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Gestational diabetes
Ponnusamy Saravanan, Diabetes in Pregnancy Working Group, Maternal Medicine Clinical Study Group, UK Royal College of Obstetricians and Gynaecologists
Apr 30, 2021
Gestational diabetes, the most common medical disorder in pregnancy, is defined as glucose intolerance resulting in hyperglycaemia that begins or is first diagnosed in pregnancy. Gestational diabetes is associated with increased...
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
Natalie R Van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R Robertson, Paul M McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Finnish Diabetic Nephropathy Study (FinnDiane), Annalisa Perna, Erica Rurali, M Loredana Marcovecchio, Robert P Igo, Rany M Salem, Norberto Perico, Maria Lajer, AnneMari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M van Dam, Guozhi Jiang, Claudia HT Tam, Andrea OY Luk, Heung Man Lee, Cadmon KP Lim, Cheuk Chun Szeto, Wing Yee So, Juliana CN Chan, Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Marcus G Pezzolesi, GENIE (GEnetics of Nephropathy an International Effort) Consortium, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T Hiraki, Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Tarunveer S Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D Paterson, David Tregouet, Alexander P Maxwell, Su Chi Lim, Ronald CW Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S Krolewski, Stephen S Rich, Joel N Hirschhorn, Jose C Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Mary Julia Brosnan, Colin NA Palmer, Per-Henrik Groop, Helen M Colhoun, Leif C Groop, Mark I McCarthy
Oct 10, 2018
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide...
Changing the name of diabetes insipidus
Working Group for Renaming Diabetes Insipidus, Hiroshi Arima, Timothy Cheetham, Mirjam Christ-Crain, Deborah Cooper, Mark Gurnell, Juliana B Drummond, Miles Levy, Ann I McCormack, Joseph Verbalis, John Newell-Price, John AH Wass
Nov 16, 2022
'What's in a name? That which we call a rose/By any other name would smell as sweet' (Juliet, from Romeo and Juliet by William Shakespeare). Shakespeare's implication is that a name is nothing but a word, and it therefore...
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
Confirmation of novel type 1 diabetes risk loci in families.
JD Cooper, JMM Howson, D Smyth, NM Walker, H Stevens, JHM Yang, J-X She, GS Eisenbarth, M Rewers, JA Todd, B Akolkar, P Concannon, HA Erlich, C Julier, G Morahan, J Nerup, C Nierras, F Pociot, SS Rich, Type 1 Diabetes Genetics Consortium
Jul 09, 2019
AIMS/HYPOTHESIS: Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were...
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Genetic basis of lacunar stroke
Matthew Traylor, Elodie Persyn, Liisa Tomppo, Sofia Klasson, Vida Abedi, Mark K Bakker, Nuria Torres, Linxin Li, Steven Bell, Loes Rutten-Jacobs, Daniel J Tozer, Christoph J Griessenauer, Yanfei Zhang, Annie Pedersen, Pankaj Sharma, Jordi Jimenez-Conde, Tatjana Rundek, Raji P Grewal, Arne Lindgren, James F Meschia, Veikko Salomaa, Aki Havulinna, Christina Kourkoulis, Katherine Crawford, Sandro Marini, Braxton D Mitchell, Steven J Kittner, Jonathan Rosand, Martin Dichgans, Christina Jern, Daniel Strbian, Israel Fernandez-Cadenas, Ramin Zand, Ynte Ruigrok, Natalia Rost, Robin Lemmens, Peter M Rothwell, Christopher D Anderson, Joanna Wardlaw, Cathryn M Lewis, Hugh S Markus, Study Dutch Parelsnoer Institute-Cerebrovascular Accident (CVA) Study Group Helsinki Stroke, National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network, UK DNA Lacunar Stroke Study Investigators, International Stroke Genetics Consortium
Apr 01, 2021
BACKGROUND: The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. METHODS: We did a...
