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Value of risk scores in the decision to palliate patients with ruptured abdominal aortic aneurysm.
Editor's Choice - Re-interventions After Repair of Ruptured Abdominal Aortic Aneurysm
Janet T Powell, Michael J Sweeting, Pinar Ulug, Matthew M Thompson, Robert J Hinchliffe, IMPROVE Trial Investigators
May 25, 2018
OBJECTIVE/BACKGROUND: The aim was to describe the re-interventions after endovascular and open repair of rupture, and investigate whether these were associated with aortic morphology. METHODS: In total, 502 patients from the...
Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair
Michael J Sweeting, Rajesh Patel, Janet T Powell, Roger M Greenhalgh, EVAR Trial Investigators
Dec 06, 2017
OBJECTIVE: The aim of the study was to compare long-term total and aneurysm-related mortality in physically frail patients with abdominal aortic aneurysm (AAA) randomized to either early endovascular aneurysm repair (EVAR) or...
Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening.
SG Thompson, HA Ashton, L Gao, MJ Buxton, RAP Scott, Multicentre Aneurysm Screening Study (MASS) Group
Jan 27, 2020
BACKGROUND: The long-term effects of abdominal aortic aneurysm (AAA) screening were investigated in extended follow-up from the UK Multicentre Aneurysm Screening Study (MASS) randomized trial. METHODS: A population-based sample...
Discrete Event Simulation for Decision Modeling in Health Care
Matthew J Glover, Edmund Jones, Katya L Masconi, Michael J Sweeting, Simon G Thompson, SWAN collaborators, SWAN Collaborative Group
May 24, 2018
Markov models are often used to evaluate the cost-effectiveness of new healthcare interventions but they are sometimes not flexible enough to allow accurate modeling or investigation of alternative scenarios and policies. A...
Abdominal aortic aneurysms part two
Large, symptomatic and ruptured abdominal aortic aneurysms are usually treated surgically if patients are deemed fit enough. This may be achieved through endovascular or open surgical repair. The type of treatment that a patient...
Indocyanine green fluorescence video angiography reduces vascular injury–related morbidity during micro-neurosurgical clipping of ruptured cerebral aneurysms
Tamara Tajsic, James Cullen, Mathew Guilfoyle, Adel Helmy, Ramez Kirollos, Peter Kirkpatrick, Rikin Trivedi
Sep 05, 2020
Abstract: Background: Specific procedural complications in aneurysm surgery are broadly related to vascular territory compromise and brain/nerve retraction; vascular complications account for about half of this. Intraoperative...
Indocyanine green fluorescence video angiography reduces vascular injury-related morbidity during micro-neurosurgical clipping of ruptured cerebral aneurysms
Tamara Tajsic, James Cullen, Mathew Guilfoyle, Adel Helmy, Ramez Kirollos, Peter Kirkpatrick, Rikin Trivedi
Sep 09, 2019
BACKGROUND: Specific procedural complications in aneurysm surgery are broadly related to vascular territory compromise and brain/nerve retraction; vascular complications account for about half of this. Intraoperative indocyanine...
Cerebral aneurysm Clipping Indocyanine green video angiography (ICG-VA) subarachnoid haemorrhage Adult Aged Aneurysm Ruptured Cerebral Angiography Female Fluorescent Dyes Humans Indocyanine Green Intracranial Aneurysm Intraoperative Complications Male Microsurgery Middle Aged Monitoring Intraoperative Vascular Surgical Procedures
Risk of Aneurysm Rupture (ROAR) study
Samuel Hall, Jacqueline Birks, Ian Anderson, Andrew Bacon, Paul M Brennan, David Bennett, Emmanuel Chavredakis, Giles Critchley, Graham Dow, Jonathan Downer, James Galea, Patrick Grover, Nihal Gurusinghe, Adel Helmy, Gueorgui Kounin, Nitin Mukerji, Hiren Patel, Jash Patel, Nicholas Ross, Jerome St George, Mario Teo, Christos Michael Tolias, Nikolaos Tzerakis, Christopher Uff, Janneke van Beijum, Kristin Veighey, Edward White, Peter Whitfield, Diederik Oliver Bulters
Apr 17, 2023
Introduction
Unruptured intracranial aneurysms (UIA) are common in the adult population, but only a relatively small proportion will rupture. It is therefore essential to have accurate estimates of rupture risk to target...
