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Surveillance arterioveNous fistulAs using ultRasound (SONAR) trial in haemodialysis patients
James Richards, Mohammed Hossain, Dominic Summers, Matthew Slater, Matthew Bartlett, Vasilis Kosmoliaptsis, Edward Cf Wilson, Regin Lagaac, Anna Sidders, Claire Foley, Emma Laing, Valerie Hopkins, Chloe Fitzpatrick-Creamer, Cara Hudson, Helen Thomas, Sam Turner, Andrew Tambyraja, Subash Somalanka, James Hunter, Sam Dutta, Sarah Lawman, Tracey Salter, Mohammed Aslam, Atul Bagul, Rajesh Sivaprakasam, George Smith, Zia Moinuddin, Simon Knight, Paul Gibbs, Reza Motallebzadeh, Nicholas Barnett, Gavin Pettigrew, SONAR trial group
Oct 21, 2019
INTRODUCTION: Arteriovenous fistulas (AVFs) are considered the best and safest modality for providing haemodialysis in patients with end-stage renal disease. Only 20% of UK centres achieve the recommended 80% target for...
The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.
Vickie S Braithwaite, Sarah R Crozier, Stefania D'Angelo, Ann Prentice, Cyrus Cooper, Nicholas C Harvey, Kerry S Jones, MAVIDOS Trial Group
Feb 18, 2019
Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D₃ supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK...
C-Reactive Protein vitamin D ferritin Hepcidin Inflammation Pregnancy Adult Anemia Iron-Deficiency C-Reactive Protein Cholecalciferol Dietary Supplements Double-Blind Method Female Ferritins Hepcidins Humans Inflammation Iron Nutritional Status Pregnancy Pregnancy Complications Pregnancy Trimesters Seasons vitamin D Vitamin D Deficiency Young Adult
Sonar target enhancement by shrinkage of incoherent wavelet coefficients
Background reverberation can obscure useful features of the target echo response in broadband low-frequency sonar images, adversely affecting detection and classification performance. This paper describes a resolution and...
Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT).
Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors Area Under Curve Atorvastatin Biomarkers Cardiomyopathies Diabetes mellitus Type 1 Diabetic Nephropathies Double-Blind Method Drug Therapy Combination Dyslipidemias Female Follow-Up Studies Heptanoic Acids Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Multicenter Studies as Topic Puberty Pyrroles Quinapril Randomized Controlled Trials as Topic Research Design risk Tetrahydroisoquinolines
Pregnancy Vitamin D Supplementation and Childhood Bone Mass at Age 4 Years
Elizabeth M Curtis, Rebecca J Moon, Stefania D'Angelo, Sarah R Crozier, Nicholas J Bishop, Jaya Sujatha Gopal-Kothandapani, Stephen H Kennedy, Aris T Papageorghiou, Robert Fraser, Saurabh V Gandhi, Inez Schoenmakers, Ann Prentice, Hazel M Inskip, Keith M Godfrey, M Kassim Javaid, Richard Eastell, Cyrus Cooper, Nicholas C Harvey, MAVIDOS Trial Group
Aug 21, 2022
In the Maternal Vitamin D Osteoporosis Study (MAVIDOS) randomized trial, vitamin D supplementation in pregnancy did not lead to greater neonatal bone mass across the trial as a whole, but, in a prespecified secondary analysis by...
Study protocol: baby-OSCAR trial
Samir Gupta, Edmund Juszczak, Pollyanna Hardy, Nimish Subhedar, Jonathan Wyllie, Wilf Kelsall, Sunil Sinha, Sam Johnson, Tracy Roberts, Elisabeth Hutchison, Justine Pepperell, Louise Linsell, Jennifer L Bell, Kayleigh Stanbury, Marketa Laube, Clare Edwards, David Field, ‘The Baby-OSCAR Collaborative Group’
Jul 30, 2021
BACKGROUND: The question of whether to treat patent ductus arteriosus (PDA) early or wait until symptoms appear remains high on the research agenda for neonatal medicine. Around 7000 extremely preterm babies under 29 weeks'...
bronchopulmonary dysplasia Echocardiography Ibuprofen Newborn PDA patent ductus arteriosus Preterm bronchopulmonary dysplasia Ductus Arteriosus Patent Humans Ibuprofen Infant Infant Low Birth Weight Infant Newborn Infant Premature Diseases Multicenter Studies as Topic Randomized Controlled Trials as Topic
Sonar target enhancement by shrinkage of incoherent wavelet coefficients
Background reverberation can obscure useful features of the target echo response in broadband low-frequency sonar images, adversely affecting detection and classification performance. This paper describes a resolution and...
