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A Novel Trust Model for Secure Group Communication in Distributed Computing
Distributed networks are networks in which each node can act as a server or client and hence any node can provide service to any other node. In such a scenario, establishing a trust model between the service providing user and...
Published by: IGI Global Scientific Publishing
The Dramatic Prologues of Alexander Nowell
Micha Lazarus
Jun 28, 2017
Alexander Nowell, headmaster of Westminster, left a rough manuscript notebook that contains Latin prose prologues to three classical plays performed by his pupils at Westminster in the 1540s: Terence’s $\textit{Adelphoe}$ and...
Environmental signal shredding on sandy coastlines
How storm events contribute to long-term shoreline change over decades to centuries remains an open question in coastal research. Sand and gravel coasts exhibit remarkable resilience to event-driven disturbances, and, in...
Environmental signal shredding on sandy coastlines
How storm events contribute to long-term shoreline change over decades to centuries remains an open question in coastal research. Sand and gravel coasts exhibit remarkable resilience to event-driven disturbances, and, in...
Impact of the Crossrail tunnelling project on masonry buildings with shallow foundations
Matthew J. DeJong, Giorgia Giardina, Benjamin Chalmers, Deborah Lazarus, David Ashworth, Robert J. Mair
Oct 01, 2019
Building monitoring and protection are important components of underground projects in urban areas. Typically the procedures applied for the assessment of settlement-induced damage to buildings are based on simplified...
Impact of the Crossrail tunnelling project on masonry buildings with shallow foundations
Matthew J. DeJong, Giorgia Giardina, Benjamin Chalmers, Deborah Lazarus, David Ashworth, Robert J. Mair
Oct 01, 2019
Building monitoring and protection are important components of underground projects in urban areas. Typically the procedures applied for the assessment of settlement-induced damage to buildings are based on simplified...
How to Set Up, Manage, and Study a UBI+ Experiment The Case of the ‘WorkFREE’ Project in Hyderabad, India
Vibhor Mathur, Neil Howard, Joel Lazarus, Tanushree Bhan, Sumiran Ardhapure, Bijita Devsharma
Nov 01, 2023
WorkFREE is a collaborative research project led by the University of Bath, UK in partnership with the Montfort Social Institute (MSI) and the India Network for Basic Income (INBI). It is funded by the European Research Council...
Strong Roots Climate Change Perception Report-Views of Community Councillors in Wales
There are 736 community and town councils in Wales, representing the tier of government closest to the people. They cover approximately 94% of the land area and 70% of the population . When considering climate change, it is at...
How to Set Up, Manage, and Study a UBI+ Experiment The Case of the ‘WorkFREE’ Project in Hyderabad, India
Vibhor Mathur, Neil Howard, Joel Lazarus, Tanushree Bhan, Sumiran Ardhapure, Bijita Devsharma
Nov 01, 2023
WorkFREE is a collaborative research project led by the University of Bath, UK in partnership with the Montfort Social Institute (MSI) and the India Network for Basic Income (INBI). It is funded by the European Research Council...
Strong Roots Climate Change Perception Report-Views of Community Councillors in Wales
There are 736 community and town councils in Wales, representing the tier of government closest to the people. They cover approximately 94% of the land area and 70% of the population . When considering climate change, it is at...
Semantic Web-Based Energy-Efficient Design of Dual-Mode Vehicles Based on Deep Neural Networks
Dual-Mode Vehicles (DMVs) represent a new and sustainable solution to the problems of urban mobility, and energy consumption. This proposed work of a DMV can operate without a conventional battery. Instead, it uses a combination...
Published by: IGI Global Scientific Publishing
The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.
Auxin transport through non-hair cells sustains root-hair development.
Angharad R Jones, Eric M Kramer, Kirsten Knox, Ranjan Swarup, Malcolm J Bennett, Colin M Lazarus, HM Ottoline Leyser, Claire S Grierson
Apr 23, 2021
The plant hormone auxin controls root epidermal cell development in a concentration-dependent manner. Root hairs are produced on a subset of epidermal cells as they increase in distance from the root tip. Auxin is required for...
Stress and Coping Experiences of UK Professional Football Managers During the COVID-19 Pandemic
Guided by transactional stress theory, this study aimed to explore elite U.K. soccer coaches’ perceived stressors, the situational properties, appraisals, and coping during the COVID-19 pandemic. This study also aimed to explore...
Stress and Coping Experiences of UK Professional Football Managers During the COVID-19 Pandemic
Guided by transactional stress theory, this study aimed to explore elite U.K. soccer coaches’ perceived stressors, the situational properties, appraisals, and coping during the COVID-19 pandemic. This study also aimed to explore...
