Search
Results: 119
Age-dependent electrocardiographic changes in Pgc-1β deficient murine hearts.
Shiraz Ahmad, Haseeb Valli, Samantha C Salvage, Andrew A Grace, Kamalan Jeevaratnam, Christopher L-H Huang
Apr 18, 2018
Increasing evidence implicates chronic energetic dysfunction in human cardiac arrhythmias. Mitochondrial impairment through Pgc-1β knockout is known to produce a murine arrhythmic phenotype. However, the cumulative effect of...
Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse.
Elena Piccinin, Maria Arconzo, Giusi Graziano, Michele Vacca, Claudia Peres, Elena Bellafante, Gaetano Villani, Antonio Moschetta
Feb 03, 2020
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players...
Ageing in Pgc-1β-/- mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology.
Charlotte E Edling, Ibrahim T Fazmin, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Andrew A Grace, Christopher L-H Huang, Kamalan Jeevaratnam
Jun 20, 2019
Mice deficient in mitochondrial promoter peroxisome proliferator activated receptor-γ co-activator-1β (Pgc-1β-/- ) is a valuable model for metabolic diseases and has been found to present with several pathologies including...
Peroxisome proliferator activated receptor-γ coactivator-1 Cardiac arrhythmia gene expression and regulation Ion Channels metabolic syndromes aging Animals Arrhythmias Cardiac Gene Deletion Gene Expression Regulation Heart Ventricles Membrane Potentials Mice Mice Inbred C57BL Mice Knockout Mitochondria Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Transcriptome Ventricular Function
Cardiomyocyte ionic currents in intact young and aged murine Pgc-1β-/- atrial preparations.
Haseeb Valli, Shiraz Ahmad, Anita Y Jiang, Robert Smyth, Kamalan Jeevaratnam, Hugh R Matthews, Christopher L-H Huang
Feb 12, 2018
INTRODUCTION: Recent studies reported that energetically deficient murine Pgc-1β-/- hearts replicate age-dependent atrial arrhythmic phenotypes associated with their corresponding clinical conditions, implicating action...
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
Christel M Middeldorp, Janine F Felix, Anubha Mahajan, EArly Genetics Lifecourse Epidemiology (EAGLE) consortium, Early Growth Genetics (EGG) Consortium, Mark I McCarthy
Jul 18, 2019
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as...
Changes in PGC-1α-Dependent Mitochondrial Biogenesis Are Associated with Inflexible Hepatic Energy Metabolism in the Offspring Born to Dexamethasone-Treated Mothers
In the present study we investigated the participation of hepatic peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) in the metabolic programming of newborn rats exposed in utero to...
Carolina Vieira Campos, Caio Jordão Teixeira, Tanyara Baliani Payolla, Amanda Rabello Crisma, Gilson Masahiro Murata, Andressa Godoy Amaral, Lucas Carminatti Pantaleão, Frhancielly Shirley Sodré, Mariana Mayumi Onari, Lorena de Souza Almeida, Gizela A Pereira, Dimitrius Santiago Simões Fróes Guimarães, Leonardo Reis Silveira, Gabriel Forato Anhê, Silvana Bordin
Oct 13, 2021
Rapid setup and management of medical device design and manufacturing consortia
The COVID‐19 pandemic caused severe ventilator shortages in many healthcare systems worldwide. The UK government reacted to this with a three‐pronged approach of importing, up‐scaling existing production and supporting new...
Published by: R&D Management
Survival Pathways of HIF-Deficient Tumour Cells
Monika A Golinska, Marion Stubbs, Adrian L Harris, Laszlo G Boros, Madhu Basetti, Dominick JO McIntyre, John R Griffiths
Jan 04, 2023
The HIF-1 and HIF-2 (HIF1/2) hypoxia responses are frequently upregulated in cancers, and HIF1/2 inhibitors are being developed as anticancer drugs. How could cancers resist anti-HIF1/2 therapy? We studied metabolic and...
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Charlotte E Edling, Ibrahim T Fazmin, Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L-H Huang, Kamalan Jeevaratnam
Jan 02, 2020
INTRODUCTION:Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP)...
Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.
Man Zhang, Harry G Leitch, Walfred WC Tang, Nicola Festuccia, Elisa Hall-Ponsele, Jennifer Nichols, M Azim Surani, Austin Smith, Ian Chambers
Mar 19, 2018
The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can...
Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction.
Charlotte E Edling, Ibrahim T Fazmin, Khalil Saadeh, Karan R Chadda, Shiraz Ahmad, Haseeb Valli, Christopher L-H Huang, Kamalan Jeevaratnam
Jan 08, 2020
INTRODUCTION: Ageing and chronic metabolic disorders are associated with mitochondrial dysfunction and cardiac pro-arrhythmic phenotypes which were recently attributed to slowed atrial and ventricular action potential (AP)...
