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Poets in the Classroom
About the Poets:
Laurie Ann Guerrero is the author of Tongue in the Mouth of the Dying (University of Notre Dame Press 2013) and A Crown for Gumecindo (Aztlan Libre Press 2015). Her latest collection, I Have Eaten the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Assessing Business-IT Alignment Maturity at a Colombian University
Over the last decades, the role of the IT department within an organization has gradually gained importance. Technology has permeated all areas within organizations and nowadays is the cornerstone of almost all business...
Published by: IGI Global Scientific Publishing
Poets in the Classroom
About the Poets:
Laurie Ann Guerrero is the author of Tongue in the Mouth of the Dying (University of Notre Dame Press 2013) and A Crown for Gumecindo (Aztlan Libre Press 2015). Her latest collection, I Have Eaten the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Poets in the Classroom
About the Poets:
Laurie Ann Guerrero is the author of Tongue in the Mouth of the Dying (University of Notre Dame Press 2013) and A Crown for Gumecindo (Aztlan Libre Press 2015). Her latest collection, I Have Eaten the...
Published by: Digital Commons @ Texas A&M University-San Antonio
Review: Torres Cacoullos and Travis. 2018. Bilingualism in the Community: Code-switching and Grammars in Contact. Cambridge
Li Nguyen
Sep 10, 2019
Torres Cacoullos and Travis's ‘Bilingualism in the Community: Code-switching and Grammars in Contact’ is a comprehensive study of language contact in New Mexico – a well-established bilingual community in the Southwest of the...
Neural correlates of the severity of cocaine, heroin, alcohol, MDMA and cannabis use in polysubstance abusers
Laura Moreno-López, Emmanuel A Stamatakis, Maria José Fernández-Serrano, Manuel Gómez-Río, Antonio Rodríguez-Fernández, Miguel Pérez-García, Antonio Verdejo-García
Aug 08, 2017
INTRODUCTION: Functional imaging studies of addiction following protracted abstinence have not been systematically conducted to look at the associations between severity of use of different drugs and brain dysfunction. Findings...
Ten Years of SME E-Commerce Performance Factors and Metrics, 2011-2021
Small and medium enterprises (SMEs) generate 90% of employment and contribute more than 50% to the world product, where e-commerce (EC) is fundamental to their development. In this study, a systematic review of literature from...
Published by: IGI Global Scientific Publishing
Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways.
James RF Hockley, Rafael González-Cano, Sheridan McMurray, Miguel A Tejada-Giraldez, Cian McGuire, Antonio Torres, Anna L Wilbrey, Vincent Cibert-Goton, Francisco R Nieto, Thomas Pitcher, Charles H Knowles, José Manuel Baeyens, John N Wood, Wendy J Winchester, David C Bulmer, Cruz Miguel Cendán, Gordon McMurray
Sep 14, 2018
Nav1.7 Colorectal heat pain visceral nociception visceral pain voltage gated sodium channel Adult Aged Aged 80 and over Animals Capsaicin Female Humans Male Mice Mice Knockout Mustard Plant NAV1.7 Voltage-Gated Sodium Channel Nociceptive Pain Nociceptors Plant Oils Signal Transduction Sodium Channel Blockers visceral pain
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
Exome array analysis identifies ETFB as a novel susceptibility gene for anthracycline-induced cardiotoxicity in cancer patients.
Sara Ruiz-Pinto, Guillermo Pita, Miguel Martín, Teresa Alonso-Gordoa, Daniel R Barnes, María R Alonso, Belén Herraez, Purificación García-Miguel, Javier Alonso, Antonio Pérez-Martínez, Antonio J Cartón, Federico Gutiérrez-Larraya, José A García-Sáenz, Javier Benítez, Douglas F Easton, Ana Patiño-García, Anna González-Neira
Jan 30, 2018
PURPOSE: Anthracyclines are widely used chemotherapeutic drugs that can cause progressive and irreversible cardiac damage and fatal heart failure. Several genetic variants associated with anthracycline-induced cardiotoxicity...
Anthracyclines Chronic cardiotoxicity ETFB Long-term cancer survivors Low-frequency variants Adult Aged Anthracyclines Breast Neoplasms Cancer Survivors Cardiotoxicity Electron-Transferring Flavoproteins Exome Female Gene Expression Regulation Neoplastic Genetic Association Studies Genetic Predisposition to Disease Heart Failure Humans Middle Aged Mitochondria
Physical principles of membrane remodelling during cell mechanoadaptation.
Anita Joanna Kosmalska, Laura Casares, Alberto Elosegui-Artola, Joseph Jose Thottacherry, Roberto Moreno-Vicente, Víctor González-Tarragó, Miguel Ángel Del Pozo, Satyajit Mayor, Marino Arroyo, Daniel Navajas, Xavier Trepat, Nils C Gauthier, Pere Roca-Cusachs
Jan 06, 2020
Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope--the bilayer membrane. However, the fundamental biophysical principles by which the cell...
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.
Morag A Lewis, Elizabeth Quint, Anne M Glazier, Helmut Fuchs, Martin Hrabé de Angelis, Cordelia Langford, Stijn van Dongen, Cei Abreu-Goodger, Matias Piipari, Nick Redshaw, Tamas Dalmay, Miguel Angel Moreno-Pelayo, Anton J Enright, Karen P Steel
Jan 23, 2018
Progressive hearing loss is common in the human population, but little is known about the molecular basis. We report a new N-ethyl-N-nitrosurea (ENU)-induced mouse mutant, diminuendo, with a single base change in the seed region...