stroke EPIDEMIOLOGY Neurosurgery Humans Intracranial Aneurysm Subarachnoid Hemorrhage Aneurysm Ruptured Risk Factors Adult Multicenter Studies as Topic United Kingdom
Published by: BMJ Open
Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial
Angelos G Kolias, Ellie Edlmann, Eric P Thelin, Diederik Bulters, Patrick Holton, Nigel Suttner, Kevin Owusu-Agyemang, Yahia Z Al-Tamimi, Daniel Gatt, Simon Thomson, Ian A Anderson, Oliver Richards, Peter Whitfield, Monica Gherle, Karen Caldwell, Carol Davis-Wilkie, Silvia Tarantino, Garry Barton, Hani J Marcus, Aswin Chari, Paul Brennan, Antonio Belli, Simon Bond, Carole Turner, Lynne Whitehead, Ian Wilkinson, Peter J Hutchinson, British Neurosurgical Trainee Research Collaborative (BNTRC) and Dex-CSDH Trial Collaborators
Feb 07, 2019
BACKGROUND: Chronic subdural haematoma (CSDH) is a common neurosurgical condition, typically treated with surgical drainage of the haematoma. However, surgery is associated with mortality and morbidity, including up to 20%...
chronic subdural haematoma Dexamethasone Neurology Neurosurgery Randomised control trial Cost-Benefit Analysis Dexamethasone Double-Blind Method Drug Administration Schedule Drug Costs Glucocorticoids Hematoma Subdural Chronic Humans Multicenter Studies as Topic Randomized Controlled Trials as Topic Time Factors Treatment Outcome United Kingdom
What Factors Determine Treatment Outcome in Aneurysmal Subarachnoid Hemorrhage in the Modern Era? A Post Hoc STASH Analysis.
BACKGROUND: The management of aneurysmal subarachnoid hemorrhage (aSAH) has changed dramatically in the last few decades with the publication of a few major studies, including ISAT (International Subarachnoid Aneurysm Trial, the...
Endovascular coiling Neurosurgical clipping Post hoc analysis Propensity matched analysis aSAH Adolescent Adult Age Factors Aged Angiography Digital Subtraction Anticholesteremic Agents Endovascular Procedures Female Humans International Cooperation Intracranial Aneurysm Male Middle Aged Outcome Assessment Health Care Regression Analysis Risk Factors Simvastatin Subarachnoid Hemorrhage Tomography Scanners X-Ray Computed Treatment Outcome Young Adult
Graduated compression stockings as adjuvant to pharmaco-thromboprophylaxis in elective surgical patients (GAPS study)
Joseph Shalhoub, Rebecca Lawton, Jemma Hudson, Christopher Baker, Andrew Bradbury, Karen Dhillon, Tamara Everington, Manjit S Gohel, Zaed Hamady, Beverley J Hunt, Gerrard Stansby, David Warwick, John Norrie, Alun H Davies, GAPS trial investigators
May 15, 2020
OBJECTIVES: To investigate whether the use of graduated compression stockings (GCS) offers any adjuvant benefit when pharmaco-thromboprophylaxis is used for venous thromboembolism prophylaxis in patients undergoing elective...
External data required timely response by the Trial Steering-Data Monitoring Committee for the NALoxone InVEstigation (N-ALIVE) pilot trial
The prison-based N-ALIVE pilot trial had undertaken to notify the Research Ethics Committee and participants if we had reason to believe that the N-ALIVE pilot trial would not proceed to the main trial. In this paper, we...
