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ENT audit and research in the era of trainee collaboratives.
Matthew E Smith, John Hardman, Matthew Ellis, Richard J Williams, The UK National ENT Trainee Research Network INTEGRATE
Sep 20, 2018
Large surgical audits and research projects are complex and costly to deliver, but increasingly surgical trainees are delivering these projects within formal collaboratives and research networks. Surgical trainee collaboratives...
The British Neurosurgical Trainee Research Collaborative
Aswin Chari, Aimun A Jamjoom, Ellie Edlmann, Aminul I Ahmed, Ian C Coulter, Ruichong Ma, Paul May, Paul M Brennan, Peter JA Hutchinson, Angelos G Kolias, British Neurosurgical Trainee Research Collaborative
Nov 28, 2018
Since its inception in 2012, the British Neurosurgical Trainee Research Collaborative (BNTRC) has established itself as a robust example of a trainee-led research collaborative. This article summarises the work of the...
Comment on Herring et al. The Use of "Retardation" in FRAXA, FMRP, FMR1 and Other Designations. Cells 2022, 11, 1044.
This commentary is written in response to the recent article from Herring et al., discussing the eradication of the offensive term "retardation" from gene nomenclature. We discuss the work of the HUGO (Human Genome Organisation)...
The National Institute for Health Research
V Goh, National Institute for Health Research Clinical Research Network Imaging Network Steering Group, Royal College of Radiologists' Academic Committee
Oct 01, 2019
Since the inception of the National Institute for Health Research (NIHR) in 2006, the landscape for the delivery of clinical research within the National Health Service (NHS) has been transformed. Clinical radiology has...
Current opportunities to catalyze research in nutrition and cancer prevention – an interdisciplinary perspective
The Cancer Research UK - Ludwig Cancer Research Nutrition and Cancer Prevention Collaborative Group
Jul 31, 2019
Cancer Research UK and Ludwig Cancer Research convened an inaugural international Cancer Prevention and Nutrition Conference in London on December 3–4, 2018. Much of the discussion focused on the need for systematic...
cancer prevention Developmental origins Diet EPIDEMIOLOGY epigenetics interdisciplinary metabolism Nutrition obesity physical activity Public Health Biomedical Research Body Weight Congresses as Topic Diet Exercise food Humans Interdisciplinary Communication Interdisciplinary Research Neoplasms Nutrition Therapy Nutritional Status obesity Risk Factors United Kingdom
Did advice on the prescription of sodium valproate reduce prescriptions to women? An observational study in three European countries between 2007 and 2016
Rachel Charlton, Christine Damase-Michel, Caroline Hurault-Delarue, Rosa Gini, Maria Loane, Anna Pierini, Aurora Puccini, Amanda Neville, Julia Snowball, Joan Morris, on behalf of the EUROmediSAFE Consortium
Nov 01, 2019
Objectives
In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant...
In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant...
Did advice on the prescription of sodium valproate reduce prescriptions to women? An observational study in three European countries between 2007 and 2016
Rachel Charlton, Christine Damase-Michel, Caroline Hurault-Delarue, Rosa Gini, Maria Loane, Anna Pierini, Aurora Puccini, Amanda Neville, Julia Snowball, Joan Morris, on behalf of the EUROmediSAFE Consortium
Nov 01, 2019
Objectives
In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant...
In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant...
W404-010J-01 - Office of the Vice President for Academic Affairs: Office of Sponsored Programs and Research (SPAR): Correspondence and Memoranda
Office of Vice President for Academic Affairs, Sponsored Programs and Research, Office of, Grants and Sponsored Research Development, Office of
Jan 01, 0001
Published by: Winthrop University
Evaluation of a very brief pedometer-based physical activity intervention delivered in NHS Health Checks in England
Wendy Hardeman, Joanna Mitchell, Sally Pears, Miranda Van Emmenis, Florence Theil, Vijay S. Gc, Joana C. Vasconcelos, Kate Westgate, Søren Brage, Marc Suhrcke, Simon J. Griffin, Ann Louise Kinmonth, Edward C. F. Wilson, A. Toby Prevost, Stephen Sutton, on behalf of the VBI Research Team
Mar 06, 2020
Background: The majority of people do not achieve recommended levels of physical activity. There is a need for effective, scalable interventions to promote activity. Self-monitoring by pedometer is a potentially suitable...
