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Primary Selective Laser Trabeculoplasty for Open-Angle Glaucoma and Ocular Hypertension
Anurag Garg, Victoria Vickerstaff, Neil Nathwani, David Garway-Heath, Evgenia Konstantakopoulou, Gareth Ambler, Catey Bunce, Richard Wormald, Keith Barton, Gus Gazzard, Laser in Glaucoma and Ocular Hypertension Trial Study Group
Sep 11, 2020
PURPOSE: To report clinical efficacy, predictors of success, and safety of primary selective laser trabeculoplasty (SLT) used in treatment-naive patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). DESIGN: Post...
Glaucoma and intraocular pressure in EPIC-Norfolk Eye Study
Michelle PY Chan, David C Broadway, Anthony P Khawaja, Jennifer LY Yip, David F Garway-Heath, Jennifer M Burr, Robert Luben, Shabina Hayat, Nichola Dalzell, Kay-Tee Khaw, Paul J Foster
Jul 31, 2018
Objectives To report the distribution of intraocular pressure (IOP) by age and sex and the prevalence of glaucoma.Design Community based cross sectional observational study.Setting EPIC-Norfolk cohort in Norwich and the...
Comparison of Latanoprostene Bunod 0.024% and Timolol Maleate 0.5% in Open-Angle Glaucoma or Ocular Hypertension
Felipe A Medeiros, Keith R Martin, James Peace, Baldo Scassellati Sforzolini, Jason L Vittitow, Robert N Weinreb
Sep 03, 2019
PURPOSE: To compare the intraocular pressure (IOP)-lowering effect of latanoprostene bunod (LBN) 0.024% with timolol maleate 0.5% in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT). DESIGN: Prospective...
Retinal Vasculometry Associations With Glaucoma
Alicja R Rudnicka, Christopher G Owen, Roshan A Welikala, Sarah A Barman, Peter H Whincup, David P Strachan, Michelle PY Chan, Anthony P Khawaja, David C Broadway, Robert Luben, Shabina A Hayat, Kay-Tee Khaw, Paul J Foster
Sep 18, 2020
PURPOSE: To examine retinal vasculometry associations with different glaucomas in older British people. DESIGN: Cross-sectional study. METHODS: A total of 8,623 European Prospective Investigation into Cancer-Norfolk Eye study...
A study to assess the feasibility of undertaking a randomized controlled trial of adherence with eye drops in glaucoma patients.
Cliff Richardson, Lisa Brunton, Nicola Olleveant, David B Henson, Mark Pilling, Jane Mottershead, Cecilia H Fenerty, Anne Fiona Spencer, Heather Waterman
May 31, 2018
BACKGROUND: Adherence with therapy could influence the progression of glaucoma and ultimately affect the onset of visual impairment in some individuals. This feasibility study evaluated the measures to be used for a future...
Post Penetrating Keratoplasty Glaucoma
Aim: To study of incidence, etiological factors contributing to secondary glaucoma following Penetrating Keratoplasty (PK).Materials and methods: It was a prospective study carried out at tertiary eye care centre for period of 2...
Published by: IJHS Medical Association
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
Post Penetrating Keratoplasty Glaucoma
Aim: To study of incidence, etiological factors contributing to secondary glaucoma following Penetrating Keratoplasty (PK).Materials and methods: It was a prospective study carried out at tertiary eye care centre for period of 2...
Published by: IJHS Medical Association
Risk factors for previously undiagnosed primary open-angle glaucoma
Michelle PY Chan, Anthony P Khawaja, David C Broadway, Jennifer Yip, Robert Luben, Shabina Hayat, Tunde Peto, Kay-Tee Khaw, Paul J Foster
Jun 29, 2021
BACKGROUND AND AIM: Undiagnosed glaucoma is an invisible but important public health issue. At least half of glaucoma cases are estimated to be undiagnosed in western populations. The aim of this study is to examine risk factors...
Neuroprotection in Glaucoma
Purpose: The eye is currently at the forefront of translational medicine and therapeutics. However, despite advances in technology, primary open-angle glaucoma remains the leading cause of irreversible blindness worldwide....