A mycotic aneurysm related to Salmonella Rissen infection
Abstract: Background: Salmonella species commonly causes infection in humans and on occasion leads to serious complications, such as mycotic aneurysms. Here, we present the first case reported of a patient with a mycotic...
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
JT Powell, MJ Sweeting, P Ulug, JD Blankensteijn, FA Lederle, J-P Becquemin, RM Greenhalgh, DREAM, OVER and ACE Trialists EVAR-1
Nov 13, 2017
BACKGROUND: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS: An...
Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production.
Andreas Giraud, Lynda Zeboudj, Marie Vandestienne, Jérémie Joffre, Bruno Esposito, Stéphane Potteaux, José Vilar, Daniela Cabuzu, Johannes Kluwe, Sylvie Seguier, Alain Tedgui, Ziad Mallat, Antoine Lafont, Hafid Ait-Oufella
Apr 09, 2019
AIMS: Abdominal aortic aneurysm (AAA), frequently diagnosed in old patients, is characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix destruction. Despite improvement...
abdominal aortic aneurysm Cell therapy Gingival fibroblasts Metalloproteases Remodelling Angiotensin II Animals Aorta Abdominal Aortic Aneurysm Abdominal Aortic Rupture Disease Models Animal Extracellular Matrix FIBROBLASTS Gingiva Mice Inbred C57BL Mice Knockout Protective Agents Tissue Inhibitor of Metalloproteinase-1 Transforming Growth Factor beta
Abdominal aortic aneurysms part one
An abdominal aortic aneurysm is an irreversible dilatation of the abdominal aorta. The majority of abdominal aortic aneurysms are asymptomatic and identified incidentally while investigating a separate pathology. Others are...
A mycotic aneurysm related to Salmonella Rissen infection
BACKGROUND: Salmonella species commonly causes infection in humans and on occasion leads to serious complications, such as mycotic aneurysms. Here, we present the first case reported of a patient with a mycotic aneurysm likely...
A mycotic aneurysm related to Salmonella Rissen infection
BACKGROUND:Salmonella species commonly causes infection in humans and on occasion leads to serious complications, such as mycotic aneurysms. Here, we present the first case reported of a patient with a mycotic aneurysm likely...
Published by: BMC infectious diseases
The Positive Choices trial
Ruth Ponsford, Rebecca Meiksin, Elizabeth Allen, GJ Melendez-Torres, Stephen Morris, Catherine Mercer, Rona Campbell, Honor Young, Maria Lohan, Karin Coyle, Chris Bonell
Nov 22, 2021
BACKGROUND: Positive Choices is a whole-school social marketing intervention to promote sexual health among secondary school students. Intervention comprises school health promotion council involving staff and students...
The Positive Choices trial
Ruth Ponsford, Rebecca Meiksin, Elizabeth Allen, GJ Melendez-Torres, Steve Morris, Catherine Mercer, Rona Campbell, Honor Young, Maria Lohan, Karin Coyle, Chris Bonell
Apr 11, 2022
BACKGROUND: Positive Choices is a whole-school social marketing intervention to promote sexual health among secondary school students. Intervention comprises school health promotion council involving staff and students...
ADOLESCENTS Cluster trials Pregnancy Public Health Schools Sexual competence Sexual health Sexually Transmitted Infections Whole-school Adolescent Child Female Health Status Disparities Humans Male Pregnancy Randomized Controlled Trials as Topic School Health Services Schools Sexual health Social Marketing
An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH)
The Positive Choices trial
Ruth Ponsford, Rebecca Meiksin, Elizabeth Allen, GJ Melendez-Torres, Stephen Morris, Catherine Mercer, Rona Campbell, Honor Young, Maria Lohan, Karin Coyle, Chris Bonell
Jan 07, 2022
BACKGROUND: Positive Choices is a whole-school social marketing intervention to promote sexual health among secondary school students. Intervention comprises school health promotion council involving staff and students...
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