Search
Results: 3055
Using VR for Collaborative Learning
Although virtual reality (VR) has been technologically possible for decades, both logistical and pedagogical limitations have slowed progress relating to collaborating with others in virtual reality environments. This article...
Global Information Technology Computer Science and Information Technology Global Information Technology Physical Sciences and Engineering Business and Management
Published by: IGI Global Scientific Publishing
Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?
Jason K Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Gregg Wallis, Roshani Patel, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray Kruse Iles
Jul 10, 2022
The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is...
Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why?
Jason K Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Gregg Wallis, Roshani Patel, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray Kruse Iles
May 30, 2022
The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is...
SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases.
Jason Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Jernej Ule, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray K Iles
May 24, 2022
The immune response to SARS-CoV-2 infection requires antibody recognition of the spike protein. In a study designed to examine the molecular features of anti-spike and anti-nucleocapsid antibodies, patient plasma proteins...
SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases.
Jason Iles, Raminta Zmuidinaite, Christoph Sadee, Anna Gardiner, Jonathan Lacey, Stephen Harding, Jernej Ule, Debra Roblett, Jonathan Heeney, Helen Baxendale, Ray K Iles
Apr 09, 2022
The immune response to SARS-CoV-2 infection requires antibody recognition of the spike protein. In a study designed to examine the molecular features of anti-spike and anti-nucleocapsid antibodies, patient plasma proteins...
Impacts of Spike Shape Variations on Synaptic Communication.
Understanding the communication theoretical capabilities of information transmission among neurons, known as neuro-spike communication, is a significant step in developing bio-inspired solutions for nanonetworking. In this...
A chemometric study of ageing in lead-based paints
The development of non-invasive analytical methods is of widespread interest to the field of conservation science, providing chemical insight into the materials used to create painted works of art, which can, for example, inform...
A New Method for Neural Spike Alignment
Recordings made directly from the nervous system are a key tool in experimental electrophysiology and the development of bioelectronic medicines. Analysis of these recordings involves the identification of signals from...
A chemometric study of ageing in lead-based paints
The development of non-invasive analytical methods is of widespread interest to the field of conservation science, providing chemical insight into the materials used to create painted works of art, which can, for example, inform...
A New Method for Neural Spike Alignment
Recordings made directly from the nervous system are a key tool in experimental electrophysiology and the development of bioelectronic medicines. Analysis of these recordings involves the identification of signals from...
Sum Rate of MISO Neuro-Spike Communication Channel With Constant Spiking Threshold.
Communication among neurons, known as neuro-spike communication, is the most promising technique for realization of a bio-inspired nanoscale communication paradigm to achieve biocompatible nanonetworks. In neuro-spike...
Pull-out and shear-strength models for FRP spike anchors
Paula Villanueva Llauradó, Tim Ibell, Jaime Fernández Gómez, Francisco J. González Ramos
May 01, 2017
Spike anchors are a promising way to enhance the maximum capacity and post-peak load-strain response of externally-bonded fibre-reinforced polymer (FRP) materials for retrofitting of concrete structures. Although laboratory...
Estimating the concentrations of pigments and binders in lead-based paints using FT-Raman spectroscopy and principal component analysis
Anuradha Pallipurath, Róza Villȍ Vȍfély, Jonathan Skelton, Paola Ricciardi, Spike Bucklow, Stephen Elliott
Nov 01, 2014
Understanding the composition of the paints used on works of art is crucial in attributing them to the artist or workshop that created them, as well as to devising strategies for their preservation and restoration. Much current...
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
Erik Volz, Verity Hill, John T McCrone, Anna Price, David Jorgensen, Áine O'Toole, Joel Southgate, Robert Johnson, Ben Jackson, Fabricia F Nascimento, Sara M Rey, Samuel M Nicholls, Rachel M Colquhoun, Ana da Silva Filipe, James Shepherd, David J Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, COG-UK Consortium, Ian Goodfellow, Nicholas J Loman, Oliver G Pybus, David L Robertson, Emma C Thomson, Andrew Rambaut, Thomas R Connor
Jan 12, 2021
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection...