An ontological foundation for ocular phenotypes and rare eye diseases.
Panagiotis I Sergouniotis, Emmanuel Maxime, Dorothée Leroux, Annie Olry, Rachel Thompson, Ana Rath, Peter N Robinson, Hélène Dollfus, ERN-EYE Ontology Study Group
Feb 15, 2019
BACKGROUND: The optical accessibility of the eye and technological advances in ophthalmic diagnostics have put ophthalmology at the forefront of data-driven medicine. The focus of this study is rare eye disorders, a group of...
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.
Vickie S Braithwaite, Sarah R Crozier, Stefania D'Angelo, Ann Prentice, Cyrus Cooper, Nicholas C Harvey, Kerry S Jones, MAVIDOS Trial Group
Feb 18, 2019
Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D₃ supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK...
C-Reactive Protein vitamin D ferritin Hepcidin Inflammation Pregnancy Adult Anemia Iron-Deficiency C-Reactive Protein Cholecalciferol Dietary Supplements Double-Blind Method Female Ferritins Hepcidins Humans Inflammation Iron Nutritional Status Pregnancy Pregnancy Complications Pregnancy Trimesters Seasons vitamin D Vitamin D Deficiency Young Adult
Study protocol: baby-OSCAR trial
Samir Gupta, Edmund Juszczak, Pollyanna Hardy, Nimish Subhedar, Jonathan Wyllie, Wilf Kelsall, Sunil Sinha, Sam Johnson, Tracy Roberts, Elisabeth Hutchison, Justine Pepperell, Louise Linsell, Jennifer L Bell, Kayleigh Stanbury, Marketa Laube, Clare Edwards, David Field, ‘The Baby-OSCAR Collaborative Group’
Jul 30, 2021
BACKGROUND: The question of whether to treat patent ductus arteriosus (PDA) early or wait until symptoms appear remains high on the research agenda for neonatal medicine. Around 7000 extremely preterm babies under 29 weeks'...
bronchopulmonary dysplasia Echocardiography Ibuprofen Newborn PDA patent ductus arteriosus Preterm bronchopulmonary dysplasia Ductus Arteriosus Patent Humans Ibuprofen Infant Infant Low Birth Weight Infant Newborn Infant Premature Diseases Multicenter Studies as Topic Randomized Controlled Trials as Topic
Final follow-up of the Multicentre Aneurysm Screening Study (MASS) randomized trial of abdominal aortic aneurysm screening.
SG Thompson, HA Ashton, L Gao, MJ Buxton, RAP Scott, Multicentre Aneurysm Screening Study (MASS) Group
Jan 27, 2020
BACKGROUND: The long-term effects of abdominal aortic aneurysm (AAA) screening were investigated in extended follow-up from the UK Multicentre Aneurysm Screening Study (MASS) randomized trial. METHODS: A population-based sample...
Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel–Lindau Disease
Hugh Furness, Louay Salfity, Johanna Devereux, Dorothy Halliday, Helen Hanson, Deborah M. Ruddy, UK VHL Study Group UK VHL Study Group, Neha Shah, George Sultana, Emma R. Woodward, Richard N. Sandford, Katie M. Snape, Eamonn R. Maher
Sep 17, 2021
Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel–Lindau (VHL) disease....
The HAVEN study-hydroxychloroquine in ANCA vasculitis evaluation-a multicentre, randomised, double-blind, placebo-controlled trial
Annastazia E Learoyd, Lauren Arnold, Fiona Reid, Nicholas Beckley-Hoelscher, Alina Casian, Shirish Sangle, Neil Morton, Louise Nel, Angela Cape, Susan John, Sangmi Kim, Dharshene Shivapatham, Raashid Luqmani, David Jayne, James Galloway, Abdel Douiri, David D'Cruz, HAVEN study group
Apr 06, 2023
BACKGROUND: Patients with non-severe ANCA-associated vasculitis (AAV) are often prescribed immunosuppressive medications that are associated with severe side effects and a reduced quality of life. There is an unmet need for...
