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Results: 1879
Consensus for genes to be included on cancer panel tests offered by UK genetics services
Amy Taylor, Angela F Brady, Ian M Frayling, Helen Hanson, Marc Tischkowitz, Clare Turnbull, Lucy Side, UK Cancer Genetics Group (UK-CGG)
May 18, 2018
Genetic testing for hereditary cancer predisposition has evolved rapidly in recent years with the discovery of new genes, but there is much debate over the clinical utility of testing genes for which there are currently limited...
Diffuse Intracranial Injury Patterns Are Associated with Impaired Cerebrovascular Reactivity in Adult Traumatic Brain Injury
Frederick A Zeiler, François Mathieu, Miguel Monteiro, Ben Glocker, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Nino Stocchetti, Peter Smielewski, Marek Czosnyka, Virginia Newcombe, David K Menon, the CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Feb 28, 2020
Recent single-center retrospective analysis displayed the association between admission computed tomography (CT) markers of diffuse intracranial injury and worse cerebrovascular reactivity. The goal of this study was to further...
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe
Jilske A Huijben, Eveline JA Wiegers, Hester F Lingsma, Giuseppe Citerio, Andrew IR Maas, David K Menon, Ari Ercole, David Nelson, Mathieu van der Jagt, Ewout W Steyerberg, Raimund Helbok, Fiona Lecky, Wilco Peul, Tatiana Birg, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, CENTER-TBI Investigators and Participants
Feb 12, 2020
PURPOSE: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. METHODS: This is a prospective...
Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury
Charlie Aletta Sewalt, Benjamin Yaël Gravesteijn, David Menon, Hester Floor Lingsma, Andrew IR Maas, Nino Stocchetti, Esmee Venema, Fiona E Lecky, CENTER TBI Participants and Investigators
Aug 26, 2021
BACKGROUND: Prehospital care for patients with traumatic brain injury (TBI) varies with some emergency medical systems recommending direct transport of patients with moderate to severe TBI to hospitals with specialist...
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Derek Klarin, Scott M Damrauer, Kelly Cho, Yan V Sun, Tanya M Teslovich, Jacqueline Honerlaw, David R Gagnon, Scott L DuVall, Jin Li, Gina M Peloso, Mark Chaffin, Aeron M Small, Jie Huang, Hua Tang, Julie A Lynch, Yuk-Lam Ho, Dajiang J Liu, Connor A Emdin, Alexander H Li, Jennifer E Huffman, Jennifer S Lee, Pradeep Natarajan, Rajiv Chowdhury, Danish Saleheen, Marijana Vujkovic, Aris Baras, Saiju Pyarajan, Emanuele Di Angelantonio, Benjamin M Neale, Aliya Naheed, Amit V Khera, John Danesh, Kyong-Mi Chang, Gonçalo Abecasis, Cristen Willer, Frederick E Dewey, David J Carey, Global Lipids Genetics Consortium, Myocardial Infarction Genetics (MIGen) Consortium, Geisinger-Regeneron DiscovEHR Collaboration, VA Million Veteran Program, John Concato, J Michael Gaziano, Christopher J O'Donnell, Philip S Tsao, Sekar Kathiresan, Daniel J Rader, Peter WF Wilson, Themistocles L Assimes
Sep 08, 2018
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a...
Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients
François Mathieu, Frederick A Zeiler, Ari Ercole, Miguel Monteiro, Konstantinos Kamnitsas, Ben Glocker, Daniel P Whitehouse, Tilak Das, Peter Smielewski, Marek Czosnyka, Peter J Hutchinson, Virginia FJ Newcombe, David K Menon, CENTER-TBI High Resolution Sub-Study Participants and Investigators
May 05, 2020
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may...