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes
Ulrike Schierloh, Malgorzata E Wilinska, Ineke M Pit-Ten Cate, Petra Baumann, Roman Hovorka, Carine de Beaufort, Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management
Mar 11, 2019
BACKGROUND: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1...
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
Rachel M Freathy, M Geoffrey Hayes, Margrit Urbanek, Lynn P Lowe, Hoon Lee, Christine Ackerman, Timothy M Frayling, Nancy J Cox, David B Dunger, Alan R Dyer, Andrew T Hattersley, Boyd E Metzger, William L Lowe, HAPO Study Cooperative Research Group
Feb 21, 2020
OBJECTIVE: Common genetic variants in GCK and TCF7L2 are associated with higher fasting glucose and type 2 diabetes in nonpregnant populations. However, their associations with glucose levels from oral glucose tolerance tests...
Birth Weight Female genetic variation Genotype Germinal Center Kinases Humans Hyperglycemia Infant Newborn Polymorphism Single Nucleotide Pregnancy Pregnancy Complications Pregnancy Outcome Pregnancy in Diabetics Protein Serine-Threonine Kinases TCF Transcription Factors Transcription Factor 7-Like 2 Protein White People
A new strategy for vascular complications in young people with type 1 diabetes mellitus.
M Loredana Marcovecchio, R Neil Dalton, Denis Daneman, John Deanfield, Timothy W Jones, H Andrew W Neil, David B Dunger, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Apr 16, 2019
Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic...
A Rule-Based Monitoring System for Accurate Prediction of Diabetes
Diabetes is a chronic disease that can affect the life of people due to high sugar level in their blood. The sugar level is increased due to a lack of production of insulin in the human body. Large numbers of people are affected...
Published by: IGI Global Scientific Publishing
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
Adebowale A Adeyemo, Norann A Zaghloul, Guanjie Chen, Ayo P Doumatey, Carmen C Leitch, Timothy L Hostelley, Jessica E Nesmith, Jie Zhou, Amy R Bentley, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Settara Chandrasekharappa, Jokotade Adeleye, William Balogun, Samuel Owusu, Albert Amoah, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Clement Adebamowo, South Africa Zulu Type 2 Diabetes Case-Control Study, Francis Collins, Georgia Dunston, Charles N Rotimi
Aug 19, 2019
Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in...
Africa Northern Animals Apoptosis Base Sequence Blood Glucose CRISPR-Cas Systems DNA Helicases Diabetes mellitus Type 2 Disease Models Animal Female Gene Editing Gene Knockout Techniques Genetic Association Studies Genetic Predisposition to Disease Genotype Ghana Glucose Homozygote Humans Insulin Insulin-Secreting Cells Kenya Male Mice Middle Aged Mutation Nigeria Polymorphism Single Nucleotide RNA Small Interfering Transcription Factor 7-Like 2 Protein Transcriptome Zebrafish
Composite Measures for Clinical Trials in Psoriatic Arthritis
William Tillett, Oliver FitzGerald, Laura C Coates, Jon Packham, Deepak R Jadon, Marco Massarotti, Mel Brook, Suzanne Lane, Paul Creamer, Anna Antony, Eleanor Korendowych, Adwaye Rambojun, Neil J McHugh, Philip S Helliwell, and Philip S. Helliwell on behalf of the PROMPT Study Group
Aug 02, 2021
OBJECTIVE: To test the addition of pain and fatigue to the Composite Psoriatic Arthritis Disease Activity (CPDAI) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) Composite Exercise (GRACE) composite...
Effect of screening for type 2 diabetes on healthcare costs
Camilla Sortsø, Anastasija Komkova, Annelli Sandbæk, Simon J Griffin, Martha Emneus, Torsten Lauritzen, Rebecca K Simmons
May 16, 2018
AIMS/HYPOTHESIS: Trials have not demonstrated benefits to the population of screening for type 2 diabetes. However, there may be cost savings for those found to have diabetes. We therefore aimed to compare healthcare costs among...