Study within a trial (SWAT) protocol. Participants' perspectives and preferences on clinical trial result dissemination
Emmy Racine, Caroline Hurley, Aoife Cheung, Carol Sinnott, Karen Matvienko-Sikar, William H Smithson, Patricia M Kearney
Jan 18, 2018
INTRODUCTION: Dissemination of results of randomised controlled trials is traditionally limited to academic and professional groups rather than clinical trial participants. While there is increasing consensus that results should...
Surveillance arterioveNous fistulAs using ultRasound (SONAR) trial in haemodialysis patients
James Richards, Mohammed Hossain, Dominic Summers, Matthew Slater, Matthew Bartlett, Vasilis Kosmoliaptsis, Edward Cf Wilson, Regin Lagaac, Anna Sidders, Claire Foley, Emma Laing, Valerie Hopkins, Chloe Fitzpatrick-Creamer, Cara Hudson, Helen Thomas, Sam Turner, Andrew Tambyraja, Subash Somalanka, James Hunter, Sam Dutta, Sarah Lawman, Tracey Salter, Mohammed Aslam, Atul Bagul, Rajesh Sivaprakasam, George Smith, Zia Moinuddin, Simon Knight, Paul Gibbs, Reza Motallebzadeh, Nicholas Barnett, Gavin Pettigrew, SONAR trial group
Oct 21, 2019
INTRODUCTION: Arteriovenous fistulas (AVFs) are considered the best and safest modality for providing haemodialysis in patients with end-stage renal disease. Only 20% of UK centres achieve the recommended 80% target for...
A Modified Progressive Supranuclear Palsy Rating Scale.
Marie-Therese Grötsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea FM Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macías-García, Wassilios G Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B Rowe, Klaus Seppi, Maria Stamelou, John C van Swieten, Gregor Wenning, Teodoro del Ser, Lawrence I Golbe, Günter U Höglinger, the ProPSP Study Group, and the Movement Disorder Society-Endorsed PSP Study Group Describe PSP Study Group
Jan 26, 2021
BACKGROUND: The Progressive Supranuclear Palsy Rating Scale is a prospectively validated physician-rated measure of disease severity for progressive supranuclear palsy. We hypothesized that, according to experts' opinion...
Hypertensive patients and its association with age and gender
Objective: To evaluate the resistant hypertension in hypertensive patients and its association with age and gender.
Material and methods: This cross sectional study was conducted at Basic Health Unit, Hassan Mandi Bahauddin...
Published by: IJHS Medical Association
Hypertensive patients and its association with age and gender
Objective: To evaluate the resistant hypertension in hypertensive patients and its association with age and gender.
Material and methods: This cross sectional study was conducted at Basic Health Unit, Hassan Mandi Bahauddin...
Published by: IJHS Medical Association
Diffusional Kurtosis Imaging of White Matter Degeneration in Glaucoma.
Carlo Nucci, Francesco Garaci, Simone Altobelli, Francesco Di Ciò, Alessio Martucci, Francesco Aiello, Simona Lanzafame, Francesca Di Giuliano, Eliseo Picchi, Silvia Minosse, Massimo Cesareo, Maria Giovanna Guerrisi, Roberto Floris, Luca Passamonti, Nicola Toschi
Sep 24, 2020
Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells and loss of their axons, progressively leading to blindness. Recently, glaucoma has been conceptualized as a more diffuse neurodegenerative...
Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
Anthony P Khawaja, Jessica N Cooke Bailey, Nicholas J Wareham, Robert A Scott, Mark Simcoe, Robert P Igo, Yeunjoo E Song, Robert Wojciechowski, Ching-Yu Cheng, Peng T Khaw, Louis R Pasquale, Jonathan L Haines, Paul J Foster, Janey L Wiggs, Chris J Hammond, Pirro G Hysi, UK Biobank Eye and Vision Consortium, NEIGHBORHOOD Consortium
Aug 07, 2019
Glaucoma is the leading cause of irreversible blindness globally 1 . Despite its gravity, the disease is frequently undiagnosed in the community 2 . Raised intraocular pressure (IOP) is the most important risk factor for primary...
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