Intermittent schedules of the oral RAF-MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-mutant solid tumours and multiple myeloma
Christina Guo, Maxime Chénard-Poirier, Desamparados Roda, Maria de Miguel, Samuel J Harris, Irene Moreno Candilejo, Priya Sriskandarajah, Wen Xu, Mariana Scaranti, Anastasia Constantinidou, Jenny King, Mona Parmar, Alison J Turner, Suzanne Carreira, Ruth Riisnaes, Laura Finneran, Emma Hall, Yuji Ishikawa, Kiyohiko Nakai, Nina Tunariu, Bristi Basu, Martin Kaiser, Juanita Suzanne Lopez, Anna Minchom, Johann S de Bono, Udai Banerji
Oct 29, 2020
BACKGROUND: CH5126766 (also known as VS-6766, and previously named RO5126766), a novel MEK-pan-RAF inhibitor, has shown antitumour activity across various solid tumours; however, its initial development was limited by toxicity....
Quantitative XRD characterisation and gas-phase photocatalytic activity testing for visible-light (indoor applications) of KRONOClean 7000®
D Tobaldi, M Seabra, G. Otero-Irurueta, Yolanda Miguel, Richard Ball, M. K. Singh, R. C. Pullar, J A Labrincha
Nov 30, 2015
Carbon-modified commercial anatase (KRONOClean 7000®) was quantitatively characterised with XRD for the first time – full phase composition (both crystalline and amorphous content) and microstructure. The material was found to...
Enhancing Mitofusin/Marf ameliorates neuromuscular dysfunction in Drosophila models of TDP-43 proteinopathies.
Bilal Khalil, Marie-Jeanne Cabirol-Pol, Laetitia Miguel, Alexander J Whitworth, Magalie Lecourtois, Jean-Charles Liévens
Apr 05, 2019
ALS Dynamin-related protein 1 FTLD Mitochondria Mitochondrial Dynamics Animals DNA-Binding Proteins Disease Models Animal Drosophila Drosophila Proteins Dynamins Gene Expression Locomotion Membrane Proteins Mitochondria Mitochondrial Dynamics Molecular Targeted Therapy Neuromuscular Junction Neurons RNA Messenger TDP-43 Proteinopathies
Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner.
Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L Torres-Leal, Brian YH Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez, Omar Al-Massadi, Ruben Nogueiras
Apr 26, 2021
Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuin homologs of the yeast Sir2 gene that has emerged as an important player in the regulation of energy metabolism in peripheral tissues. However, its role in the hypothalamus...
dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.
Neurons rely on mitochondria as their preferred source of energy. Mutations in PINK1 and PARKIN cause neuronal death in early-onset Parkinson's disease (PD), thought to be due to mitochondrial dysfunction. In Drosophila pink1...
Activating Transcription Factor 4 Animals Drosophila Drosophila Proteins Folic Acid Glycine Hydroxymethyltransferase Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Mutagenesis Neuroprotection Parkinson Disease Phenotype Protein Serine-Threonine Kinases RNA Interference RNA Small Interfering Ubiquitin-Protein Ligases Up-Regulation
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity.
Estela González-Gualda, Marta Pàez-Ribes, Beatriz Lozano-Torres, David Macias, Joseph R Wilson, Cristina González-López, Hui-Ling Ou, Sofía Mirón-Barroso, Zhenguang Zhang, Araceli Lérida-Viso, Juan F Blandez, Andrea Bernardos, Félix Sancenón, Miguel Rovira, Ljiljana Fruk, Carla P Martins, Manuel Serrano, Gary J Doherty, Ramón Martínez-Máñez, Daniel Muñoz-Espín
Mar 24, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease...
Navitoclax (ABT-263) Cellular Senescence chemotherapy-induced senescence Lung cancer prodrug senolytics Thrombocytopenia Aniline Compounds Animals Antineoplastic Agents Apoptosis Blood Platelets Cell Survival Cellular Senescence Drug Screening Assays Antitumor Female Galactose Humans Mice Mice Inbred C57BL Mice SCID Molecular Structure Neoplasms Experimental prodrugs Sulfonamides Tumor Cells Cultured
The Influence of Organizational Ambidexterity on SME Speed of Internationalization
Small and medium enterprises (SMEs) require a combination of organizational and individual skills to grow more rapidly in international markets. The question is whether there is an ideal combination to compete in the present...
Published by: IGI Global Scientific Publishing
Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson's disease.
Rebeka Popovic, Amrita Mukherjee, Nuno Santos Leal, Lydia Morris, Yizhou Yu, Samantha H Y Loh, L Miguel Martins
Apr 17, 2023
Parkinson's disease (PD) is characterised by selective death of dopaminergic (DA) neurons in the midbrain and motor function impairment. Gastrointestinal issues often precede motor deficits in PD, indicating that the gut-brain...
Animals Drosophila Drosophila melanogaster Parkinson Disease Drosophila Proteins Unfolded Protein Response Protein Serine-Threonine Kinases
Published by: Cell Death & Disease
What Is an Algorithm?
Algorithms have emerged in past years as an object of public interest and debate. However, this term is used to name very different conceptions. The chapter presents the different definitions of the term “algorithm,” especially...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Quantitative XRD characterisation and gas-phase photocatalytic activity testing for visible-light (indoor applications) of KRONOClean 7000®
D Tobaldi, M Seabra, G. Otero-Irurueta, Yolanda Miguel, Richard Ball, M. K. Singh, R. C. Pullar, J A Labrincha
Nov 30, 2015
Carbon-modified commercial anatase (KRONOClean 7000®) was quantitatively characterised with XRD for the first time – full phase composition (both crystalline and amorphous content) and microstructure. The material was found to...
The Limits of Conventional Justification
Miguel Ohnesorge
Dec 28, 2020
This article develops a constructive criticism of methodological conventionalism. Methodological conventionalism asserts that standards of inductive risk ought to be justified in virtue of their ability to facilitate...
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