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes.
Scott T Chiesa, M Loredana Marcovecchio, Paul Benitez-Aguirre, Fergus J Cameron, Maria E Craig, Jennifer J Couper, Elizabeth A Davis, R Neil Dalton, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, John E Deanfield, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Nov 03, 2020
An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial...
Adolescent arteries Diabetes Type 1 Puberty Vascular diseases Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors C-Reactive Protein Creatinine Diabetes mellitus Type 1 Double-Blind Method Drug Therapy Combination Endothelium Vascular Female Glycated Hemoglobin Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipids Male Pulse Wave Analysis Vascular Stiffness
Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.
Vassiliki Bravis, Akaal Kaur, Helen C Walkey, Ian F Godsland, Shivani Misra, Polly J Bingley, Alistair JK Williams, David B Dunger, Colin M Dayan, Mark Peakman, Nick S Oliver, Desmond G Johnston, Patient Advocate Group and Investigators ADDRESS-2 Management Committee
Jul 30, 2018
OBJECTIVES: To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive. DESIGN...
W451-002B-06 - Division of Student Life: Office of Health and Counseling Services: Office of Accessibility- Correspondence and Memoranda
Division of Student Life, Health and Counseling Services, Office of, Disability Services, Office of, Accessibility, Office of, Testing Program
Jan 01, 0001
Published by: Winthrop University
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.
Amit V Khera, Hong-Hee Won, Gina M Peloso, Colm O'Dushlaine, Dajiang Liu, Nathan O Stitziel, Pradeep Natarajan, Akihiro Nomura, Connor A Emdin, Namrata Gupta, Ingrid B Borecki, Rosanna Asselta, Stefano Duga, Piera Angelica Merlini, Adolfo Correa, Thorsten Kessler, James G Wilson, Matthew J Bown, Alistair S Hall, Peter S Braund, David J Carey, Michael F Murray, H Lester Kirchner, Joseph B Leader, Daniel R Lavage, J Neil Manus, Dustin N Hartzel, Nilesh J Samani, Heribert Schunkert, Jaume Marrugat, Roberto Elosua, Ruth McPherson, Martin Farrall, Hugh Watkins, Eric S Lander, Daniel J Rader, John Danesh, Diego Ardissino, Stacey Gabriel, Cristen Willer, Gonçalo R Abecasis, Danish Saleheen, Frederick E Dewey, Sekar Kathiresan, DiscovEHR Study Group, CARDIoGRAM Exome Consortium, and Global Lipids Genetics Consortium Myocardial Infarction Genetics Consortium
Jun 25, 2018
IMPORTANCE: The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic...
W404-010J-01 - Office of the Vice President for Academic Affairs: Office of Sponsored Programs and Research (SPAR): Correspondence and Memoranda
Office of Vice President for Academic Affairs, Sponsored Programs and Research, Office of, Grants and Sponsored Research Development, Office of
Jan 01, 0001
Published by: Winthrop University
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
Tanya M Teslovich, Daniel Seung Kim, Xianyong Yin, Alena Stancáková, Anne U Jackson, Matthias Wielscher, Adam Naj, John RB Perry, Jeroen R Huyghe, Heather M Stringham, James P Davis, Chelsea K Raulerson, Ryan P Welch, Christian Fuchsberger, Adam E Locke, Xueling Sim, Peter S Chines, Narisu Narisu, Antti J Kangas, Pasi Soininen, The Alzheimer's Disease Genetics Consortium (ADGC), The DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Genetics of Obesity-Related Liver Disease Consortium (GOLD), Mika Ala-Korpela, Vilmundur Gudnason, Solomon K Musani, Marjo-Riitta Jarvelin, Gerard D Schellenberg, Elizabeth K Speliotes, Johanna Kuusisto, Francis S Collins, Michael Boehnke, Markku Laakso, Karen L Mohlke
Oct 01, 2018
Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic...
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