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A. Lazarus, Mona Shehata, Bruno M. Simões, Alice R. Greenhalgh, Sacha J. Howell, Robert B. Clarke, Carlos Caldas, Timotheus Y. F. Halim, John C. Marioni, Walid T. Khaled
Mar 09, 2021
Abstract: It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little...
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
Karsten Bach, Sara Pensa, Marija Zarocsinceva, Katarzyna Kania, Julie Stockis, Silvain Pinaud, Kyren A Lazarus, Mona Shehata, Bruno M Simões, Alice R Greenhalgh, Sacha J Howell, Robert B Clarke, Carlos Caldas, Timotheus YF Halim, John C Marioni, Walid T Khaled
Feb 12, 2021
It is unclear how genetic aberrations impact the state of nascent tumour cells and their microenvironment. BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known...
BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma.
Kyren A Lazarus, Fazal Hadi, Elisabetta Zambon, Karsten Bach, Maria-Francesca Santolla, Julie K Watson, Lucia L Correia, Madhumita Das, Rosemary Ugur, Sara Pensa, Lukas Becker, Lia S Campos, Graham Ladds, Pentao Liu, Gerard I Evan, Frank M McCaughan, John Le Quesne, Joo-Hyeon Lee, Dinis Calado, Walid T Khaled
Sep 20, 2018
Animals Carcinoma Squamous Cell Carrier Proteins Cell Line Tumor Cell Proliferation Epigenesis Genetic Gene Expression Regulation Neoplastic Gene Knockdown Techniques Genetic Loci Histone-Lysine N-Methyltransferase Humans Lung Lung Neoplasms Mice Nuclear Proteins Oncogenes Organoids Protein Binding Repressor Proteins SOXB1 Transcription Factors
Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates
Weidong Zhang, Loc Le, Gul Ahmad, Adebayo J Molehin, Arif J Siddiqui, Workineh Torben, Souvik Karmakar, Juan U Rojo, Souad Sennoune, Samara Lazarus, Sabiha Khatoon, Jasmin Freeborn, Justin Sudduth, Ashraf F Rezk, David Carey, Roman F Wolf, James F Papin, Ray Damian, Sean A Gray, Florian Marks, Darrick Carter, Afzal A Siddiqui
Jul 03, 2020
Recent advances in systems biology have shifted vaccine development from a largely trial-and-error approach to an approach that promote rational design through the search for immune signatures and predictive correlates of...
Sm-p80-based schistosomiasis vaccine
Weidong Zhang, Adebayo J Molehin, Juan U Rojo, Justin Sudduth, Pramodh K Ganapathy, Eunjee Kim, Arif J Siddiqui, Jasmin Freeborn, Souad R Sennoune, Jordan May, Samra Lazarus, Catherine Nguyen, Whitni K Redman, Gul Ahmad, Workineh Torben, Souvik Karmakar, Loc Le, Kameswara R Kottapalli, Pratibha Kottapalli, Roman F Wolf, James F Papin, David Carey, Sean A Gray, Jenn D Bergthold, Raymond T Damian, Bryan T Mayer, Florian Marks, Steven G Reed, Darrick Carter, Afzal A Siddiqui
Jul 31, 2019
Schistosomiasis is of public health importance to an estimated one billion people in 79 countries. A vaccine is urgently needed. Here, we report the results of four independent, double-blind studies of an Sm-p80-based vaccine in...
Schistosoma mansoni Sm-p80 vaccine baboons EFFICACY Schistosomiasis Systems Biology Animals Antibodies Protozoan Double-Blind Method Female Gene Expression Profiling Male Papio Parasite Egg Count Protozoan Proteins Protozoan Vaccines Real-Time Polymerase Chain Reaction Reproducibility of Results Schistosoma mansoni Schistosomiasis Transcription Genetic
The EASL–Lancet Liver Commission
Tom H. Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J. Hutchinson, Bruno Sangro, Natasha K. Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y. Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J. Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Järvinen, Chris D. Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y. Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Núria Fabrellas, Ann T. Ma, Juan M. Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey V. Lazarus, Pere Ginès, Maria Buti, Philip N. Newsome, Patrizia Burra, Michael P. Manns
Jan 01, 2022
Liver diseases have become a major health threat across Europe, and the face of European hepatology is changing due to the cure of viral hepatitis C and the control of chronic viral hepatitis B, the increasingly widespread...
