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Results: 86365
Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes.
Factorial Structure and Validity of Depression (PHQ-9) and Anxiety (GAD-7) Scales after Traumatic Brain Injury
Ali Teymoori, Anastasia Gorbunova, Fardzadeh E. Haghish, Ruben Real, Marina Zeldovich, Yi-Jhen Wu, Suzanne Polinder, Thomas Asendorf, David Menon, CENTER-TBI Investigators and Participants CENTER-TBI Investigators and Participants, Nicole v. Steinbüchel
Mar 25, 2020
Background: The dimensionality of depression and anxiety instruments have recently been a source of controversy. Objectives and Design: In a European-wide sample of patients after Traumatic Brain Injury (TBI), we aim to examine...
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Alexandra K Davies, Daniel N Itzhak, James R Edgar, Tara L Archuleta, Jennifer Hirst, Lauren P Jackson, Margaret S Robinson, Georg HH Borner
Dec 13, 2018
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic...
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.
Jennifer Hirst, Georg HH Borner, James Edgar, Marco Y Hein, Matthias Mann, Frank Buchholz, Robin Antrobus, Margaret S Robinson
Feb 13, 2019
The AP-5 complex is a recently identified but evolutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes). It is associated with two proteins that are mutated in patients with hereditary...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.
Adaptor protein complex 5 (AP-5) and its partners, SPG11 and SPG15, are recruited onto late endosomes and lysosomes. Here we show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells and occurs by coincidence...
Adaptor Proteins Vesicular Transport Carrier Proteins Endosomes HEK293 Cells HeLa Cells Humans Lysosomes Mechanistic Target of Rapamycin Complex 1 Models Biological Monomeric GTP-Binding Proteins Multiprotein Complexes Nucleotides Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Protein Domains Proteins
Outcome Measures for Artificial Pancreas Clinical Trials
David M Maahs, Bruce A Buckingham, Jessica R Castle, Ali Cinar, Edward R Damiano, Eyal Dassau, J Hans DeVries, Francis J Doyle, Steven C Griffen, Ahmad Haidar, Lutz Heinemann, Roman Hovorka, Timothy W Jones, Craig Kollman, Boris Kovatchev, Brian L Levy, Revital Nimri, David N O'Neal, Moshe Philip, Eric Renard, Steven J Russell, Stuart A Weinzimer, Howard Zisser, John W Lum
Jun 07, 2018
Research on and commercial development of the artificial pancreas (AP) continue to progress rapidly, and the AP promises to become a part of clinical care. In this report, members of the JDRF Artificial Pancreas Project...
Prediction of three-dimensional femoral offset from AP pelvis radiographs in primary hip osteoarthritis
C Merle, W Waldstein, Elise Pegg, M R Streit, T Gotterbarm, P R Aldinger, D W Murray, H S Gill
Aug 01, 2013
BACKGROUND: In pre-operative planning for total hip arthroplasty (THA), femoral offset (FO) is frequently underestimated on AP pelvis radiographs as a result of inaccurate patient positioning, imprecise magnification, and...
The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma.
Nikolai Schleussner, Olaf Merkel, Mariantonia Costanza, Huan-Chang Liang, Franziska Hummel, Chiara Romagnani, Pawel Durek, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Antonia Niedobitek, Patrick R Griffin, Roberto Piva, Henrike L Sczakiel, Wilhelm Woessmann, Christine Damm-Welk, Christian Hinze, Dagmar Stoiber, Bernd Gillissen, Suzanne D Turner, Eva Kaergel, Linda von Hoff, Michael Grau, Georg Lenz, Bernd Dörken, Claus Scheidereit, Lukas Kenner, Martin Janz, Stephan Mathas
Mar 20, 2018
Transcription factor AP-1 is constitutively activated and IRF4 drives growth and survival in ALK+ and ALK- anaplastic large cell lymphoma (ALCL). Here we demonstrate high-level BATF and BATF3 expression in ALCL. Both BATFs bind...
Basic-Leucine Zipper Transcription Factors Binding Sites CRISPR-Cas Systems Carrier Proteins Cell Death Cell Line Tumor Cell Survival Cytokines Gene Editing Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans Lymphoma Large-Cell Anaplastic Protein Binding Protein Kinase Inhibitors RNA Small Interfering T-Lymphocyte Subsets Th17 Cells Transcription Factor AP-1 Transcriptome
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2.
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K Whiteside, Charlotte J Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Oct 15, 2020
Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and cancer...
Prediction of three-dimensional femoral offset from AP pelvis radiographs in primary hip osteoarthritis
C Merle, W Waldstein, Elise Pegg, M R Streit, T Gotterbarm, P R Aldinger, D W Murray, H S Gill
Aug 01, 2013
BACKGROUND: In pre-operative planning for total hip arthroplasty (THA), femoral offset (FO) is frequently underestimated on AP pelvis radiographs as a result of inaccurate patient positioning, imprecise magnification, and...
Brain death and postmortem organ donation
Ernest van Veen, Mathieu van der Jagt, Maryse C Cnossen, Andrew IR Maas, Inez D de Beaufort, David K Menon, Giuseppe Citerio, Nino Stocchetti, Wim JR Rietdijk, Jeroen TJM van Dijck, Erwin JO Kompanje, CENTER-TBI Investigators and Participants
Apr 14, 2020
BACKGROUND: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. METHODS: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic...
A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers.