Specification and epigenetic programming of the human germ line.
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a unique gene regulatory network in germline-competent...
Germ cell specification and pluripotency in mammals
Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving rise to the next generation in mammals and many other multicellular organisms. How germ cells acquire this ability has been of...
Determinants of the changes in glycemic control with exercise training in type 2 diabetes
Neil M Johannsen, Lauren M. Sparks, Zhengyu Zhang, Conrad Earnest, Steven R. Smith, Timothy S. Church, Eric Ravussin
Jun 21, 2013
AIMS: To assess the determinants of exercise training-induced improvements in glucose control (HbA1C) including changes in serum total adiponectin and FFA concentrations, and skeletal muscle peroxisome proliferator-activated...
Determinants of the changes in glycemic control with exercise training in type 2 diabetes
Neil M Johannsen, Lauren M. Sparks, Zhengyu Zhang, Conrad Earnest, Steven R. Smith, Timothy S. Church, Eric Ravussin
Jun 21, 2013
AIMS: To assess the determinants of exercise training-induced improvements in glucose control (HbA1C) including changes in serum total adiponectin and FFA concentrations, and skeletal muscle peroxisome proliferator-activated...
Comprehensive genetic and functional analyses of Fc gamma receptors influence on response to rituximab therapy for autoimmunity.
James I Robinson, Md Yuzaiful Md Yusof, Vinny Davies, Dawn Wild, Michael Morgan, John C Taylor, Yasser El-Sherbiny, David L Morris, Lu Liu, Andy C Rawstron, Maya H Buch, Darren Plant, Heather J Cordell, John D Isaacs, Ian N Bruce, Paul Emery, Anne Barton, Timothy J Vyse, Jennifer H Barrett, Edward M Vital, Ann W Morgan, MATURA Consortia, MASTERPLANS Consortia
Dec 14, 2022
BACKGROUND: Rituximab is widely used to treat autoimmunity but clinical response varies. Efficacy is determined by the efficiency of B-cell depletion, which may depend on various Fc gamma receptor (FcγR)-dependent mechanisms....
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M. Mason, Stephen Burgess, Susanna C. Larsson
Jul 29, 2021
Background: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index...
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Aug 29, 2021
Background
Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass...
Published by: PLoS Medicine
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia
Mathew Vithayathil, Paul Carter, Siddhartha Kar, Amy M Mason, Stephen Burgess, Susanna C Larsson
Sep 13, 2021
BACKGROUND: Evidence for the impact of body size and composition on cancer risk is limited. This mendelian randomisation (MR) study investigates evidence supporting causal relationships of body mass index (BMI), fat mass index...
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Sukru Anil Dogan, Raffaele Cerutti, Cristiane Benincá, Gloria Brea-Calvo, Howard Trevor Jacobs, Massimo Zeviani, Marten Szibor, Carlo Viscomi
Sep 08, 2018
Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O2. They have therefore been proposed as a potential therapeutic tool for mitochondrial diseases. We...
ROS alternative oxidase antioxidant Autophagy mitochondrial biogenesis mitochondrial disease redox signaling satellite cells stress responses Animals Autophagy Female Male Mice Mice Inbred C57BL Mice Knockout Mitochondrial Myopathies Mitochondrial Proteins Muscle Skeletal Organelle Biogenesis Oxidation-Reduction Oxidoreductases Plant Proteins Reactive Oxygen Species Signal Transduction
Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes.
The human body at cellular resolution
HuBMAP Consortium
Nov 29, 2019
Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program...
Smoking, alcohol consumption, and cancer
Susanna C Larsson, Paul Carter, Siddhartha Kar, Mathew Vithayathil, Amy M Mason, Karl Michaëlsson, Stephen Burgess
Aug 25, 2020
BACKGROUND: Smoking is a well-established cause of lung cancer and there is strong evidence that smoking also increases the risk of several other cancers. Alcohol consumption has been inconsistently associated with cancer risk...
Updates to data versions and analytic methods influence the reproducibility of results from epigenome-wide association studies
Alexandre A. Lussier, Yiwen Zhu, Brooke J. Smith, Andrew J. Simpkin, Andrew D.A.C. Smith, Matthew J. Suderman, Esther Walton, Kerry J. Ressler, Erin C. Dunn
Dec 31, 2022
Biomedical research has grown increasingly cooperative through the sharing of consortia-level epigenetic data. Since consortia preprocess data prior to distribution, new processing pipelines can lead to different versions of...
|
|< |
< |
1 |