Blood Pressure Changes Following Antihypertensive Medication Reduction, by Drug Class and Dose Chosen for Withdrawal
James P. Sheppard, Mark Lown, Jenni Burt, Gary A. Ford, F. D. Richard Hobbs, Paul Little, Jonathan Mant, Rupert A. Payne, Richard J. McManus, On behalf of the OPTiMISE Investigators
May 04, 2021
Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with polypharmacy, but there is little evidence to inform which drug (or dose) should be withdrawn. This study used data from the OPTiMISE...
Composite Measures for Clinical Trials in Psoriatic Arthritis
William Tillett, Oliver FitzGerald, Laura C Coates, Jon Packham, Deepak R Jadon, Marco Massarotti, Mel Brook, Suzanne Lane, Paul Creamer, Anna Antony, Eleanor Korendowych, Adwaye Rambojun, Neil J McHugh, Philip S Helliwell, and Philip S. Helliwell on behalf of the PROMPT Study Group
Aug 02, 2021
OBJECTIVE: To test the addition of pain and fatigue to the Composite Psoriatic Arthritis Disease Activity (CPDAI) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) Composite Exercise (GRACE) composite...
An integrated national scale SARS-CoV-2 genomic surveillance network.
The Coronavirus Disease 2019 (COVID-19) Genomics UK Consortium (COG-UK) was launched in March, 2020, with £20 million support from UK Research and Innovation, the UK Department of Health and Social Care, and Wellcome Trust. The...
Modifiable pathways in Alzheimer's disease
Susanna C Larsson, Matthew Traylor, Rainer Malik, Martin Dichgans, Stephen Burgess, Hugh S Markus, on behalf of the International Genomics of Alzheimer’s Project CoSTREAM Consortium
Mar 07, 2018
OBJECTIVE: To determine which potentially modifiable risk factors, including socioeconomic, lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's disease. DESIGN: Mendelian randomisation...
Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases
Killian Donovan, William G Herrington, Guillaume Paré, Marie Pigeyre, Richard Haynes, Rebecca Sardell, Adam S Butterworth, Lasse Folkersen, Stefan Gustafsson, Qin Wang, Colin Baigent, Anders Mälarstig, Michael V Holmes, Natalie Staplin, on behalf of the SCALLOP Consortium
Mar 03, 2023
BACKGROUND: Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian...
Acute otitis externa
Matthew E. Smith, John C. Hardman, Nishchay Mehta, Gareth H. Jones, Rishi Mandavia, Caroline Anderson, Maha Khan, Aula Abdelaziz, Bakir Al-Dulaimy, Nikul Amin, Rajesh Anmolsingh, Bilal Anwar, Manohar Bance, Katherine Belfield, Mahmood Bhutta, Ruaridh Buchanan, Deepak Chandrasekharan, Michael Chu, Srikanth Chundu, Katherine Conroy, Gemma Crundwell, Mat Daniel, Jessica Daniels, Sujata De, Sian Dobbs, Jayesh Doshi, Matthew Farr, Tanjinah Ferdous, Eleni Fragkouli, Simon Freeman, Samit Ghosh, Emma Gosnell, S. Alam Hannan, Elliot Heward, Faisal Javed, Deepa John, Helen Nicholls, Anand V. Kasbekar, Haroon Khan, Hammad Khan, Sadie Khwaja, Bhik Kotecha, Madhankumar Krishnan, Nirmal Kumar, Tamara Lamb, Hannah Lancer, Joseph G. Manjaly, Marcos Martinez Del Pero, Fiona McClenaghan, Kristijonas Milinis, Nina Mistry, Hassan Mohammed, Elizabeth Morris, Stephen Morris-Jones, Jessica Padee, Surojit Pal, Sanjay Patel, Agamemnon Pericleous, Asad Qayyum, Maral Rouhani, Haroon Saeed, Mirusanthan Santhiyapillai, Kay Seymour, Sunil Sharma, Richard Siau, Arvind Singh, Emma Stapleton, Kate Stephenson, Gill Stynes, Bharathi Subramanian, Neil Summerfield, Chloe Swords, Aaron Trinidade, Antonia Tse, Emmanuel Twumasi, Harmony Ubhi, Samit Unadkat, Ananth Vijendren, Joe Wasson, Glen Watson, Glennis Williams, Janet Wilson, Alexander Yao, Ahmed Youssef, Simon K. W. Lloyd, James R. Tysome, on behalf of INTEGRATE (The UK ENT Trainee Research Network)
May 20, 2021
Objective: Evidence for the management of acute otitis externa (AOE) is limited, with unclear diagnostic criteria and variably reported outcome measures that may not reflect key stakeholder priorities. We aimed to develop 1) a...