Shanna L Bowman, Linh Le, Yueyao Zhu, Dawn C Harper, Anand Sitaram, Alexander C Theos, Elena V Sviderskaya, Dorothy C Bennett, Graça Raposo-Benedetti, David J Owen, Megan K Dennis, Michael S Marks
Apr 12, 2021
Membrane transport carriers fuse with target membranes through engagement of cognate vSNAREs and tSNAREs on each membrane. How vSNAREs are sorted into transport carriers is incompletely understood. Here we show that VAMP7, the...
The WDR11 complex facilitates the tethering of AP-1-derived vesicles.
Paloma Navarro Negredo, James R Edgar, Paul T Manna, Robin Antrobus, Margaret S Robinson
Jul 20, 2018
Vesicluar transport of proteins from endosomes to the trans-Golgi network (TGN) is an essential cellular pathway, but much of its machinery is still unknown. A screen for genes involved in endosome-to-TGN trafficking produced...
Adaptor Protein Complex 1 Autoantigens CRISPR-Cas Systems Cytoplasmic Vesicles Endosomes GTPase-Activating Proteins HEK293 Cells HeLa Cells Humans Membrane Proteins Microscopy Fluorescence Multiprotein Complexes Protein Binding Protein Transport Proto-Oncogene Proteins RNA Interference trans-Golgi Network
Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection
Hugh S Markus, Christopher Levi, Alice King, Jeremy Madigan, John Norris, Cervical Artery Dissection in Stroke Study (CADISS) Investigators
Mar 19, 2019
IMPORTANCE: Extracranial carotid and vertebral artery dissection is an important cause of stroke, particularly in younger individuals. In some but not all observational studies, it has been associated with a high risk of...
Adolescent Adult Aged Aged 80 and over Anticoagulants Aspirin Carotid Artery Internal Dissection Clopidogrel Dipyridamole Female Hemorrhage Heparin Humans Male Middle Aged Mortality Platelet Aggregation Inhibitors Recurrence Secondary Prevention stroke Treatment Outcome Vertebral Artery Dissection Warfarin Young Adult
A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2
Panagiota Vardaka, Teresa Lozano, Christopher Bot, Jonathan Ellery, Sarah K. Whiteside, Charlotte J. Imianowski, Stuart Farrow, Simon Walker, Hanneke Okkenhaug, Jie Yang, Klaus Okkenhaug, Paula Kuo, Rahul Roychoudhuri
Nov 03, 2020
Abstract: Whereas effector CD4+ and CD8+ T cells promote immune activation and can drive clearance of infections and cancer, CD4+ regulatory T (Treg) cells suppress their function, contributing to both immune homeostasis and...
High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury
Evolving antithrombotic treatment patterns for patients with newly diagnosed atrial fibrillation.
A John Camm, Gabriele Accetta, Giuseppe Ambrosio, Dan Atar, Jean-Pierre Bassand, Eivind Berge, Frank Cools, David A Fitzmaurice, Samuel Z Goldhaber, Shinya Goto, Sylvia Haas, Gloria Kayani, Yukihiro Koretsune, Lorenzo G Mantovani, Frank Misselwitz, Seil Oh, Alexander GG Turpie, Freek WA Verheugt, Ajay K Kakkar, GARFIELD-AF Investigators
Mar 30, 2020
OBJECTIVE: We studied evolving antithrombotic therapy patterns in patients with newly diagnosed non-valvular atrial fibrillation (AF) and ≥1 additional stroke risk factor between 2010 and 2015. METHODS: 39 670 patients were...
stroke Administration Oral Age Factors Aged Aged 80 and over Atrial fibrillation Comorbidity Female Fibrinolytic Agents Guideline Adherence Humans Male Middle Aged Practice Guidelines as Topic Practice Patterns Physicians' Prospective Studies Registries Risk Assessment Risk Factors Sex Factors stroke Time Factors Treatment Outcome
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells.
In polarized epithelial cells, newly synthesized membrane proteins are delivered on specific pathways to either the apical or basolateral domains, depending on the sorting motifs present in these proteins. Because myosin VI has...
Adaptor Protein Complex 1 Amino Acid Motifs Animals Cell Cycle Proteins Cell Line Cell Polarity Dogs Endosomes Humans Membrane Glycoproteins Membrane Transport Proteins Mutagenesis Site-Directed Myosin Heavy Chains Protein Isoforms Protein Transport Transcription Factor TFIIIA Viral Envelope Proteins
High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury
The United Kingdom Childhood Cancer Study
UK Childhood Cancer Study Investigators
Feb 21, 2020
An investigation into the possible causes of childhood cancer has been carried out throughout England, Scotland and Wales over the period 1991-1998. All children known to be suffering from one or other type of the disease over...
Young Children Have Higher Variability of Insulin Requirements
Klemen Dovc, Charlotte Boughton, Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Carlo L Acerini, Sabine Arnolds, Carine de Beaufort, Richard M Bergenstal, Fiona Campbell, Amy Criego, David B Dunger, Daniella Elleri, Mark L Evans, Elke Fröhlich-Reiterer, Sabine Hofer, Thomas Kapellen, Lalantha Leelarathna, Thomas R Pieber, Birgit Rami-Merhar, Viral N Shah, Judy Sibayan, Malgorzata E Wilinska, Roman Hovorka, AP@Home, and KidsAP Consortia APCam11
Apr 30, 2019
OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young...
Adolescent Adult Age Factors Aged Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Dose-Response Relationship Drug Female Humans Hypoglycemic Agents Individuality Infant Insulin Insulin Infusion Systems Male Middle Aged Multicenter Studies as Topic Randomized Controlled Trials as Topic Retrospective Studies Young Adult
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