No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor
Jarrod Shilts, Thomas W. M. Crozier, Edward J. D. Greenwood, Paul J. Lehner, Gavin J. Wright
Jan 11, 2021
Abstract: The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be...
Estimating the concentrations of pigments and binders in lead-based paints using FT-Raman spectroscopy and principal component analysis
Anuradha Pallipurath, Róza Villȍ Vȍfély, Jonathan Skelton, Paola Ricciardi, Spike Bucklow, Stephen Elliott
Nov 01, 2014
Understanding the composition of the paints used on works of art is crucial in attributing them to the artist or workshop that created them, as well as to devising strategies for their preservation and restoration. Much current...
Pull-out and shear-strength models for FRP spike anchors
Paula Villanueva Llauradó, Tim Ibell, Jaime Fernández Gómez, Francisco J. González Ramos
May 01, 2017
Spike anchors are a promising way to enhance the maximum capacity and post-peak load-strain response of externally-bonded fibre-reinforced polymer (FRP) materials for retrofitting of concrete structures. Although laboratory...
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses.
Christopher A Beaudoin, Arian R Jamasb, Ali F Alsulami, Liviu Copoiu, Andries J van Tonder, Sharif Hala, Bridget P Bannerman, Sherine E Thomas, Sundeep Chaitanya Vedithi, Pedro HM Torres, Tom L Blundell
Jul 16, 2021
Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the...
Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction.
Drug repositioning continues to be the most effective, practicable possibility to treat COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters target cells by binding to the ACE2...
Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
Carine Waase-Maurer
Jan 01, 0001
Work in Caenorhabditis elegans has been instrumental in deciphering the molecular basis of programmed cell death. However, despite extensive characterization of broadacting cell death genes, the molecular events triggering...
Published by: Rockefeller University
Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a highly infectious disease that is severely affecting our society and welfare systems. In order to develop therapeutic interventions against...
No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor.
The spike protein of SARS-CoV-2 is known to enable viral invasion into human cells through direct binding to host receptors including ACE2. An alternate entry receptor for the virus was recently proposed to be basigin/CD147....
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C James, Katarzyna A Ciazynska, Xiaoli Xiong, John AG Briggs, James A Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth GC Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni Gkrania-Klotsas, Susie Hardwick, Adrian Boyle, Ian Goodfellow, Ravindra K Gupta, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration
Sep 29, 2020
Rapid COVID-19 diagnosis in the hospital is essential, although this is complicated by 30%-50% of nose/throat swabs being negative by SARS-CoV-2 nucleic acid amplification testing (NAAT). Furthermore, the D614G spike mutant...
covid-19 D614G SARS-CoV-2 point of care testing rapid diagnoses Aged Aged 80 and over Antibodies Viral covid-19 COVID-19 Testing Female Humans Immunoassay Male Middle Aged Neutralization Tests Nucleic Acid Amplification Techniques Point-of-care testing SARS-CoV-2 Sensitivity and Specificity Spike Glycoprotein Coronavirus
Determination of intermediate state structures in the opening pathway of SARS-CoV-2 spike using cryo-electron microscopy.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a highly infectious disease that is severely affecting our society and welfare systems. In order to develop therapeutic interventions against...
Published by: Chemical science
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Halina Mikolajek, Miriam Weckener, Z Faidon Brotzakis, Jiandong Huo, Evmorfia V Dalietou, Audrey Le Bas, Pietro Sormanni, Peter J Harrison, Philip N Ward, Steven Truong, Lucile Moynie, Daniel K Clare, Maud Dumoux, Joshua Dormon, Chelsea Norman, Naveed Hussain, Vinod Vogirala, Raymond J Owens, Michele Vendruscolo, James H Naismith
Aug 20, 2022
Camelid single-domain antibodies, also known as nanobodies, can be readily isolated from naïve libraries for specific targets but often bind too weakly to their targets to be immediately useful. Laboratory-based genetic...
|
|< |
< |
1 |