CONSORT-SPI 2018 Explanation and Elaboration
Sean Grant, Evan Mayo-Wilson, Paul Montgomery, Geraldine Macdonald, Susan Michie, Sally Hopewell, David Moher, on behalf of the CONSORT-SPI Group
Jan 08, 2019
BACKGROUND: The CONSORT (Consolidated Standards of Reporting Trials) Statement was developed to help biomedical researchers report randomised controlled trials (RCTs) transparently. We have developed an extension to the CONSORT...
CONSORT randomised controlled trial Reporting guideline reporting standards Transparency Behavior Therapy Checklist Consensus Data Accuracy Delphi Technique Endpoint Determination Humans Outcome Assessment Health Care Randomized Controlled Trials as Topic Research Design Social Environment Treatment Outcome
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M Svensson, Michael P Menden, Ulrika SH Simonsson, On Behalf Of The Unite Tb Consortium
Jul 23, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic...
Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data
Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M Svensson, Michael P Menden, Ulrika SH Simonsson, On Behalf Of The Unite Tb Consortium
Sep 02, 2022
Pharmacometrics (PM) and machine learning (ML) are both valuable for drug development to characterize pharmacokinetics (PK) and pharmacodynamics (PD). Pharmacokinetic/pharmacodynamic (PKPD) analysis using PM provides mechanistic...
The global diet and activity research (GDAR) network
Tolu Oni, Felix Assah, Agnes Erzse, Louise Foley, Ishtar Govia, Karen J Hofman, Estelle Victoria Lambert, Lisa K Micklesfield, Maylene Shung-King, Joanne Smith, Eleanor Turner-Moss, Nigel Unwin, Pamela Wadende, James Woodcock, Jean Claude Mbanya, Shane A Norris, Charles O Obonyo, Marshall Tulloch-Reid, Nicholas J Wareham, GDAR network
Nov 16, 2020
BACKGROUND: Non-communicable diseases (NCDs) are the leading cause of death globally. While upstream approaches to tackle NCD risk factors of poor quality diets and physical inactivity have been trialled in high income countries...
Diet Global Health LMICs Non-communicable diseases partnerships physical activity Upstream determinants Adolescent Africa South of the Sahara Caribbean Region Developing Countries Diet Global Health Health Policy Humans Income International Cooperation Noncommunicable Diseases Public Health Research Risk Factors
Composite Measures for Routine Clinical Practice in Psoriatic Arthritis
Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension.
Anna Ulrich, Pablo Otero-Núñez, John Wharton, Emilia M Swietlik, Stefan Gräf, Nicholas W Morrell, Dennis Wang, Allan Lawrie, Martin R Wilkins, Inga Prokopenko, Christopher J Rhodes, On Behalf Of The Nihr BioResource-Rare Diseases Consortium, UK PAH Cohort Study Consortium
Jan 08, 2021
Expression quantitative trait loci (eQTL) can provide a link between disease susceptibility variants discovered by genetic association studies and biology. To date, eQTL mapping studies have been primarily conducted in healthy...
Blood eQTL expression quantitative trait locus Genetics pulmonary arterial hypertension Base Sequence Familial Primary Pulmonary Hypertension Female Genetic Association Studies Genetic Predisposition to Disease Genome Genome-Wide Association Study Humans Male Polymorphism Single Nucleotide pulmonary arterial hypertension Quantitative Trait Loci Sequence Analysis RNA Transcriptome
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