The EASL–Lancet Liver Commission
Tom H. Karlsen, Nick Sheron, Shira Zelber-Sagi, Patrizia Carrieri, Geoffrey Dusheiko, Elisabetta Bugianesi, Rachel Pryke, Sharon J. Hutchinson, Bruno Sangro, Natasha K. Martin, Michele Cecchini, Mae Ashworth Dirac, Annalisa Belloni, Miquel Serra-Burriel, Cyriel Y. Ponsioen, Brittney Sheena, Alienor Lerouge, Marion Devaux, Nick Scott, Margaret Hellard, Henkjan J. Verkade, Ekkehard Sturm, Giulio Marchesini, Hannele Yki-Järvinen, Chris D. Byrne, Giovanni Targher, Aviad Tur-Sinai, Damon Barrett, Michael Ninburg, Tatjana Reic, Alison Taylor, Tim Rhodes, Carla Treloar, Claus Petersen, Christoph Schramm, Robert Flisiak, Marieta Y. Simonova, Albert Pares, Philip Johnson, Alessandro Cucchetti, Isabel Graupera, Christos Lionis, Elisa Pose, Núria Fabrellas, Ann T. Ma, Juan M. Mendive, Vincenzo Mazzaferro, Harry Rutter, Helena Cortez-Pinto, Deirdre Kelly, Robyn Burton, Jeffrey V. Lazarus, Pere Ginès, Maria Buti, Philip N. Newsome, Patrizia Burra, Michael P. Manns
Jan 01, 2022
Liver diseases have become a major health threat across Europe, and the face of European hepatology is changing due to the cure of viral hepatitis C and the control of chronic viral hepatitis B, the increasingly widespread...
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7)
Katherine RW Emary, Tanya Golubchik, Parvinder K Aley, Cristina V Ariani, Brian Angus, Sagida Bibi, Beth Blane, David Bonsall, Paola Cicconi, Sue Charlton, Elizabeth A Clutterbuck, Andrea M Collins, Tony Cox, Thomas C Darton, Christina Dold, Alexander D Douglas, Christopher JA Duncan, Katie J Ewer, Amy L Flaxman, Saul N Faust, Daniela M Ferreira, Shuo Feng, Adam Finn, Pedro M Folegatti, Michelle Fuskova, Eva Galiza, Anna L Goodman, Catherine M Green, Christopher A Green, Melanie Greenland, Bassam Hallis, Paul T Heath, Jodie Hay, Helen C Hill, Daniel Jenkin, Simon Kerridge, Rajeka Lazarus, Vincenzo Libri, Patrick J Lillie, Catherine Ludden, Natalie G Marchevsky, Angela M Minassian, Alastair C McGregor, Yama F Mujadidi, Daniel J Phillips, Emma Plested, Katrina M Pollock, Hannah Robinson, Andrew Smith, Rinn Song, Matthew D Snape, Rebecca K Sutherland, Emma C Thomson, Mark Toshner, David PJ Turner, Johan Vekemans, Tonya L Villafana, Christopher J Williams, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Merryn Voysey, Maheshi N Ramasamy, Andrew J Pollard, COVID-19 Genomics UK Consortium, AMPHEUS Project, Oxford COVID-19 Vaccine Trial Group
May 06, 2021
BACKGROUND: A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19...
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 VOC 202012/01 (B.1.1.7), an exploratory analysis of a randomised controlled trial
Katherine RW Emary, Tanya Golubchik, Parvinder K Aley, Cristina V Ariani, Brian Angus, Sagida Bibi, Beth Blane, David Bonsall, Paola Cicconi, Sue Charlton, Elizabeth A Clutterbuck, Andrea M Collins, Tony Cox, Thomas C Darton, Christina Dold, Alexander D Douglas, Christopher JA Duncan, Katie J Ewer, Amy L Flaxman, Saul N Faust, Daniela M Ferreir, Shuo Feng, Adam Finn, Pedro M Folegatti, Michelle Fuskova, Eva Galiza, Anna L Goodman, Catherine M Green, Christopher A Green, Melanie Greenland, Bassam Hallis, Paul T Heath, Jodie Hay, Helen C Hill, Daniel Jenkin, Simon Kerridge, Rajeka Lazarus, Vincenzo Libri, Patrick J Lillie, Catherine Ludden, Natalie G Marchevsky, Angela M Minassian, Alastair C McGregor, Yama F Mujadidi, Daniel J Phillips, Emma Plested, Katrina M Pollock, Hannah Robinson, Andrew Smith, Rinn Song, Matthew D Snape, Rebecca K Sutherland, Emma C Thomson, Mark Toshner, David PJ Turner, Johan Vekemans, Tonya L Villafana, Christopher J Williams, Adrian VS Hill, Teresa Lambe, Sarah C Gilbert, Merryn Voysey, Maheshi N Ramasamy, Andrew J Pollard, the COVID-19 Genomics UK consortium, the AMPHEUS Project, the Oxford COVID-19 Vaccine Trial Group
Jun 04, 2021
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