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Results: 86468
Young Children Have Higher Variability of Insulin Requirements
Klemen Dovc, Charlotte Boughton, Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Carlo L Acerini, Sabine Arnolds, Carine de Beaufort, Richard M Bergenstal, Fiona Campbell, Amy Criego, David B Dunger, Daniella Elleri, Mark L Evans, Elke Fröhlich-Reiterer, Sabine Hofer, Thomas Kapellen, Lalantha Leelarathna, Thomas R Pieber, Birgit Rami-Merhar, Viral N Shah, Judy Sibayan, Malgorzata E Wilinska, Roman Hovorka, AP@Home, and KidsAP Consortia APCam11
Apr 30, 2019
OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young...
Adolescent Adult Age Factors Aged Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Dose-Response Relationship Drug Female Humans Hypoglycemic Agents Individuality Infant Insulin Insulin Infusion Systems Male Middle Aged Multicenter Studies as Topic Randomized Controlled Trials as Topic Retrospective Studies Young Adult
Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes.
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
Assessing the effectiveness of 3 months day and night home closed-loop insulin delivery in adults with suboptimally controlled type 1 diabetes
Lalantha Leelarathna, Sibylle Dellweg, Julia K Mader, Katharine Barnard, Carsten Benesch, Martin Ellmerer, Lutz Heinemann, Harald Kojzar, Hood Thabit, Malgorzata E Wilinska, Tim Wysocki, Thomas R Pieber, Sabine Arnolds, Mark L Evans, Roman Hovorka, AP@home Consortium
Feb 14, 2020
INTRODUCTION: Despite therapeutic advances, many people with type 1 diabetes are still unable to achieve optimal glycaemic control, limited by the occurrence of hypoglycaemia. The objective of the present study is to determine...
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Alexandra K Davies, Daniel N Itzhak, James R Edgar, Tara L Archuleta, Jennifer Hirst, Lauren P Jackson, Margaret S Robinson, Georg HH Borner
Dec 13, 2018
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic...
Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis
Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill
Jan 01, 0001
The objectives of the present study were to determine (1) whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and (2) whether...
Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.
Jennifer Hirst, Georg HH Borner, James Edgar, Marco Y Hein, Matthias Mann, Frank Buchholz, Robin Antrobus, Margaret S Robinson
Feb 13, 2019
The AP-5 complex is a recently identified but evolutionarily ancient member of the family of heterotetrameric adaptor proteins (AP complexes). It is associated with two proteins that are mutated in patients with hereditary...
Day and night home closed-loop insulin delivery in adults with type 1 diabetes
Lalantha Leelarathna, Sibylle Dellweg, Julia K Mader, Janet M Allen, Carsten Benesch, Werner Doll, Martin Ellmerer, Sara Hartnell, Lutz Heinemann, Harald Kojzar, Lucy Michalewski, Marianna Nodale, Hood Thabit, Malgorzata E Wilinska, Thomas R Pieber, Sabine Arnolds, Mark L Evans, Roman Hovorka, AP@home Consortium
Aug 06, 2014
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.
Adaptor protein complex 5 (AP-5) and its partners, SPG11 and SPG15, are recruited onto late endosomes and lysosomes. Here we show that recruitment of AP-5/SPG11/SPG15 is enhanced in starved cells and occurs by coincidence...
Adaptor Proteins Vesicular Transport Carrier Proteins Endosomes HEK293 Cells HeLa Cells Humans Lysosomes Mechanistic Target of Rapamycin Complex 1 Models Biological Monomeric GTP-Binding Proteins Multiprotein Complexes Nucleotides Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Protein Domains Proteins
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
Strategic Renewal at Home and Work
In this weekly diary study, we integrated research on strategic renewal and the Work-Home Resources model (i.e., W-HR model) to explore the associations between strategic renewal at home and strategic renewal at work domains...
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