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, Christine Baumgartner, Nicolas Rodondi, William H Smithson, Patricia M Kearney
Mar 02, 2020
Background: While there is an increasing consensus that clinical trial results should be shared with trial participants, there is a lack of evidence on the most appropriate methods. The aim of this study is to use a patient and...
patient and public involvement Research Dissemination SWAT Study Results Study within a trial Clinical trial result dissemination Patient Involvement In Clinical Trials Trial Results.
Published by: HRB Open Research
Group sequential crossover trial designs with strong control of the familywise error rate.
Crossover designs are an extremely useful tool to investigators, and group sequential methods have proven highly proficient at improving the efficiency of parallel group trials. Yet, group sequential methods and crossover...
Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair
Michael J Sweeting, Rajesh Patel, Janet T Powell, Roger M Greenhalgh, EVAR Trial Investigators
Dec 06, 2017
OBJECTIVE: The aim of the study was to compare long-term total and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) randomized to either early endovascular aneurysm repair (EVAR) or...
Study within a trial (SWAT) protocol. Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, William H Smithson, Patricia M Kearney
Jan 18, 2018
INTRODUCTION: Dissemination of results of randomised controlled trials is traditionally limited to academic and professional groups rather than clinical trial participants. While there is increasing consensus that results should...
The ProtecT trial
Richard J Bryant, Jon Oxley, Grace J Young, Janet A Lane, Chris Metcalfe, Michael Davis, Emma L Turner, Richard M Martin, John R Goepel, Murali Varma, David F Griffiths, Ken Grigor, Nick Mayer, Anne Y Warren, Selina Bhattarai, John Dormer, Malcolm Mason, John Staffurth, Eleanor Walsh, Derek J Rosario, James WF Catto, David E Neal, Jenny L Donovan, Freddie C Hamdy, ProtecT study group
May 19, 2020
OBJECTIVE: To test the hypothesis that the baseline clinico-pathological features of the men with localized prostate cancer (PCa) included in the ProtecT (Prostate Testing for Cancer and Treatment) trial who progressed (n = 198)...
Sequential screening for lung cancer in a high-risk group: randomised controlled trial: LungSEARCH
Stephen G Spiro, Pallav L Shah, Robert C Rintoul, Jeremy George, Samuel Janes, Matthew Callister, Marco Novelli, Penny Shaw, Gabrijela Kocjan, Chris Griffiths, Mary Falzon, Richard Booton, Nicholas Magee, Michael Peake, Paul Dhillon, Kishore Sridharan, Andrew G Nicholson, Simon Padley, Magali N Taylor, Asia Ahmed, Jack Allen, Yenting Ngai, Nyasha Chinyanganya, Victoria Ashford-Turner, Sarah Lewis, Dahmane Oukrif, Pamela Rabbitts, Nicholas Counsell, Allan Hackshaw
Feb 08, 2021
BACKGROUND: Low-dose computed tomography (LDCT) screening detects early-stage lung cancer and reduces mortality. We proposed a sequential approach targeted to a high-risk group as a potentially efficient screening strategy....
Adenocarcinoma of Lung Bronchoscopy Carcinoma Large Cell Carcinoma Non-Small-Cell Lung Carcinoma Small Cell Carcinoma Squamous Cell Cytological Techniques Early Detection of Cancer Female Humans Lung Neoplasms Male Middle Aged Neoplasm Staging Optical Imaging Pulmonary Disease Chronic Obstructive Risk Assessment Sensitivity and Specificity Sputum Tomography X-Ray Computed United Kingdom
The Max-Min Group Contest
We investigate a group all-pay auction in which each group's effort is represented by the minimum among the effort levels exerted by the group members and the prize is a group-specific public good. We fully characterize the...
Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study)
Joseph Shalhoub, Rebecca Lawton, Jemma Hudson, Christopher Baker, Andrew Bradbury, Karen Dhillon, Tamara Everington, Manjit S Gohel, Zaed Hamady, Beverley J Hunt, Gerrard Stansby, David Warwick, John Norrie, Alun H Davies, GAPS trial investigators
May 15, 2020
OBJECTIVES: To investigate whether the use of graduated compression stockings (GCS) offers any adjuvant benefit when pharmaco-thromboprophylaxis is used for venous thromboembolism prophylaxis in patients undergoing elective...
Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial
Angelos G Kolias, Ellie Edlmann, Eric P Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J Hutchinson, British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Feb 07, 2019
BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20%...
chronic subdural haematoma Dexamethasone Neurology Neurosurgery Randomised control trial Cost-Benefit Analysis Dexamethasone Double-Blind Method Drug Administration Schedule Drug Costs Glucocorticoids Hematoma Subdural Chronic Humans Multicenter Studies as Topic Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
The Max-Min Group Contest
We investigate a group all-pay auction in which each group's effort is represented by the minimum among the effort levels exerted by the group members and the prize is a group-specific public good. We fully characterize the...
Research in progress--LungSEARCH
UNLABELLED: Low-dose CT screening for lung cancer is effective but expensive. Therefore, cheaper or more focused screening strategies may be required. LungSEARCH is a randomised prospective trial of 1568 high-risk individuals...
The COSI trial
Camilla Rosan, Kim Alyousefi-van Dijk, Zoe Darwin, Daphne Babalis, Victoria Cornelius, Rachel Phillips, Lani Richards, Hannah Wright, Steve Pilling, Pasco Fearon, Elena Pizzo, Peter Fonagy
Mar 14, 2023
BACKGROUND: Perinatal mental health difficulties affect up to 27% of birthing parents during pregnancy and the first postnatal year, and if untreated are associated with difficulties in bonding and long-term adverse outcomes to...
Child Attachment Child Development Circle Of Security-parenting Parent-infant Bonding Perinatal mental health randomised controlled trial Child Female Pregnancy Humans Parenting Cost-Benefit Analysis Quality of life Single-Blind Method England Community Mental Health Services Randomized Controlled Trials as Topic Multicenter Studies as Topic
The COSI trial
Camilla Rosan, Kim Alyousefi-van Dijk, Zoe Darwin, Daphne Babalis, Victoria Cornelius, Rachel Phillips, Lani Richards, Hannah Wright, Steve Pilling, Pasco Fearon, Elena Pizzo, Peter Fonagy
Apr 13, 2023
Background
Perinatal mental health difficulties affect up to 27% of birthing parents during pregnancy and the first postnatal year, and if untreated are associated with difficulties in bonding and long-term adverse...
Child Development randomised controlled trial Perinatal mental health Child Attachment Circle Of Security-parenting Parent-infant Bonding Humans Single-Blind Method Parenting Community Mental Health Services Pregnancy Quality of life Child Cost-Benefit Analysis England Female Multicenter Studies as Topic Randomized Controlled Trials as Topic
Published by: Trials
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis
Rachel B Jones, Thomas F Hiemstra, Jose Ballarin, Daniel Engelbert Blockmans, Paul Brogan, Annette Bruchfeld, Maria C Cid, Karen Dahlsveen, Janak De Zoysa, Georgína Espigol-Frigolé, Peter Lanyon, Chen Au Peh, Vladimir Tesar, Augusto Vaglio, Michael Walsh, Dorothy Walsh, Giles Walters, Lorraine Harper, David Jayne, European Vasculitis Study Group (EUVAS)
Feb 06, 2019
OBJECTIVES: Cyclophosphamide induction regimens are effective for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but are associated with infections, malignancies and infertility. Mycophenolate mofetil...
ANCA-associated vasculitis cyclophosphamide induction therapy mycophenolate Randomised trial Adolescent Adult Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Azathioprine Child cyclophosphamide Female Humans Immunosuppressive Agents Induction Chemotherapy Male Mycophenolic Acid Recurrence Treatment Outcome
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