk, Michael PH Stumpf
Jul 16, 2018
MOTIVATION: Many biochemical systems require stochastic descriptions. Unfortunately these can only be solved for the simplest cases and their direct simulation can become prohibitively expensive, precluding thorough analysis. As...
A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.
Matthew Traylor, Kari-Matti Mäkelä, Laura L Kilarski, Elizabeth G Holliday, William J Devan, Mike A Nalls, Kerri L Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2) METASTROKE, Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M Maguire, Matthew Walters, Ale Algra, Pankaj Sharma, John R Attia, Giorgio B Boncoraglio, Peter M Rothwell, Paul IW de Bakker, Joshua C Bis, Danish Saleheen, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, James F Meschia, Christopher Levi, Martin Dichgans, Terho Lehtimäki, Cathryn M Lewis, Hugh S Markus
Nov 08, 2018
Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of...
Language networks in aphasia and health
Aphasia recovery post-stroke is classically and most commonly hypothesised to rely on regions that were not involved in language premorbidly, through 'neurocomputational invasion' or engagement of 'quiescent homologues'....
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Neural correlates of conversion disorder
BACKGROUND: Conversion Disorders (CD) are prevalent functional disorders. Although the pathogenesis is still not completely understood, an interaction of genetic, neurobiological, and psychosocial factors is quite likely. The...
Quelques designations de l'arum tachete (Arum macula/urn L.) dans les dialectes gallo-romans et daco-roumains
La motivation sémantique, source de la création lexicale, est une réalité qui a été mise en évidence dans de nombreuses études, partant sur le lexique lui-meme (voir l'Atlas Linguarum Europae ALE, l'Atlas Linguistique Roman...
Published by: Atlantic Provinces Linguistic Association
Short-Term Forecasting of Household Water Demand in the UK Using an Interpretable Machine-Learning Approach
This study utilizes a rich UK data set of smart demand metering data, household characteristics, and weather data to develop a demand forecasting methodology that combines the high accuracy of machine learning models with the...
Short-Term Forecasting of Household Water Demand in the UK Using an Interpretable Machine-Learning Approach
This study utilizes a rich UK data set of smart demand metering data, household characteristics, and weather data to develop a demand forecasting methodology that combines the high accuracy of machine learning models with the...
Functional localization and categorization of intentional decisions in humans
Brain-imaging research on intentional decision-making often employs a "free-choice" paradigm, in which participants choose among options with identical values or outcomes. Although the medial prefrontal cortex has commonly been...
Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis.
Rosa Andres-Ejarque, Hira Bahadur Ale, Katarzyna Grys, Isabella Tosi, Shane Solanky, Chrysanthi Ainali, Zeynep Catak, Hemawtee Sreeneebus, Jake Saklatvala, Nick Dand, Emanuele de Rinaldis, Anna Chapman, Frank O Nestle, Michael R Barnes, Richard B Warren, Nick J Reynolds, Christopher EM Griffiths, Jonathan N Barker, Catherine H Smith, Paola Di Meglio, PSORT Consortium
Sep 08, 2021
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight
Daniel I Swerdlow, David Preiss, Karoline B Kuchenbaecker, Michael V Holmes, Jorgen EL Engmann, Tina Shah, Reecha Sofat, Stefan Stender, Paul CD Johnson, Robert A Scott, Maarten Leusink, Niek Verweij, Stephen J Sharp, Yiran Guo, Claudia Giambartolomei, Christina Chung, Anne Peasey, Antoinette Amuzu, KaWah Li, Jutta Palmen, Philip Howard, Jackie A Cooper, Fotios Drenos, Yun R Li, Gordon Lowe, John Gallacher, Marlene CW Stewart, Ioanna Tzoulaki, Sarah G Buxbaum, Daphne L van der A, Nita G Forouhi, N Charlotte Onland-Moret, Yvonne T van der Schouw, Renate B Schnabel, Jaroslav A Hubacek, Ruzena Kubinova, Migle Baceviciene, Abdonas Tamosiunas, Andrzej Pajak, Roman Topor-Madry, Urszula Stepaniak, Sofia Malyutina, Damiano Baldassarre, Bengt Sennblad, Elena Tremoli, Ulf de Faire, Fabrizio Veglia, Ian Ford, J Wouter Jukema, Rudi GJ Westendorp, Gert Jan de Borst, Pim A de Jong, Ale Algra, Wilko Spiering, Anke H Maitland-van der Zee, Olaf H Klungel, Anthonius de Boer, Pieter A Doevendans, Charles B Eaton, Jennifer G Robinson, David Duggan, DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium, John Kjekshus, John R Downs, Antonio M Gotto, Anthony C Keech, Roberto Marchioli, Gianni Tognoni, Peter S Sever, Neil R Poulter, David D Waters, Terje R Pedersen, Pierre Amarenco, Haruo Nakamura, John JV McMurray, James D Lewsey, Daniel I Chasman, Paul M Ridker, Aldo P Maggioni, Luigi Tavazzi, Kausik K Ray, Sreenivasa Rao Kondapally Seshasai, JoAnn E Manson, Jackie F Price, Peter H Whincup, Richard W Morris, Debbie A Lawlor, George Davey Smith, Yoav Ben-Shlomo, Pamela J Schreiner, Myriam Fornage, David S Siscovick, Mary Cushman, Meena Kumari, Nick J Wareham, WM Monique Verschuren, Susan Redline, Sanjay R Patel, John C Whittaker, Anders Hamsten, Joseph A Delaney, Caroline Dale, Tom R Gaunt, Andrew Wong, Diana Kuh, Rebecca Hardy, Sekar Kathiresan, Berta A Castillo, Pim van der Harst, Eric J Brunner, Anne Tybjaerg-Hansen, Michael G Marmot, Ronald M Krauss, Michael Tsai, Josef Coresh, Ronald C Hoogeveen, Bruce M Psaty, Leslie A Lange, Hakon Hakonarson, Frank Dudbridge, Steve E Humphries, Philippa J Talmud, Mika Kivimäki, Nicholas J Timpson, Claudia Langenberg, Folkert W Asselbergs, Mikhail Voevoda, Martin Bobak, Hynek Pikhart, James G Wilson, Alex P Reiner, Brendan J Keating, Aroon D Hingorani, Naveed Sattar
Nov 07, 2018
BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug...
Aged Body Mass Index Body Weight Cholesterol HDL Cholesterol LDL Diabetes mellitus Type 2 Female Genetic Testing Humans Hydroxymethylglutaryl CoA Reductases Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Polymorphism Single Nucleotide Randomized Controlled Trials as Topic Risk Factors