cerebral autoregulation Intracranial hemorrhage Traumatic brain injury Adult Brain Injuries Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Disease Progression Europe Female Humans Intensive Care Units Intersectoral Collaboration Male Middle Aged Tomography X-Ray Computed Treatment Outcome
Exome-wide association study to identify rare variants influencing COVID-19 outcomes
Guillaume Butler-Laporte, Gundula Povysil, Jack A Kosmicki, Elizabeth T Cirulli, Theodore Drivas, Simone Furini, Chadi Saad, Axel Schmidt, Pawel Olszewski, Urszula Korotko, Mathieu Quinodoz, Elifnaz Çelik, Kousik Kundu, Klaudia Walter, Junghyun Jung, Amy D Stockwell, Laura G Sloofman, Daniel M Jordan, Ryan C Thompson, Diane Del Valle, Nicole Simons, Esther Cheng, Robert Sebra, Eric E Schadt, Seunghee Kim-schulze, Sacha Gnjatic, Miriam Merad, Joseph D Buxbaum, Noam D Beckmann, Alexander W Charney, Bartlomiej Przychodzen, Timothy Chang, Tess D Pottinger, Ning Shang, Fabian Brand, Francesca Fava, Francesca Mari, Karolina Chwialkowska, Magdalena Niemira, Szymon Pula, J Kenneth Baillie, Alex Stuckey, Antonio Salas, Xabier Bello, Jacobo Pardo-Seco, Alberto Gómez-Carballa, Irene Rivero-Calle, Federico Martinón-Torres, Andrea Ganna, Konrad J Karczewski, Kumar Veerapen, Mathieu Bourgey, Guillaume Bourque, Robert Jm Eveleigh, Vincenzo Forgetta, David Morrison, David Langlais, Mark Lathrop, Vincent Mooser, Tomoko Nakanishi, Robert Frithiof, Michael Hultström, Miklos Lipcsey, Yanara Marincevic-Zuniga, Jessica Nordlund, Kelly M Schiabor Barrett, William Lee, Alexandre Bolze, Simon White, Stephen Riffle, Francisco Tanudjaja, Efren Sandoval, Iva Neveux, Shaun Dabe, Nicolas Casadei, Susanne Motameny, Manal Alaamery, Salam Massadeh, Nora Aljawini, Mansour S Almutairi, Yaseen M Arabi, Saleh A Alqahtani, Fawz S Al Harthi, Amal Almutairi, Fatima Alqubaishi, Sarah Alotaibi, Albandari Binowayn, Ebtehal A Alsolm, Hadeel El Bardisy, Mohammad Fawzy, Fang Cai, Nicole Soranzo, Adam Butterworth, COVID-19 Host Genetics Initiative, DeCOI Host Genetics Group, GEN-COVID Multicenter Study (Italy), Mount Sinai Clinical Intelligence Center, GEN-COVID consortium (Spain), GenOMICC Consortium, Japan COVID-19 Task Force, Regeneron Genetics Center, Daniel H Geschwind, Stephanie Arteaga, Alexis Stephens, Manish J Butte, Paul C Boutros, Takafumi N Yamaguchi, Shu Tao, Stefan Eng, Timothy Sanders, Paul J Tung, Michael E Broudy, Yu Pan, Alfredo Gonzalez, Nikhil Chavan, Ruth Johnson, Bogdan Pasaniuc, Brian Yaspan, Sandra Smieszek, Carlo Rivolta, Stephanie Bibert, Pierre-Yves Bochud, Maciej Dabrowski, Pawel Zawadzki, Mateusz Sypniewski, Elżbieta Kaja, Pajaree Chariyavilaskul, Voraphoj Nilaratanakul, Nattiya Hirankarn, Vorasuk Shotelersuk, Monnat Pongpanich, Chureerat Phokaew, Wanna Chetruengchai, Katsushi Tokunaga, Masaya Sugiyama, Yosuke Kawai, Takanori Hasegawa, Tatsuhiko Naito, Ho Namkoong, Ryuya Edahiro, Akinori Kimura, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada, Seiya Imoto, Satoru Miyano, Serghei Mangul, Malak S Abedalthagafi, Hugo Zeberg, Joseph J Grzymski, Nicole L Washington, Stephan Ossowski, Kerstin U Ludwig, Eva C Schulte, Olaf Riess, Marcin Moniuszko, Miroslaw Kwasniewski, Hamdi Mbarek, Said I Ismail, Anurag Verma, David B Goldstein, Krzysztof Kiryluk, Alessandra Renieri, Manuel AR Ferreira, J Brent Richards
Dec 08, 2022
Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However...
Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe
Jilske A. Huijben, Eveline J. A. Wiegers, Hester F. Lingsma, Giuseppe Citerio, Andrew I. R. Maas, David K. Menon, Ari Ercole, David Nelson, Mathieu van der Jagt, Ewout W. Steyerberg, Raimund Helbok, Fiona Lecky, Wilco Peul, Tatiana Birg, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Ana M. Castaño-León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Véronique DeKeyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Dulière, Erzsébet Ezer, Martin Fabricius, Kelly Foks, Shirin Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro A. Gomez, Francesca Grossi, Deepak Gupta, Iain Haitsma, Eirik Helseth, Peter J. Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, AngelosG. Kolias, Daniel Kondziella, Evgenios Koraropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Steven Laureys, Didier Ledoux, Aurelie Lejeune, Roger Lightfoot, Alex Manara, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, Virginia Newcombe, József Nyirádi, Fabrizio Ortolano, Jean-François Payen, Vincent Perlbarg, Paolo Persona, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oddrun Sandrød, Oliver Sakowitz, Renan Sanchez-Porras, Kari Schirmer-Mikalsen, Rico Frederik Schou, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, CristinaMaria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Gregory Van der Steen, Roel P. J. van Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Petar Vulekovic, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick A. Zeiler, Agate Ziverte Hans Clusmann, Daphne Voormolen, Jeroen T. J. M. van Dijck, Thomas A. van Essen
Feb 24, 2021
Abstract: Purpose: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. Methods: This is a...
Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients
Ernest van Veen, Mathieu van der Jagt, Giuseppe Citerio, Nino Stocchetti, Diederik Gommers, Alex Burdorf, David K Menon, Andrew IR Maas, Erwin JO Kompanje, Hester F Lingsma, CENTER-TBI Investigators and Participants
Nov 05, 2021
BACKGROUND: In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting WLSM too early could result in death despite the...
Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe
Jilske A. Huijben, Eveline J. A. Wiegers, Hester F. Lingsma, Giuseppe Citerio, Andrew I. R. Maas, David K. Menon, Ari Ercole, David Nelson, Mathieu van der Jagt, Ewout W. Steyerberg, Raimund Helbok, Fiona Lecky, Wilco Peul, Tatiana Birg, Tommaso Zoerle, Marco Carbonara, Nino Stocchetti, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Ana M. Castaño-León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Véronique DeKeyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Dulière, Erzsébet Ezer, Martin Fabricius, Kelly Foks, Shirin Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro A. Gomez, Francesca Grossi, Deepak Gupta, Iain Haitsma, Eirik Helseth, Peter J. Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, AngelosG. Kolias, Daniel Kondziella, Evgenios Koraropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Steven Laureys, Didier Ledoux, Aurelie Lejeune, Roger Lightfoot, Alex Manara, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, Virginia Newcombe, József Nyirádi, Fabrizio Ortolano, Jean-François Payen, Vincent Perlbarg, Paolo Persona, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oddrun Sandrød, Oliver Sakowitz, Renan Sanchez-Porras, Kari Schirmer-Mikalsen, Rico Frederik Schou, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, CristinaMaria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Gregory Van der Steen, Roel P. J. van Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Petar Vulekovic, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick A. Zeiler, Agate Ziverte Hans Clusmann, Daphne Voormolen, Jeroen T. J. M. van Dijck, Thomas A. van Essen
Jun 06, 2020
Abstract: Purpose: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. Methods: This is a...
Descriptive analysis of low versus elevated intracranial pressure on cerebral physiology in adult traumatic brain injury
Frederick A Zeiler, Ari Ercole, Manuel Cabeleira, Nino Stocchetti, Peter J Hutchinson, Peter Smielewski, Marek Czosnyka, CENTER-TBI High Resolution (HR ICU) Sub-Study Participants and Investigators
Nov 11, 2020
BACKGROUND: To date, the cerebral physiologic consequences of persistently elevated intracranial pressure (ICP) have been based on either low-resolution physiologic data or retrospective high-frequency data from single centers....
Quality indicators for patients with traumatic brain injury in European intensive care units
Jilske A Huijben, Eveline JA Wiegers, Ari Ercole, Nicolette F de Keizer, Andrew IR Maas, Ewout W Steyerberg, Giuseppe Citerio, Lindsay Wilson, Suzanne Polinder, Daan Nieboer, David Menon, Hester F Lingsma, Mathieu van der Jagt, CENTER-TBI investigators and participants for the ICU stratum
Feb 17, 2020
BACKGROUND: The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study...
Association between Cerebrovascular Reactivity Monitoring and Mortality Is Preserved When Adjusting for Baseline Admission Characteristics in Adult Traumatic Brain Injury
Frederick A Zeiler, Ari Ercole, Erta Beqiri, Manuel Cabeleira, Eric P Thelin, Nino Stocchetti, Ewout W Steyerberg, Andrew IR Maas, David K Menon, Marek Czosnyka, Peter Smielewski, CENTER-TBI High Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Nov 25, 2019
Cerebral autoregulation, as measured using the pressure reactivity index (PRx), has been related to global patient outcome in adult patients with traumatic brain injury (TBI). To date, this has been documented without accounting...
Mapping the human genetic architecture of COVID-19.
COVID-19 Host Genetics Initiative
Jan 05, 2022
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of...
Autoimmunity Body Mass Index covid-19 Critical Illness Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Geographic Mapping Hospitalization Host-Pathogen Interactions Humans Inflammation Information Dissemination Male Multifactorial Inheritance Racial Groups SARS-CoV-2 Smoking
Association between Physiological Signal Complexity and Outcomes in Moderate and Severe Traumatic Brain Injury
Frederick A Zeiler, Ari Ercole, Michal M Placek, Peter J Hutchinson, Nino Stocchetti, Marek Czosnyka, Peter Smielewski, CENTER-TBI High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Jul 27, 2020
In traumatic brain injury (TBI), preliminary retrospective work on signal entropy suggests an association with global outcome. The goal of this study was to provide multi-center validation of the association between multi-scale...
Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI)
Julia K Böhm, Helge Güting, Sophie Thorn, Nadine Schäfer, Victoria Rambach, Herbert Schöchl, Oliver Grottke, Rolf Rossaint, Simon Stanworth, Nicola Curry, Rolf Lefering, Marc Maegele, CENTER-TBI Participants and Investigators
Sep 10, 2021
BACKGROUND: Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated...
Variation in neurosurgical management of traumatic brain injury
Thomas A van Essen, Hugo F den Boogert, Maryse C Cnossen, Godard CW de Ruiter, Iain Haitsma, Suzanne Polinder, Ewout W Steyerberg, David Menon, Andrew IR Maas, Hester F Lingsma, Wilco C Peul, CENTER-TBI Investigators and Participants
Apr 09, 2020
BACKGROUND: Neurosurgical management of traumatic brain injury (TBI) is challenging, with only low-quality evidence. We aimed to explore differences in neurosurgical strategies for TBI across Europe. METHODS: A survey was sent...
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